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- Candlewood Suites Cape Girardeau by IHG
- Best Western Marion Hotel
- Pear Tree Inn Cape Girardeau West
- Super 8 by Wyndham Carbondale
- Quality Inn & Suites Marion
- Quality Inn Cape Girardeau North
- Best Western Saluki Inn
- Courtyard by Marriott Cape Girardeau Downtown
- University Inn of Carbondale by Hotel O
- Holiday Inn Express & Suites Carbondale - University Area by IHG
- Comfort Inn & Suites Marion I-57
- Drury Inn & Suites Cape Girardeau
- Country Inn & Suites by Radisson, Marion, IL
- Home2 Suites by Hilton Carbondale
- Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
- Motel 6 Marion, IL
- Hampton Inn Carbondale
- Tru By Hilton Cape Girardeau
- Holiday Inn Express Hotel & Suites Marion Northeast by IHG
- Peaceful secluded cabin located near Horseshoe Lake