Are there any 5-star vacation rentals in Big Pine Key?

Although there aren't any 5-star vacation rentals in Big Pine Key on our site, we have a range of stays that promise a fantastic getaway. Discover one that matches your style by checking out our vacation rentals in Big Pine Key .

Big Pine Key featuring a river or creek, a bay or harbor and general coastal views

Find 5 Star Hotels in Big Pine Key, FL from SAR 645

Change your mind

Book hotels with free cancellation

Treat yourself

Be picky

Search almost a million properties worldwide

Check availability on Big Pine Key 5 Star Hotels

Tonight

Tomorrow

Next weekend

In two weeks

Compare Big Pine Key 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

"Great views. Beautiful property. "

SAR 1,365 total

includes taxes & fees

6 Jul - 7 Jul

Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Big Pine Key.

Tranquility Bay Beachfront Hotel and Resort

2600 Overseas Hwy, Marathon, FL

SAR 926

SAR 1,285 total

6 Jul - 7 Jul

includes taxes & fees

8.8/10 Excellent! (1,002 reviews)

Still don't see what you're looking for?

See all properties in Big Pine Key.

You can also use these popular filters to refine your search.

Pool Spa Hot tub Breakfast included Waterpark

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Big Pine Key

Meet the local wildlife, splash in the shallows and enjoy the calm of the quieter Keys on this stretch of serene waterfront and wetlands.

See all hotels in Big Pine Key

Recent reviews of Big Pine Key hotels

5/5 Excellent

"Fabulous gem! This hotel is beautiful and provides an amazing set of pools and amenities to enjoy throughout the property. We enjoyed the free rental bikes and went to the old 7 mile bridge area for some cool views. Also loved having a private beach front area, the 4-5 pools, the sunsets and hammocks around the resort. The Market had great options for breakfast, lighter meals and snacks. All the staff were very friendly. The resort was beautiful."

A verified traveler stayed at Isla Bella Beach Resort & Spa

Posted 7 days ago

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Big Pine Key Hotels by Star Rating

Stay near popular Big Pine Key attractions

More Hotel Options in Big Pine Key

More Accommodation Types in

Recommended Cities for You

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Big Pine Key?

You’ll find a variety of pricing options for a 5-star hotel in Big Pine Key on Expedia. The amount you pay will depend on when you travel, length of your trip and other factors. Compare available properties for your desired dates and use our pricing and other filters to score the perfect high-end stay.

Search for the lowest price per night from SAR 645

What makes a hotel 5 stars in Big Pine Key?

Outstanding guest service characterizes every 5-star hotel in Big Pine Key. From the moment you arrive, staff are at your beck and call, whether arranging valet parking or providing in-room massages. Additionally, hotels have to feature upscale amenities to meet the standard for a 5-star rating. These can include luxury bathrobes, saunas or spas, pools, gastronomic restaurants and knowledgeable concierge.

Are there any 5-star all-inclusive resorts in Big Pine Key?

Use Expedia’s filter tool to find a high-end escape in Big Pine Key where everything you need is included in the price. From there, narrow down your results for properties that have a 5-star rating and are listed as “All inclusive.” The most important thing to look forward to at these stays? Pure relaxation and indulgence.