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Check prices for these dates

In two weeks
6 Mar - 8 Mar
In two months
17 Apr - 19 Apr
In three months
15 May - 17 May
In four months
12 Jun - 14 Jun

Our top choices for Defiance apartments

Exterior

Stay on Main Historic Studio

Stay on Main Historic Studio
St. Charles Historic District
9.0 out of 10, Wonderful, (33 reviews)
"Nice property.. Clean. "
United States
Belinda J.
The price is SAR 328
SAR 767 total
includes taxes & fees
17 Feb - 18 Feb
Stay on Main Historic Studio
Exterior

Sunny SparkingClean King bed Apt- CreveCoeurPark

Sunny SparkingClean King bed Apt- CreveCoeurPark
Maryland Heights
9.8 out of 10, Exceptional, (12 reviews)
"Good Stay"
United States
Lanai
Sunny SparkingClean King bed Apt- CreveCoeurPark
TV

Main Street Balcony Apartment by StayLage!

Main Street Balcony Apartment by StayLage!
St. Charles Historic District
9.6 out of 10, Exceptional, (36 reviews)
"Great location for shopping and a lot of restaurants nearby. Beds were very comfortable. "
United States
Brooke I.
The price is SAR 640
SAR 1,710 total
includes taxes & fees
17 Feb - 18 Feb
Main Street Balcony Apartment by StayLage!
Interior

The Historic Bricks on Main

The Historic Bricks on Main
St. Charles Historic District
9.0 out of 10, Wonderful, (16 reviews)
"Host was very welcoming and helpful when we have any questions no matter what time of day. The place was very quaint and comfy. We would highly recommend. "
United States
Chelsea L.
The price is SAR 401
SAR 851 total
includes taxes & fees
17 Feb - 18 Feb
The Historic Bricks on Main
Interior

Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (58 reviews)
"Great place and location. Owners were easy to work with."
United States
Cory M.
The price is SAR 446
SAR 947 total
includes taxes & fees
19 Feb - 20 Feb
Amazing Renovated Historic Loft on Main Street
TV

Back Door Guest Suite, Zia My Retreat

Back Door Guest Suite, Zia My Retreat
New Haven
10.0 out of 10, Exceptional, (6 reviews)
"Very comfortable, spacious, great location for canoe trip. "
United States
Carolyn B.
The price is SAR 506
SAR 845 total
includes taxes & fees
17 Feb - 18 Feb
Back Door Guest Suite, Zia My Retreat
Interior

The Lofts of North Main Street

The Lofts of North Main Street
St. Charles Historic District
9.6 out of 10, Exceptional, (162 reviews)
"Very nice place near all the action. "
United States
Weston G.
The price is SAR 368
SAR 831 total
includes taxes & fees
17 Feb - 18 Feb
The Lofts of North Main Street
Fridge, microwave, oven, stovetop

Main Street Living! 2 Bedroom Unit right On Main!

Main Street Living! 2 Bedroom Unit right On Main!
St. Charles Historic District
9.6 out of 10, Exceptional, (35 reviews)
"Great Stay and great location! "
United States
Angela
The price is SAR 547
SAR 1,405 total
includes taxes & fees
17 Feb - 18 Feb
Main Street Living! 2 Bedroom Unit right On Main!
Dining

Great for Business Travelers! Studio Suite Near Edward Jones! Shared Pool + Free Breakfast!

Great for Business Travelers! Studio Suite Near Edward Jones! Shared Pool + Free Breakfast!
Maryland Heights
9.6 out of 10, Exceptional, (4 reviews)
"It was an easy experience renting this place"
United States
Dominic M.
The price is SAR 664
SAR 845 total
includes taxes & fees
19 Mar - 20 Mar
Great for Business Travelers! Studio Suite Near Edward Jones! Shared Pool + Free Breakfast!
Living area

The Cul-de-Sac Retreat

The Cul-de-Sac Retreat
Saint Charles
8.4 out of 10, Very Good, (9 reviews)
"Great house, great location - close to the St. Charles convention center"
United States
Joe H.
The price is SAR 619
SAR 1,163 total
includes taxes & fees
24 Feb - 25 Feb
The Cul-de-Sac Retreat
TV

1st Capitol Mansion - Suite 401

1st Capitol Mansion - Suite 401
St. Charles Historic District
7.6 out of 10, Good, (8 reviews)
"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"
United States
Emily L.
The price is SAR 371
SAR 926 total
includes taxes & fees
22 Feb - 23 Feb
1st Capitol Mansion - Suite 401
Interior

Luxurious 2-Bedroom Abode with Elevated Comforts Near Main Street

Luxurious 2-Bedroom Abode with Elevated Comforts Near Main Street
Saint Charles
9.0 out of 10, Wonderful, (2 reviews)
"The overall vibe struck me as a college town apartment: the building was fine, but finishes were underwhelming. The unit itself was a little small, but workable. We had a scenario where the heater seemed to be acting up; the room actually got warmer after we shut the heat off. It was a pleasant enough stay, and served the purpose we had come for: visiting our adult children. It was a bit of a walk to get to the historic district."
United States
Greg L.
The price is SAR 454
SAR 1,146 total
includes taxes & fees
17 Feb - 18 Feb
Luxurious 2-Bedroom Abode with Elevated Comforts Near Main Street
1 bedroom, WiFi, bed sheets

