Santee Vacations

Book a Hotel + Flight together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to SARĀ 5,400 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Find the Best Santee Vacation Packages

Santee Hotel Deals

Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
Fully refundableReserve now, pay when you stay
The price is SARĀ 366 per night from Aug 9 to Aug 10
SARĀ 366
SARĀ 407 total
9 Aug - 10 Aug
includes taxes & fees
Tru By Hilton Santee
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98 Santee SC
Fully refundableReserve now, pay when you stay
The price is SARĀ 441 per night from Jul 29 to Jul 30
SARĀ 441
SARĀ 489 total
29 Jul - 30 Jul
includes taxes & fees
Best Western Plus Santee Inn
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
Fully refundableReserve now, pay when you stay
The price is SARĀ 300 per night from Jul 19 to Jul 20
SARĀ 300
SARĀ 333 total
19 Jul - 20 Jul
includes taxes & fees
8/10 Very Good! (1,461 reviews)
"The staff is friendly and professional. I have stay at the baymont several times and have always been greeted and helped. I get the room I have requested. And the breakfast is wonderful. I eat the yogurt and muffins and my partner loves the waffles. If I was t pleased with the baymont I certainly ..."

Reviewed on 17 July 2026

Baymont by Wyndham Santee
See all 315 properties in Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Santee attractions

Santee State Park

8.0/10 (219 reviews)
Perched on Lake Marion's shores, Santee State Park offers unique rondette cabins built over water. Hike through cypress swamps and sinkholes while spotting alligators, fox squirrels, and diverse birdlife.
See properties

Frequently asked questions

How much does a Santee vacation package cost?
You'll find cheap prices on Expedia for your Santee getaway. However, factors like your choice of hotel, the season and length of stay will determine how much your vacation to Santee costs.
What are the cheapest months to go to Santee?
You can usually find lower prices and greater availability in February, September and October. Check out our cheap Santee vacation packages and you could land some great off-season discounts.
How to find the best Santee package deals?
Bagging a cheap Santee package deal is easy with Expedia. After you've entered your trip dates and destination under our "Packages" tab, set your budget range, add a few filters and see what's available. You can tweak your search by "Amenities," "Property type," "Guest rating" and more. Order the results by "Price: low to high" to view the most affordable Santee package deals. Want a simple trick to score even more savings? Have some flexibility with your departure dates and consider going away on a weekday, when prices are generally lower.
Is it cheaper to book a Santee vacation as a package?
Expedia vacation packages are designed to give you more bang for your buck. Bundle your flight, car rental and hotel into one great-value price and you could save hundreds of dollars. You'll usually score a better deal than booking each component individually. And you'll still get the flexibility to create a tailored Santee vacation by choosing your preferred accommodation type, airline and car class.
When to book a vacation package to Santee?
If you're considering a spur-of-the-moment Santee trip, browse our last-minute deals that can be booked up to a week before you take off. Prefer not to wait until the last minute? You can score sensational deals on your flights and hotels by booking ahead.
How to plan a trip to Santee?

  1. Choose your travel dates: What you want to do in Santee and your favorite season can help you decide when to get away.
  2. Calculate your budget: Make sure you have enough money to pay for everything from transportation and dining out to flights and activities. Your hotel will likely be the biggest expense during your trip to Santee.
  3. Decide how long to go for: Now that you know more about Santee, you can figure out the ideal length of your vacation. Put together a rough plan and give yourself enough time for all the things you want to do.
  4. Bundle your flights and hotel: Epic destination, check. Length of stay, check. All that's left is to pick a Santee vacation package that brings all your bookings together.