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28 Sep - 29 Sep
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29 Sep - 30 Sep
This weekend
2 Oct - 4 Oct
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9 Oct - 11 Oct

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Our top choices for Santa Fe hotels

A spacious indoor dining area with multiple tables and chairs, large windows offering a view of palm trees and greenery outside.
A lobby with a patterned carpet, two green armchairs, a white sofa, a small round table with a plant, and framed artwork on the wall.
A Holiday Inn Express & Suites hotel with a modern design, multiple floors, and a parking lot.
A hotel room with a bed, a desk with a chair, a television, and a blue sofa.

1. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Alachua
United States
Tobias
SAR 390
SAR 439 total
includes taxes & fees
5 Oct - 6 Oct
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
A modern kitchen area with a central counter, various food stations, and a chalkboard menu.
A hotel room with two beds, a desk, a chair, a TV, and a couch.
Fitness facility
Pool

2. Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
Alachua
United States
Pamela
SAR 397
SAR 447 total
includes taxes & fees
19 Oct - 20 Oct
Hampton Inn & Suites Alachua I-75
A large, multi-story hotel with a central courtyard, palm trees, and an American flag.
A spacious dining area with multiple tables and chairs, a kitchen area with a coffee station, and large windows allowing natural light.
A living room with a brown leather sofa, a glass-top coffee table, and a framed picture on the wall.
A bar area with wooden chairs, a bar counter, and a television mounted on the wall.

3. Best Western Gateway Grand

Best Western Gateway Grand
Gainesville
United States
Jason
SAR 317
SAR 357 total
includes taxes & fees
7 Oct - 8 Oct
Best Western Gateway Grand
A cozy restaurant with wooden beams, yellow walls, and a bar area with coffee machines.
A hotel room with a bed, a desk with a chair, a television, a mirror, and a wardrobe.
A spacious lobby with a dining area, a kitchen, and a large window providing a view of the outdoors.
A reception desk with a sign reading "Quality by Choice Hotels," surrounded by various reptile decorations.

4. Quality Inn Alachua - Gainesville Area

Quality Inn Alachua - Gainesville Area
Alachua
United States
Deborah
SAR 285
SAR 321 total
includes taxes & fees
19 Oct - 20 Oct
Quality Inn Alachua - Gainesville Area
A swimming pool with a 5 ft 8 in depth marker, surrounded by lounge chairs and red umbrellas, with a fence and trees in the background.
A modern hotel lobby with a reception desk, seating area, and a wall-mounted television.
A fitness center with treadmills, exercise bikes, and weights.
A workspace with two chairs, a desk, a computer monitor, and a wall-mounted sign reading 'BUSINESS CENTER'.

5. Clarion Pointe Alachua - Gainesville Area

Clarion Pointe Alachua - Gainesville Area
Alachua
United States
María Teresa
SAR 226
SAR 273 total
includes taxes & fees
19 Oct - 20 Oct
Clarion Pointe Alachua - Gainesville Area
A hotel room with two beds, a desk, a chair, and a television.
A motel with a two-story structure, a covered front entrance, and a parking lot with several cars.
A parking lot with marked lanes and a grassy area on one side.
A bathroom with a white sink, mirror, and towel rack.

6. Royal Inn

Royal Inn
Alachua
United States
Alec
SAR 270
SAR 304 total
includes taxes & fees
29 Sep - 30 Sep
Royal Inn
A stone water feature with cascading water, surrounded by a brick wall and greenery.
A covered outdoor area with a paved walkway leading to a seating area, surrounded by greenery and a clear sky.
A reception desk with a modern design, a ceiling fan, and a seating area with chairs and a table.
A neatly arranged bedroom with a bed, bedside lamps, a TV, and a mirror.

7. BlueGem Motel

BlueGem Motel
High Springs
United States
Wesley
SAR 350
SAR 394 total
includes taxes & fees
5 Oct - 6 Oct
BlueGem Motel
A modern interior with a staircase, a seating area, and a colorful abstract wall design.
A rooftop pool area with lounge chairs, a small table, and a fire pit.
A modern bar area with a marble countertop, bar stools, and pendant lighting.
A spacious lobby with modern furniture, large windows, and a colorful abstract wall.

8. Hyatt Place Gainesville Downtown

Hyatt Place Gainesville Downtown
Downtown Gainesville
United States
Claire
SAR 368
SAR 414 total
includes taxes & fees
4 Oct - 5 Oct
Hyatt Place Gainesville Downtown
A spacious lobby with a sectional sofa, a wooden cabinet, and a television mounted on the wall.
A hotel lobby with a stone wall, a flat-screen TV, orange upholstered seating, and a lamp.
A hotel room with two beds, a large headboard, bedside lamps, and a view of the outdoors through sheer curtains.
A modern kitchen with wooden cabinets, a granite countertop, and pendant lighting.

