The Best Hotels Closest to Substance in Las Vegas for 2026

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Our top choices for Substance hotels

A rooftop lounge with a fire pit, large windows, and a city view.

A modern hotel room with a large window offering a city view, a comfortable seating area with red and white chairs, and a small table.

A modern lobby with a marble coffee table, blue sofas, and a 'Be Our Guest' sign.

A hotel room with a large bed, a blue sofa, a small table, and a view of the city at night.

1. Circa Resort & Casino – Adults Only

Downtown Las Vegas, 0.5 km from Substance

Cesar

SAR 393

SAR 656 total

includes taxes & fees

29 Oct - 30 Oct

A storefront with a glass door, a black awning, and a floral archway.

A modern outdoor seating area with wooden furniture and a variety of plants.

A modern hotel lobby with a view of a cityscape, a plush orange chair, and a glass partition.

A modern outdoor pool area with lounge chairs and sofas, a clear pool, and a building with large windows in the background.

2. The ENGLISH Hotel, Las Vegas, a Tribute Portfolio Hotel, 21 and over

Arts District, 1.4 km from Substance

Enrico

SAR 638

SAR 721 total

includes taxes & fees

8 Nov - 9 Nov

A spacious dining area with wooden tables and chairs, ornate ceiling design, and a central decorative piece.

A vintage train carriage interior with leather armchairs, a wooden table, and ornate ceiling details.

A bar area with marble counters, leather chairs, and a red carpet.

A grand hotel lobby with a long wooden corridor, ornate chandeliers, and a central decorative fireplace.

3. Main Street Station Hotel, Casino and Brewery

Downtown Las Vegas, 0.6 km from Substance

Michelle

SAR 110

SAR 265 total

includes taxes & fees

9 Nov - 10 Nov

A bar area with a leather couch, red chairs, and a bar counter.

A modern lounge area with a flat-screen TV, wooden furniture, and outdoor seating with yellow umbrellas.

A bar area with a round bar, multiple chandeliers, and a variety of seating options.

An outdoor dining area with tables and chairs, umbrellas, and candles.

4. Downtown Grand Las Vegas

Downtown Las Vegas, 0.2 km from Substance

Fernando

SAR 156

SAR 342 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a large bed, a desk, a chair, a lamp, and a window with curtains.

A bar area with multiple seating options, including bar stools and tables, and a brick wall with neon signage.

A bar area with multiple gaming machines, a bar counter, and several bar stools.

A bar area with multiple seating arrangements, a bar counter, and a variety of bottles and glasses on the shelves.

5. Four Queens Hotel and Casino

Downtown Las Vegas, 0.3 km from Substance

Tim

SAR 233

SAR 263 total

includes taxes & fees

28 Oct - 29 Oct

A brick-walled interior with a wooden floor and a black metal railing.

A hotel room with a dining area, a sofa, and a large window offering a city view.

A hotel room with a bed, a desk, a chair, a bathroom with a mirror, and a view of the city.

6. the D Las Vegas

Downtown Las Vegas, 0.2 km from Substance

Lee Ian

SAR 91

SAR 273 total

includes taxes & fees

29 Oct - 30 Oct

An outdoor seating area with a wooden bench, a table with food, potted plants, and a view of the building's interior through a glass door.

A modern lobby with seating, a reception desk, and a decorative wall.

A modern interior with seating, a large flat-screen TV, and a view through large windows.

A hotel with a modern facade, palm trees, and a distinctive wall with circular patterns.

7. AC Hotel by Marriott Las Vegas Symphony Park

1.2 km from Substance

Janaina

SAR 443

SAR 594 total

includes taxes & fees

29 Oct - 30 Oct

A modern reception desk with vertical light fixtures and a marble counter.

A modern lounge area with a sectional sofa, round tables, and chairs. Large windows offer views of the outdoors.

A rooftop pool area with a hot tub, outdoor seating, and palm trees.

A modern interior with round tables and green chairs, wooden shelves with decorative items, and large windows offering a view.

8. Element by Marriott Las Vegas Symphony Park

1.2 km from Substance

Suzanne

SAR 570

SAR 738 total

includes taxes & fees

1 Nov - 2 Nov

A restaurant with a view of a neon-lit building and a large screen displaying an image of a person.

A modern bar area with multiple seating arrangements, a wooden bar counter, and several screens displaying content.

