Top 10 Hotels in O Brien, FL from SAR 208 - Competitive Prices

A calm river with clear water, surrounded by dense trees and rocky banks.

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Waterpark

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Our top choices for O Brien hotels

Suite, 2 Queen Beds, Non Smoking | In-room safe, desk, laptop workspace, WiFi

1. Hampton Inn & Suites Alachua I-75

Alachua

Jasmine

SAR 397

SAR 447 total

includes taxes & fees

27 Aug - 28 Aug

Standard Room, 2 Double Beds | Blackout drapes, WiFi (free), bed sheets

Standard Room, 2 Double Beds | Bathroom sink

2. Royal Inn

Alachua

Alec

SAR 258

SAR 290 total

includes taxes & fees

20 Sep - 21 Sep

3. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Alachua

Diane

SAR 334

SAR 376 total

includes taxes & fees

20 Sep - 21 Sep

1 bedroom, laptop workspace, WiFi (free), bed sheets

40-inch Smart TV with digital channels, Netflix, streaming services

Cabin, 1 Queen Bed with Sofa bed, Kitchen | Private kitchen | Coffee/tea maker, full-size fridge, microwave, stovetop

4. Vista Verde Farm Retreat

Lake City

Stacy

SAR 428

SAR 743 total

includes taxes & fees

1 Sep - 2 Sep

Grand Room | Blackout drapes, iron/ironing board (on request), WiFi (free)

5. BlueGem Motel

High Springs

REINIER

SAR 333

SAR 375 total

includes taxes & fees

25 Aug - 26 Aug

Double Room, Non Smoking | Laptop workspace, WiFi (free)

Single Room, Non Smoking | Laptop workspace, WiFi (free)

6. High Springs Country Inn

High Springs

Antonio

SAR 294

SAR 331 total

includes taxes & fees

23 Aug - 24 Aug

Premium bedding, desk, blackout drapes, soundproofing

Studio, 1 King Bed | Bathroom | Combined shower/tub, free toiletries, hair dryer, towels

Room, 1 King Bed, Non Smoking | Living room | Flat-screen TV

7. Palms Garden Inn

Lake City

Teresa

SAR 259

SAR 291 total

includes taxes & fees

24 Aug - 25 Aug

8. The Blanche

Lake City

Brandi

SAR 519

SAR 583 total

includes taxes & fees

26 Aug - 27 Aug

Desk, laptop workspace, iron/ironing board, cribs (free)

Studio Suite, Multiple Beds, Non Smoking | Desk, laptop workspace, iron/ironing board, cribs (free)

9. Days Inn by Wyndham Lake City I-10

Lake City

Serhii

SAR 222

SAR 250 total

includes taxes & fees

23 Aug - 24 Aug

1 bedroom, desk, laptop workspace, bed sheets

Cabin, 1 Queen Bed | Private kitchen | Mini-fridge, stovetop, cookware/dishes/utensils, paper towels

Cabin, 1 Queen Bed (View) | Breakfast meal

10. Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

High Springs

Julienne

SAR 477

SAR 855 total

includes taxes & fees

20 Sep - 21 Sep

Down comforters, pillowtop beds, blackout drapes, WiFi (free)

Outdoor pool, open 9:00 AM to 10:00 PM, sun loungers

11. Super 8 by Wyndham Lake City

Lake City

Mari

SAR 246

SAR 276 total

includes taxes & fees

25 Aug - 26 Aug

Basic 2 Queen Beds Non Smoking | Soundproofing, bed sheets

12. Driftwood Inn

Lake City

Dmitriy

SAR 185

SAR 208 total

includes taxes & fees

23 Aug - 24 Aug

Basic Single Room | Bathroom | Hair dryer, towels

Iron/ironing board, WiFi (free), bed sheets

13. Regal Inn

Lake City

Samuel

SAR 217

SAR 244 total

includes taxes & fees

1 Sep - 2 Sep

Premium bedding, desk, laptop workspace, blackout drapes

14. Courtyard By Marriott Lake City

Lake City

Tonya

SAR 402

SAR 452 total

includes taxes & fees

6 Sep - 7 Sep

15. Knights Inn Lake City

Lake City

Melissa

SAR 207

SAR 232 total

includes taxes & fees

21 Aug - 22 Aug

16. Holiday Inn & Suites Lake City by IHG

Lake City

Renee

SAR 364

SAR 410 total

includes taxes & fees

23 Aug - 24 Aug

Standard Room, 2 Double Beds, Non Smoking | Pillowtop beds, desk, iron/ironing board, WiFi (free)