9. Drury Inn & Suites Gainesville

Drury Inn & Suites Gainesville
Gainesville
United States
Joan
SAR 394
SAR 443 total
includes taxes & fees
4 Oct - 5 Oct
Drury Inn & Suites Gainesville
A room with a wooden ceiling, two beds with patterned bedding, a desk, and a chair.
A row of motel buildings with a fire hydrant and trees in front.
A bedroom with a bed, a chair, a dresser, a ceiling fan, a window with blinds, and a wall-mounted air conditioner.
A stone outdoor seating area with a table and benches, a trash bin, and a building in the background.

10. High Springs Country Inn

High Springs Country Inn
High Springs
United States
Luis
SAR 253
SAR 285 total
includes taxes & fees
29 Sep - 30 Sep
High Springs Country Inn
A modern breakfast area with labeled dispensers for yogurt, eggs, and milk, a coffee machine, and a chalkboard menu.
An outdoor patio with tables and chairs, a stone wall, and a view of a street with trees and buildings.
A Holiday Inn Express building with a modern design, featuring multiple windows and a flat roof.
A modern reception desk area with a blue geometric wall design, wooden accents, and a visible reception counter.

11. Holiday Inn Express Starke by IHG

Holiday Inn Express Starke by IHG
Starke
United States
Judy
SAR 413
SAR 458 total
includes taxes & fees
4 Oct - 5 Oct
Holiday Inn Express Starke by IHG
A hotel room with a bed, bedside tables, a desk, a chair, a mirror, and a window.
A bathroom with a large mirror, a sink, and a towel rack.
A reception area with a counter, a computer, and a bulletin board with pamphlets.
A building with a Coca-Cola vending machine, a window with a 'OPEN' sign, and a red awning.

12. Palms Garden Inn

Palms Garden Inn
Lake City
United States
Igor
SAR 238
SAR 268 total
includes taxes & fees
29 Oct - 30 Oct
Palms Garden Inn
A modern kitchen with a flat-screen TV, a microwave, and a coffee maker on a wooden cabinet. There is a window with a view of a green landscape.
A living room with a grey sofa, a wooden coffee table, and a framed horse picture on the wall.
A kitchen with a green refrigerator, a wooden countertop, a black kettle, and a wooden cutting board.
Room

13. Vista Verde Farm Retreat

Vista Verde Farm Retreat
Lake City
United States
Stacy
SAR 442
SAR 761 total
includes taxes & fees
30 Sep - 1 Oct
Vista Verde Farm Retreat
A modern living room with a fireplace, comfortable seating, a flat-screen TV, and a large window.
A fire pit area surrounded by stone tiles, with a metal fence in the background.
A hotel room with a bed, a desk, a chair, a sofa, and a window.
A modern hotel lobby with a long dining table, multiple seating areas, and a large window with curtains.

14. Comfort Suites Gainesville near University

Comfort Suites Gainesville near University
Gainesville
United States
thomas
SAR 295
SAR 344 total
includes taxes & fees
18 Oct - 19 Oct
Comfort Suites Gainesville near University
A swimming pool with a metal ladder, surrounded by a white fence and green chairs.
A refrigerated display case with beverages and snacks, and a shelf with bottled water and other beverages.
A living room with a curved sofa, a wooden cabinet, and a fish tank.
A hotel room with a bed, a sofa, a coffee table, and a small table with a lamp.

15. Best Western Waldo Inn and Suites

Best Western Waldo Inn and Suites
Waldo
United States
Ana Laura
SAR 511
SAR 574 total
includes taxes & fees
6 Oct - 7 Oct
Best Western Waldo Inn and Suites
A multi-story hotel with a central entrance, palm trees, and a clear sky.
A modern living room with a green sofa, a round coffee table, and a fireplace.
A hotel room with a wooden floor, a red armchair, a beige sofa, a TV, and framed artwork on the wall.
A spacious hotel lobby with a modern staircase, a seating area with a sofa and chairs, and a dining area in the background.

16. Country Inn & Suites by Radisson, Gainesville, FL

Country Inn & Suites by Radisson, Gainesville, FL
Gainesville
United States
sherry
SAR 332
SAR 373 total
includes taxes & fees
4 Oct - 5 Oct
Country Inn & Suites by Radisson, Gainesville, FL
A modern bar area with wooden bar stools, pendant lighting, and artwork on the walls.
A hotel hallway with carpeted floors, doors on both sides, and overhead lighting.
A hotel room with a kitchenette, a bed, a desk with a chair, and a bathroom.
A hotel reception desk with a wooden panel design, a digital kiosk, and a "Welcome to the Sun Shine State" sign.

