The Best Hotels Closest to Mayo Clinic Florida in Jacksonville for 2026

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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

A modern kitchen with a bar area, seating, and a view of the outdoors.

An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.

A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

1.1 km from Mayo Clinic Florida

LISA

SAR 552

SAR 626 total

includes taxes & fees

13 Nov - 14 Nov

A modern restaurant with a bar area, wooden ceiling, and large windows.

A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.

A modern lobby with a curved sofa, round coffee tables, and a large pillar.

2. Hilton Jacksonville at Mayo Clinic near Beaches

0.8 km from Mayo Clinic Florida

Brandy

SAR 597

SAR 677 total

includes taxes & fees

22 Nov - 23 Nov

An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

A hotel room with a bed, a sofa, a nightstand, and a wall-mounted lamp.

A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.

An outdoor patio with a pool, wooden pergola, and seating area.

3. TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

Lana

SAR 462

SAR 524 total

includes taxes & fees

1 Nov - 2 Nov

A lobby with a reception desk, seating area, and a staircase.

A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.

An indoor swimming pool with clear views of trees outside, a tiled floor, and a covered seating area.

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.6 km from Mayo Clinic Florida

frances

SAR 387

SAR 439 total

includes taxes & fees

22 Nov - 23 Nov

A hotel lobby with a bar area, seating arrangements, and a reception desk.

A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.

An outdoor patio with a brick wall, a round table with striped chairs, and two large umbrellas.

A hotel pool area with a long, narrow pool, multiple lounge chairs, and a covered seating area.

5. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

Kerry

SAR 445

SAR 506 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.

A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

0.4 km from Mayo Clinic Florida

Patricia

SAR 571

SAR 648 total

includes taxes & fees

31 Oct - 1 Nov

A bedroom with a bed, a pillow, a surfboard, and wall decorations.

A marble table with a book and a cup, a vase with green plants, and a brown sofa in the background.

A cafe with a front desk, a coffee machine, and two chairs outside.

A room with a sofa, a chair, a table, a dresser, a suitcase, a hanging light fixture, a wall decoration, and a window with blinds.

7. Hotel Palms

7.8 km from Mayo Clinic Florida

Vinny

SAR 734

SAR 833 total

includes taxes & fees

1 Nov - 2 Nov

A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.

A hotel lobby with a reception desk, seating area, and a large window.

A beverage refrigerator stocked with various drinks, a small refrigerator, and a wall-mounted display with promotional items.

A hotel room with two beds, a desk, a chair, and a large window with a view.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Southside, 7.7 km from Mayo Clinic Florida

Aneudi

SAR 360

SAR 409 total

includes taxes & fees

23 Nov - 24 Nov

A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.

A modern conference room with a long table, several chairs, and pendant lighting.

A pathway leading to a sunset over a beach with sand and grass.

A modern hotel lobby with a long reception desk, seating area, and large windows.

9. Element by Marriott Jacksonville Beach

5.4 km from Mayo Clinic Florida

ariel

SAR 540

SAR 613 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with two beds, a desk, a chair, a small table, a TV, and a kitchen area.

A modern kitchen with built-in appliances, wooden cabinetry, and a stainless steel refrigerator.

10. Hyatt Studios Jacksonville/St Johns Town Center

Deerwood, 7.8 km from Mayo Clinic Florida

Mandy

SAR 465

SAR 528 total

includes taxes & fees

12 Nov - 13 Nov

A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.

A modern hotel with a pool, palm trees, and a clear blue sky.

A modern hotel building with a flat facade, large windows, and a sign reading "ACHTEL JACKSONVILLE".

A modern bar area with seating, a bar counter, and a view of the city through large windows.

11. AC Hotel Jacksonville St Johns Town Center

Southside, 8.1 km from Mayo Clinic Florida

Emily

SAR 559

SAR 635 total

includes taxes & fees

22 Nov - 23 Nov

A pool with a waterfall feature, surrounded by large rock formations.

A hotel room with two beds, a desk with a flat-screen TV, a chair, and a large window with a view of palm trees.

