Find 5 Star Hotels in Big Pine Key, FL from SAR 571
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Compare Big Pine Key 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Our top choices for Big Pine Key 5-star hotels

Isla Bella Beach Resort & Spa
Isla Bella Beach Resort & Spa
9.2 out of 10, Wonderful, (1036)
The price is SAR 804
SAR 1,126 total
includes taxes & fees
10 Sep - 11 Sep
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Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Big Pine Key.

Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
1996 Overseas Highway, Marathon, FL
The price is SAR 571 per night from Sep 10 to Sep 11
SAR 571
SAR 790 total
10 Sep - 11 Sep
includes taxes & fees
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Learn more about Big Pine Key
Meet the local wildlife, splash in the shallows and enjoy the calm of the quieter Keys on this stretch of serene waterfront and wetlands.

Top Big Pine Key Hotel Reviews

Isla Bella Beach Resort & Spa
10/10 Excellent
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Big Pine Key Hotels by Star Rating
Stay near popular Big Pine Key attractions
- Hotels near Key West Visitors Center
- Hotels near National Key Deer Refuge Visitor Center
- Hotels near Big Pine Key Flea Market
- Hotels near Coupon Bight Aquatic Preserve
- Hotels near Blue Hole
- Hotels near Veterans Memorial Park & Beach
- Hotels near Sombrero Beach
- Hotels near Seven Mile Bridge
- Hotels near Curry Hammock State Park
- Hotels near Sunset Park Beach
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