17. Hampton Inn Gainesville

Hampton Inn Gainesville
Gainesville
United States
Charles
SAR 325
SAR 366 total
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn Gainesville
A modern hotel lobby with a curved ceiling, a central seating area with a sofa and ottoman, a bar area, and a dining space with chairs and tables.
A modern hotel lobby with a breakfast bar, seating area, and a large window.
A spacious lobby with a modern design, featuring a large seating area with sofas and chairs, a patterned carpet, and large windows offering views of the outside.
A hotel reception area with a curved reception desk, a refrigerator stocked with beverages, and a wall with a blue abstract design.

18. SpringHill Suites by Marriott Gainesville

SpringHill Suites by Marriott Gainesville
Gainesville
United States
Robert
SAR 320
SAR 360 total
includes taxes & fees
4 Oct - 5 Oct
SpringHill Suites by Marriott Gainesville
A spacious hotel lobby with a curved sofa, a patterned carpet, and a large window with sheer curtains.
A large banquet hall with round tables, chairs, and floral centerpieces.
A Hilton hotel with a brick facade, multiple windows, and a well-lit entrance.
A hotel lobby with a blue patterned carpet, black round tables with candles, beige sofas, and a curved seating area.

19. Hilton University of Florida Conference Center Gainesville

Hilton University of Florida Conference Center Gainesville
Gainesville
United States
Nandini
SAR 397
SAR 447 total
includes taxes & fees
4 Oct - 5 Oct
Hilton University of Florida Conference Center Gainesville
A modern bar area with a long counter, green bar stools, and a television displaying a golf game.
A modern living room with a fireplace, comfortable seating, and a large TV.
A modern kitchen with a central island, bar stools, pendant lighting, and a dining area with a sofa and chairs.
A modern hotel room with a large bed, a desk, a chair, and a TV mounted on the wall.

20. Fairfield Inn & Suites by Marriott Gainesville I-75

Fairfield Inn & Suites by Marriott Gainesville I-75
Gainesville
United States
Robert
SAR 447
SAR 503 total
includes taxes & fees
2 Oct - 3 Oct
Fairfield Inn & Suites by Marriott Gainesville I-75
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Top Santa Fe Hotel Reviews

Hilton University of Florida Conference Center Gainesville

Hilton University of Florida Conference Center Gainesville

10/10 Excellent
"So many options for entertainment and dining without even leaving the hotel."
Ashley 3-night trip
Posted 2 hours ago
Hilton University of Florida Conference Center Gainesville
HOM Hotel Gainesville, SureStay Collection by Best Western

HOM Hotel Gainesville, SureStay Collection by Best Western

10/10 Excellent
"Great hotel with nice staff!"
Cassandra 1-night trip
Posted 4 hours ago
HOM Hotel Gainesville, SureStay Collection by Best Western
Drury Inn & Suites Gainesville

Drury Inn & Suites Gainesville

10/10 Excellent
"Great location & staff!"
MARTA 1-night trip
Posted 4 hours ago
Drury Inn & Suites Gainesville
Red Roof Inn PLUS+ Gainesville

Red Roof Inn PLUS+ Gainesville

8/10 Good
"Everything was great!"
MARIA 3-night trip
Posted 6 hours ago
Red Roof Inn PLUS+ Gainesville
Comfort Suites Gainesville near University

Comfort Suites Gainesville near University

8/10 Good
"The hotel is nice"
Javier 3-night trip
Posted 6 hours ago
Comfort Suites Gainesville near University
Country Inn & Suites by Radisson, Gainesville, FL

Country Inn & Suites by Radisson, Gainesville, FL

8/10 Good
"Clean and simple. Nice staff."
Jorge 1-night trip
Posted 8 hours ago
Country Inn & Suites by Radisson, Gainesville, FL
Hotel Indigo Gainesville-Celebration Pointe by IHG

Hotel Indigo Gainesville-Celebration Pointe by IHG

8/10 Good
"H"
Stefanie 2-night trip
Posted 9 hours ago
Hotel Indigo Gainesville-Celebration Pointe by IHG
Best Western Gateway Grand

Best Western Gateway Grand

8/10 Good
"Nice staff, clean hotel, good location and good breakfast"
Carlos 3-night trip
Posted 11 hours ago
Best Western Gateway Grand
Sleep Inn & Suites University/Shands

