Photo by Cindy Keese

Search Vacation Homes in Seneca

  • Plan, book, stay with confidence

    • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    today icon
    Change your mind
    Book hotels with free cancellation

Check prices for these dates

Next weekend
9 Jum. I - 11 Jum. I
In two weeks
16 Jum. I - 18 Jum. I
In one month
30 Jum. I - 1 Jum. II
In two months
27 Jum. II - 29 Jum. II

Compare 715 Vacation Homes in Seneca with updated reviews, rates, and availability.

Lake Hartwell House - Sunsets & Deep Water Dock - Close to Clemson & Anderson
Property grounds

Lake Hartwell House - Sunsets & Deep Water Dock - Close to Clemson & Anderson

10.0 out of 10, Exceptional, (79)
"Enjoyed our stay at this property! "
Lake Hartwell House - Sunsets & Deep Water Dock - Close to Clemson & Anderson
Young@Hart is a Lakefront home w/ Covered Dock, Game Room, 4 Kayaks & Hot Tub!!
Terrace/patio

Young@Hart is a Lakefront home w/ Covered Dock, Game Room, 4 Kayaks & Hot Tub!!

10.0 out of 10, Exceptional, (84)
"Everything was great"
Young@Hart is a Lakefront home w/ Covered Dock, Game Room, 4 Kayaks & Hot Tub!!
Beautiful 5 Acre Lakefront Private Retreat w/ Boat Dock, Hot Tub, 5 Bdrm/ 5 bath
Terrace/patio

Beautiful 5 Acre Lakefront Private Retreat w/ Boat Dock, Hot Tub, 5 Bdrm/ 5 bath

10.0 out of 10, Exceptional, (64)
"This was the perfect place for our family trip. The house was beautiful and my nieces loved the game room!"
Beautiful 5 Acre Lakefront Private Retreat w/ Boat Dock, Hot Tub, 5 Bdrm/ 5 bath
Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger
Fridge, microwave, oven, stovetop

Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger

9.8 out of 10, Exceptional, (116)
"We were so pleased with this home and our overall stay at this property. The kitchen was very well stocked, it was very spacious, kayaks were such a fun bonus! "
The price is SAR 1,481
SAR 2,780 total
includes taxes & fees
11 May - 12 May
Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger
Great weekend getaway just a mile from downtown!
Fridge, microwave, oven, stovetop

Great weekend getaway just a mile from downtown!

10.0 out of 10, Exceptional, (10)
"It was a great experience overall and very well kept!"
Great weekend getaway just a mile from downtown!
The Brick House At Currahee
Fridge, microwave, oven, stovetop

The Brick House At Currahee

9.6 out of 10, Exceptional, (54)
"Nice place, reasonably priced in a great area."
The price is SAR 398
SAR 753 total
includes taxes & fees
5 May - 6 May
The Brick House At Currahee
Clemson House 1 mile from University & Stadium!
3 bedrooms, desk, iron/ironing board, free WiFi

Clemson House 1 mile from University & Stadium!

9.4 out of 10, Exceptional, (14)
"Lovely property, very comfortable and convenient for baseball."
The price is SAR 675
SAR 1,407 total
includes taxes & fees
5 May - 6 May
Clemson House 1 mile from University & Stadium!
Relaxed, pet-friendly home walkable to Clemson campus, stadiums or downtown.
Fridge, microwave, oven, stovetop

Relaxed, pet-friendly home walkable to Clemson campus, stadiums or downtown.

10.0 out of 10, Exceptional, (18)
"Overall fantastic experience! Great location and property manager was amazing with communication."
Relaxed, pet-friendly home walkable to Clemson campus, stadiums or downtown.
Guesthouse located in historic Toccoa Ga
Exterior detail

Guesthouse located in historic Toccoa Ga

10.0 out of 10, Exceptional, (26)
"This little home away from home was wonderful ♥️ Owners were amazing and very helpful. Very spacious and open. We will definitely be making a return trip🎉"
Guesthouse located in historic Toccoa Ga
Lake Hartwell Waterfront, Dock, Clemson, Fire Pit, Fenced Yard, Pets & Game Room
Smart TV, fireplace, books, music library

Lake Hartwell Waterfront, Dock, Clemson, Fire Pit, Fenced Yard, Pets & Game Room

10.0 out of 10, Exceptional, (105)
"We had a wonderful stay, the property is kid and dog friendly. Will definitely look to book it again when we’re in town for our agility competitions. "
Lake Hartwell Waterfront, Dock, Clemson, Fire Pit, Fenced Yard, Pets & Game Room
North Keowee Family Lake House on Private Cove With Dock / 5 MIN FROM JOCASSEE
Miscellaneous

North Keowee Family Lake House on Private Cove With Dock / 5 MIN FROM JOCASSEE

10.0 out of 10, Exceptional, (104)
"This was a great property. "
North Keowee Family Lake House on Private Cove With Dock / 5 MIN FROM JOCASSEE
Cute House on Lake Hartwell- Dock Access! PETS ALLOWED!
Terrace/patio

Cute House on Lake Hartwell- Dock Access! PETS ALLOWED!

