Perryville Vacation Rentals

Q: What are some of the best vacation rentals that Perryville has to offer?

Silo Farm Haus- located in the heart of wine country! : This vacation home rental outside of Perryville is in a rural location and offers a Smart TV to help you feel perfectly comfortable in your new surroundings.

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Dates

November 2026

December 2026

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Our top choices for Perryville vacation rentals

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

1. The Atrium - A Boutique Hotel

Perryville

Matt

SAR 637 total

includes taxes & fees

11 Nov - 12 Nov

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

2. Urban Lofts

Perryville

Grace

SAR 1,167 total

includes taxes & fees

6 Dec - 7 Dec

A modern kitchen with dark wood cabinets, a central island, and a brick wall.

3. Downtown Urban Loft #9

Perryville

Hunter

SAR 1,141 total

includes taxes & fees

11 Nov - 12 Nov

A spacious loft with exposed brick walls, large windows, a kitchen with bar seating, and a ceiling fan.

4. Downtown Urban Loft #1

Perryville

SAR 1,141 total

includes taxes & fees

11 Nov - 12 Nov

A modern kitchen with stainless steel appliances, a large window, and a breakfast setup on the counter.

5. Gorgeous, downtown house!

Perryville

Doyle or Cheryl D.

SAR 3,015 total

includes taxes & fees

16 Nov - 17 Nov

A bedroom with a bed, a ceiling fan, a window with curtains, and a flat-screen TV on the wall.

6. Charming 3-bedroom Lake House near Perryville

Perryville

SAR 1,093 total

includes taxes & fees

15 Nov - 16 Nov

7. Cozy 2-bedroom cottage in charming Ste. Genevieve

Ste. Genevieve

Katie M.

SAR 605 total

includes taxes & fees

2 Dec - 3 Dec

A white two-story house with a covered porch, a chimney, and a small garden area with chairs and a table.

8. Beautiful Modern Loft In Wine Country!

Ste. Genevieve

Jimmy B.

SAR 726 total

includes taxes & fees

23 Nov - 24 Nov

A compact kitchen with a stone floor, a microwave, a stove, and a refrigerator. There are wooden cabinets and a window with blinds.

9. Fishing Cabin next to Kinkaid Lake

Murphysboro

Dustin M.

SAR 907 total

includes taxes & fees

14 Nov - 15 Nov

A hot tub in a covered outdoor area with a view of a swimming pool and a wooden play structure in the background.

10. Charming 2-bedroom country mobile home with game room, hot tub, seasonal pool

Fredericktown

hannah

SAR 757 total

includes taxes & fees

11 Nov - 12 Nov

A modern kitchen with grey cabinets, a black refrigerator, and a microwave.

11. "The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

Farmington

Ben C.

SAR 908 total

includes taxes & fees

20 Nov - 21 Nov

A hot tub with a wooden deck surrounding it, a window above, and a view of trees outside.

12. Gorgeous 5 Bedroom Log Home Less Than 5 Minutes From Chaumette And Charleville.

Ste. Genevieve

Don D.

SAR 1,398 total

includes taxes & fees

15 Nov - 16 Nov

A two-story cylindrical building with a covered porch and a welcoming sign.

13. Silo Farm Haus- located in the heart of wine country!

Ste. Genevieve

Anthony S.

SAR 1,390 total

includes taxes & fees

12 Nov - 13 Nov

A single-story house with a front porch, a garage, and a well-maintained lawn.

14. Sleeps 8 | Private Hot Tub + Fenced Yard | Near Historic Ste. Genevieve

Saint Mary

Deborah H.

SAR 1,525 total

includes taxes & fees

15 Nov - 16 Nov

A small, single-story building with a porch, a covered outdoor seating area, and a stone foundation.

15. 5 Charles Farms Cabin #1 - NEW CABIN - Wineries, Hiking, & Camp Cana

Ste. Genevieve

Matt H.

A kitchen with white cabinets, a wooden dining table, a built-in stove, and a trash can.

16. Cozy Three bedroom home in Central Farmington

Farmington

Theresa

17. The Cabin at Charleville

Ste. Genevieve

SAR 1,408 total

includes taxes & fees

15 Nov - 16 Nov

A small, single-story building with a porch, red chairs, and a fan.

18. 5 Charles Farms #4 - NEW CABIN - Wineries, Hiking, and Camp Cana

New Offenburg

"This was one of the best places I’ve ever stayed. Owner thought of everything and it was so comfortable. The space was perfect, extra blankets, both types of coffee makers, firewood on site. This is a very new property and everything was immaculate and clean. Was easy to navigate check-in and house was so cute! Would definitely recommend to anyone heading to St Gen or any of surrounding areas."

Carole J.

A narrow hallway with a loft bedroom above, a ladder, and a small window.

19. Authentic Train Caboose with Loft & Firepit Near Elephant Rocks

Fredericktown

Bob A.

A red barn with a sloped roof, surrounded by a grassy field and trees.

20. The Weber Farm - Enjoy a beautiful 100 acre farm!

Frohna

Alison C.

SAR 749 total

includes taxes & fees

11 Dec - 12 Dec

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Find vacation rentals that suit your style

Top Perryville Hotel Reviews

The Atrium - A Boutique Hotel

Perryville

10/10 Excellent

Matt

Urban Lofts

Perryville

10/10 Excellent

Gregory

A hotel room with a large bed, a bathroom with a bathtub, and a mirror reflecting the room.