Sleep Inn & Suites University/Shands

8/10 Good
"We stayed here for UF Family weekend. We booked early, and the rate wasn’t too inflated. Things really book up around that time and there is price gouging, so we chose an affordable hotel. The staff was very kind and helpful and made us aware of amenities. They offered a shuttle for the UF football game. Your stay includes free breakfast. Coffee, fresh popcorn and cookies are available most of the day. The condition of the elevator and the carpet and chair in our room needed some attention. The hotel has a bit of a damp or musty smell. We went nose blind to it pretty quickly, though. I know moisture is a big challenge in Florida. The bed and pillows were quite comfortable, and my teenage son said he slept like a baby on the sofa bed, for which the front desk gave us clean sheets, blanket and pillow. Overall, a positive experience. We would stay here again."
Erica 3-night trip
Posted 1 day ago
Sleep Inn & Suites University/Shands

More cheap stays in Santa Fe

Red Roof Inn PLUS+ Gainesville

Red Roof Inn PLUS+ Gainesville

3500 Southwest 42nd St Gainesville FL
SAR 226
SAR 255 total
1 Oct - 2 Oct
includes taxes & fees
7.4/10 Good! (1,333 reviews)
Red Roof Inn PLUS+ Gainesville
Days Inn by Wyndham Gainesville University I-75

Days Inn by Wyndham Gainesville University I-75

920 Nw 69th Ter Gainesville FL
SAR 271
SAR 305 total
30 Sep - 1 Oct
includes taxes & fees
Days Inn by Wyndham Gainesville University I-75
HOM Hotel Gainesville, SureStay Collection by Best Western

HOM Hotel Gainesville, SureStay Collection by Best Western

3905 Sw 43Rd St Gainesville FL
SAR 272
SAR 306 total
4 Oct - 5 Oct
includes taxes & fees
8.6/10 Excellent! (2,148 reviews)
HOM Hotel Gainesville, SureStay Collection by Best Western
Sleep Inn & Suites University/Shands

Sleep Inn & Suites University/Shands

4110 SW 40th Boulevard Gainesville FL
SAR 284
SAR 341 total
18 Oct - 19 Oct
includes taxes & fees
8.8/10 Excellent! (1,304 reviews)
Sleep Inn & Suites University/Shands
Comfort Suites Gainesville near University

Comfort Suites Gainesville near University

2603 SW 13TH STREET Gainesville FL
SAR 295
SAR 344 total
18 Oct - 19 Oct
includes taxes & fees
9.2/10 Wonderful! (1,505 reviews)
Comfort Suites Gainesville near University
Comfort Inn Gainesville - University Area

Comfort Inn Gainesville - University Area

3440 SW 40th Blvd Gainesville FL
SAR 287
SAR 344 total
18 Oct - 19 Oct
includes taxes & fees
8.2/10 Very Good! (1,102 reviews)
Comfort Inn Gainesville - University Area

Frequently asked questions

What's the best place for a stay in Santa Fe?
Located 18.6 mi (30 km) from the heart of Santa Fe, Drury Inn & Suites Gainesville is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Sleep Inn & Suites University/Shands and Country Inn & Suites by Radisson, Gainesville, FL. See all available top hotels, or vacation rentals in Santa Fe.
What are some of the best vacation rentals in Santa Fe?
Private Resort-Style Oasis, Pool, Lanai & Court – Backyard Paradise w/ BBQ: This vacation home rental outside of Santa Fe is located in the city center and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a dishwasher, a stovetop, and a microwave, so you can cook with friends or family. See all vacation rentals in Santa Fe.
If I need to cancel my hotel reservation in Santa Fe, will I receive a refund?
Yes, most hotel bookings are fully refundable if cancelled before the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you have a non-refundable reservation, you might still have the option to cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Fe.
Where can I learn more about changing or cancelling my trip to Santa Fe?
To access more information about picking new dates or cancelling your trip to Santa Fe, go to https://www.expedia.com/service/.
What is staying in Santa Fe like?
Travelers to Santa Fe will find plenty to explore and enjoy. There are 802 hotels and other accommodations in the surrounding area. Find out more about Santa Fe.
What are the top places to visit in Santa Fe?
Places to visit in the wider area include O'Leno State Park, San Felasco Hammock Preserve State Park, and Devil's Milhopper Geological State Park. You'll also find Gainesville Raceway and Poe Springs Park in the area. Check out what more to see and do in Expedia's Santa Fe guide.
What's the seasonal weather like in Santa Fe?
The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 59°F. The rainiest months in Santa Fe are August, June, July, and September, with each month seeing an average of 7 inches of rainfall.