A coastal town with terracotta-roofed houses, a beach, and a castle on a hill.

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Check availability on Mytilene Resorts & Hotels with Spas

This weekend
6 Nov - 8 Nov
Next weekend
13 Nov - 15 Nov

Our top choices for Mytilene hotels with a spa

A modern kitchen with stainless steel appliances, a wooden countertop, and a dining area with a table and chairs.

1. Agora Apartments

Agora Apartments
Lesvos
10.0 out of 10, Exceptional, (5 reviews)
"Excellent host, amazing apartment, enjoyed every single minute spent at the apartment."
United States
Rüçhan Ferit
The price is SAR 269
SAR 297 total
includes taxes & fees
20 Nov - 21 Nov
Agora Apartments
A hotel room with two beds, a desk, and a view of the ocean.

2. Akti Vigla Premium

Akti Vigla Premium
Lesvos
10.0 out of 10, Exceptional, (26 reviews)
"Very clean room, excellent easy check in. Easy to find and free parking. Perfect location close to the airport. Ocean view."
United States
Gertrud
The price is SAR 200
SAR 221 total
includes taxes & fees
16 Nov - 17 Nov
Akti Vigla Premium
A hotel lobby with a reception desk, a sofa, a chair, and a dining area.

3. Theofilos Paradise Boutique Hotel

Theofilos Paradise Boutique Hotel
4.0 star property
Lesvos
9.6 out of 10, Exceptional, (176 reviews)
"Staff was nice. Large breakfast spread. Location is great."
United States
Caroline
The price is SAR 435
SAR 489 total
includes taxes & fees
9 Nov - 10 Nov
Theofilos Paradise Boutique Hotel
Reception

4. Hotel Lesvion

Hotel Lesvion
3.0 star property
Lesvos
9.4 out of 10, Exceptional, (147 reviews)
"We stayed here for a few nights while visiting the island. The breakfast is top-notch, the staff was very helpful and the property is walkable distance to everything in town. We will stay here in heartbeat again."
Canada
Gunjan
The price is SAR 221
SAR 249 total
includes taxes & fees
22 Nov - 23 Nov
Hotel Lesvion
A room with a green sofa, a wooden bench, a chair, a small table, and a window with curtains.

5. Heliotrope The Studios

Heliotrope The Studios
Lesvos
9.0 out of 10, Wonderful, (62 reviews)
"Very nice clean hotel. I liked absolutely everything. Maria, thank you very much for the pleasant impressions and for your hospitality!"
Turkey
Yasar
The price is SAR 351
SAR 386 total
includes taxes & fees
7 Dec - 8 Dec
Heliotrope The Studios
A swimming pool with tiled flooring, lounge chairs, and a bar area.

6. Heliotrope Hotels

Heliotrope Hotels
4.0 star property
Lesvos
8.6 out of 10, Excellent, (203 reviews)
"The breakfast was so rich and delicious. Rooms"
Turkey
Ufuk
The price is SAR 296
SAR 337 total
includes taxes & fees
15 Nov - 16 Nov
Heliotrope Hotels
A patio area with outdoor seating, palm trees, and a view of the sea.

7. Loriet Hotel

Loriet Hotel
4.0 star property
Lesvos
8.4 out of 10, Very good, (96 reviews)
"Lovely mansion house and a great breakfast."
United States
Malcolm
The price is SAR 257
SAR 294 total
includes taxes & fees
12 Nov - 13 Nov
Loriet Hotel
Two white ceramic cups on a tray with a spoon, a blue sign with 'HB5' logo, and a bowl of snacks in the background.

8. Blue Sea

Blue Sea
3.0 star property
Lesvos
7.2 out of 10, Good, (15 reviews)
"Very convenient to the ferry port, decent hotel, nice views, could use an upgrade"
United States
Jak
The price is SAR 356
SAR 408 total
includes taxes & fees
9 Nov - 10 Nov
Blue Sea
A pool area with lounge chairs and a dining table, surrounded by a building with multiple balconies and a palm tree.

