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Our top choices for Northeast Missouri hotels

An indoor swimming pool with a view of the outside, a sign reading 'Depot Inn,' and a 'RAILROAD CROSSING' sign on the wall.

1. Depot Inn and Suites

La Plata

Kimberly

SAR 371 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

2. Best Western On The River

Hannibal

Rob

SAR 437 total

includes taxes & fees

9 Nov - 10 Nov

A lobby with a reception desk, a seating area with sofas and armchairs, a large potted plant, and a door leading outside.

3. Sleep Inn & Suites Hannibal West

Hannibal

ELAINE

SAR 479 total

includes taxes & fees

6 Dec - 7 Dec

A hotel room with a large bed, a desk with a computer, a television, and a bathtub.

4. Oak Hill Inn & Suites

Canton

Peter

SAR 390 total

includes taxes & fees

7 Dec - 8 Dec

A buffet with various food items, including omelets and other dishes, arranged in metal serving trays.

5. Holiday Inn Express & Suites Kirksville - University Area by IHG

Kirksville

Jimmy

SAR 438 total

includes taxes & fees

6 Dec - 7 Dec

An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.

6. Quality Inn & Suites Hannibal West

Hannibal

Gayle

SAR 324 total

includes taxes & fees

29 Nov - 30 Nov

A modern kitchen with a dining area, featuring a kitchen island with appliances and a coffee station.

7. Super 8 by Wyndham Kirksville-University Area

Kirksville

Maria Modesta

SAR 274 total

includes taxes & fees

22 Nov - 23 Nov

A bathroom with a large bathtub, a chair, and a small shelf with plants.

8. Pinemark Inn & Suites

St. Clair

Michael

SAR 519 total

includes taxes & fees

8 Nov - 9 Nov

A hotel reception desk with a modern design, a sign indicating it's a Hilton Honors location, and a variety of snacks and beverages on shelves.

9. Hampton Inn By Hilton Warrenton I-70

Warrenton

Richard

SAR 560 total

includes taxes & fees

13 Nov - 14 Nov

A Comfort Inn hotel with a modern design, featuring a covered entrance and a clear sky in the background.

10. Comfort Inn Sullivan

Sullivan

Wayne

SAR 466 total

includes taxes & fees

26 Nov - 27 Nov

A stainless steel ice dispenser with a blue button labeled 'PUSH FOR ICE' in a kitchen setting.

11. Travelier Motel

Macon

Dovey

SAR 250 total

includes taxes & fees

7 Nov - 8 Nov

A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

12. Best Western Plus Washington Hotel

Washington

Carl

SAR 573 total

includes taxes & fees

8 Nov - 9 Nov

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

13. The Wildwood Hotel

Wildwood

Lori

SAR 362 total

includes taxes & fees

1 Dec - 2 Dec

A hotel lobby with a seating area, a dining table, a kitchen, and an exit sign.

14. Super 8 by Wyndham Washington

Washington

Gary

SAR 342 total

includes taxes & fees

16 Nov - 17 Nov

A hotel room with a bed, a lamp, a mirror, and a door.

15. Town & Country Inn and Suites

Quincy

Tracy

SAR 535 total

includes taxes & fees

8 Nov - 9 Nov

A lobby with a reception desk, blue sofas, a coffee table, and a plant display.

16. Drury Inn & Suites St. Louis Arnold

Arnold

Kristine

SAR 547 total

includes taxes & fees

10 Nov - 11 Nov

A hot tub with a rocky backdrop and a mural.

17. Stoney Creek Inn Quincy

Quincy

Kent

SAR 418 total

includes taxes & fees

8 Nov - 9 Nov

A swimming pool with a metal ladder, surrounded by chairs and large windows offering a view of the sunset.

18. La Quinta Inn & Suites by Wyndham St Louis Route 66

St. Louis

Edward

SAR 426 total

includes taxes & fees

29 Nov - 30 Nov

A spacious lobby with a high ceiling, modern lighting fixtures, a seating area with sofas and chairs, and a bar area with stools.

19. Hampton Inn & Suites St. Louis/South I-55

St. Louis

Areege

SAR 473 total

includes taxes & fees

22 Nov - 23 Nov

A hotel room with two beds, a desk, and a window with a view of trees.

20. Best Western Plus Fenton

Fenton

Judy

SAR 402 total

includes taxes & fees

8 Nov - 9 Nov

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Vacation Rentals in Northeast Missouri

Cottage

A covered porch with a white door, two folding chairs, and a concrete walkway.

