The Best Hotels Closest to Buffalo Museum of Science in Buffalo for 2026

A large mammoth skeleton in a museum with classical architecture.

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Our top choices for Buffalo Museum of Science hotels

A grand staircase with ornate woodwork and a chandelier, leading to a room with a large wooden door and a stained glass window.

A room with a red patterned sofa, wooden bookshelves, a chandelier, and a traditional wooden coffee table.

A large, two-story building with a prominent entrance, multiple windows, and a well-maintained garden.

A spacious room with a wooden floor, a fireplace, a dining area with a table and chairs, and a large rug.

1. InnBuffalo off Elmwood

Elmwood Village, 3 km from Buffalo Museum of Science

Terese

SAR 603

SAR 692 total

includes taxes & fees

20 Oct - 21 Oct

A spacious room with a wooden floor, a fireplace, a dining table, and several chairs.

A historic building with a prominent tower and a traditional brick facade.

A traditional living room with a green sofa, a wooden coffee table with books, a blue armchair, and various potted plants.

A room with a textured ceiling, a chandelier, and walls painted in a two-tone color scheme.

2. Buffalo Harmony House

Allentown, 3.2 km from Buffalo Museum of Science

John

SAR 1,223

SAR 1,422 total

includes taxes & fees

7 Oct - 8 Oct

A spacious dining area with a long table, multiple chairs, a chandelier, and a fireplace.

A spacious room with a large wooden table, several chairs, a sofa, and two chandeliers.

A bedroom with a four-poster bed, a yellow sofa, a white coffee table, and a desk with a chair.

A living room with a fireplace, two leather armchairs, a coffee table, and a chandelier.

3. The Edward Hotel

Elmwood Village, 2.4 km from Buffalo Museum of Science

Grace

SAR 436

SAR 600 total

includes taxes & fees

11 Oct - 12 Oct

A grand entrance with a staircase leading to a door, surrounded by lush greenery and a well-maintained garden.

A pool table in a room with dark walls, large windows, and green upholstered chairs.

A bar area with wooden furniture, a large wooden cabinet, and a clock on the wall.

A pool table in a room with patterned carpet, a dining table with chairs, and a red sofa.

4. The Mansion On Delaware Ave

Allentown, 3 km from Buffalo Museum of Science

Marilyn

SAR 740

SAR 849 total

includes taxes & fees

18 Oct - 19 Oct

A two-story building with a white exterior, a red door, and large windows.

A spacious living area with a granite island, wooden chairs, a fireplace, and a television.

A hot tub with a wooden fence and a brick building in the background.

A living room with a fireplace, leather sofa, and a television mounted on the wall.

5. Buffalo Guesthouse

Allentown, 2.4 km from Buffalo Museum of Science

Jan

SAR 588

SAR 675 total

includes taxes & fees

23 Oct - 24 Oct

A modern hotel lobby with a bar area, seating, and a large TV screen.

A modern restaurant with a long counter, bar stools, and a refrigerated display.

A modern indoor swimming pool with clear blue water, surrounded by lounge chairs and a glass-enclosed area.

A modern building with a Starbucks on the ground floor, featuring large windows and a flat roof.

6. Residence Inn by Marriott Buffalo Downtown

Allentown, 2.6 km from Buffalo Museum of Science

Karen

SAR 890

SAR 1,039 total

includes taxes & fees

12 Oct - 13 Oct

A spacious lobby with a large sofa, a coffee table, and potted plants. There is a decorative wall with a painting and a large window providing natural light.

A multi-story hotel with a modern facade, large windows, and a covered entrance area.

A compact kitchen with wooden cabinets, a black refrigerator, a microwave, and a coffee maker.

A hotel dining area with multiple tables and chairs, a reception desk, and framed pictures on the walls.

7. Wyndham Garden Buffalo Downtown

Downtown Buffalo, 1.9 km from Buffalo Museum of Science

Julian

SAR 591

SAR 690 total

includes taxes & fees

14 Oct - 15 Oct

A hotel room with a bed, desk, chair, TV, and a bathroom with a sink and mirror.

A modern hotel lobby with a round coffee table, two grey armchairs, a TV, and a reception desk.

A modern kitchen with a central island, bar stools, and various appliances.

