The Best Hotels Closest to Mayo Clinic Florida in Jacksonville for 2026

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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.

A modern kitchen with a bar area, seating, and a view of the outdoors.

An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

1.1 km from Mayo Clinic Florida

Michaelanne

SAR 552

SAR 627 total

includes taxes & fees

23 Oct - 24 Oct

An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

A hotel room with a bed, a sofa, a nightstand, and a wall-mounted lamp.

A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.

An outdoor patio with a pool, wooden pergola, and seating area.

2. TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

gregory

SAR 462

SAR 524 total

includes taxes & fees

25 Oct - 26 Oct

A modern restaurant with a bar area, wooden ceiling, and large windows.

A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.

A modern lobby with a curved sofa, round coffee tables, and a large pillar.

3. Hilton Jacksonville at Mayo Clinic near Beaches

0.8 km from Mayo Clinic Florida

Patricia

SAR 635

SAR 721 total

includes taxes & fees

30 Oct - 31 Oct

A hotel lobby with a bar area, seating arrangements, and a reception desk.

A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.

An outdoor patio with a brick wall, a round table with striped chairs, and two large umbrellas.

A hotel pool area with a long, narrow pool, multiple lounge chairs, and a covered seating area.

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

Patsy

SAR 411

SAR 467 total

includes taxes & fees

25 Oct - 26 Oct

A lobby with a reception desk, seating area, and a staircase.

A modern kitchen with a refrigerator, coffee machine, and a bakery display.

A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.

5. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.6 km from Mayo Clinic Florida

frances

SAR 361

SAR 409 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.

A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

0.4 km from Mayo Clinic Florida

Patricia

SAR 571

SAR 648 total

includes taxes & fees

24 Oct - 25 Oct

A bedroom with a bed, a dresser, a mirror with a floral frame, a green door, and a potted plant.

A swimming pool with a wooden deck, lounge chairs, and umbrellas.

A kitchen with a sink, a coffee maker, a bottle of Mountain Valley Spring Water, and a jar of cream cheese stuffed olives.

A door with the number 312, a window with blinds, a green door mat, a chair with a geometric pattern, and small plants.

7. Hotel Palms

7.8 km from Mayo Clinic Florida

Vinny

SAR 716

SAR 813 total

includes taxes & fees

15 Oct - 16 Oct

A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.

A kitchen counter with a flat-screen TV displaying a breakfast menu, a coffee machine, and a sign for fresh pancakes.

A hotel room with two beds, a desk, a chair, and a large window with a view.

A coastal cityscape with a long beach, a large hotel with a curved facade, and a clear sky.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Southside, 7.7 km from Mayo Clinic Florida

Aneudi

SAR 447

SAR 507 total

includes taxes & fees

29 Oct - 30 Oct

An outdoor patio area with seating, a fire pit, and a barbecue grill.

A modern living room with sofas, a coffee table, and a dining area.

A reception area with a modern design, featuring a reception desk, a refrigerator with snacks, and a wooden slatted wall.

A modern hotel with a sign reading "Towneplace Suites by Marriott" and a parking lot in front.

9. TownePlace Suites by Marriott® Jacksonville Mayport

10.8 km from Mayo Clinic Florida

irina

SAR 477

SAR 541 total

includes taxes & fees

20 Oct - 21 Oct

A laptop on a wooden desk with a white mug, a spoon, and a smartphone.

A conference room with multiple tables and chairs, large windows with curtains, and a flat-screen TV mounted on the wall.

10. Hyatt Studios Jacksonville/St Johns Town Center

Deerwood, 7.8 km from Mayo Clinic Florida

Camoya

SAR 454

SAR 516 total

includes taxes & fees

29 Oct - 30 Oct

An outdoor seating area with a fire feature, chairs, and a table.

A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.

A modern bar area with a curved counter, multiple bar stools, and a variety of liquor bottles.

A gym with treadmills, dumbbells, and exercise balls, overlooking a swimming pool.

11. Hotel Indigo Jacksonville-Deerwood Park by IHG

Southside, 10.8 km from Mayo Clinic Florida

Carol

SAR 443

SAR 503 total

includes taxes & fees

12 Nov - 13 Nov

A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.

