Find Resorts & Hotels with Spas in St. Louis, MO

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Check prices for these dates

Tonight
14 Nov - 15 Nov
Tomorrow
15 Nov - 16 Nov
Next weekend
20 Nov - 22 Nov
In two weeks
27 Nov - 29 Nov

Our top choices for St. Louis hotels with a spa

A spa area with a tiled floor, a glass enclosure, and a pool visible through the glass.

1. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
4.5 star property
Downtown West
9.0 out of 10, Wonderful, (2,129 reviews)
  • cleanliness
    Discover spa services, a steam room, and an Olympic-sized indoor pool at this modern hotel, all designed for rejuvenating getaways.
The price is SAR 539
SAR 649 total
includes taxes & fees
6 Dec - 7 Dec
21C Museum Hotel St Louis
A room with a dark wooden door, a chandelier, green plants, and a seating area with a sofa and chairs.

2. Truitt Hotel

Truitt Hotel
2.0 star property
Lafayette Square
10.0 out of 10, Exceptional, (32 reviews)
The price is SAR 631
SAR 765 total
includes taxes & fees
15 Nov - 16 Nov
Truitt Hotel
A couple relaxing by a window overlooking a bridge and water.

3. Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1,000 reviews)
  • cleanliness
    Discover a tranquil haven with 12 treatment rooms, outdoor pool, and breathtaking views at this rejuvenating spa retreat.
The price is SAR 1,407
SAR 1,646 total
includes taxes & fees
15 Nov - 16 Nov
Four Seasons Hotel St Louis
A modern bathroom with a glass shower enclosure, a built-in jacuzzi, and a tiled floor.

4. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.8 out of 10, Excellent, (1,090 reviews)
  • cleanliness
    Riverside wellness oasis offers full-service spa with aromatherapy and hydrotherapy for a restorative retreat.
The price is SAR 562
SAR 719 total
includes taxes & fees
15 Dec - 16 Dec
Ameristar Casino Resort and Spa
A modern kitchen with wooden cabinets, a central island, and framed artwork on the walls.

5. The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Clayton
9.2 out of 10, Wonderful, (589 reviews)
  • cleanliness
    Revel in a rejuvenating spa retreat with aromatherapy treatments and hot stone massages at this luxury St. Louis hotel.
The price is SAR 2,098
SAR 2,449 total
includes taxes & fees
27 Nov - 28 Nov
The Ritz-Carlton, St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in St. Louis

Pool
Hot tub

Top St. Louis Hotel Reviews

A room with a dark wooden door, a chandelier, green plants, and a seating area with a sofa and chairs.
Truitt Hotel

Truitt Hotel

Truitt Hotel
Lafayette Square

10/10 Excellent

It was a nice getaway feel
United States
Whitney
Reviewed November 10, 2026
Truitt Hotel

Frequently Asked Questions

Looking to vacation at a spa hotel in St. Louis?

Soothe the senses with some time in one of our wonderful spa hotels. Travelers love the fascinating museums and live music scene in St. Louis so get ready for a cultural tour. Hotels with spas are the perfect way to take a break from your daily routine and add a layer of luxury to your holiday.

What is the best spa hotel in St. Louis?

Ameristar Casino Resort and Spa is a top luxury spa hotel featuring 6 restaurants, a casino, a 24-hour fitness center, and an outdoor pool. Treat yourself to a facial, body scrub, or hydrotherapy at Ara. Another popular spa hotel in St. Louis is Four Seasons Hotel St Louis.

How many spa hotels will I find in St. Louis?

Among Expedia's 1964 accommodation options in St. Louis, there are 2 spa hotels.

What's there to see and do in St. Louis?

Experience St. Louis and visit St. Louis Union Station, St. Louis Zoo, and St. Louis Aquarium at Union Station. If you have spare time during your trip, you might want to make a stop at The St. Louis Wheel and Energizer Park.

What is a St. Louis spa hotel?

Spa hotels in St. Louis provide lodging and have an on-site spa offering services like couples massages and beauty treatments. Some also offer in-room treatments. Spa hotels are ideal if you are looking for some R&R during your vacation.