A hotel lobby with a curved reception desk, a chandelier, a seating area with leather chairs, and a tiled floor.

8. Best Western on the Avenue

Allentown, 2.8 km from Buffalo Museum of Science

John

SAR 571

SAR 667 total

includes taxes & fees

20 Oct - 21 Oct

A dining area with a wooden table and chairs, a fireplace, and large windows with a view of greenery outside.

A modern kitchen with a large window, stainless steel appliances, and wooden cabinetry.

A grand staircase with a decorative railing and a Christmas tree adorned with ornaments and ribbons.

A casino interior with slot machines, a large illuminated pillar, and comfortable seating areas.

9. Summer Street Guest House

Bryant, 3 km from Buffalo Museum of Science

Anthony

SAR 1,348

SAR 1,978 total

includes taxes & fees

7 Oct - 8 Oct

A hotel room with a bed, a TV, a desk, a chair, and a sofa.

A modern hotel room with a wooden dresser, a flat-screen TV, a kitchenette, a blue sofa, and a small table.

A gym with exercise equipment, a mirror, and a television.

A coffee station with two coffee makers, a coffee dispenser, and various coffee cups and containers.

10. Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

Buffalo Theater District, 3.1 km from Buffalo Museum of Science

Dennis

SAR 492

SAR 574 total

includes taxes & fees

15 Oct - 16 Oct

A lobby with a staircase, seating area, and a view of the outdoors.

A hotel room with two beds, a desk, a television, and a window.

A reception area with a marble wall, a reception desk with glass panels, a clock, and a television mounted on the wall.

A bathroom with a toilet, sink, and shower curtain.

11. Lenox Hotel and Suites

Allentown, 2.6 km from Buffalo Museum of Science

Richarda

SAR 336

SAR 385 total

includes taxes & fees

27 Oct - 28 Oct

A rooftop terrace with wicker furniture, a bar area, and a view of the cityscape.

A bar area with a circular bar counter, multiple hanging light fixtures, and bar stools.

A modern living room with a large window, a flat-screen TV, a sofa, a coffee table, and a patterned rug.

A modern hotel with a glass facade, multiple floors, and a prominent 'Aloft' sign.

12. Aloft by Marriott Buffalo Downtown

Buffalo Theater District, 3 km from Buffalo Museum of Science

Anthony T

SAR 658

SAR 768 total

includes taxes & fees

18 Oct - 19 Oct

A dining area with a wooden table set for four, surrounded by chairs. There is a kitchen area with cabinets and appliances in the background.

A kitchen with wooden cabinets, stainless steel appliances, and a red toaster.

A modern living room with a sectional sofa, a dining area, and a kitchen in the background.

A kitchen with wooden cabinets, a dishwasher, and a dining area with a table and chairs.

13. 4 Mi to Dtwn: Family Home in Buffalo

Masten Park, 1.4 km from Buffalo Museum of Science

SAR 1,115

SAR 1,975 total

includes taxes & fees

7 Oct - 8 Oct

A living room with a fireplace, a television mounted on the wall, a sofa, a coffee table, and a lamp.

A hotel room with a large bed, a desk with a chair, a bathroom with a bathtub, and a mirror.

A buffet setup with various food items and utensils.

A hotel room with a sofa, a bed, a desk, and a chair. There are lamps on the desk and bedside tables.

14. Salvatores Grand Hotel

13.1 km from Buffalo Museum of Science

Margaret

SAR 634

SAR 722 total

includes taxes & fees

8 Oct - 9 Oct

A hotel with a prominent entrance, a clock tower, and the name "REIKART HOUSE" displayed above the entrance.

An outdoor patio area with tables and chairs, string lights, and greenery.

A spacious living area with a fireplace, a large sofa, and a dining area with a table and chairs.

15. Reikart House, Buffalo, a Tribute Portfolio Hotel

8.3 km from Buffalo Museum of Science

Brandon

SAR 1,078

SAR 1,226 total

includes taxes & fees

18 Oct - 19 Oct

A modern hotel room with a bed, a desk with a chair, a flat-screen TV, a microwave, and a large mirror.

16. Hampton Inn Buffalo - Amherst, NY

10.6 km from Buffalo Museum of Science

Warren

SAR 475

SAR 541 total

includes taxes & fees

2 Nov - 3 Nov

A modern lounge area with sofas, round tables, and a stone accent wall.