A modern bar area with seating, a bar counter, and a view of the city through large windows.

An outdoor seating area with white furniture and a well-maintained lawn, surrounded by large windows and a modern building facade.

A modern hotel building with a flat facade, large windows, and a sign reading "ACHTEL JACKSONVILLE".

12. AC Hotel Jacksonville St Johns Town Center

Southside, 8.1 km from Mayo Clinic Florida

Emily

SAR 672

SAR 763 total

includes taxes & fees

15 Oct - 16 Oct

A pool with a waterfall feature, surrounded by large rock formations.

A beachfront hotel with multiple balconies, a sandy beach, and ocean views.

A hotel room with two beds, a desk with a flat-screen TV, a chair, and a large window with a view of palm trees.

13. Hampton Inn Jacksonville Beach/Oceanfront

6.3 km from Mayo Clinic Florida

Hope

SAR 603

SAR 685 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor patio with seating, a fire pit, and string lights.

A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a fence.

A modern living room with a dining area, a flat-screen TV, and a bookshelf.

A multi-story hotel with a modern design, featuring a large number of windows and a flat roof.

14. Hyatt Place Jacksonville / St. Johns Town Center

Southside, 8.6 km from Mayo Clinic Florida

Becky

SAR 478

SAR 542 total

includes taxes & fees

18 Oct - 19 Oct

A modern bar area with wooden accents, a variety of beverages, and seating arrangements.

A multi-story hotel with a prominent entrance, a parking lot, and well-maintained landscaping.

A patio area with a stone fire pit, outdoor furniture, and a brick floor.

A modern bar area with a wooden counter, multiple seating options including bar stools and round tables, and a menu board.

15. Courtyard by Marriott Jacksonville I-295/East Beltway

Arlington, 13.2 km from Mayo Clinic Florida

Chloie Marie

SAR 363

SAR 412 total

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a reception desk, seating area, and large windows.

A modern coffee shop interior with a central counter, shelves stocked with snacks, and a refrigerated section labeled 'FROZEN' and 'CHILLED'.

A multi-story hotel with a central entrance, large windows, and a well-lit facade.

An indoor dining area with tables and chairs, a ceiling fan, and a view of the outdoors.

16. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

8.5 km from Mayo Clinic Florida

William

SAR 442

SAR 493 total

includes taxes & fees

21 Oct - 22 Oct

A self-service beverage station with a refrigerated display and a coffee machine.

A hotel room with two beds, a desk, a chair, a TV, and a large window with a view.

A modern lounge area with seating, tables, and hanging lights.

A snack display in a store with various chips and snacks.

17. Tru By Hilton Jacksonville St Johns Town Center

Southside, 8.7 km from Mayo Clinic Florida

Josephine

SAR 411

SAR 467 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.

A hotel room with a microwave, coffee maker, and refrigerator on the counter. There is a door with a sign and a towel rack visible.

A pier extending into the ocean at sunset with birds flying above.

A golf course with a water hazard and a bridge.

18. Holiday Inn Express Jacksonville Beach by IHG

4.6 km from Mayo Clinic Florida

Bobby

SAR 413

SAR 469 total

includes taxes & fees

18 Oct - 19 Oct

A beach with a sandy shore, waves, and buildings in the background.

A Best Western hotel with a modern design, located near a beach with a pier.

A modern cafe with a central counter, seating area, and a wooden accent wall with 'BW' letters.

A modern lobby with a grey sofa, two round tables, a reception desk, and a wooden wall with shelves displaying trophies and awards.

19. Best Western Oceanfront

5.7 km from Mayo Clinic Florida

Svetlana

SAR 496

SAR 563 total

includes taxes & fees

20 Oct - 21 Oct

A hotel with a beach view, multiple parking levels, and a prominent 'Four Points' sign.

A hotel room with a large bed, a desk, a chair, a TV, and a view of the ocean.

A coastal hotel with a long promenade, beach access, and a pier in the distance.