Peaceful Missouri Cabin Rental on 55 Acres!

Canton

"This is a great place to stay if you want to get away from the city. Rural enough to be quiet, but within easy driving distance to a city. Also perfect if you just want to stay on the property and really get away from city life, just bring your groceries. "

Cabin

A park with a pond, picnic tables, and a gazebo.

Cannon Dam Cabins

Perry

"Amazing place to stay! You can’t beat the indoor pool whether it is storming or feels like the fires from hell are raining on earth you can still enjoy a great swim without worrying about lightning or burning to death. The people are incredibly kind and on top of anything you may need and the cabins are a perfect relaxing get away with nice a/c and plenty of sleeping space! Thank you for another amazing stay!"

Aparthotel

A compact living space with a sofa, a TV, a kitchen area with a fridge, microwave, and coffee maker, and a dining table.

The Mercantile on the Katy Trail

Hermann

"We loved this place- very unique! Clean and great communication from hosts."

Apartment

A spacious room with a wooden dining table, chairs, a chandelier, and a bed with white bedding.

Spacious 3-Bedroom with King Bed

Central West End

"Had a great stay! I hosted a birthday dinner for my best friend! Everything was clean and looked great"

Apartment

A modern hotel lobby with a marble reception desk, a TV mounted on the wall, and a seating area with chairs and a sofa.

Landing Furnished Apartments - Central West End

Central West End

"Parking was behind a large mechanical gate which did not always work. Could sometimes be noisy outside in the evening due to college clientele. Had to park on the street most of the time because of gate issues."

Vacation Home

A two-story building with a balcony, outdoor seating area, and string lights.

StayAtlas Retreat w/ Pool, Gym, Games, BBQ

Mount Pleasant

"The property was such a fun surprise- the neighborhood was a little sketchy, but it was great on the inside and the backyard... Great experience, fun complimentary toiletries, etc"

Cottage

Peaceful Missouri Cabin Rental on Large Property

Canton

"The cabin rental was a great stay. Had some connection problems with the t.v. couldn't get past the check out date. The wifi was easy to hook up. The cabin was clean and smelled fresh. Did have some problems with ants on the countertop. Great place to stay, enjoyed our visit."

Apartment

A sauna room with wooden benches and frosted glass windows.

Augusta Studio at Halcyon Spa Bed & Breakfast

Augusta

"Everything was great with this place"

Apartment

A covered outdoor patio with wooden flooring, metal chairs, tables, and ceiling fans.

Studio Stay w/ Deck in Missouri Wine Country

New Haven

"It is a clean efficiency with modern amenities but with a touch of country flair! Sara is the property manager and is absolutely wonderful! Based on their availability, I would absolutely stay there again!!!!! Even if I can't stay there, I am definitely going to get some of thar great ice cream and home cooking at the restaurant in the same building!"

Apartment

A red building with a sign for 'Catala House' and a 'Massage House' sign.

New Melle Apartment Near Missouri Wine Country

Wentzville

"Apartment was wonderful! Very spacious and lots of furniture. Had a flat screen in the living room and bedroom that included Netflix and Prime. Air conditioner worked very well. Was very quiet and in a good location. Property manager was very friendly. There was even a very nice tea selection included with our stay. All amenities including, fridge, sinks, countertop burner, shower, washer, dryer, and toilet worked with no issues. All the dishes and mugs were clean. Plenty of towels to use during...

Cottage

A modern kitchen with wooden cabinets, a central island with stools, stainless steel appliances, and a large window providing natural light.

Peaceful Guest Home w/ Patio on 152-acre Farm

Berger

"What an amazing place! The photos don't do it justice. Very easy communication with our host and, if you want space, not too far out of Hermann, this is it! They thought of everything in this house; washer, dryer, every pot and pan you can think of, extra towels, charging cables, hairdryer, and we especially loved the honey taster! It was truly a getaway location while we attended our daughter's wedding nearby and to come back to the guest house every night was exactly what we needed. Being...

Cottage

A wooden interior with a sofa, a table with books, a lamp, and a window with blinds.

Close to Vineyards: Updated New Haven Retreat!

New Haven

"Very clean and relaxing environment!! "

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Stay near popular Northeast Missouri attractions

The Saint Louis Zoo sign with vines on the wall.

St. Louis Zoo

9.2/10 (4,367 reviews)

Why not visit the animals who live at St. Louis Zoo and see why this is a popular attraction in St. Louis? Amble around the area's lush forest or attend a sporting event.

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Learn more about Northeast Missouri

Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.

See all hotels in Northeast Missouri