Top La Quinta Inn & Suites in Seneca, SC

A calm lake with mountains in the background.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Save an average of 15% on thousands of hotels when you're signed in

Top Seneca Hotel Reviews

Days Inn by Wyndham Anderson

10/10 Excellent

"Was a great stay"

4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit, Pet Friendly!

10/10 Excellent

"Such a beautiful lake view from the house and decks, close to the water, even better in person than pictures shared. House was well equipped, even supplying basics for the week like toilet paper, paper towel, trash bags, dishwasher tablets and soap. Communication with owner was always simple, he was quick to respond; and house was very clean. We ranged from age 2 to age 65, great week at the lake making fun family memories!! Thanks again for sharing your home with us!!"

Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

10/10 Excellent

"My family had a wonderful time at this lakehouse. We enjoyed swimming and paddleboarding in the quiet cove. The entire checkin, checkout, communications with owner, were all easy and fast. The hot tub was a wonderful bonus that we used frequently. We had one small issue and the host quickly addressed it. Communication at its finest! Many thanks for our relaxing time at Lake Keowee.I give my very highest approval to everything about this lakehome."

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"This cabin is SMALL and it is well appointed and feels bigger than it is because of the very high ceilings. The bed was comfortable, the room was very clean, the bathroom products smelled good, and the treats were a nice touch. My only real complaint is that we were supposed to receive a text the morning of our arrival with a cabin assignment and key code; we did not receive the text until 30 minutes before check in time. Had we been told that we wouldn't receive it until that time, we would not have worried. As it was, when we didn't receive it, we became concerned that we would not have a place to stay for the evening. It took a number of phone calls and chat sessions to get past AI and find some help."

Lake House Near Clemson Private Boat Dock WiFi 65" TV Grill Kayaks Deep Water

10/10 Excellent

"The lake house is very comfortable and has all of the amenities that we needed. It felt like being at home except that we were able to enjoy the beautiful lake. The host was very helpful in helping us deal with a minor issue. Her response was very timely. Our three days went by very quickly. We will definitely consider staying there again!"

Room 1

Change your mind

Treat yourself

Be picky

Check prices for these dates

Top Seneca Hotel Reviews

Days Inn by Wyndham Anderson

Fairfield Inn & Suites Seneca Clemson Univ Area

4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit, Pet Friendly!

Tru by Hilton Seneca Clemson

Quality Inn Seneca Clemson Area US-123

Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Lakeside Lodge Clemson

Lake House Near Clemson Private Boat Dock WiFi 65" TV Grill Kayaks Deep Water

Explore a world of travel with Expedia

More Hotel Options in Seneca

More Accommodation Types in Seneca

Hotels in Popular Destinations

Explore more hotels

Find all hotels by La Quinta Inn & Suites in Seneca, SC

Change your mind

Treat yourself

Be picky

Check prices for these dates

Top Seneca Hotel Reviews

Days Inn by Wyndham Anderson

Explore a world of travel with Expedia

More Hotel Options in Seneca

More Accommodation Types in Seneca

Hotels in Popular Destinations

Explore more hotels