The Best Hotels Closest to Mcleod Regional Medical Center in Florence for 2026

A modern building with a curved glass facade, surrounded by a well-maintained lawn and several trees.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Mcleod Regional Medical Center hotels

A rooftop terrace with outdoor seating, including sofas and chairs, and a round table.

A modern lounge area with brick walls, large windows, and contemporary furniture.

A modern bar area with a long counter, multiple bar stools, and a variety of bottles and glasses.

A multi-story hotel with a modern facade, featuring a prominent 'Hyatt Place' sign on the right.

1. Hyatt Place Florence Downtown

0.7 km from Mcleod Regional Medical Center

JEFFREY

SAR 375

SAR 420 total

includes taxes & fees

3 Nov - 4 Nov

A restaurant with brick walls, framed awards, and a bar area.

A bar area with a curved counter, multiple stools, and a brick wall backdrop.

A spacious living room with a wooden floor, a ceiling fan, and a dining area with a wooden table and chairs.

A spacious kitchen with a dining area, a living room with a fireplace, and a cozy seating arrangement.

2. Hotel Florence, Tapestry Collection by Hilton

0.8 km from Mcleod Regional Medical Center

Ankh

SAR 520

SAR 582 total

includes taxes & fees

31 Oct - 1 Nov

3. Rodeway Inn Florence Downtown

1.2 km from Mcleod Regional Medical Center

SAR 169

SAR 194 total

includes taxes & fees

4 Nov - 5 Nov

A modern kitchen with stainless steel appliances, a gray sofa, and a ceiling fan.

A modern living room with a brick wall, a grey sofa, a wooden coffee table, and a view through large windows.

A modern kitchen with grey cabinets, stainless steel appliances, and bar stools.

A modern living room with a grey sofa, a round coffee table, a grey armchair with patterned cushions, a floor lamp, and a large TV mounted on the wall.

4. The Urban Flats

0.8 km from Mcleod Regional Medical Center

SAR 923

SAR 1,596 total

includes taxes & fees

27 Oct - 28 Oct

A modern living room with a grey sofa, two black hanging chairs, a small table, and a TV mounted on the wall.

A modern living room with a grey sofa, a flat-screen TV, geometric wall art, and a bookshelf with decorative items.

A hotel room with a large bed, a desk with a lamp, a chair, a TV, and a window with curtains.

A modern hotel with a 'Park Inn by Radisson' sign, featuring a covered entrance, multiple windows, and a parking lot.

5. Park Inn by Radisson Florence, SC

5.5 km from Mcleod Regional Medical Center

Juan

SAR 339

SAR 379 total

includes taxes & fees

8 Nov - 9 Nov

A hotel lobby with a reception desk, seating area, and a television screen.

A Comfort Inn & Suites hotel with a covered entrance, brick facade, and multiple windows.

A hotel room with a bed, a sofa, an ottoman, and a lamp.

A hotel room with a sectional sofa, two ottomans, a bed with a green bedspread, and framed pictures on the wall.

6. Comfort Inn & Suites Florence Center Area

7 km from Mcleod Regional Medical Center

Mila

SAR 379

SAR 425 total

includes taxes & fees

10 Nov - 11 Nov

A spacious lobby with a checkered floor, a reception desk, and a chandelier.

A hotel room with two beds, a desk with a computer, a chair, and a bathroom with a mirror.

A vending area with snack and drink options, including Pepsi refrigerators and a 'MARKET' display with various products.

A two-story building with a brick facade, a flat roof, and a covered entrance area.

7. Howard Johnson by Wyndham Florence

5.5 km from Mcleod Regional Medical Center

Alanda

SAR 242

SAR 271 total

includes taxes & fees

22 Oct - 23 Oct

A modern kitchen with dark wooden cabinets, a stainless steel refrigerator, a microwave, and a coffee maker. There is a dining area with two red chairs and a table.

A hotel room with a sofa, a dining table, a coffee maker, a TV, and artwork on the wall.

A hotel room with a bed, a desk, a TV, a refrigerator, and a painting on the wall.

A modern kitchen with a central island, built-in appliances, and a stone backsplash.

8. Staybridge Suites Florence - Civic Center by IHG

8.1 km from Mcleod Regional Medical Center

Tishia

SAR 491

SAR 550 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with two beds, a desk with a TV, and a bathroom visible through an open door.

A coffee station with two coffee machines, a coffee press, and various coffee-related items on a wooden counter.

