Upstate South Carolina Vacations

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Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
A pedestrian bridge with colorful lights, surrounded by trees and a distant building.

Greenville Downtown

3 out of top 10 points of interest in this area

The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.

Find hotels in Greenville Downtown

Find the Best Upstate South Carolina Vacation Packages

Upstate South Carolina Hotel Deals

Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
The price is SARĀ 668 per night from Jul 30 to Jul 31
SARĀ 668
SARĀ 757 total
30 Jul - 31 Jul
includes taxes & fees
8.8/10 Excellent! (1,002 reviews)
"Nice, clean and well designed."

Reviewed on 16 July 2026

Hyatt Regency Greenville
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
The price is SARĀ 1,348 per night from Aug 13 to Aug 14
SARĀ 1,348
SARĀ 1,523 total
13 Aug - 14 Aug
includes taxes & fees
Grand Bohemian Lodge Greenville, Autograph Collection
Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

2.5 out of 5
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
The price is SARĀ 387 per night from Jul 19 to Jul 20
SARĀ 387
SARĀ 426 total
19 Jul - 20 Jul
includes taxes & fees
9.2/10 Wonderful! (1,540 reviews)
"The breakfast was normal. The staff were helpful. The only down side was their elevators during busy hours. It took a while, use the stairs!"

Reviewed on 18 July 2026

Best Western Plus Greenville I-385 Inn & Suites
See all 3,120 properties in Upstate South Carolina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)
Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.
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