Find 5 Star Hotels in Edisto Island, SC
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Check availability on Edisto Island 5 Star Hotels
Tonight
Tomorrow
This weekend
Next weekend
Compare Edisto Island 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Learn more about Edisto Island
Escape to relaxing Edisto Island! Enjoy its island views, beaches, and camping.

Explore a world of travel with Expedia
Explore a world of travel with Expedia
Edisto Island Hotels by Star Rating
Stay near popular Edisto Island attractions
- Hotels near Edisto Beach State Park
- Hotels near Botany Bay Plantation
- Hotels near Botany Bay Plantation Heritage Preserve and Wildlife Management Area
- Hotels near Edisto Island Serpentarium
- Hotels near Plantation Course at Edisto
- Hotels near Edisto Island Museum
- Hotels near With These Hands Gallery
- Hotels near Bay Street
- Hotels near Folly Beach Fishing Pier
- Hotels near James Island County Park
- Hotels near Marine Corps Air Station Beaufort
- Hotels near Henry C. Chambers Waterfront Park
- Hotels near Kiawah Beachwalker Park
- Hotels near Angel Oak Tree
- Hotels near Freshfields Village
- Hotels near Night Heron Park
- Hotels near University of South Carolina-Beaufort
- Hotels near Folly Beach County Park
- Hotels near Turtle Point Golf Course
- Hotels near Bohicket Marina
More Hotel Options in Edisto Island
- Adventure Hotels in Edisto Island
- Beach Hotels in Edisto Island
- Business Hotels in Edisto Island
- Family Hotels in Edisto Island
- Golf Hotels in Edisto Island
- Historic Hotels in Edisto Island
- Hotels with Bars in Edisto Island
- Hotels with Free Parking in Edisto Island
- Hotels with Hot Tubs in Edisto Island
- Hotels with WiFi in Edisto Island
- Hotels with a Pool in Edisto Island
- Romantic Hotels in Edisto Island
- Shopping Hotels in Edisto Island
More Accommodation Types in Edisto Island
Explore more hotels
- Oceanfront Showplace - Island Manor
- Welcoming villa with elegant screened porch
- Family-Friendly Townhome with Resort Amenities Included - 1/2 Mile to Beach
- Private 4 bedroom home near beach and on golf course
- Edisto Beach Getaway!- Beach Walk!
- A Room With a View-1 BR Efficiency Condo Close to Everything.
- Beach home with huge lawn, open deck, covered patio & grill
- Near Edisto Beach State Park: Home w/ Lanais!
- Dog-friendly condo with full kitchen
- All Inn on Edisto - Cozy Studio Condo Close to Everything
- Inviting Dog-Friendly Home w/Free WiFi, Private W/D, & Central A/C
- 4 Bedroom 2 Bath Ocean Front Vacation Rental on Edisto Beach
- Coastal townhome with riverfront views, deck, & W/D - pool and athletic courts
- Second-Floor Condo w/Private Covered Balcony, Views, Free WiFi, and Shared Pool
- Cozy Golf Course Front Condo - Games, Deck, Walk to the beach/marina, King Bed!
- Dog-friendly beach home with screened porch, charming interior, & W/D
- Edisto Condo
- Edisto Beach Peach!—beautiful renovated condo on golf course & close to beaches
- Cozy Edisto Condo-Close to the Beach!
- Experience the Edisto Lowcountry in Style