Santa Cruz Vacation Rentals

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Check prices for these dates

In two weeks
27 Nov - 29 Nov
In two months
8 Jan - 10 Jan
In three months
5 Feb - 7 Feb
In four months
5 Mar - 7 Mar

Our top choices for Santa Cruz vacation rentals

A modern reception area with a marble reception desk, a vertical garden, and a logo for 'GO Living & Suites'.

1. Go Living and Suites by Jalo

Go Living and Suites by Jalo
3.0 star property
El Poblado
9.2 out of 10, Wonderful, (144 reviews)
"Excellent Stay!"
United States
Esdras
The price is SAR 202
SAR 202 total
16 Nov - 17 Nov
Go Living and Suites by Jalo
A modern living room with a large window, a sofa set, a coffee table, and a potted plant.

2. Metropolitan Living by HOUSY

Metropolitan Living by HOUSY
4.0 star property
San Diego
9.0 out of 10, Wonderful, (94 reviews)
"Clean, good location, nice staff"
United States
Sau Yeng
The price is SAR 204
SAR 286 total
14 Nov - 15 Nov
Metropolitan Living by HOUSY
A multi-story building with a brick facade, multiple balconies with greenery, and a sign indicating a business or commercial use.

3. Portal del Rodeo ApartaHotel - Arkadia Mall

Portal del Rodeo ApartaHotel - Arkadia Mall
3.5 star property
Medellín
9.2 out of 10, Wonderful, (301 reviews)
"Nice location; clean; helpful staff."
United States
Shivon
The price is SAR 249
SAR 249 total
16 Nov - 17 Nov
Portal del Rodeo ApartaHotel - Arkadia Mall
A multi-story hotel with a modern design, featuring a rooftop garden and a fountain.

4. Travelers Rio Verde Living Suites

Travelers Rio Verde Living Suites
3.5 star property
Rionegro
8.2 out of 10, Very good, (495 reviews)
"Very clean and a good rear view of landscape"
United States
roberto
The price is SAR 414
SAR 414 total
13 Dec - 14 Dec
Travelers Rio Verde Living Suites
A tall, modern building with the name 'KYUX' on its facade, surrounded by lush greenery and a wet street reflecting city lights.

5. Kyux by Jalo

Kyux by Jalo
4.0 star property
Laureles
9.2 out of 10, Wonderful, (210 reviews)
"Great place to stay at"
United States
Miguel
The price is SAR 194
SAR 194 total
29 Nov - 30 Nov
Kyux by Jalo
A modern bedroom with a large bed, a desk, and a balcony.

6. Hotel Moore 45

Hotel Moore 45
4.0 star property
Buenos Aires
9.0 out of 10, Wonderful, (8 reviews)
"I like the service and it’s really comfortable. And the people in their recession. Bety. Help. Take you guys. I Enjoy the State. I’m planning to Come Back. How old is go back to the hotel again!"
United States
Welinton
The price is SAR 90
SAR 90 total
16 Nov - 17 Nov
Hotel Moore 45
A reception area with a wooden desk, wicker chairs, and a patterned floor.

7. Origen Local Suites

Origen Local Suites
3.0 star property
Laureles
9.4 out of 10, Exceptional, (229 reviews)
"Hiding Gem , close to everything , 5 Stars Staff and Costumer Services!!"
United States
Luis
The price is SAR 211
SAR 211 total
18 Nov - 19 Nov
Origen Local Suites
A person in a hot tub with a can of Hatsu beer and snacks on a wooden table.

8. Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House

Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House
3.5 star property
Laureles
9.2 out of 10, Wonderful, (109 reviews)
"Excellent breakfast, good location "
United States
dickie
The price is SAR 157
SAR 157 total
15 Nov - 16 Nov
Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House
A tall building with multiple balconies and a clear sky.

9. Hotel Santa Ana

Hotel Santa Ana
4.0 star property
El Poblado
9.0 out of 10, Wonderful, (46 reviews)
"Great location, superb staff and service and great breakfasts and food options."
United States
Juan Vicente
The price is SAR 205
SAR 205 total
17 Nov - 18 Nov
Hotel Santa Ana
A modern spa area with a hot tub, seating, and a view of a hillside village.

10. Edificio Helena

Edificio Helena
3.0 star property
Medellín
8.8 out of 10, Excellent, (75 reviews)
"Room was as expected, didn’t reward the fine print of cooling condition for the room , had a fan available in the room which helped. Appreciate the host, and the security of the building and room especially being I was a solo traveler"
United States
jocelyne
The price is SAR 174
SAR 174 total
2 Dec - 3 Dec
Edificio Helena
A modern bedroom with a large bed, a desk, and a view of a cityscape.

11. Feeling Residences

Feeling Residences
4.0 star property
El Poblado
9.4 out of 10, Exceptional, (311 reviews)
"Great place to stay!"
United States
marcos
The price is SAR 338
SAR 338 total
14 Nov - 15 Nov
Feeling Residences
A modern building with a prominent 'N' logo, outdoor seating, and lush greenery.