A bar with a tiled roof, outdoor seating, and a view of the ocean.

A beachfront hotel with multiple balconies, a sandy beach, and ocean views.

12. Hampton Inn Jacksonville Beach/Oceanfront

6.3 km from Mayo Clinic Florida

Maya

SAR 603

SAR 684 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor seating area with a fire feature, chairs, and a table.

A modern bar area with a counter, bar stools, and a television screen.

A modern bar area with a curved counter, multiple bar stools, and a variety of liquor bottles.

A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.

13. Hotel Indigo Jacksonville-Deerwood Park by IHG

Southside, 10.8 km from Mayo Clinic Florida

Carol

SAR 387

SAR 439 total

includes taxes & fees

22 Nov - 23 Nov

A spacious lobby with a reception desk, seating area, and large windows.

A multi-story hotel with a central entrance, large windows, and a well-lit facade.

An indoor dining area with tables and chairs, a ceiling fan, and a view of the outdoors.

A bar area with wooden chairs, a round table, and a brick wall.

14. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

8.5 km from Mayo Clinic Florida

Madison

SAR 428

SAR 477 total

includes taxes & fees

16 Nov - 17 Nov

An outdoor patio with seating, a fire pit, and string lights.

A multi-story hotel with a modern design, featuring a large number of windows and a flat roof.

A modern living room with a dining area, a flat-screen TV, and a bookshelf.

A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a fence.

15. Hyatt Place Jacksonville / St. Johns Town Center

Southside, 8.6 km from Mayo Clinic Florida

Becky

SAR 477

SAR 542 total

includes taxes & fees

28 Oct - 29 Oct

A self-service beverage station with a refrigerated display and a coffee machine.

A modern hotel reception area with a curved wooden reception desk, a digital display, and a view of the lobby.

A snack display in a store with various chips and snacks.

A hotel room with two beds, a desk, a chair, a TV, and a large window with a view.

16. Tru By Hilton Jacksonville St Johns Town Center

Southside, 8.7 km from Mayo Clinic Florida

Janice

SAR 411

SAR 466 total

includes taxes & fees

1 Nov - 2 Nov

A modern bar area with wooden accents, a variety of beverages, and seating arrangements.

A modern hotel lobby with a sofa set, armchairs, a coffee table, and a patterned carpet.

A multi-story hotel with a prominent entrance, a parking lot, and well-maintained landscaping.

A patio area with a stone fire pit, outdoor furniture, and a brick floor.

17. Courtyard by Marriott Jacksonville I-295/East Beltway

Arlington, 13.2 km from Mayo Clinic Florida

Chloie Marie

SAR 335

SAR 380 total

includes taxes & fees

31 Oct - 1 Nov

An outdoor patio with blue and red chairs, tables, and potted plants.

A conference room with a large table, chairs, a projector screen, and a view of greenery outside.

A buffet with labeled containers of turkey sausage and cookies.

A room with a window, a sofa, and an air conditioning unit.

18. Holiday Inn Express Jacksonville South Bartram Prk by IHG

17.1 km from Mayo Clinic Florida

Max

SAR 357

SAR 405 total

includes taxes & fees

22 Nov - 23 Nov

An outdoor patio area with a stone fire pit, wicker furniture, and a grill.

A modern living room with a fireplace, leather armchairs, a sofa, and ottomans.

A modern kitchen with dark wooden cabinets, a stainless steel refrigerator, a microwave, and a dishwasher.

A gym with treadmills, elliptical machines, and weight benches.

19. Residence Inn by Marriott Jacksonville South/Bartram Park

17.1 km from Mayo Clinic Florida

Nicholas

SAR 470

SAR 533 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a dining area, two beds, a TV, and a kitchenette.

Two people near a grill with a plate of food and a bottle.

A hotel room with a dining area featuring a table, chairs, a television, a microwave, and a coffee maker.

A hotel gym with treadmills, an elliptical, a bench, and dumbbells.

