Santa Cruz Vacations

Book a Hotel + Flight together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to SARĀ 5,400 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Find the Best Santa Cruz Vacation Packages

Santa Cruz Hotel Deals

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is SARĀ 201 per night from Aug 3 to Aug 4
SARĀ 201
SARĀ 201 total
3 Aug - 4 Aug
9.4/10 Exceptional! (125 reviews)
"I was a solo traveler, the room was clean, I felt safe, there was a restaurant, and I even was able to walk to the zoo one day (30 min walk)! When I had to leave at 3 AM to catch a flight, the hotel helped arrange a taxi."

Reviewed on 16 July 2026

Ibis Santa Cruz DE LA Sierra
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is SARĀ 492 per night from Aug 18 to Aug 19
SARĀ 492
SARĀ 492 total
18 Aug - 19 Aug
9/10 Wonderful! (389 reviews)
"Very nice hotel! Everthibg was perfect, clean and the breakfast was perfect"

Reviewed on 17 July 2026

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San MartĆ­n y 4to. Anillo Santa Cruz
The price is SARĀ 545 per night from Aug 5 to Aug 6
SARĀ 545
SARĀ 545 total
5 Aug - 6 Aug
9/10 Wonderful! (433 reviews)
"Wonderful place to stay while visiting Santa Cruz Bolivia."

Reviewed on 7 July 2026

Camino Real Hotel
See all 298 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Santa Cruz attractions

A historic building with arched windows and a clock. People are sitting and standing on the steps in front of the building.

Plaza 24 de Septiembre

8.8/10 (164 reviews)
Plaza 24 de Septiembre buzzes with local culture beneath swaying palms and colonial architecture. Climb the Cathedral's bell tower for spectacular city views while sampling authentic Bolivian coffee from vendors.
See properties

Frequently asked questions

How much does a Santa Cruz vacation package cost?
Offering excellent value package deals on Expedia, you'll be surprised at how little a vacation to Santa Cruz costs! Our packages mean less travel planning for you and greater savings.
What are the cheapest months to go to Santa Cruz?
If you're hoping to score a cheap Santa Cruz vacation package, consider planning a trip in February, April and May. You're likely to find lower prices on accommodations and flights during these months ā€” ideal for travelers wishing to save money.
How to find the best Santa Cruz package deals?
Begin your search for a Santa Cruz package deal by entering your destination and preferred travel dates under our "Packages" tab. Then apply a few filters, like "Property type" and "Amenities," to tailor the results to your exact needs. You can also sort by "Package discount" and discover offers that come with big savings. If you don't find the perfect Santa Cruz package deal right away, simply play around with your dates and search again. Remember that deals are only available for a limited time, so book early and get your Santa Cruz adventure off to a flying start.
Is it cheaper to book a Santa Cruz vacation as a package?
Expedia vacation packages are designed to give you more bang for your buck. Bundle your hotel, flight and car rental into one great-value price and enjoy significant savings. You'll usually land a better deal than booking each component separately. And you'll still enjoy the flexibility to create a customized Santa Cruz vacation by choosing your favorite type of stay, airline and car class.
When to book a vacation package to Santa Cruz?
If you're planning a spontaneous Santa Cruz getaway, browse our last-minute deals that can be booked up to a week before you go. Don't want to leave things to the last minute? You can find terrific deals on your flights and hotels by booking ahead.
How to plan a trip to Santa Cruz?

  1. Choose your dates: What you'd like to do in Santa Cruz and your preferred season can help you decide when to travel.
  2. Figure out your budget: Ensure you have enough money to pay for everything from food and transportation to activities and airfares. Your hotel will likely be the largest expense during your trip to Santa Cruz.
  3. Decide your trip length: Think about how long you'd like to spend discovering Santa Cruz. Plan your itinerary so you can get to all the experiences and attractions you're interested in at a leisurely pace.
  4. Combine your accommodations and airfare: Once you've settled on your travel dates and duration, book the right Santa Cruz vacation package for you.