Cute House on Lake Hartwell- Dock Access! PETS ALLOWED!
Keowee Key Condo w/ Lake Access & Community Pools!
Aerial view

Keowee Key Condo w/ Lake Access & Community Pools!

2.0 star property
10.0 out of 10, Exceptional, (8)
"The condo was spacious, clean, and well stocked with essentials. Just a short walk to the pool and lake access, but also close enough to Clemson. I highly recommend this condo, and I am looking forward to our next visit. "
Keowee Key Condo w/ Lake Access & Community Pools!
Cozy House on the way to Clemson, Pendleton, Anderson and T. Ed Garrison Arena
Exterior

Cozy House on the way to Clemson, Pendleton, Anderson and T. Ed Garrison Arena

2.0 star property
9.8 out of 10, Exceptional, (6)
"This home was a perfect location to stay for our Clemson Tiger’s ring ceremony. Perfect layout, lovely neighborhood, and fully stocked. Snack basket upon arrival was very much appreciated! Will definitely consider this home again for a future visit to the area. "
Cozy House on the way to Clemson, Pendleton, Anderson and T. Ed Garrison Arena
Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub
Outdoor spa tub

Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

10.0 out of 10, Exceptional, (139)
"Great set up for family Christmas reunion "
Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub
Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock
Property grounds

Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock

9.6 out of 10, Exceptional, (162)
"The home was cozy and super close to grocery stores and Clemson! Too cold to get in the water in November but everything was great!"
Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock
Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub
Exterior

Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub

10.0 out of 10, Exceptional, (44)
"Loved this home. Lots of room, great area, beautiful views. "
Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub
Lakehouse Retreat with dock, paddle boat, canoe & kayaks!
Terrace/patio

Lakehouse Retreat with dock, paddle boat, canoe & kayaks!

10.0 out of 10, Exceptional, (168)
"This place was great for our whole family. It was stocked with everything we needed for our stay. Could not have been happier. "
Lakehouse Retreat with dock, paddle boat, canoe & kayaks!
Lake Front, Quiet, Private cove on 4.75 acres, Canoe, 2 Kayak, 2 boat docks
Property grounds

Lake Front, Quiet, Private cove on 4.75 acres, Canoe, 2 Kayak, 2 boat docks

10.0 out of 10, Exceptional, (216)
"Very nice, large house. Stocked kitchen with plenty of dishes and towels! Enjoyed the canoe and the quiet! "
Lake Front, Quiet, Private cove on 4.75 acres, Canoe, 2 Kayak, 2 boat docks
4-928L Hartwell Marina Vista - Pets welcome - WIFI - Level LAKEFRONT Lot
Beach

4-928L Hartwell Marina Vista - Pets welcome - WIFI - Level LAKEFRONT Lot

9.0 out of 10, Wonderful, (44)
"Great location convenient to town for dinner and shopping"
4-928L Hartwell Marina Vista - Pets welcome - WIFI - Level LAKEFRONT Lot
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Seneca
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Other property types in Seneca

Postcard Cabins Lake Hartwell
Exterior

Postcard Cabins Lake Hartwell

2.0 star property
10.0 out of 10, Exceptional, (4)
"My boyfriend and I decided to stay here on a whim last year and had to come back again on our way back to Philly! Easily our favorite place we’ve stayed in together, perfect spot to wind down after a lot of traveling."
Postcard Cabins Lake Hartwell
3 Bedroom/2 Full Bath House in Seneca, SC. 4 miles from Clemson Campus!
Interior

3 Bedroom/2 Full Bath House in Seneca, SC. 4 miles from Clemson Campus!

10.0 out of 10, Exceptional, (1)
"Communication with Katie was amazing from the get go! The house was clean and plenty big enough for the 6 of us that stayed. Plenty of towels provided, beds were comfortable, and it was easy to connect the tv to a hotspot if we wanted to. Definitely will be keeping this on my list of places to stay in Clemson! "
3 Bedroom/2 Full Bath House in Seneca, SC. 4 miles from Clemson Campus!
6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.
Property grounds

6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.

9.8 out of 10, Exceptional, (139)
"Very nice overall. Comfortable for big groups. "
6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.