Days Inn by Wyndham Perryville

Perryville

10/10 Excellent

Anonymous traveler

A large, two-story house with a wrap-around porch and a central tower.

The Conner House B&B

Prairie du Rocher

10/10 Excellent

Waited until the last minute to book a place to stay for an event in Redbud. Everything there was booked so had to expand our search and boy was that a blessing. Ended up at the Conner House and found a beautifully restored 1906 bed and breakfast. Very charming and inviting and took us back in time. Had a wonderful stay, learned a little history and had a great breakfast all thanks to our hostesses Pat & Connie. Forget the national chain - this is a must see house and getting to spend the...

Anonymous traveler

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

Drury Inn & Suites Jackson MO

Jackson

10/10 Excellent

Nicole

A modern restaurant with high tables and orange chairs, a bar area, and large windows with a view.

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Murphysboro

10/10 Excellent

Brianna

A buffet with various food items, including omelets and other dishes, arranged on a counter with a patterned tile backsplash.

Holiday Inn Express Hotel & Suites Sparta by IHG

Sparta

10/10 Excellent

stayed here for a business trip and it was perfect. Staff was very friendly, beds were comfortable, and I appreciated the "fitness center." Breakfast was also great, with a huge array of choices. My only complaint would be that there was a light right outside the window in my room (first floor) and there were no blackout curtains to hide that mean light. Even so, it was a very good overall experience and I would stay there again.

Sarah

A row of single-story houses with attached garages, a paved driveway, and a clear sky.

Microtel Inn & Suites by Wyndham Sainte Genevieve

Ste Genevieve

10/10 Excellent

Ron and Paula

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

10/10 Excellent

Alexandra

A hotel room with a bed, a desk with a chair, a small table, a sofa, a bathtub, and a window with curtains.

Baymont by Wyndham Chester IL

Chester

10/10 Excellent

Michael

A spacious lobby with large windows, comfortable seating, and a modern ceiling design.

Comfort Suites Jackson-Cape Girardeau

Jackson

10/10 Excellent

Jeff

A motel with a covered entrance, a flag, and a phone number.

Madison Inn Lodge

Fredericktown

10/10 Excellent

Anonymous traveler

A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.

Town House Inn

Jackson

10/10 Excellent

larry

A modern bedroom with a large bed, a desk with a computer, a chair, and a window with a view of a lake.

Briarwood Inn of Sparta

Sparta

10/10 Excellent

Daniel

Frequently Asked Questions

Can I find a vacation rental in Perryville?

Yes, you can find vacation rentals near top local attractions in Perryville, or you can choose a more secluded option if you'd like a relaxing place to stay. Perryville is known for its wineries and golf courses. Make sure you have time to check out the coffeehouses and festivals during your trip.

What are some of the best vacation rentals that Perryville has to offer?

Silo Farm Haus- located in the heart of wine country!: This vacation home rental outside of Perryville is in a rural location and offers a Smart TV to help you feel perfectly comfortable in your new surroundings.

How many vacation rentals will I find in Perryville?

With 3 Expedia vacation rentals, you're sure to find just the right place for your Perryville stay.

What’s there to see and do in Perryville?

Mark Twain National Forest and Mississippi River are a couple of lovely local spots to get outside and enjoy nature. While here, National Shrine of Our Lady of the Miraculous Medal and Saint Marys Lake are other places worth a visit.

What’s a vacation rental in Perryville like?

Vacation rentals are privately owned properties you can book for short or long periods in Perryville. Vacation rentals offer amenities such as laundry facilities and kitchens so you'll have all the comforts of home. If you're concerned about a clean environment, vacation rentals can provide a sense of security away from public hotel elevators and bustling concierge desks while still allowing you to travel. You'll also find more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is an attractive choice for family gatherings.

Perryville Vacation Rentals

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Perryville vacation rentals

1. The Atrium - A Boutique Hotel

2. Urban Lofts

3. Downtown Urban Loft #9

4. Downtown Urban Loft #1

5. Gorgeous, downtown house!

6. Charming 3-bedroom Lake House near Perryville

7. Cozy 2-bedroom cottage in charming Ste. Genevieve

8. Beautiful Modern Loft In Wine Country!

9. Fishing Cabin next to Kinkaid Lake

10. Charming 2-bedroom country mobile home with game room, hot tub, seasonal pool

11. "The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

12. Gorgeous 5 Bedroom Log Home Less Than 5 Minutes From Chaumette And Charleville.

13. Silo Farm Haus- located in the heart of wine country!

14. Sleeps 8 | Private Hot Tub + Fenced Yard | Near Historic Ste. Genevieve

15. 5 Charles Farms Cabin #1 - NEW CABIN - Wineries, Hiking, & Camp Cana

16. Cozy Three bedroom home in Central Farmington

17. The Cabin at Charleville

18. 5 Charles Farms #4 - NEW CABIN - Wineries, Hiking, and Camp Cana

19. Authentic Train Caboose with Loft & Firepit Near Elephant Rocks

20. The Weber Farm - Enjoy a beautiful 100 acre farm!

Find vacation rentals that suit your style

Top Perryville Hotel Reviews

The Atrium - A Boutique Hotel

10/10 Excellent

Frequently Asked Questions

Can I find a vacation rental in Perryville?

What are some of the best vacation rentals that Perryville has to offer?

How many vacation rentals will I find in Perryville?

What’s there to see and do in Perryville?

What’s a vacation rental in Perryville like?