17. Quality Inn Lake City

Lake City

Lucille

SAR 287

SAR 323 total

includes taxes & fees

1 Sep - 2 Sep

Desk, laptop workspace, blackout drapes, iron/ironing board

18. La Quinta Inn & Suite by Wyndham Lake City

Lake City

Priscilla J

SAR 351

SAR 395 total

includes taxes & fees

6 Sep - 7 Sep

Pillowtop beds, in-room safe, desk, blackout drapes

19. Days Inn by Wyndham Lake City I-75

Lake City

Brizheet

SAR 237

SAR 267 total

includes taxes & fees

23 Aug - 24 Aug

20. Rodeway Inn Lake City I-75

Lake City

Norma

SAR 203

SAR 228 total

includes taxes & fees

26 Aug - 27 Aug

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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien

A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Baymont by Wyndham Lake City I-75

10/10 Excellent

"Nice place"

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

10/10 Excellent

"Good breakfast, great staff & clean room."

Comfort Suites Lake City

10/10 Excellent

"Clean, comfortable, roomy"

Tru by Hilton Lake City

10/10 Excellent

"Great"

Hampton Inn & Suites Lake City

10/10 Excellent

"Everything was perfect for our stay. The staff was friendly and helpful when we had questions. The rooms were clean and had everything we needed."

La Quinta Inn & Suite by Wyndham Lake City

10/10 Excellent

"From check in to check out, I had a great experience. I was traveling for a funeral and had not slept for 2 days! The staff helped me at the front to get to my room. The room was better than expected and the breakfast was just what I needed. I’d recommend this stay to anyone"

Best Western Plus Lake City

10/10 Excellent

"Todo bien"

Quality Inn Lake City

10/10 Excellent

"I stayed at Quality Inn Lake City FL for a few days per week for several months for work. It is clean and spacious. The staff are friendly and welcoming. There is always a hot breakfast on mornings. Staying there felt like home."

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

8/10 Good

"Christine was absolutely wonderful from beginning to end. She even came by to say hello on our first day. Very responsive. I do wish the river was closer and not quite a small walk because my in laws are elderly and couldn’t enjoy it. The walk to the river is quite tough, hard to get kayaks out to the water, It’s a very steep walk. The ac wouldn’t go any colder than 70. Only one television which is in the livingroom so that was rough. Kitchen and home Fully stocked with all the things we needed and the kids enjoyed the play room. Overall the home and the host was great for the price"

More cheap stays in O Brien

Days Inn by Wyndham Lake City I-10

3430 N Us Highway 441 Lake City FL

SAR 222

SAR 250 total

23 Aug - 24 Aug

includes taxes & fees

Quality Inn Lake City

285 Sw Commerce Dr Lake City FL

SAR 287

SAR 323 total

1 Sep - 2 Sep

includes taxes & fees

8.2/10 Very Good! (1,004 reviews)

Best Western Plus Lake City

350 SW Florida Gateway Dr Lake City FL

SAR 314

SAR 354 total

13 Sep - 14 Sep

includes taxes & fees

Comfort Suites Lake City

3690 W Us Highway 90 Lake City FL

SAR 348

SAR 391 total

26 Aug - 27 Aug

includes taxes & fees

9.4/10 Exceptional! (1,007 reviews)

Hampton Inn & Suites Alachua I-75

15930 Northwest 163rd Lane Alachua FL

SAR 397

SAR 447 total

27 Aug - 28 Aug

includes taxes & fees

Tru by Hilton Lake City

284 NW Centurion Court Lake City FL

SAR 409

SAR 460 total

23 Aug - 24 Aug

includes taxes & fees

9.2/10 Wonderful! (1,003 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?