20. Candlewood Suites Jacksonville - Mayport by IHG

9.2 km from Mayo Clinic Florida

Nasar

SAR 375

SAR 426 total

includes taxes & fees

15 Nov - 16 Nov

View all properties

Compare popular hotels close to Mayo Clinic Florida

Property	Property class	Guest rating
Residence Inn By Marriott Jacksonville - Mayo Clinic Area	9.4 Exceptional 612 reviews	View
Hilton Jacksonville at Mayo Clinic near Beaches	9.2 Wonderful 386 reviews	View
TownePlace Suites by Marriott Jacksonville East	9.2 Wonderful 667 reviews	View
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG	9.0 Wonderful 1,019 reviews	View
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic	9.0 Wonderful 1,002 reviews	View

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

10/10 Excellent

"Good luck with parking unless you valet everyday"

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

8/10 Good

"Staff was great, breakfast was very good as well"

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

8/10 Good

"I chose this hotel. Because it is close to Mayo Clinic."

Cozy & Comfy 3 bedroom residential home

10/10 Excellent

"Nice clean. The amenities were great! Master bedroom bed was comfortable. Location was perfect short drive to beaches, resteraunts & entertainment"

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

10/10 Excellent

"Clean, cozy house with a quiet neighborhood, close to several restaurants and shopping. The only downfall was there was no tv in the bunk bed room, there was no grill as listed, and the beds were a little too firm. Would def stay here again! Very clean and well kept."

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

10/10 Excellent

"Carson was a great host. The communication process was excellent. He responded back to me fast and the property was cleaned and had everything that we needed. Would definitely come back again."

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

10/10 Excellent

"The property was very clean and spacious. The host was responsive.She was also helpful with area recommendations. She went above and beyond our expectations. The home is well-supplied with just about anything you could need.The beds were very comfortable.The property is located in a safe and convenient neighborhood.We would definitely stay again."

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

8/10 Good

"The location was perfect for us, as I had appointments at Mayo Clinic. Leo was a great host and addressed our concerns promptly."

5/2 Pool Cottage, Walk to Beach close to Mayo

10/10 Excellent

"Very clean and had everything we needed. Well worth it. Easy access to Mayo Clinic, beach and shopping. Tons of space in a quite neighborhood. The pool and pool house was bonus !"

Frequently asked questions

What's the area like around Mayo Clinic Florida?

Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, check out the 44 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic Florida?

Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

How many hotels will I find near Mayo Clinic Florida?

Expedia has 44 hotels and other accommodations within a mile from Mayo Clinic Florida.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review the best deals available near Mayo Clinic Florida.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Florida?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Florida, head over to our customer service page.

What can I see and do near Mayo Clinic Florida?

You can catch a show at SeaWalk Pavillion, Players by the Sea, and Blue Jay Listening Room. Spend some time exploring the natural beauty of Huguenot Park, Oceanfront Park, and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

Find hotels near Mayo Clinic Florida, Jacksonville from SAR 380

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Our top choices for Mayo Clinic Florida hotels

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

2. Hilton Jacksonville at Mayo Clinic near Beaches

3. TownePlace Suites by Marriott Jacksonville East

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

5. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

7. Hotel Palms

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

9. Element by Marriott Jacksonville Beach

10. Hyatt Studios Jacksonville/St Johns Town Center

11. AC Hotel Jacksonville St Johns Town Center

12. Hampton Inn Jacksonville Beach/Oceanfront

13. Hotel Indigo Jacksonville-Deerwood Park by IHG

14. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

15. Hyatt Place Jacksonville / St. Johns Town Center

16. Tru By Hilton Jacksonville St Johns Town Center

17. Courtyard by Marriott Jacksonville I-295/East Beltway

18. Holiday Inn Express Jacksonville South Bartram Prk by IHG

19. Residence Inn by Marriott Jacksonville South/Bartram Park

20. Candlewood Suites Jacksonville - Mayport by IHG

Compare popular hotels close to Mayo Clinic Florida

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Cozy & Comfy 3 bedroom residential home

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

5/2 Pool Cottage, Walk to Beach close to Mayo

Frequently asked questions