A calm river with clear water, surrounded by dense trees and rocky banks.

Find hotels in O Brien, FL from SAR 207

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
13 Nov - 15 Nov
Next weekend
20 Nov - 22 Nov

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for O Brien hotels

A multi-story hotel with a modern design, featuring a covered entrance and a parking lot.

1. Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
3.0 star property
Lake City
9.0 out of 10, Wonderful, (300 reviews)
"Stayed here on the way to Disney so wouldn't have to drive so far one way for the family. It was a nice place to stay."
United States
Anthony
The price is SAR 353
SAR 397 total
includes taxes & fees
5 Dec - 6 Dec
Fairfield Inn & Suites Lake City
A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.

2. Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,001 reviews)
"Overall great stay!"
United States
Jim
The price is SAR 351
SAR 395 total
includes taxes & fees
6 Dec - 7 Dec
Comfort Suites Lake City
An outdoor patio with a stone fire feature, blue cushioned seating, and a grill.

3. Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1,001 reviews)
"Always a great stay."
United States
Gary
The price is SAR 349
SAR 393 total
includes taxes & fees
6 Dec - 7 Dec
Tru by Hilton Lake City
A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.

4. La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
3.0 star property
Lake City
8.8 out of 10, Excellent, (1,208 reviews)
"Very nice visit, very clean room, excellent staff, great breakfast, easy parking"
United States
Emory
The price is SAR 351
SAR 395 total
includes taxes & fees
2 Dec - 3 Dec
La Quinta Inn & Suite by Wyndham Lake City
A spacious indoor area with a pool view, multiple seating arrangements, and a central plant.

5. Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,000 reviews)
"I have stayed here several times. Staff is at least very friendly and accommodating properties very clean. We enjoyed our stay."
United States
Eileen
The price is SAR 359
SAR 404 total
includes taxes & fees
13 Dec - 14 Dec
Hampton Inn & Suites Lake City
A spacious living area with a grey sofa, a coffee table, and a TV stand.

6. Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,139 reviews)
"Convenient clean and met our needs for the weekend"
United States
Sherry
The price is SAR 301
SAR 338 total
includes taxes & fees
1 Dec - 2 Dec
Best Western Plus Lake City
An outdoor patio area with wicker chairs, a round table, and a fire pit.

7. TownePlace Suites by Marriott Lake City

TownePlace Suites by Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (152 reviews)
"Very clean! Comfy beds!"
United States
John
The price is SAR 484
SAR 545 total
includes taxes & fees
15 Nov - 16 Nov
TownePlace Suites by Marriott Lake City
An outdoor patio with a stone fire pit, grey cushioned seating, and wicker ottomans.

8. Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (834 reviews)
"Big, clean room and the staff was very friendly"
United States
Laurie
The price is SAR 445
SAR 501 total
includes taxes & fees
22 Nov - 23 Nov
Home2 Suites by Hilton Lake City
A multi-story hotel with a modern design, featuring a prominent entrance and a parking area.

9. Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (315 reviews)
"Nice overnight stay."
United States
Zanza
The price is SAR 402
SAR 452 total
includes taxes & fees
22 Nov - 23 Nov
Courtyard By Marriott Lake City
A multi-story hotel with a central entrance, palm trees, and a covered walkway.

10. Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
3.0 star property
Lake City
8.6 out of 10, Excellent, (1,001 reviews)
"Next time I am needing motel in Lake City, will plan to stay at this location."
United States
William
The price is SAR 379
SAR 426 total
includes taxes & fees
6 Dec - 7 Dec
Holiday Inn & Suites Lake City by IHG
A spacious lobby with a high ceiling, a large window, a dining area with green chairs, and a black door leading outside.

11. Quality Inn Lake City

Quality Inn Lake City
2.5 star property
Lake City
8.2 out of 10, Very good, (1,002 reviews)
"Very nice hotel!"
United States
Mary
The price is SAR 257
SAR 289 total
includes taxes & fees
13 Dec - 14 Dec
Quality Inn Lake City
A hotel lobby with a reception desk, a clock, a plant, a water dispenser, and a coffee station.

12. Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.6 out of 10, Excellent, (1,000 reviews)
"This is a great hotel for the price. Clean, room was small. Close to restaurants and parking lot is well lite."
United States
Brenda
The price is SAR 267
SAR 300 total
includes taxes & fees
15 Nov - 16 Nov
Americas Best Value Inn Lake City
Room

13. Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (767 reviews)
"Complimentary dinner and cooked to order eggs at breakfast. Neat and clean. Comfy bed."
United States
Allan
The price is SAR 230
SAR 258 total
includes taxes & fees
1 Dec - 2 Dec
Super 8 by Wyndham Lake City
A compact kitchen with a blue refrigerator, a black coffee maker, a microwave, and a small black refrigerator.

14. Cindys Motel

Cindys Motel
2.5 star property
Mayo
8.8 out of 10, Excellent, (142 reviews)
"It was a clean room. We could park outside our room door."
United States
Keith
The price is SAR 323
SAR 349 total
includes taxes & fees
14 Dec - 15 Dec
Cindys Motel
A buffet with various food items, including omelets and baked goods, served in metal containers.

15. Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG
2.5 star property
Live Oak
8.4 out of 10, Very good, (901 reviews)
"Nice place"
United States
Andrew
The price is SAR 372
SAR 409 total
includes taxes & fees
13 Dec - 14 Dec
Holiday Inn Express & Suites Live Oak by IHG
A hotel room with two beds, a TV, a desk, and a painting of a sunset.

16. Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1,000 reviews)
"Nice breakfast."
United States
Nathan
The price is SAR 252
SAR 284 total
includes taxes & fees
1 Dec - 2 Dec
Days Inn by Wyndham Lake City I-75
A modern kitchen with a large window, a flat-screen TV, and a coffee machine.

17. Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
White Springs
7.2 out of 10, Good, (710 reviews)
"Great breakfast options quiet clean place to stay"
United States
Pennee
The price is SAR 227
SAR 249 total
includes taxes & fees
6 Dec - 7 Dec
Quality Inn White Springs Suwanee
A reception area with a wooden floor, a reception desk, a seating area with chairs, and a view through the glass doors to the outside.

18. Econo Lodge Live Oak

Econo Lodge Live Oak
2.0 star property
Live Oak
7.0 out of 10, Good, (327 reviews)
"I definitely will not recommend anyone to book a room there. The rooms are in bad sharp. The whole hotel need remodel."
United States
Alexia
The price is SAR 275
SAR 302 total
includes taxes & fees
15 Nov - 16 Nov
Econo Lodge Live Oak
A reception area with a stone wall, a blue accent wall, a clock, and a window with a view of the parking lot.

19. Regal Inn

Regal Inn
2.5 star property
Lake City
8.4 out of 10, Very good, (623 reviews)
"This is the second time I’ve stayed at this hotel. Convenient to restaurants and gas stations. Look forward to staying again."
United States
Gerardo
The price is SAR 247
SAR 277 total
includes taxes & fees
14 Nov - 15 Nov
Regal Inn
A reception area with a Baymont Inn & Suites sign, a reception desk, a glass-top table, and a door.

20. Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75
2.5 star property
Lake City
5.0 out of 10, (1,001 reviews)
"Easy parking room clean"
United States
Pennee
The price is SAR 217
SAR 244 total
includes taxes & fees
17 Nov - 18 Nov
Baymont by Wyndham Lake City I-75
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Tru by Hilton Lake City

Tru by Hilton Lake City

10/10 Excellent
"na"
Pam 1-night trip
Posted 16 hours ago
Tru by Hilton Lake City

More cheap stays in O Brien

Quality Inn Lake City

Quality Inn Lake City

285 Sw Commerce Dr Lake City FL
The price is SAR 257 per night from Dec 13 to Dec 14
SAR 257
SAR 289 total
13 Dec - 14 Dec
includes taxes & fees

Frequently asked questions

Where is the best place to stay in O Brien?
La Quinta Inn & Suite by Wyndham Lake City, located 18.2 mi (29.3 km) from the heart of O Brien, is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy. See all available top hotels, or vacation rentals in O Brien.
What's the top vacation rental in O Brien?
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: Visitors give good reviews to this O Brien vacation home rental, which is located on the beach and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. Our travelers also rate MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY as a favorite home for rent in O Brien. See all vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
Where can I learn more about changing or cancelling my trip to O Brien?
To access more information about picking new dates or cancelling your trip to O Brien, click here.
Where is the best hotel to stay near Ichetucknee Springs State Park?
Escape to Nature - 2 miles from Ichetucknee park is one of the top choices for your stay based on our traveler data, and this property features in-room kitchens and fireplaces. It's located 2.3 mi (3.8 km) from Ichetucknee Springs State Park. Another good choice is A Riverview of a Magical Sunrise every morning, located 5.6 mi (9.1 km) away.
What are some accommodations with pools in O Brien?
La Quinta Inn & Suite by Wyndham Lake City: Provides buffet, an indoor pool, and free self parking. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and Holiday Inn Express & Suites Alachua - Gainesville Area by IHG are two additional hotels that feature an onsite pool. View all hotels with pools in O Brien.
What's the best hotel for staying near Gainesville Regional Airport (GNV)?
Hampton Inn & Suites Gainesville Downtown is one of the top choices for your stay and is a popular hotel, featuring free breakfast and an outdoor pool. It's located 3.7 mi (6 km) from Gainesville Regional Airport. Other good choices close to the airport include Sweetwater Branch Inn and Travelers Inn.
How is it to stay in O Brien?
Visitors to O Brien are sure to find plenty to explore and enjoy. In O Brien, there are 9 hotels and other accommodations to choose from. Find out more about O Brien.
What should I see while I'm in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River, and Ichetucknee Springs State Park. You'll also find Lafayette Blue Springs State Park and Lake City Mall in the area. Check out what more to see and do in Expedia's O Brien guide.
What's the seasonal weather like in O Brien?
The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 58°F. Average annual precipitation for O Brien is 50 inches.