Muscatine Vacations

Book a Hotel + Flight together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to SARĀ 5,400 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Find the Best Muscatine Vacation Packages

Muscatine Hotel Deals

Best Western Muscatine / Pearl City Hotel

Best Western Muscatine / Pearl City Hotel

2.5 out of 5
305 Cleveland St Muscatine IA
Fully refundableReserve now, pay when you stay
The price is SARĀ 341 per night from Jul 21 to Jul 22
SARĀ 341
SARĀ 382 total
21 Jul - 22 Jul
includes taxes & fees
8.6/10 Excellent! (533 reviews)
"Good place"

Reviewed on 15 July 2026

Best Western Muscatine / Pearl City Hotel
AmericInn by Wyndham Muscatine

AmericInn by Wyndham Muscatine

3 out of 5
3115 Hwy 61 North Muscatine IA
Fully refundableReserve now, pay when you stay
The price is SARĀ 335 per night from Jul 23 to Jul 24
SARĀ 335
SARĀ 375 total
23 Jul - 24 Jul
includes taxes & fees
AmericInn by Wyndham Muscatine
Super 8 by Wyndham Muscatine

Super 8 by Wyndham Muscatine

2 out of 5
2900 N Highway 61 Muscatine IA
Fully refundableReserve now, pay when you stay
The price is SARĀ 239 per night from Jul 23 to Jul 24
SARĀ 239
SARĀ 268 total
23 Jul - 24 Jul
includes taxes & fees
6.4/10 (288 reviews)
"It was good"

Reviewed on 11 July 2026

Super 8 by Wyndham Muscatine
See all 304 properties in Muscatine
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Muscatine attractions

A calm river with a fallen tree in the foreground and a stone structure on the left.
Photo by Carlos Lima
Open Photo by Carlos Lima

Wildcat Den State Park

Explore dramatic sandstone bluffs and the historic Pine Creek Grist Mill, dating to 1848, at this scenic park. Hike through diverse terrain with views of unique rock formations like Steamboat Rock and Devil's Punch Bowl.
See properties

Frequently asked questions

How much does a Muscatine vacation package cost?
Offering excellent value package deals on Expedia, you'll be pleasantly surprised at how much a vacation to Muscatine costs! Our packages make travel planning easier and your savings go further.
What are the cheapest months to go to Muscatine?
You can typically find lower prices and better availability in January, February and November. Take a look at our cheap Muscatine vacation packages and you could land some excellent off-season deals.
How to find the best Muscatine package deals?
Use Expedia's filters to find some fabulous Muscatine package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you want to save, plan your trip for midweek, or search for Muscatine package deals in the off-season. Switch up your travel dates and you may score even better discounts. As a rule of thumb, it's typically best to book your vacation package well in advance.
Is it cheaper to book a Muscatine vacation as a package?
An Expedia vacation package could score you significant savings when compared to arranging flights and stays separately. Better still, you can personalize your Muscatine escape to match your exact needs. Choose your preferred flight time, select the hotel type and add a rental car. Browse our great deals to see how much you can save.
When to book a vacation package to Muscatine?
Score fantastic discounts by reserving your flights in advance with Expedia. If being spontaneous is more your thing, take advantage of our last-minute deals for a spur-of-the-moment Muscatine vacation.
How to plan a trip to Muscatine?

  1. Choose your dates: The things you want to do in Muscatine and your favorite season will help you decide when to get away.
  2. Set a budget: Consider costs such as flights, food and transportation when calculating how much to set aside for your trip to Muscatine. Then, choose a hotel that works with your budget, whether that's a low-cost stay or a lavish getaway.
  3. Work out your trip length: Think about how much time you'd like to spend exploring Muscatine. Plan your days so you can get to all the activities and attractions you're interested in at a leisurely pace.
  4. Bundle your bookings: With your travel dates in order, you can combine your car rental, hotels, flights and more into a tailored Muscatine vacation package.