Best Western Plus Lake City, located 17.9 mi (28.8 km) from the heart of O Brien, is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and La Quinta Inn & Suite by Wyndham Lake City. See all available top hotels, or vacation rentals in O Brien.

What's the top vacation rental in O Brien?

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: Visitors give good reviews to this O Brien vacation home rental, which is located on the beach and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. Our travelers also rate MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY as a favorite home for rent in O Brien. See all vacation rentals in O Brien.

If I need to cancel my hotel reservation in O Brien, will I receive a refund?

Yes! You'll find that most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.

Where can I learn more about changing or cancelling my trip to O Brien?

To access more information about picking new dates or cancelling your trip to O Brien, click here.

Where is the best hotel to stay near Ichetucknee Springs State Park?

Escape to Nature - 2 miles from Ichetucknee park is one of the top choices for your stay based on our traveler data, and this property features in-room kitchens and fireplaces. It's located 2.3 mi (3.8 km) from Ichetucknee Springs State Park. Another good choice is A Riverview of a Magical Sunrise every morning, located 5.6 mi (9.1 km) away.

What are some accommodations with pools in O Brien?

Best Western Plus Lake City: Provides a snack bar/deli, an indoor pool, and buffet. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and Holiday Inn Express & Suites Alachua - Gainesville Area by IHG are two additional hotels that feature an onsite pool. View all hotels with pools in O Brien.

What's the best hotel for staying near Gainesville Regional Airport (GNV)?

Hampton Inn & Suites Gainesville Downtown is one of the top choices for your stay and is a popular hotel, featuring free breakfast and an outdoor pool. It's located 3.7 mi (6 km) from Gainesville Regional Airport. Other good choices close to the airport include Sweetwater Branch Inn and Travelers Inn.

How is it to stay in O Brien?

Visitors to O Brien are sure to find plenty to explore and enjoy. In O Brien, there are 9 hotels and other accommodations to choose from. Find out more about O Brien.

What should I see while I'm in O Brien?

Natural beauty is on display at Suwannee River, Ichetucknee River, and Ichetucknee Springs State Park. You'll also find Troy Spring State Park and Lafayette Blue Springs State Park in the area. Check out what more to see and do in Expedia's O Brien guide.

What's the seasonal weather like in O Brien?

The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 58°F. Average annual precipitation for O Brien is 50 inches.

Find hotels in O Brien, FL from SAR 208

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in O Brien

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for O Brien hotels

1. Hampton Inn & Suites Alachua I-75

2. Royal Inn

3. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

4. Vista Verde Farm Retreat

5. BlueGem Motel

6. High Springs Country Inn

7. Palms Garden Inn

8. The Blanche

9. Days Inn by Wyndham Lake City I-10

10. Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

11. Super 8 by Wyndham Lake City

12. Driftwood Inn

13. Regal Inn

14. Courtyard By Marriott Lake City

15. Knights Inn Lake City

16. Holiday Inn & Suites Lake City by IHG

17. Quality Inn Lake City

18. La Quinta Inn & Suite by Wyndham Lake City

19. Days Inn by Wyndham Lake City I-75

20. Rodeway Inn Lake City I-75

Learn more about O Brien

Top O Brien Hotel Reviews

Baymont by Wyndham Lake City I-75

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Comfort Suites Lake City

Tru by Hilton Lake City

Hampton Inn & Suites Lake City

La Quinta Inn & Suite by Wyndham Lake City

Best Western Plus Lake City

Quality Inn Lake City

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

More cheap stays in O Brien

Days Inn by Wyndham Lake City I-10

Quality Inn Lake City

Best Western Plus Lake City

Comfort Suites Lake City

Hampton Inn & Suites Alachua I-75

Tru by Hilton Lake City

Frequently asked questions

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