Top Main Street Fort Pierce Hotels

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Compare popular hotels in Main Street Fort Pierce

Property	Property class	Guest rating
Hampton Inn & Suites Ft. Pierce	2.5 star property	9.2 Wonderful 1,000 reviews	View
Home2 Suites by Hilton Ft. Pierce I-95	3.0 star property	9.4 Exceptional 277 reviews	View
Days Inn & Suites by Wyndham Fort Pierce Midtown	2.0 star property	9.0 Wonderful 16 reviews	View
Fairfield Inn & Suites by Marriott Fort Pierce	3.0 star property	8.8 Excellent 1,002 reviews	View
Hutchinson Island Hotel	2.5 star property	8.2 Very good 1,371 reviews	View

Where to stay in Main Street Fort Pierce

Find the best Main Street Fort Pierce areas and neighborhoods for the activities you enjoy most.

A coastal area with a narrow waterway, a beach, and residential buildings.

Lakewood Park

While Lakewood Park isn't home to many top sights, McKee Botanical Garden and Avalon State Park are some notable places to visit nearby.

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Spanish Lakes Country Club Village

While there might not be top attractions in Spanish Lakes Country Club Village, you can explore the larger area and discover places like Harbor Branch Ocean Discovery Center and McKee Botanical Garden.

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A calm lake reflecting trees and a clear sky.

Spanish Lakes Fairways

While Spanish Lakes Fairways might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Lakewood Park Regional Park / Pool and Indrio Road Park / Schoolhouse.

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A coastal city with a bay, mangrove islands, and a clear blue sky.

Meadowood

If you're looking for some top things to see and do in Meadowood and surrounding area, you can visit Endless Summer Vineyard & Winery and Al's Family Farms.

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A mosaic sign with 'Mainstreet Fort Pierce' written on it.

Panther Woods

If you're looking for some top things to see and do in Panther Woods and surrounding area, you can visit Endless Summer Vineyard & Winery and Al's Family Farms.

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Top Main Street Fort Pierce Hotel Reviews

Residence Inn by Marriott Port St. Lucie

10/10 Excellent

"The staff was friendly, breakfast was hot and lots of great options and our room was a king studio - very spacious!"

Tru by Hilton Port St. Lucie Tradition

8/10 Good

"Nice hotel but a bit odd/weird. Furnishings just did'nt make sense. Literally HUGE room with king bed but nothing other than a very small table. No substantial place to keep essential items near the bed. The bed-side table was a round orange thimble-looking "thing". Barely room for an ipad or book. The bed was firm and comfy with nice fabrics but it was extremely low to the ground. The block-out shades are awesome, although the proximity to the main road left much to be desired for sound isolation in the room. The parking lot is part of a strip mall and seems under-sized compared to the size of the hotel. Due to the newness of the building and the designers selection of shower faucets, it was extremely difficult to operate (small and stiff). While the roll-in shower was rather spacious, water from the shower managed to get everywhere outside the shower into the rest of the bathroom. Perhaps shower curtain that isn't a foot+ from the floor may help. For the price and location right in town, it's pretty good and if you're looking for something non-conventional in a hotel room - you found it!"

Hutchinson Shores Resort & Spa

10/10 Excellent

"An absolutely beautiful resort. Scenic, large beach, incredible vibes and an amazing staff and an even better pool. They are conscious of the environment and local animals, so be ready to make certain small concessions for sea turtles. It offers a laid back, relaxed vacation experience that I would recommend."

Holiday Inn Express Vero Beach-West (I-95) by IHG

8/10 Good

"Not sure on the smell when I arrived, smelled moldy and had a humidifier or dehumidifier in the room quit running after I checked in. The breakfast was good as usual however I was there in May 2026. The biscuits were great. They wasn’t hard like they were this time and they had bacon on the breakfast menu last May and they didn’t have any bacon the whole week I was there. Need a little more convenience on the parking because back in May when I was there and then October when I was there, there’s a lot of construction guys. I guess that was there take up the whole parking lot."

Frequently asked questions

What is Main Street Fort Pierce like?

Main Street Fort Pierce is a neighborhood that travelers like for its waterfront, art, and shopping. Be sure to check out Sunrise Theater and Fort Pierce Farmer's Market as part of your Main Street Fort Pierce travel plans.

How many hotels can I expect to find in Main Street Fort Pierce?

Book one of Expedia's 7 hotels and other accommodations in Main Street Fort Pierce and start exploring everything Fort Pierce has to offer.

If I need to cancel my hotel reservation in Main Street Fort Pierce, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then use the filter option "fully refundable" to review the top deals on offer in Main Street Fort Pierce.

Where can I learn more about changing or cancelling my trip to Main Street Fort Pierce?

For additional details about changing or cancelling your trip to Main Street Fort Pierce, head over to our customer service page.

What is there to do in this Fort Pierce neighborhood?

Sights like Sunrise Theater and Official Highwaymen Art Gallery can be part of your cultural tour of Main Street Fort Pierce. Fort Pierce Farmer's Market and Fort Pierce City Marina are also a couple of places to visit in the neighborhood. A few places to visit in the area around Main Street Fort Pierce include Manatee Education and Observation Center, House of Seven Gables, and A.E. Backus Museum. Marina at Fort Pierce and Causeway Cove are also worth a visit when you're out sightseeing in Fort Pierce.

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Our top choices for Main Street Fort Pierce hotels

1. Hampton Inn & Suites Ft. Pierce

2. Hutchinson Island Hotel

3. Fairfield Inn & Suites by Marriott Fort Pierce

4. Holiday Inn Express Hotel & Suites Fort Pierce West by IHG

5. Home2 Suites by Hilton Ft. Pierce I-95

6. La Quinta Inn & Suites by Wyndham Ft. Pierce

7. Days Inn & Suites by Wyndham Fort Pierce Midtown

8. At Home Inn

9. Comfort Suites Fort Pierce I-95

10. Hampton Inn & Suites Vero Beach Downtown

11. Royal Inn Beach Hotel Hutchinson Island

12. Staybridge Suites Vero Beach by IHG

13. Hampton Inn & Suites Port St. Lucie, West

14. Best Western Port St. Lucie

15. SpringHill Suites Port St. Lucie

16. Sleep Inn Fort Pierce I-95

17. Days Inn & Suites by Wyndham Fort Pierce I-95

18. Residence Inn by Marriott Port St. Lucie

19. Red Roof Inn Ft Pierce

20. Holiday Inn Express & Suites Port St. Lucie West by IHG

Compare popular hotels in Main Street Fort Pierce

Where to stay in Main Street Fort Pierce

Lakewood Park

Spanish Lakes Country Club Village

Spanish Lakes Fairways

Meadowood

Panther Woods

Top Main Street Fort Pierce Hotel Reviews

Residence Inn by Marriott Port St. Lucie

Frequently asked questions