12. Nomadic Boutique Living and Experience Center

Nomadic Boutique Living and Experience Center
4.0 star property
El Poblado
9.2 out of 10, Wonderful, (50 reviews)
"Nice quite area close to everything definitely a good area to stay"
United States
Javier
The price is SAR 226
SAR 255 total
15 Nov - 16 Nov
Nomadic Boutique Living and Experience Center
A rooftop terrace with two hot tubs, a dining area with chairs and a table, and a view of a cityscape with mountains in the background.

13. Quadrato Studios

Quadrato Studios
3.0 star property
Laureles
9.4 out of 10, Exceptional, (117 reviews)
"Great hotel. Loved the views at the hot tub!"
United States
Maria Lucia
The price is SAR 172
SAR 172 total
18 Nov - 19 Nov
Quadrato Studios
A modern bedroom with a bed, a sofa, a desk, and a large window with a city view.

14. Apartment Go Living & Suites by HOUSY HOST

Apartment Go Living & Suites by HOUSY HOST
3.5 star property
El Poblado
8.4 out of 10, Very good, (468 reviews)
"Great location, secure place, quiet, private parking"
United States
CAMILO
The price is SAR 160
SAR 272 total
29 Nov - 30 Nov
Apartment Go Living & Suites by HOUSY HOST
A modern building with a curved balcony, large windows, and a stone-paved walkway.

15. Estelar Apartamentos Medellin

Estelar Apartamentos Medellin
3.5 star property
El Poblado
8.8 out of 10, Excellent, (504 reviews)
"Feel very safe and close to Sante Fe Mall"
United States
Gilbert
The price is SAR 373
SAR 373 total
13 Dec - 14 Dec
Estelar Apartamentos Medellin
A modern hotel room with a large bed, a wooden headboard, a bedside table with a lamp, and a view of the city through a large window.

16. ONCE SUITES

ONCE SUITES
3.0 star property
Envigado
10.0 out of 10, Exceptional, (3 reviews)
"Very close to everything"
United States
PAOLA
The price is SAR 181
SAR 181 total
16 Nov - 17 Nov
ONCE SUITES
A hallway with a metal railing, green plants, and a wall with a mural.

17. hotel civitas medellin

hotel civitas medellin
2.5 star property
La Candelaria
8.4 out of 10, Very good, (11 reviews)
"Staff was very friendly and attentive."
United States
Ulysses
The price is SAR 129
SAR 129 total
14 Nov - 15 Nov
hotel civitas medellin
A modern bedroom with a large bed, a bedside table, a built-in bench, a wall-mounted air conditioner, and a sliding glass door leading to an outdoor area with a table and chairs.

18. B 48 Living by B Rent

B 48 Living by B Rent
4.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (29 reviews)
"Exceptionally friendly staff, the property is top notch. Cafe Soler is incredible."
United States
Frederick
The price is SAR 189
SAR 189 total
14 Nov - 15 Nov
B 48 Living by B Rent
Room

19. Factory Lofts

Factory Lofts
4.0 star property
Laureles - Estadio
9.6 out of 10, Exceptional, (147 reviews)
"Everything was great we will definitely be back Super clean, great location and everyone was wonderful"
United States
Michelle
The price is SAR 263
SAR 366 total
19 Nov - 20 Nov
Factory Lofts
A wooden shelf unit with multiple compartments, each containing various decorative items and a framed sign.

20. Soy Local Primavera

Soy Local Primavera
3.0 star property
El Poblado
8.2 out of 10, Very good, (132 reviews)
"Great place to stay."
United States
Yomar
The price is SAR 144
SAR 144 total
14 Nov - 15 Nov
Soy Local Primavera
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Find vacation rentals that suit your style

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Top Santa Cruz Hotel Reviews

A modern building with a sign reading "FIREZE" and a visible address.
Firenze Lofts

Firenze Lofts

Firenze Lofts
La América

10/10 Excellent

The rooms were very accommodating and clean with a very comfortable bed and usable kitchenette.
United States
Alan
Reviewed April 9, 2025
Firenze Lofts

Frequently Asked Questions

Can I find a vacation rental in Santa Cruz?

Yes, we offer vacation rentals close to popular attractions in Santa Cruz, or you can choose a more secluded option if you want a relaxing place to stay.

What's the top vacation rental in Santa Cruz?

6 Bedrooms House near Tourist Spots with backyard, Bar, Jacuzzi and heated pool: Visitors like this Santa Cruz vacation home rental. It offers an outdoor pool, a patio, and air-conditioning to help you feel perfectly comfortable in your new surroundings. It has 6 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. You can relax into your vacation with a garden and a hot tub.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the larger area, you’ll find University of Antioquia and Arvi Park.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties where you can stay for a long or short time in Santa Cruz. Vacation rentals feature extras such as hot tubs, fire pits, and patios so you'll feel just like you're at home. If you're concerned about cleanliness, a vacation rental can offer a sense of safety away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for families.