A calm river with boats, lush greenery, and a clear blue sky.

Find 5 Star Hotels in Big Pine Key, FL from SAR 761

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Our top choices for Big Pine Key 5-star hotels

An aerial view of a resort with a central pool, multiple buildings, and a beach area with sun loungers.

1. Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa
5.0 star property
Marathon
9.2 out of 10, Wonderful, (1,302 reviews)
"Great Property, beautiful location, will stay again!"
United States
Karolina
The price is SAR 842
SAR 1,174 total
includes taxes & fees
15 Nov - 16 Nov
Isla Bella Beach Resort & Spa
A resort pool with a view of the sea, surrounded by palm trees and lounge chairs.

2. Sea Glass Cove

Sea Glass Cove
5.0 star property
Marathon
Sea Glass Cove
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Big Pine Key.
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

2600 Overseas Hwy Marathon FL
The price is SAR 844 per night from Dec 6 to Dec 7
SAR 844
SAR 1,191 total
6 Dec - 7 Dec
includes taxes & fees
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Big Pine Key

Snorkel crystal-clear waters teeming with colorful fish, then spot adorable Key deer at the National Key Deer Refuge. Unwind on pristine beaches like Calusa or Sandspur, where soft sand meets turquoise waves.

See all hotels in Big Pine Key
A coastal town with a beach, clear waters, a pier, and lush greenery.

Top Big Pine Key Hotel Reviews

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

10/10 Excellent
"Truly a unique resort within the keys. It’s located such that there are many things to do nearby, or you can stay on the property and get anything you need. Staff were very friendly and responded to your questions and requests. The gated property provides seclusion which is sometimes hard to find in Marathon. Food was excellent, everywhere, but especially at Mahinas. Highly recommend if you’re looking for a resort type stay."
John 4-night trip
Posted 16 hours ago
Isla Bella Beach Resort & Spa

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Big Pine Key?
You'll find a variety of pricing options for a 5-star hotel in Big Pine Key on Expedia. The amount you pay will depend on when you travel, length of your trip and other factors. Compare available properties for your desired dates and use our pricing and other filters to score the perfect high-end stay.

  • Search for the lowest price per night from SAR 761

What makes a hotel 5 stars in Big Pine Key?
Outstanding guest service characterizes every 5-star hotel in Big Pine Key. From the moment you arrive, staff are at your beck and call, whether arranging valet parking or providing in-room massages. Additionally, hotels have to feature upscale amenities to meet the standard for a 5-star rating. These can include luxury bathrobes, saunas or spas, pools, gastronomic restaurants and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Big Pine Key?
Use Expedia's filter tool to find a high-end escape in Big Pine Key where everything you need is included in the price. From there, narrow down your results for properties that have a 5-star rating and are listed as "All inclusive." The most important thing to look forward to at these stays? Pure relaxation and indulgence.