20. Four Points by Sheraton Jacksonville Beachfront

5.6 km from Mayo Clinic Florida

Rachel

SAR 635

SAR 721 total

includes taxes & fees

1 Nov - 2 Nov

View all properties

Compare popular hotels close to Mayo Clinic Florida

Property	Property class	Guest rating
Residence Inn By Marriott Jacksonville - Mayo Clinic Area	9.4 Exceptional 607 reviews	View
TownePlace Suites by Marriott Jacksonville East	9.2 Wonderful 663 reviews	View
Hilton Jacksonville at Mayo Clinic near Beaches	9.2 Wonderful 373 reviews	View
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic	9.0 Wonderful 1,000 reviews	View
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG	9.0 Wonderful 1,002 reviews	View

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

10/10 Excellent

"Truly enjoyed the property and stay! Great coffee and good drinks"

Hilton Jacksonville at Mayo Clinic near Beaches

10/10 Excellent

"I didn't use the amenities much because I was out exploring the region most of the time when I wasn't sleeping, but everything I experienced was very clean and well maintained. The front desk staff were very friendly and helpful. I know some people may find it a bit intrusive, but I personally love that they send text messages occasionally to see how things are going with their guests' stays. The one very minor issue I brought to their attention during one of these text messages was resolved very quickly."

Holiday Inn Express Jacksonville Beach by IHG

10/10 Excellent

"Clean and updated. Excellent staff. Breakfast was very good. Easy access to the highway."

Cozy & Comfy 3 bedroom residential home

10/10 Excellent

"Nice clean. The amenities were great! Master bedroom bed was comfortable. Location was perfect short drive to beaches, resteraunts & entertainment"

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent

"Overall nice, very slight issue with kid noise let evening/ after 10 pm."

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

10/10 Excellent

"Clean and spacious room. Breakfast was good and had different options."

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

10/10 Excellent

"Clean, cozy house with a quiet neighborhood, close to several restaurants and shopping. The only downfall was there was no tv in the bunk bed room, there was no grill as listed, and the beds were a little too firm. Would def stay here again! Very clean and well kept."

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

10/10 Excellent

"Carson was a great host. The communication process was excellent. He responded back to me fast and the property was cleaned and had everything that we needed. Would definitely come back again."

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

10/10 Excellent

"The property was very clean and spacious. The host was responsive.She was also helpful with area recommendations. She went above and beyond our expectations. The home is well-supplied with just about anything you could need.The beds were very comfortable.The property is located in a safe and convenient neighborhood.We would definitely stay again."

Frequently asked questions

What's the area like around Mayo Clinic Florida?

Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, check out the 44 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic Florida?

Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

How many hotels will I find near Mayo Clinic Florida?

Expedia has 44 hotels and other accommodations within a mile from Mayo Clinic Florida.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review the best deals available near Mayo Clinic Florida.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Florida?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Florida, head over to our customer service page.

What can I see and do near Mayo Clinic Florida?

You can catch a show at SeaWalk Pavillion, Players by the Sea, and Blue Jay Listening Room. Spend some time exploring the natural beauty of Huguenot Park, Oceanfront Park, and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

Find hotels near Mayo Clinic Florida, Jacksonville from SAR 409

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Our top choices for Mayo Clinic Florida hotels

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

2. TownePlace Suites by Marriott Jacksonville East

3. Hilton Jacksonville at Mayo Clinic near Beaches

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

5. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

7. Hotel Palms

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

9. TownePlace Suites by Marriott® Jacksonville Mayport

10. Hyatt Studios Jacksonville/St Johns Town Center

11. Hotel Indigo Jacksonville-Deerwood Park by IHG

12. AC Hotel Jacksonville St Johns Town Center

13. Hampton Inn Jacksonville Beach/Oceanfront

14. Hyatt Place Jacksonville / St. Johns Town Center

15. Courtyard by Marriott Jacksonville I-295/East Beltway

16. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

17. Tru By Hilton Jacksonville St Johns Town Center

18. Holiday Inn Express Jacksonville Beach by IHG

19. Best Western Oceanfront

20. Four Points by Sheraton Jacksonville Beachfront

Compare popular hotels close to Mayo Clinic Florida

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

Hilton Jacksonville at Mayo Clinic near Beaches

Holiday Inn Express Jacksonville Beach by IHG

Cozy & Comfy 3 bedroom residential home

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

Frequently asked questions