Isle of Palms Vacations

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Where to stay in Isle of Palms

Find the best Isle of Palms areas and neighborhoods for the activities you enjoy most. Learn more about Isle of Palms
A coastal town at dusk with a prominent clock tower, waterfront, and illuminated buildings.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

Find hotels in Amelia City

Isle of Palms Hotel Deals

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3 out of 5
4905 SAN PABLO ROAD SOUTH Jacksonville FL
The price is SARĀ 497 per night from Aug 8 to Aug 9
SARĀ 497
SARĀ 564 total
8 Aug - 9 Aug
includes taxes & fees
9.4/10 Exceptional! (559 reviews)
"Great clean hotel. The location is perfect for Mayo Clinic guests. Our bed was comfortable and the room is laid out very nicely with a small kitchen, full-size refrigerator, and a walk-in shower. We had dinner in the hotel bar area and it was very good. The staff is very funny."

Reviewed on 17 July 2026

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

2.5 out of 5
715 1st St N Jacksonville Beach FL
Fully refundableReserve now, pay when you stay
The price is SARĀ 632 per night from Aug 3 to Aug 4
SARĀ 632
SARĀ 717 total
3 Aug - 4 Aug
includes taxes & fees
Margaritaville Jacksonville Beach
Wyndham Garden Jacksonville

Wyndham Garden Jacksonville

3 out of 5
4660 Salisbury Road Jacksonville FL
Fully refundableReserve now, pay when you stay
The price is SARĀ 301 per night from Jul 19 to Jul 20
SARĀ 301
SARĀ 341 total
19 Jul - 20 Jul
includes taxes & fees
7.8/10 Good! (1,958 reviews)
"I stayed for a week and my room was never cleaned. I had to ask for new sheets twice but never received them. The cleaning crews spoke on speaker phone at full volume at 8am. I had to empty my own garbage."

Reviewed on 17 July 2026

Wyndham Garden Jacksonville
See all 3,360 properties in Isle of Palms
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.