A banquet hall with round tables set for a formal event, featuring white tablecloths and red napkins.

A restaurant with tables set for dining, a city view, and a large window.

9. Hotel Apache

Downtown Las Vegas, 0.4 km from Substance

Joe

SAR 183

SAR 206 total

includes taxes & fees

10 Nov - 11 Nov

A spacious lobby with a stone floor, wooden beams, and a large chandelier.

A lobby with a grand staircase, a bar area, and multiple gaming machines.

A well-lit food court with a variety of food options, seating areas, and a counter with beverages.

A hotel room with a large bed, a desk, a TV, and a view of the city.

10. El Cortez Hotel and Casino - 21 and Over

Downtown Las Vegas, 0.2 km from Substance

Theresa C

SAR 143

SAR 289 total

includes taxes & fees

18 Nov - 19 Nov

A large, modern steakhouse with a curved roof and multiple dining areas, surrounded by other buildings.

A swimming pool with lounge chairs and a building with a large mural in the background.

A multi-story building with a prominent sign reading "Plaza Hotel Casino Bingo" and a carousel at the ground level.

A restaurant with tables set for dining, a view of the street outside, and a neon sign for Oscar's.

11. Plaza Hotel & Casino

Downtown Las Vegas, 0.6 km from Substance

Jose

SAR 132

SAR 314 total

includes taxes & fees

9 Nov - 10 Nov

A bedroom with a bed, a small table, and a chair. There is a bathroom with a sink, mirror, and shower.

The World Market Center building with a prominent glass facade and a distinctive angular design.

A narrow outdoor area with artificial green turf, a palm tree, and a metal fence.

A compact kitchen with white cabinetry, a built-in microwave, and a stainless steel refrigerator.

12. Desert Moon Motel

Downtown Las Vegas, 1.5 km from Substance

Grant

SAR 180

SAR 204 total

includes taxes & fees

19 Nov - 20 Nov

A hotel with a prominent sign reading "California Hotel & Casino."

A modern interior with a 'VALET' sign, a 'Mahalo' wall, and a clean, well-lit parking area.

A bar area with a digital screen displaying a bartender, a long counter with bar stools, and a sign above reading "Holo The Happy Bar".

A bar area with multiple seating options, including bar stools and cushioned chairs, and a bar counter with a variety of bottles.

13. California Hotel and Casino

Downtown Las Vegas, 0.5 km from Substance

Norman Paul Cruz

SAR 120

SAR 275 total

includes taxes & fees

16 Nov - 17 Nov

A hotel with a large indoor pool, palm trees, and a modern building in the background.

A hotel with a pool area, outdoor seating, and a view of the city skyline at night.

A modern living room with a curved staircase, a sofa set, and a view of the cityscape through large windows.

A bar area with a large aquarium, bar stools, and a decorative railing.

14. Golden Nugget Las Vegas Hotel & Casino

Downtown Las Vegas, 0.4 km from Substance

PSBII

SAR 182

SAR 401 total

includes taxes & fees

2 Nov - 3 Nov

A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a high-rise building.

A fitness center with treadmills, a wall-mounted TV, and a rack of dumbbells.

A modern room with a flat-screen TV mounted on a brick wall, a wooden vanity with a sink, a small trash bin, and a round table.

A hotel pool area with lounge chairs and umbrellas, surrounded by palm trees and a multi-story building.

15. Oasis at Gold Spike

Downtown Las Vegas, < 0.1 km from Substance

Zachary

SAR 164

SAR 291 total

includes taxes & fees

21 Oct - 22 Oct

A hotel room with two beds, a desk, a chair, a large mirror, and a decorative wall with geometric patterns.

A bar area with white chairs, a wooden counter, and a vending machine labeled "Goodies".

A bar area with a blue wall, white chairs, and a bar counter.

A wall with a colorful mural reading "Greetings From Downtown Las Vegas Nevada."

16. Downtowner Boutique Hotel

Downtown Las Vegas, 0.4 km from Substance

Nicholas

SAR 132

SAR 234 total

includes taxes & fees

8 Nov - 9 Nov

A nighttime view of a pool area with a city skyline in the background, including a prominent tower.

Two wooden beds with white linens, a wooden headboard, a bedside lamp, and a framed picture on the wall.

A hotel corridor with wicker furniture and orange cushions, a yellow door, and a balcony with railings.

