Panama Vacations

Book a Hotel + Flight together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to SARĀ 5,400 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Find the Best Panama Vacation Packages

Panama Hotel Deals

Baymont by Wyndham Litchfield

Baymont by Wyndham Litchfield

2.5 out of 5
1405 W Hudson Dr Litchfield IL
Fully refundableReserve now, pay when you stay
The price is SARĀ 372 per night from Jul 23 to Jul 24
SARĀ 372
SARĀ 409 total
23 Jul - 24 Jul
includes taxes & fees
8.4/10 Very Good! (1,004 reviews)
"Nice hotel"

Reviewed on 21 July 2026

Baymont by Wyndham Litchfield
Super 8 by Wyndham Staunton

Super 8 by Wyndham Staunton

2 out of 5
1527 Herman Rd Staunton IL
Fully refundableReserve now, pay when you stay
The price is SARĀ 289 per night from Jul 23 to Jul 24
SARĀ 289
SARĀ 321 total
23 Jul - 24 Jul
includes taxes & fees
Super 8 by Wyndham Staunton
Comfort Inn & Suites Greenville I-70

Comfort Inn & Suites Greenville I-70

2.5 out of 5
2265 S. State Route 127 Greenville IL
Fully refundable
The price is SARĀ 368 per night from Aug 16 to Aug 17
SARĀ 368
SARĀ 409 total
16 Aug - 17 Aug
includes taxes & fees
8.4/10 Very Good! (455 reviews)
"Breakfast was adequate. Air worked we, and we experienced a quiet peaceful night."

Reviewed on 20 July 2026

Comfort Inn & Suites Greenville I-70
See all 47 properties in Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Panama vacation package cost?
You can snap up a vacation package to this popular destination on Expedia. However, how much your vacation to Panama costs will depend on factors like the length of stay, season and hotel choice.
What are the cheapest months to go to Panama?
You're likely to find lower rates and greater availability in January, February and November. Explore our cheap Panama vacation packages and you could score some great off-season deals.
How to find the best Panama package deals?
Use Expedia's handy filters to help you find some fabulous Panama package deals. When you start your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your break for midweek, or look for Panama package deals in the off-season. Play around with your travel dates and you may land even better discounts. As a rule of thumb, it's usually best to book your vacation package well in advance.
Is it cheaper to book a Panama vacation as a package?
Expedia vacation packages are designed to make your money go further. Bundle your car rental, flight and hotel into one great-value price and you could save hundreds of dollars. You'll typically score a better deal than booking each component individually. And you'll still have the freedom to create a customized Panama vacation by choosing your preferred accommodation type, airline and car class.
When to book a vacation package to Panama?
If you've got your Panama travel dates confirmed, book as early as you can to score some terrific deals. With Expedia, you can typically reserve some flights up to one year ahead of time. Prefer spur-of-the-moment trips? Our last-minute deals are perfect for quick escapes.
How to plan a trip to Panama?

  1. Choose when to get away: Check your schedule and pack your bags. Your favorite time of year and the activities available will also help you decide when to vacation in Panama.
  2. Budget wisely: In addition to the price of your accommodations, you'll need to consider other expenses. These include flights, food and transportation. Also, set aside a little extra for unexpected expenses that may crop up during your trip to Panama.
  3. Determine how many days away: Start by compiling a list of the attractions and activities you'd like to get to in Panama. Then, estimate how long you'll need for each, as well as any travel time.
  4. Combine your airfare and accommodations: After you've nailed down your travel dates and duration, book the perfect Panama vacation package for you.