Duplex Hideaway in St. Charles, MO

Duplex Hideaway in St. Charles, MO
St. Charles Historic District
10.0 out of 10, Exceptional, (5 reviews)
"I will stay here again. It was a great location for my visit. Lots of room and amenities. Highly recommend this location if you are visiting the St Louis area. Barely a mile to get to Hwy 70, so easy access to St Louis, St Peter's, Wentzville etc. Maybe two blocks from Historic St Charles and Ameristar Casino."
United States
Karen M.
The price is SAR 401
SAR 937 total
includes taxes & fees
17 Feb - 18 Feb
Duplex Hideaway in St. Charles, MO
Smart TV

Prime Loft of Main Street

Prime Loft of Main Street
St. Charles Historic District
9.8 out of 10, Exceptional, (104 reviews)
"The loft was very nice, very clean, well appointed, and in a perfect location. I highly recommend this property!"
United States
Mary ann S.
The price is SAR 409
SAR 878 total
includes taxes & fees
17 Feb - 18 Feb
Prime Loft of Main Street
TV

6th street 101 - Walk to Main St

6th street 101 - Walk to Main St
St. Charles Historic District
10.0 out of 10, Exceptional, (1 review)
The price is SAR 308
SAR 986 total
includes taxes & fees
17 Feb - 18 Feb
6th street 101 - Walk to Main St
Fridge, microwave, oven, stovetop

The Hidden Gem - 2BR Basement Apartment on 7 Acres

The Hidden Gem - 2BR Basement Apartment on 7 Acres
Moscow Mills
10.0 out of 10, Exceptional, (12 reviews)
"Great place, nice neighborhood. "
United States
Julie L.
The price is SAR 516
SAR 1,048 total
includes taxes & fees
21 Feb - 22 Feb
The Hidden Gem - 2BR Basement Apartment on 7 Acres
A heated pool

Great for Business Travelers! Pool + Gym

Great for Business Travelers! Pool + Gym
O'Fallon
The price is SAR 429
SAR 583 total
includes taxes & fees
1 Mar - 2 Mar
Great for Business Travelers! Pool + Gym
Interior

AK`s STL Pearl Grey House - Game Room

AK`s STL Pearl Grey House - Game Room
Maryland Heights
9.0 out of 10, Wonderful, (8 reviews)
"My kids loved this house! It was very comfortable for my family of 7. We were able to cook dinner, play games, watch TV, and were within close proximity to all things St. Louis. We would definitely stay here again. "
United States
Tiffanny B.
AK`s STL Pearl Grey House - Game Room
Exterior detail

2nd Street Loft - Riverview

2nd Street Loft - Riverview
Washington
The price is SAR 320
SAR 583 total
includes taxes & fees
19 Feb - 20 Feb
2nd Street Loft - Riverview
Fridge, microwave, stovetop, toaster

Charming Duplex on Main

Charming Duplex on Main
St. Charles Historic District
10.0 out of 10, Exceptional, (16 reviews)
"We had an AMAZING time here and you can't beat the close walking distance to main st!! Absolutely loved our stay. "
United States
Wendy K.
Charming Duplex on Main
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis

10/10 Excellent
"Convenient location and comfy beds!"
Tim 1-night trip
Posted 7 hours ago
Drury Inn & Suites Southwest St. Louis

Frequently asked questions

What's it like to stay at an apartment in Defiance?
You'll find 10 apartments to choose from in Defiance for your stay.
Why choose an apartment versus a traditional hotel?
Often more spacious than a traditional hotel room, an apartment includes a kitchen for convenient home-cooked meals. Apartments are ideal for families who want the conveniences of home, and also for couples who want something in a quieter part of town.
What's a favorite apartment for a stay in Defiance?
Here's a top apartment in the area: 'the Ruebling House': Bright, Modern, & Renovated!: Situated in Defiance, 0.1 mi/0.2 km from the heart of Defiance.
How many apartments will I be able to find in Defiance?
Expedia has 10 apartments to book in Defiance.
What can I expect from the weather during my trip to Defiance?
Weather is only one factor, but it can really affect your travel plans, especially if you're planning an extended stay in Defiance. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.
What are the must-see places to visit in Defiance?
Matson Hill Park Trailhead and August A. Busch Memorial Conservation Area are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. While here, Yellow Farmhouse Winery and Chandler Hill Vineyards are other places worth a visit.
What's the best way to get to and around Defiance?
Knowing a bit about the transportation options can save you time when you get to your destination. Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) from the heart of the city. You can also search for flights into St. Louis Lambert Intl. Airport (STL), which is 23.5 mi (37.8 km) away. If you'd like to explore around the area, you may want a rental car for your journey.