17. Bposhtels Las Vegas

1.8 km from Substance

Nichole

SAR 92

SAR 146 total

includes taxes & fees

21 Oct - 22 Oct

A hotel with a prominent tower and the name "STRAT" illuminated on the facade.

A bar area with a modern design, featuring a central bar counter, multiple seating options, and a patterned ceiling.

A building with a sign reading "ATOMIC GOLF" and a large illuminated spherical sculpture in front.

A restaurant setting with a table set for dining, a city view in the background, and a sunset over the mountains.

18. The STRAT Hotel, Casino & Tower

Las Vegas Strip, 2.9 km from Substance

Laurence

SAR 56

SAR 276 total

includes taxes & fees

15 Nov - 16 Nov

The exterior of the Golden Gate Hotel with a prominent sign, a modern architectural design, and a parking lot with visible cars.

A lobby with a wooden floor, a large chandelier, an elevator, and a poster advertising a spring points party.

A hotel room with a large bed, a leather sofa, a TV, a minibar, and a city view.

A hotel lobby with a large black carpet, a wall with 'GOLDEN GATE' signage, and a row of vintage arcade machines.

19. Golden Gate Hotel and Casino

Downtown Las Vegas, 0.5 km from Substance

Christian

SAR 90

SAR 271 total

includes taxes & fees

27 Oct - 28 Oct

An outdoor seating area with wicker furniture, palm trees, and a clear sky.

A spacious indoor area with multiple seating arrangements including couches and tables, exposed ductwork, and hanging pendant lights.

A bar area with a long counter, multiple bar stools, and various bar equipment.

A wooden bed with a headboard, two bedside tables with lamps, and a patterned rug.

20. Thunderbird Hotel

Gateway District, 1.8 km from Substance

Edgar

SAR 147

SAR 239 total

includes taxes & fees

8 Nov - 9 Nov

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Compare popular hotels close to Substance

Property	Property class	Guest rating
Circa Resort & Casino – Adults Only	9.4 Exceptional 5,732 reviews	View
The ENGLISH Hotel, Las Vegas, a Tribute Portfolio Hotel, 21 and over	9.4 Exceptional 155 reviews	View
Main Street Station Hotel, Casino and Brewery	9.0 Wonderful 3,901 reviews	View
Downtown Grand Las Vegas	8.6 Excellent 10,032 reviews	View
Four Queens Hotel and Casino	8.6 Excellent 7,438 reviews	View

Top Substance Hotel Reviews

Four Queens Hotel and Casino

10/10 Excellent

"no soda/icemachines on all floors. rooms large and clean"

Downtown Grand Las Vegas

10/10 Excellent

"Great, well-maintained, quiet, clean, small, amazing staff, super reasonable and thoughtful hotel in downtown Fremont."

Golden Nugget Las Vegas Hotel & Casino

10/10 Excellent

"Close to Fremont Street."

El Cortez Hotel and Casino - 21 and Over

8/10 Good

"The El Cortez maintains the old Vegas essence and supernatural mystique as a charming and reasonably priced landmark in the downtown area. The staff were attentive and helpful, and a Starbucks is conveniently located in the lobby by the elevators. The newly refurbished rooms in the South Tower are great for the price, but I would suggest staying on the side facing the mountains because the Fremont action is very loud at night. The shower and bathroom floor were somewhat dirty, but other than that, it’s a really great spot for the price."

Circa Resort & Casino – Adults Only

10/10 Excellent

"Always enjoy my stay when in Vegas."

Golden Gate Hotel and Casino

10/10 Excellent

"Insane to have a 45 dollar resort fee! Ac wouldn’t come on it was still 80 degrees outside!!!!"

Hotel Apache

8/10 Good

"It was good for the cheap price. Straight on the strip - fun fun fun. Old but clean and worked for what we needed."

Downtowner Boutique Hotel

10/10 Excellent

"The staff were absolutely amazing! They were accommodating in every way and very helpful! Dee and Lesley were great!"

DTLV, a Baymont by Wyndham

10/10 Excellent

"Good 😌"

Other attractions near Substance

Neonopolis

You can spend time studying the exhibits at Neonopolis during your travels in Las Vegas. Discover the entertainment choices and casinos in this family-friendly area.

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A large indoor amusement ride with a digital display of a cityscape.

SlotZilla Zipline

You can take time to visit SlotZilla Zipline during your travels to Las Vegas. Discover the area's top-notch restaurants and its great live music.

