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Check prices for these dates

Tonight
23 Sep - 24 Sep
Tomorrow
24 Sep - 25 Sep
This weekend
25 Sep - 27 Sep
Next weekend
2 Oct - 4 Oct

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Our top choices for Puxico hotels

1. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
Poplar Bluff
United States
Rhonda
SAR 329
SAR 369 total
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn Poplar Bluff

2. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
Poplar Bluff
United States
Vicki
SAR 380
SAR 429 total
includes taxes & fees
4 Oct - 5 Oct
Fairfield Inn & Suites by Marriott Poplar Bluff

3. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
Poplar Bluff
United States
Dean
SAR 360
SAR 407 total
includes taxes & fees
18 Oct - 19 Oct
Drury Inn & Suites Poplar Bluff

4. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
Dexter
United States
Kendall
SAR 366
SAR 411 total
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn By Hilton Dexter

5. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
Poplar Bluff
United States
Cindy
SAR 278
SAR 311 total
includes taxes & fees
25 Sep - 26 Sep
Motel 6 Poplar Bluff, MO

6. Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
Poplar Bluff
United States
Nathan
SAR 312
SAR 352 total
includes taxes & fees
25 Oct - 26 Oct
Holiday Inn Poplar Bluff by IHG

7. Econo Lodge Dexter

Econo Lodge Dexter
Dexter
United States
Herman
SAR 191
SAR 215 total
includes taxes & fees
24 Oct - 25 Oct
Econo Lodge Dexter

8. Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
Dexter
United States
Steven
SAR 357
SAR 401 total
includes taxes & fees
8 Oct - 9 Oct
Travelodge by Wyndham Dexter

9. Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North
Poplar Bluff
United States
Muhammad
SAR 312
SAR 352 total
includes taxes & fees
25 Oct - 26 Oct
Comfort Inn Poplar Bluff North

10. Dexter Inn

Dexter Inn
Dexter
United States
Edward
SAR 246
SAR 276 total
includes taxes & fees
25 Oct - 26 Oct
Dexter Inn

11. OYO Hickory House Inn

OYO Hickory House Inn
Dexter
United States
Tammy
SAR 168
SAR 205 total
includes taxes & fees
7 Oct - 8 Oct
OYO Hickory House Inn

12. Lake Wappapello

Lake Wappapello
Williamsville
United States
Tonya
SAR 338
SAR 356 total
includes taxes & fees
25 Sep - 26 Sep
Lake Wappapello

13. 40-acre Poplar Bluff Nature Lovers Paradise!

40-acre Poplar Bluff Nature Lovers Paradise!
Poplar Bluff
United States
Anonymous traveler
SAR 451
SAR 1,115 total
includes taxes & fees
25 Sep - 26 Sep
40-acre Poplar Bluff Nature Lovers Paradise!

14. Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
Poplar Bluff
United States
Diana
SAR 207
SAR 234 total
includes taxes & fees
15 Oct - 16 Oct
Super 8 by Wyndham Poplar Bluff Missouri

15. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
United States
JANEEN
SAR 371
SAR 404 total
includes taxes & fees
5 Oct - 6 Oct
EC Reed's Mercantile and Hotel
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Learn more about Puxico

Check out the local area in Puxico—home to attractions like Mark Twain National Forest and Mingo Wilderness.

See all hotels in Puxico
A night scene with a clear sky, a crescent moon, and two silhouetted trees against a twilight sky.
Photo by Mike McClain

Top Puxico Hotel Reviews

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

10/10 Excellent
"Clean room, staff"
Lavonne 2-night trip
Posted 22 hours ago
Drury Inn & Suites Poplar Bluff
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

10/10 Excellent
"It was a great experience."
JESUS M 1-night trip
Posted 3 days ago
Hampton Inn Poplar Bluff
Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri

10/10 Excellent
"Clean room. Would liked to of had a trash can in the room. But that didn't affect our stay."
Patricia 1-night trip
Posted 3 days ago
Super 8 by Wyndham Poplar Bluff Missouri
Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

8/10 Good
"Very nice hotel - our favorite when we visit the grandkids! Our only issue this time was with housekeeping. We arrived Friday afternoon, asked that our room be serviced on Sunday, (they only do it every other day), and it was not done. Also, in the shower were the usual shampoo and shower gel, but instead of conditioner, the 3rd dispenser was body lotion! I asked if the lotion could be replaced with conditioner - didn’t happen. Disappointed!"
Paul 3-night trip
Posted 9 days ago
Hampton Inn By Hilton Dexter
Lake Wappapello

Lake Wappapello

10/10 Excellent
"This a cabin in a state park. It was very clean and had newer upgrades. Bring the food you need because it's fairly distance from a grocery. We came later in the day because we needed one night and this was a great price and not a chain hotel which we like. There is a little store not too far from the park. We ordered deli sandwiches from here and picked up some icecream. The sandwiches were delicious and the store had pretty much whatever you might need. The checkin process was great with good communication about which cabin to go to, what the door code was etc... We plan to come back for a longer stay so we can have another evening around the firepit and see all of the stars. Great place to stay."
Dottie 1-night trip
Posted 2 weeks ago
Lake Wappapello
Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided

Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided

10/10 Excellent
"My wife and I stayed here for anniversary trip. The fox den is a perfect combination of 1970's vibes, while still having modern conveniences. We appreciated the fresh eggs provided and well stocked kitchen for making breakfast.The host put much effort in making sure it was great experience with great guidebook that provided information on everything in the fox den and recommended local places for dining and exploring. We also had the charcuterie add-on, which looked and tasted amazing and was perfect for snacking on during our stay.The location is very secluded as described. My only advice would be to plan your excursions from the fox den as it does take some extra travel time (especially if you normally live in more populated areas) than what you may be used to. That being said the natural beauty of the area, along with the peace and quiet was worth the extra distance. Overall, we had a great stay and would recommend the fox den to anyone looking for escape into both nature and the 1970's."
Stephen J. 2-night trip
Posted 2 months ago
Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided
Private lake, beach & hot tub,  romantic getaway or family vaca

Private lake, beach & hot tub, romantic getaway or family vaca

8/10 Good
"Great location to access the lake close by. Very picturesque location.Pics are a lil deceiving in that things are actually on a smaller scale IRL but still good amenities.Be aware, the pond is not swimmable but paddle boat is fun."
BELINDA W. 11-night trip
Posted 2 months ago
Private lake, beach & hot tub, romantic getaway or family vaca
OYO Hickory House Inn

OYO Hickory House Inn

10/10 Excellent
"Nice for overnight stop"
Tammy 1-night trip
Posted 2 months ago
OYO Hickory House Inn
1/4 Mile To The Boat Launch & Beach 2 miles the Camp! Free WiFi, beautiful space

1/4 Mile To The Boat Launch & Beach 2 miles the Camp! Free WiFi, beautiful space

10/10 Excellent
"We have stayed at this cabin for the past two years. Janet, the host, is quick to reply with any questions youmay have. The cabin was clean. Check in was easy. No doubt we will try to book cabin again for next year."
jackie m. 2-night trip
Posted 3 months ago
1/4 Mile To The Boat Launch & Beach 2 miles the Camp! Free WiFi, beautiful space

More cheap stays in Puxico

Econo Lodge Dexter

Econo Lodge Dexter

913 Outer Rd Dexter MO
SAR 203
SAR 228 total
30 Sep - 1 Oct
includes taxes & fees
6.8/10 (283 reviews)
Econo Lodge Dexter
Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri

2831 N Westwood Blvd Poplar Bluff MO
SAR 207
SAR 234 total
15 Oct - 16 Oct
includes taxes & fees
6.6/10 (673 reviews)
Super 8 by Wyndham Poplar Bluff Missouri
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO
SAR 278
SAR 311 total
25 Sep - 26 Sep
includes taxes & fees
8/10 Very Good! (1,000 reviews)
Motel 6 Poplar Bluff, MO
Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North

2582 N Westwood Blvd Poplar Bluff MO
SAR 312
SAR 352 total
25 Oct - 26 Oct
includes taxes & fees
Comfort Inn Poplar Bluff North
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO
SAR 329
SAR 369 total
18 Oct - 19 Oct
includes taxes & fees
9.4/10 Exceptional! (949 reviews)
Hampton Inn Poplar Bluff
Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

2179 Gill Plaza Drive Dexter MO
SAR 366
SAR 411 total
4 Oct - 5 Oct
includes taxes & fees
9.6/10 Exceptional! (71 reviews)
Hampton Inn By Hilton Dexter

Frequently asked questions

What's the best place for a stay in Puxico?
Holiday Inn Poplar Bluff by IHG, located 18.8 mi (30.3 km) from the heart of Puxico, is a top choice for your stay based on our traveler data. Two other choices for your trip to the area are Hampton Inn Poplar Bluff and Motel 6 Poplar Bluff, MO. See all available top hotels, or vacation rentals in Puxico.
What are some of the best vacation home rentals in Puxico?
Lake Wappapello 2 Bedroom Home 1/8 mile to beach and boat ramp: This vacation home rental near Puxico has air-conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings. See all vacation rentals in Puxico.
If I need to cancel my hotel reservation in Puxico, will I receive a refund?
Yes, you'll find most hotel bookings are refundable provided that you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Puxico.
Where can I learn more about changing or cancelling my trip to Puxico?
To find more details about picking new dates or cancelling your trip to Puxico, click here.
What is staying in Puxico like?
Travelers to Puxico will find plenty to explore and enjoy. There are 52 hotels and other accommodations in the surrounding area. Find out more about Puxico.
What is there to see in Puxico?
A couple of favorite places to visit are Mark Twain National Forest and Mingo Wilderness. You'll also find Lake Wappapello and Lake Wappapello State Park in the area. Check out what more to see and do in Expedia's Puxico guide.
What's the seasonal weather like in Puxico?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Puxico is 59 inches.