Photo by Cindy Keese

Find Resorts & Hotels with Spas in Seneca, SC

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Check availability on Seneca Resorts & Hotels with Spas

Top Seneca Resorts & Hotels with Spas

Lakeside Lodge Clemson
Aerial view

Lakeside Lodge Clemson

2.5 star property
9.0 out of 10, Wonderful, (904)
"Great overall stay."
The price is SAR 371
SAR 461 total
includes taxes & fees
21 Jun - 22 Jun
Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson
Lobby

Tru by Hilton Seneca Clemson

2.5 star property
9.2 out of 10, Wonderful, (726)
"Great overall stay."
The price is SAR 411
SAR 453 total
includes taxes & fees
29 Jun - 30 Jun
Tru by Hilton Seneca Clemson
Quality Inn Seneca Clemson Area US-123
Free daily on-the-go breakfast

Quality Inn Seneca Clemson Area US-123

2.5 star property
8.0 out of 10, Very Good, (599)
"Really good place "
The price is SAR 282
SAR 346 total
includes taxes & fees
22 Jun - 23 Jun
Quality Inn Seneca Clemson Area US-123
Days Inn by Wyndham Seneca / Clemson Area
Lobby

Days Inn by Wyndham Seneca / Clemson Area

2.0 star property
6.8 out of 10, (684)
"Clean and comfortable. Good location. Close to Clemson University "
The price is SAR 252
SAR 277 total
includes taxes & fees
6 Jul - 7 Jul
Days Inn by Wyndham Seneca / Clemson Area
Best Western Seneca-Clemson
Lobby

Best Western Seneca-Clemson

2.5 star property
8.4 out of 10, Very Good, (592)
"The admission attendant was friendly"
The price is SAR 348
SAR 382 total
includes taxes & fees
26 Jun - 27 Jun
Best Western Seneca-Clemson
Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub
Outdoor spa tub

Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

10.0 out of 10, Exceptional, (142)
"Great set up for family Christmas reunion "
Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
Fridge, microwave, oven, stovetop

5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

10.0 out of 10, Exceptional, (84)
"Great stay!"
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
Serenity Bay on Lake Keowee!
Exterior

Serenity Bay on Lake Keowee!

2.0 star property
8.0 out of 10, Very Good, (2)
"The place is an excellent location and it has everything we need. Excellent for kids."
Serenity Bay on Lake Keowee!
Lakefront Lake Keowee Home with flat lawn & private dock. 14 miles to Clemson!
Exterior

Lakefront Lake Keowee Home with flat lawn & private dock. 14 miles to Clemson!

10.0 out of 10, Exceptional, (108)
"We had two familes stay and had a great time at the lake. The house was clean and in a calm cove on the lake, convient to town and the restaurants on the lake."
Lakefront Lake Keowee Home with flat lawn & private dock. 14 miles to Clemson!
NEW! Beautiful 5 bedroom Lake Keowee Cove Home!
Fridge, microwave, oven, stovetop

NEW! Beautiful 5 bedroom Lake Keowee Cove Home!

9.4 out of 10, Exceptional, (9)
"Terrific listing with easy access to the lake. The location is great for a football weekend and plenty of activities for children. Peaceful setting with games for young ones. Would highly recommend for a getaway."
NEW! Beautiful 5 bedroom Lake Keowee Cove Home!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the lakeside setting in Seneca - worth a picture or two! Be sure to enjoy the coffeehouses during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
How many spa hotels will I find in Seneca?
Among Expedia's 147 accommodation options in Seneca, there is 1 spa hotel.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Keowee Reservoir, Lake Keowee, and Keowee Key Golf Course. If you have extra time while you're in the area, you might want to see Lake Hartwell and Oconee County Library Seneca Branch.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services including couples massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.