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The Nerd

The Nerd is just one of the places to see in Las Vegas, so why not enjoy the other things to explore during your travels? Experience the area's fascinating museums and entertainment choices.

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Fremont Street Flightlinez

Take the family on an outing to Fremont Street Flightlinez during your trip to Las Vegas. Make time to visit the area's casinos, or simply enjoy its lively bars.

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The Griffin

The Griffin is just one of the places to see in Las Vegas, so why not enjoy the other things to explore during your travels? Discover the area's lively bars and its great live music.

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We All Scream

We All Scream is just one of the places to see in Las Vegas, so why not enjoy the other things to explore during your travels? Make time to visit the area's casinos, or simply enjoy its lively bars.

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Backstage & Billiards Lounge

Backstage & Billiards Lounge is just one of the places to see in Las Vegas, so why not enjoy the other things to explore during your travels? Experience the area's entertainment choices and fascinating museums.

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LIV Beach at Fontainebleau Las Vegas

After visiting LIV Beach at Fontainebleau Las Vegas, make a plan to see the other sights and activities in Las Vegas. Discover the area's fascinating museums and shops.

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Frequently asked questions

What's the area like around Substance?

Substance is located in Las Vegas. This welcoming area is known for its array of dining options and bar scene. If you're looking for a convenient place to stay, check out the 156 hotels and other accommodations you'll find within a mile.

Where is the best place to stay near Substance?

Adjacent to Substance, Golden Nugget Las Vegas Hotel & Casino is one of the top choices for your stay based on our traveler data, and this resort offers 2 outdoor pools and a full-service spa. Other good options within a short distance include Plaza Hotel & Casino and Downtown Grand Las Vegas.

How many hotels are there close to Substance?

Expedia has 156 hotels and other accommodations within a mile from Substance.

If I need to cancel the hotel reservation for my stay near Substance, will I receive a refund?

Yes! Most hotel room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of booking. Add dates, click "Search", then use the "fully refundable" filter to review top deals close to Substance.

Where can I learn more about changing or cancelling my trip in the area near Substance?

For more details about rescheduling or cancelling your stay near Substance, click here.

What can I see and do near Substance?

You might want to spend some time browsing the exhibits at Mob Museum, The Neon Museum, or Zak Bagans Haunted Museum. Old Las Vegas Mormon Fort State Historic Park, Harrison House, and First AME Church are monuments to see when you're exploring the area around Substance. You can watch performances at Colosseum at Caesars Palace, Sphere, and Dolby Live if you're interested in local theater.

Find hotels near Substance, Las Vegas from SAR 146

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Treat yourself

Be picky

Check prices for these dates

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Star rating

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Our top choices for Substance hotels

1. Circa Resort & Casino – Adults Only

2. The ENGLISH Hotel, Las Vegas, a Tribute Portfolio Hotel, 21 and over

3. Main Street Station Hotel, Casino and Brewery

4. Downtown Grand Las Vegas

5. Four Queens Hotel and Casino

6. the D Las Vegas

7. AC Hotel by Marriott Las Vegas Symphony Park

8. Element by Marriott Las Vegas Symphony Park

9. Hotel Apache

10. El Cortez Hotel and Casino - 21 and Over

11. Plaza Hotel & Casino

12. Desert Moon Motel

13. California Hotel and Casino

14. Golden Nugget Las Vegas Hotel & Casino

15. Oasis at Gold Spike

16. Downtowner Boutique Hotel

17. Bposhtels Las Vegas

18. The STRAT Hotel, Casino & Tower

19. Golden Gate Hotel and Casino

20. Thunderbird Hotel

Compare popular hotels close to Substance

Top Substance Hotel Reviews

Four Queens Hotel and Casino

Downtown Grand Las Vegas

Golden Nugget Las Vegas Hotel & Casino

El Cortez Hotel and Casino - 21 and Over

Circa Resort & Casino – Adults Only

Golden Gate Hotel and Casino

Hotel Apache

Downtowner Boutique Hotel

DTLV, a Baymont by Wyndham

Other attractions near Substance

Neonopolis

SlotZilla Zipline

The Nerd

Fremont Street Flightlinez

The Griffin

We All Scream

Backstage & Billiards Lounge

LIV Beach at Fontainebleau Las Vegas

Frequently asked questions