A hotel with a brick facade, multiple balconies, and a sign for 'The Mosey Hotel & Residences'.

A lobby with teal armchairs, a round table, a flat-screen TV, and a stone wall with a fireplace.

17. The Mosey Buffalo Williamsville, Tapestry Collection by Hilton

9 km from Buffalo Museum of Science

Randy

SAR 635

SAR 722 total

includes taxes & fees

2 Nov - 3 Nov

A spacious lobby with high ceilings, a grand staircase, and a gift shop.

A bar area with red upholstered bar stools, a bar counter, and a chandelier.

A bar area with leather barstools, a bar counter, and a television screen.

A hotel room with two beds, a desk, a chair, a coffee machine, and a large window with curtains.

18. The Delavan Hotel & Spa

12.4 km from Buffalo Museum of Science

Peter

SAR 417

SAR 474 total

includes taxes & fees

20 Oct - 21 Oct

A patio area with outdoor seating, a barbecue grill, and a stone wall.

A modern lounge area with seating, tables, and hanging chairs.

A modern indoor space with a foosball table, seating areas, a mural, and a television screen.

19. Tru by Hilton Williamsville Buffalo Airport

13 km from Buffalo Museum of Science

Lachelle

SAR 475

SAR 541 total

includes taxes & fees

25 Oct - 26 Oct

A modern kitchen with a central island, wooden cabinets, and a bar area with stools.

A modern hotel lobby with a curved seating area, a flat-screen TV, and a dining area.

An outdoor patio with a round table, chairs, a cushioned seating area, and a barbecue grill.

A hotel room with a bed, a TV, a desk, a lamp, and a mirror.

20. Springhill Suites Buffalo Airport

13 km from Buffalo Museum of Science

Matthias

SAR 503

SAR 573 total

includes taxes & fees

2 Nov - 3 Nov

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Compare popular hotels close to Buffalo Museum of Science

Property	Property class	Guest rating
InnBuffalo off Elmwood	10.0 Exceptional 224 reviews	View
Buffalo Harmony House	10.0 Exceptional 56 reviews	View
The Edward Hotel	9.6 Exceptional 267 reviews	View
The Mansion On Delaware Ave	9.4 Exceptional 1,001 reviews	View
Buffalo Guesthouse	9.4 Exceptional 216 reviews	View

Top Buffalo Museum of Science Hotel Reviews

Lenox Hotel and Suites

10/10 Excellent

"Older building & hotel but still great location, clean, nice rooms, & friendly staff"

Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

8/10 Good

"The room was clean and not a bad breakfast spread."

The Edward Hotel

10/10 Excellent

"This place was quiet and clean and soooo comfortable."

Buffalo Guesthouse

10/10 Excellent

"Cleanliness was a ten- Staff was exceptional. Breakfast was home-cooked and plentiful. Very pleasant stay just minutes to town."

The Mansion On Delaware Ave

8/10 Good

"Nice hotel, shower needs an update"

Elmwood Village home

10/10 Excellent

"Enjoyed the stay"

Home away from home!

10/10 Excellent

"We will definitely be back to stay. Sandi’s place was perfect, a true home away from home! She is a wonderful host and we enjoyed our stay. The location is on a quiet street, so peaceful."

Spacious Historical Home by Parks, Shops, 4bd 2ba Save Weekly & monthly.

10/10 Excellent

"Great place to stay during our trip to Buffalo. House was clean and comfortable. Area was walkable to many of our activities."

Stunning Elmwood Village Lower

8/10 Good

"Great place to stay! Very clean and comfortable couches. Only downside for the lower level were the thin walls/hardwood floors upstairs. A family with toddlers and a dog stayed upstairs and we could hear everything (kid toys) and a lot of running.Overall great location and smooth place to stay! Just something to consider — book the upper level if available."

Other attractions near Buffalo Museum of Science

Buffalo Central Terminal

You can find out about the history of Buffalo when you stop by Buffalo Central Terminal. Experience the entertainment choices and great live music in this vibrant area.

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Johnnie B. Wiley Sport Pavilion

Catch an event at Johnnie B. Wiley Sport Pavilion during your trip to Buffalo. Experience the area's entertainment choices and great live music.

