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Go beyond your typical stay in Advance

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Check prices for these dates

Tonight
7 Nov - 8 Nov
Tomorrow
8 Nov - 9 Nov
Next weekend
13 Nov - 15 Nov
In two weeks
20 Nov - 22 Nov

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Our top choices for Advance hotels

A living room with a blue wall, a fireplace, a sofa, and a chair.

1. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.4 out of 10, Exceptional, (118 reviews)
"Awesome hotel and staff was first rate, everything was fantastic. If you are in the area, stay at this hotel and eat in!!"
United States
Jan
The price is SARĀ 335
SARĀ 365 total
includes taxes & fees
15 Nov - 16 Nov
EC Reed's Mercantile and Hotel
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

2. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,002 reviews)
"Great stay! Hot tub was enjoyable and the staff was super friendly!"
United States
Chris
The price is SARĀ 372
SARĀ 419 total
includes taxes & fees
15 Nov - 16 Nov
Drury Plaza Hotel Cape Girardeau Conference Center
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

3. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,000 reviews)
"Perfect location, beds were awesome & staff were friendly & accommodating!"
United States
Rebecca
The price is SARĀ 357
SARĀ 406 total
includes taxes & fees
6 Dec - 7 Dec
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

4. Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (652 reviews)
"Great hotel, clean spacious room, good breakfast choice"
United Kingdom
Deborah
The price is SARĀ 377
SARĀ 428 total
includes taxes & fees
22 Nov - 23 Nov
Hampton Inn Sikeston
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

5. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,001 reviews)
"The hotel was clean, comfortable and the breakfast was good."
United States
Leonardo
The price is SARĀ 300
SARĀ 317 total
includes taxes & fees
22 Nov - 23 Nov
Drury Inn & Suites Jackson MO
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

6. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (893 reviews)
"Breakfast was good."
United States
J
The price is SARĀ 300
SARĀ 325 total
includes taxes & fees
15 Nov - 16 Nov
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

7. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (118 reviews)
"Friendly staff, great breakfast, nice amenities"
United States
Roslyn
The price is SARĀ 379
SARĀ 431 total
includes taxes & fees
15 Nov - 16 Nov
Fairfield Inn & Suites by Marriott Sikeston
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

8. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.2 out of 10, Wonderful, (1,000 reviews)
"The stay was pleasant from start to finish. Extremely nice staff, good breakfast and convenient parking. The location was also great!"
United States
Celeste
The price is SARĀ 270
SARĀ 305 total
includes taxes & fees
15 Nov - 16 Nov
Pear Tree Inn Cape Girardeau West
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

9. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (199 reviews)
"Had a great stay friendly staff very clean facilities!"
United States
Shannon
The price is SARĀ 320
SARĀ 364 total
includes taxes & fees
16 Nov - 17 Nov
Tru By Hilton Cape Girardeau
Property amenity

10. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (31 reviews)
"I liked the lobby, bar and breakfast areas. The full breakfast buffet was awesome. Super nice room with kitchenette. Staff were great."
United States
Mark
The price is SARĀ 396
SARĀ 450 total
includes taxes & fees
15 Nov - 16 Nov
TownePlace Suites by Marriott Sikeston
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

11. The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (702 reviews)
"Every time I stay here I truly enjoy my stay Clean rooms and staff is very attentive Will stay here again"
United States
Irvin
The price is SARĀ 412
SARĀ 465 total
includes taxes & fees
15 Nov - 16 Nov
The Riverview
A spacious lobby with large windows, comfortable seating, and a modern ceiling design.

12. Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
2.5 star property
Jackson
8.0 out of 10, Very good, (785 reviews)
"Overall very nice place clean excellent staff awesome breakfast and very good coffee bed very comfortable very nice updated rooms.. I plan on staying there again šŸ˜€"
United States
Jeff
The price is SARĀ 283
SARĀ 306 total
includes taxes & fees
6 Dec - 7 Dec
Comfort Suites Jackson-Cape Girardeau
A conference room with a long table, multiple chairs, and a television screen on the wall.

13. Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.8 out of 10, Excellent, (522 reviews)
"I have always have a great stay each time Iā€™ve been here. Beds comfortable and rooms very clean."
United States
Melissa
The price is SARĀ 357
SARĀ 406 total
includes taxes & fees
6 Dec - 7 Dec
Holiday Inn Express & Suites Sikeston Southwest by IHG
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.

14. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (858 reviews)
"Everything was lovely. Great room, breakfast, pool, and staff."
United States
Vonnie
The price is SARĀ 366
SARĀ 413 total
includes taxes & fees
15 Nov - 16 Nov
Hampton Inn Cape Girardeau I 55 East
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

15. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
"Clean, spacious suite, enjoyable kick back and breakfast!"
United States
Mary
The price is SARĀ 338
SARĀ 381 total
includes taxes & fees
12 Nov - 13 Nov
Drury Inn & Suites Cape Girardeau
A hotel room with a bed, a desk, a chair, a bathroom with a bathtub, and a patterned floor.

16. Econo Lodge Dexter

Econo Lodge Dexter
2.0 star property
Dexter
6.8 out of 10, (289 reviews)
"The place was okay for a night"
United States
Herman
The price is SARĀ 191
SARĀ 217 total
includes taxes & fees
8 Dec - 9 Dec
Econo Lodge Dexter
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

17. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (240 reviews)
"Great hotelā€¦!!"
United States
Carlos
The price is SARĀ 380
SARĀ 428 total
includes taxes & fees
12 Nov - 13 Nov
Fairfield Inn & Suites by Marriott Cape Girardeau
A modern lounge area with seating arrangements, a kitchen area, and a bar.

18. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
9.6 out of 10, Exceptional, (82 reviews)
"This place is Brand new and really great!"
United States
Bryan
The price is SARĀ 366
SARĀ 415 total
includes taxes & fees
15 Nov - 16 Nov
Hampton Inn By Hilton Dexter
A spacious lobby with marble flooring, elegant seating, and a grand staircase.

19. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (557 reviews)
"The staff was very friendly and rooms were great!"
United States
Jacqueline
The price is SARĀ 436
SARĀ 494 total
includes taxes & fees
19 Nov - 20 Nov
Courtyard by Marriott Cape Girardeau Downtown
A hotel room with a bed, a desk, a chair, a large mirror, a sink, and a trash bin.

20. Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
2.0 star property
Dexter
7.6 out of 10, Good, (425 reviews)
"Staff was very friendly"
United States
Steven
The price is SARĀ 332
SARĀ 376 total
includes taxes & fees
15 Nov - 16 Nov
Travelodge by Wyndham Dexter
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Advance Hotel Reviews

A living room with a blue wall, a fireplace, a sofa, and a chair.
EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill

10/10 Excellent

Awesome hotel and staff was first rate, everything was fantastic. If you are in the area, stay at this hotel and eat in!!
United States
Jan
Reviewed October 19, 2026
EC Reed's Mercantile and Hotel

Frequently Asked Questions

What are some of the best vacation rentals that Advance has to offer?

3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau: This vacation home rental outside of Advance is equipped with a barbecue grill, air-conditioning, and laundry facilities to help you feel comfortable during your stay. Kitchen amenities include a dishwasher, a fridge, and a stovetop. See all vacation rentals in Advance.

If I need to cancel my hotel reservation in Advance, will I receive a refund?

Yes! The majority of hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Advance.

Where can I learn more about changing or cancelling my trip to Advance?

To access more information about changing or cancelling your trip to Advance, go to https://www.expedia.com/service/.