9. Galazio Asteri I

Galazio Asteri I
Lesvos
10.0 out of 10, Exceptional, (17 reviews)
"Jim was an awesome host. I arrived late, he met me at the gate. He seemed more like family than a host. He took time to make sure I was comfortable before he left. Although I stayed one night, I will come again with my family. Thanks Hotels.com for letting me meet a new friend"
United States
Chris
The price is SAR 231
SAR 255 total
includes taxes & fees
7 Nov - 8 Nov
Galazio Asteri I
A terrace with a table, chairs, and a view of a swimming pool and greenery.

10. Paradisos studios

Paradisos studios
Lesvos
9.6 out of 10, Exceptional, (5 reviews)
"This hotel is owner operated. Owner directly helped me to check in. Room was clean and spacious. Phenomenal value for the money. It is the 3rd time we have stayed at Paradisos. "
United States
Chris
The price is SAR 125
SAR 139 total
includes taxes & fees
24 Nov - 25 Nov
Paradisos studios
A reception area with a wooden reception desk, a white sofa, a small round table with a plant, and a wall-mounted sign.

11. Oikies Small Elegant Houses

Oikies Small Elegant Houses
Lesvos
9.4 out of 10, Exceptional, (30 reviews)
"Great place! Don’t look for anywhere else!"
United States
ATAMAN
The price is SAR 377
SAR 415 total
includes taxes & fees
7 Dec - 8 Dec
Oikies Small Elegant Houses
A woman sitting by a pool with a drink, overlooking a modern outdoor bar and lounge area with outdoor seating.

12. Elies Residences

Elies Residences
Lesvos
9.8 out of 10, Exceptional, (38 reviews)
"Beautiful quiet nice little place.Very cosy !!"
Australia
Anonymous traveler
The price is SAR 383
SAR 421 total
includes taxes & fees
9 Nov - 10 Nov
Elies Residences
A person standing on a balcony overlooking a pool and a modern building with a clear view of the sea.

13. Elysion Hotel

Elysion Hotel
5.0 star property
Lesvos
9.2 out of 10, Wonderful, (51 reviews)
"very good place and the staffs took very good care for us, even to prepare special diet foods. Lovely place and next to sea."
Turkey
ANINDYA
The price is SAR 351
SAR 402 total
includes taxes & fees
7 Nov - 8 Nov
Elysion Hotel
Two wicker chairs with cushions, a decorative plant, and a small round table with candles and a tray.

14. Mythical Coast Wellness Retreat

Mythical Coast Wellness Retreat
5.0 star property
Lesvos
8.6 out of 10, Excellent, (73 reviews)
"Absolutely beautiful resort with the friendliest staff! Everything was easily accessible the pools were clean and refreshing and the saunas were such a great added treat! Our room was impeccably cleaned with a stunning view! Room service with extra care; an overall wonderful experience at the Mythical Coast!!!"
United States
Konstantina
The price is SAR 346
SAR 408 total
includes taxes & fees
19 Nov - 20 Nov
Mythical Coast Wellness Retreat
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Mytilene

Pool
Breakfast included

Top Mytilene Hotel Reviews

Frequently asked questions

Looking to vacation at a spa hotel in Mytilene?
Book one of our fantastic spa hotels and pamper yourself from the moment you arrive. Check out the museums and churches in Mytilene—your cultural tour starts here. Enjoy the architecture and sea views during your vacation. Spa hotels are a great way to break out of your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Mytilene?
Mythical Coast Wellness Retreat is a top beach spa hotel featuring 5 restaurants, 5 bars, 3 indoor pools, and 5 cafes. Treat yourself to a facial, body scrub, or Swedish massage at Mythical Coast Spa. Another popular spa hotel in Mytilene is Theofilos Paradise Boutique Hotel.
How many spa hotels are there in Mytilene?
Among Expedia's 88 accommodation options in Mytilene, there are 2 spa hotels.
What's there to see and do in Mytilene?
When you're in Mytilene, enjoy exploring the sights and attractions here including Port of Mytilene, Mytilini Castle, and Roman Aqueduct at Moria. If you have a bit of extra time while you're in the area, you might want to check out Thermes Gera Hot Springs and St Hermogenes Charamida Lesvos.
What is a Mytilene spa hotel?
Spa hotels in Mytilene feature full on-site spas offering services like facials and a range of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are ideal if you are looking for some R&R during your vacation.