Located close to Piazza di Spagna and Piazza Navona, Twentyone Hotel provides a garden, a hair salon, and dry cleaning/laundry services. In addition to a bar and a gym, guests can connect to free in-room WiFi.
Located in Rome City Centre, a neighborhood in Rome, Twentyone Hotel is near a metro station. Vatican Museums and Castel Sant'Angelo are cultural highlights, and some of the area's notable landmarks include Piazza Navona and Spanish Steps. Looking to enjoy an event or a game? See what's going on at Foro Italico or Stadio Olimpico. Visit our Rome travel guide
Via Cola di Rienzo 23, Rome, RM, 00192
What's nearby
Via Cola di Rienzo
1 min walk - 0.0 km
Piazza del Popolo
7 min walk - 0.6 km
Via del Corso
8 min walk - 0.7 km
Castel Sant'Angelo
11 min walk - 1.0 km
Piazza di Spagna
15 min walk - 1.3 km
Getting around
Lepanto Station
8 min walk
Rome Piazzale Flaminio Station
11 min walk
Fiumicino - Leonardo da Vinci Intl. Airport (FCO)
40 min drive
Restaurants
Hotel NH Collection Roma Centro
1 min walk
Malaterra
3 min walk
Su&giú
4 min walk
pizza dai cinque
2 min walk
Mondo Arancina
3 min walk
About this property
Twentyone Hotel
Upscale hotel near Piazza del Popolo
Near Piazza di Spagna and Piazza Navona, Twentyone Hotel provides a garden, a hair salon, and dry cleaning/laundry services. Stay connected with free in-room WiFi, and guests can find other amenities such as a bar and a gym.
You'll also enjoy perks such as:
Limo/town car service, buffet breakfast (surcharge), and self parking (surcharge)
Express check-in, an elevator, and tour/ticket assistance
A TV in the lobby, multilingual staff, and a porter/bellhop
Guest reviews say great things about the helpful staff
Room features
All 96 individually decorated rooms offer comforts such as premium bedding and air conditioning, in addition to amenities like free WiFi and safes.
No, only service animals are welcome at the property.
How much does it cost to stay at Twentyone Hotel?
As of 24 Shawwal 2026, prices found for a 1-night stay for 2 adults at Twentyone Hotel on 15 Dhuʻl-Qiʻdah 2026 start from SAR 513, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.
How much is parking?
Self parking is available for EUR 35 per day.
What time is check-in at Twentyone Hotel?
Check-in start time: 3:00 PM; Check-in end time: midnight.
What time is check-out at Twentyone Hotel?
Check-out is at 11 AM.
Does Twentyone Hotel provide a shuttle to the airport?
Yes, there's an airport shuttle that runs on request. A fee of EUR 65 per vehicle applies.
Where is Twentyone Hotel located?
Located in Rome City Centre, this hotel is within a 10-minute walk of Via Cola di Rienzo, Piazza del Popolo, and Via del Corso. Villa Borghese and Piazza Navona are also within 15 minutes. Lepanto Station is 8 minutes by foot and Flaminio - Piazza del Popolo Station is 8 minutes.
Can I cancel my reservation for free and receive a full refund?
Yes, this property offers free cancellation on select room rates, because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.
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Reviews
Twentyone Hotel Reviews
8.2
Very Good
All reviews shown are from real guest experiences. Only travelers who have booked a stay with us can submit a review. We verify reviews according to our guidelines and publish all reviews, positive or negative.
The room was very well kept. It was a great size and provided all the bath items required. The staff were very helpful when we had questions. Breakfast was very well laid out with lots of choices. The hotel was close to many restaurants and areas to check out. I would definitely stay there if we were to come back to Rome
Very nice, well located hotel! Close enough to both the Vatican and Rome city centre.
Staff were very pleasant and very helpful.
Breakfast was very good!
Everything was just what we needed, the location was amazing, we walked to everything. The staff spoke English fluently so that was a nice break for my tired brain. The breakfast had so many choices it was hard to pick and the breakfast room had a lovely view over Rome. I only deducted a star because the room was warm even with the AC on full and the toilet kept running it would have to be re-flushed to make it stop (not the end of the world, but annoying). The room was smaller than some but elegant and had everything we needed.
Great location. Clean rooms and property. Excellent service from staff. Was not my 1st time staying here. It won't be my last. Hotel TwentyOne is my favorite hotel in Rome
Stayed 6 nights in May 2026
Verified review
10/10 Excellent
Francis
25 January 2026
Liked: Cleanliness, staff & service, amenities
Excellent location and service. Breakfast was well prepared.
Hotel for us was in a great location in easy reach of the tourist attractions but also with restaurants and shops close by and a reasonable walk from Stadio Olympico. Staff were great, breakfasts were good. Room was clean. Bathroom was quite small but compared to other hotels in area was priced ok. I would stay there again.
Stayed 4 nights in Mar 2026
Verified review
10/10 Excellent
Donald
21 June 2024
Great location great staff good breakfast and loved my room with balcony.
Stayed here for a second time and equally impressed second time round. Would stay here a third. Great location, lovely staff, clean rooms and amazing breakfast buffet. Also has a small but excellent gym which isn't advertised but was easy to access.
This was our first time visiting and we couldn’t have picked a better hotel. Everything is about 20 mins walking distance. Hotel was nice, staff were great!
The neighborhood was perfect, we were able to get to the busier parts by either walking or taxi easily. We found some nice restaurants within a 10 minute walk. The breakfast area on the top floor was very nice end the staff were friendly and attentive. The only negative was the mattress could be updated.
Property was great! About. 10-15 walk from city center. Perfect disatnce to walk off all the food. Morning breakfast was amazing.
Stayed 5 nights in May 2024
Verified review
8/10 Good
William
9 June 2024
Liked: Cleanliness, staff & service, room comfort
It was very nice. Super accommodating. Rooms are fine. Walls are very very thin. Bring ear plugs.
Stayed 2 nights in May 2024
Verified review
6/10 Okay
Verified traveler
19 June 2025
Disliked: Room comfort
Good location in nice area of Rome
Good location in very nice neighborhood. Lots of great restaurants nearby. Easy to get taxis to other areas. Hotel staff were nice and helpful. Rooms were updated and had enough space. Shower had a great rainshower head. Beds were very very firm and not comfortable. Room had AC but not a lot. No ability to make coffee or tea in the room.
Excellent property in the middle of numerous tourist friendly locations. Staff were professional and friendly, room was large and comfortable and the overall vibe of the area was perfect for us. Lots of pubs in the area so do not complain about the street noise. If I had one silly complaint, which is really a compliment…the hot water was literally boil an egg hot!! I love hot water and if you do too this is a bonus. Great location!
Stayed 3 nights in Oct 2023
Verified review
8/10 Good
Vincent
28 October 2023
Liked: Staff & service, room comfort
Dark and small room smelt like smoke
First floor room. Close to indoor smoke room. Smelt from time to time. But breakfast was great and everything who worked there was kind and great service. Location was nice for Vatican.