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Paul Robeson Theater

Enjoy a show at Paul Robeson Theater, a theater with a story to tell in Buffalo. Experience the area's entertainment choices and great live music.

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African American Cultural Center

Enjoy a stop at African American Cultural Center, an entertaining place to visit in Buffalo. Experience the area's acclaimed theater scene and great live music.

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Broadway Market

You can enjoy retail therapy at Broadway Market during your stay in Buffalo. Experience the area's acclaimed theater scene and great live music.

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Koessler Athletic Center

Catch an event at Koessler Athletic Center during your trip to Buffalo.

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Montante Cultural Center

Enjoy an outing to Montante Cultural Center during your stay in Buffalo.

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Hellenic Orthodox Church of the Annunciation

After visiting Hellenic Orthodox Church of the Annunciation, make a plan to see the other sights and activities in Buffalo.

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Frequently asked questions

What's the area like around Buffalo Museum of Science?

Buffalo Museum of Science is located in a historic area of Buffalo known for its great live music scene. If you're looking for a convenient place to stay, check out the 14 hotels and other accommodations you'll find within a mile.

What's the best hotel to stay near Buffalo Museum of Science?

Wyndham Garden Buffalo Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a 24-hour fitness center. It's located 1.2 mi (1.9 km) from Buffalo Museum of Science. Other good choices within 5 miles include Hyatt Regency Buffalo / Hotel and Conference Center and Buffalo Guesthouse.

How many hotels will I be able to find close to Buffalo Museum of Science?

Expedia has 14 hotels and other accommodations within a mile from Buffalo Museum of Science.

If I need to cancel the hotel reservation for my stay near Buffalo Museum of Science, will I receive a refund?

Yes, most hotel room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review the top deals on offer near Buffalo Museum of Science.

Where can I learn more about changing or cancelling my trip in the area near Buffalo Museum of Science?

For more information about picking new dates or cancelling your stay near Buffalo Museum of Science, go to https://www.expedia.com/service/.

What can I see and do near Buffalo Museum of Science?

Study the collections at Buffalo AKG Art Museum, Buffalo History Museum, or Buffalo and Erie County Naval and Military Park. Some landmarks that you won't want to miss include Buffalo Central Terminal, Statler Tower, and Richardson Olmsted Complex. You can watch performances at Kleinhans Music Hall, Town Ballroom, and Road Less Traveled Productions if you're interested in local theater.

Find hotels near Buffalo Museum of Science, Buffalo from SAR 385

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Treat yourself

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Our top choices for Buffalo Museum of Science hotels

1. InnBuffalo off Elmwood

2. Buffalo Harmony House

3. The Edward Hotel

4. The Mansion On Delaware Ave

5. Buffalo Guesthouse

6. Residence Inn by Marriott Buffalo Downtown

7. Wyndham Garden Buffalo Downtown

8. Best Western on the Avenue

9. Summer Street Guest House

10. Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

11. Lenox Hotel and Suites

12. Aloft by Marriott Buffalo Downtown

13. 4 Mi to Dtwn: Family Home in Buffalo

14. Salvatores Grand Hotel

15. Reikart House, Buffalo, a Tribute Portfolio Hotel

16. Hampton Inn Buffalo - Amherst, NY

17. The Mosey Buffalo Williamsville, Tapestry Collection by Hilton

18. The Delavan Hotel & Spa

19. Tru by Hilton Williamsville Buffalo Airport

20. Springhill Suites Buffalo Airport

Compare popular hotels close to Buffalo Museum of Science

Top Buffalo Museum of Science Hotel Reviews

Lenox Hotel and Suites

Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

The Edward Hotel

Buffalo Guesthouse

The Mansion On Delaware Ave

Elmwood Village home

Home away from home!

Spacious Historical Home by Parks, Shops, 4bd 2ba Save Weekly & monthly.

Stunning Elmwood Village Lower

Other attractions near Buffalo Museum of Science

Buffalo Central Terminal

Johnnie B. Wiley Sport Pavilion

Paul Robeson Theater

African American Cultural Center

Broadway Market

Koessler Athletic Center

Montante Cultural Center

Hellenic Orthodox Church of the Annunciation

Frequently asked questions