A large, two-story building with a central entrance flanked by columns, labeled "DIR FRANK B. LEE NURSING BUILDING."

A hotel reception desk with two computer monitors, a desk lamp, and framed artwork on the wall.

9. Holiday Inn Express & Suites Florence I-95 @ Hwy 327 by IHG

9.1 km from Mcleod Regional Medical Center

Christopher

SAR 458

SAR 550 total

includes taxes & fees

25 Oct - 26 Oct

A spacious hotel lobby with multiple seating areas, including tables and chairs, a reception desk, and a staircase leading to an upper level.

An indoor swimming pool with clear water, surrounded by a checkered wall pattern, and equipped with multiple seating areas and a lifeguard station.

A corridor with shelves stocked with snacks and a frozen food display.

A Hampton Inn & Suites hotel with a well-lit entrance, multiple floors, and a parking area.

10. Hampton Inn & Suites Florence-North-I-95

5.7 km from Mcleod Regional Medical Center

Ladavish

SAR 459

SAR 514 total

includes taxes & fees

28 Oct - 29 Oct

A hotel entrance with a stone facade, glass doors, and a number '501' above.

A corner market with shelves stocked with snacks and beverages, and two large refrigerators.

A hotel reception area with a wooden floor, a reception desk, a seating area with chairs, and a decorative wall with a tree pattern.

A modern living room with a stone fireplace, a blue sofa, a brown leather chair, and a round coffee table.

11. Fairfield Inn & Suites by Marriott Florence I-20

6.9 km from Mcleod Regional Medical Center

Alma

SAR 443

SAR 496 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with two beds, a desk with chairs, a television, and artwork on the walls.

A modern lounge area with a sofa, armchairs, and small tables.

A modern hotel room with a kitchenette, a grey sofa, a dining area, and a sign that reads "A Great Day Starts With Breakfast."

A reception area with a wooden desk, a map on the wall, and a sign welcoming visitors to Florence, SC.

12. TownePlace Suites by Marriott Florence

7 km from Mcleod Regional Medical Center

Crystal

SAR 411

SAR 461 total

includes taxes & fees

2 Nov - 3 Nov

An outdoor seating area with a fire pit, cushioned seating, and a pergola with string lights.

A modern hotel restaurant with a breakfast bar, seating area, and a view of the city.

A snack kiosk with a variety of snacks and beverages, a sign for a 24/7 market, and a sign for local items.

A modern lounge area with seating, tables, and a pool table.

13. Tru by Hilton Florence I-95

5.9 km from Mcleod Regional Medical Center

Margarita

SAR 411

SAR 483 total

includes taxes & fees

1 Nov - 2 Nov

A modern lobby with a stone column, a fireplace, and yellow rocking chairs around a central table.

A hotel with a modern design, featuring a prominent sign for the 'Country Inn & Suites by Radisson.'

An outdoor patio with a wooden table and wicker chairs, a barbecue grill, and a swimming pool in the background.

A modern cafeteria with long wooden tables, green chairs, and yellow accents.

14. Spark by Hilton Florence North I-95, SC

5.5 km from Mcleod Regional Medical Center

Tienia

SAR 363

SAR 422 total

includes taxes & fees

2 Nov - 3 Nov

A building with two red doors, one labeled 'Office' and the other '101'. There is a welcome sign and a mailbox on the wall.

A room with a sofa, a small table, a chair, a lamp, and a door.

A compact kitchen with a dining area, a TV, and a small table.

A compact living space with a dining area, kitchenette, and seating area.

15. Affordable Suites Florence

7 km from Mcleod Regional Medical Center

Cheyenne

SAR 321

SAR 359 total

includes taxes & fees

22 Oct - 23 Oct

A spacious lobby with a high ceiling, a central seating area with armchairs and a coffee table, a flat-screen TV, and a dining area with tables and chairs.

A hotel with a modern design, featuring multiple floors and a parking lot.

A spacious lobby with a large seating area, a flat-screen TV, and a fireplace.

A modern hotel lobby with a central seating area, a large abstract painting, and a patterned carpet.

16. Residence Inn Marriott Florence

7.2 km from Mcleod Regional Medical Center

Teri

SAR 402

SAR 450 total

includes taxes & fees

16 Nov - 17 Nov

A spacious lobby with a reception desk, seating area, and large windows.

A reception area with a counter, a sign for 'The Pavilion Pantry', and a green wall.

An indoor swimming pool with clear poolside areas, a lifeguard station, and a view of the outside.

A Hilton Garden Inn with a large, multi-story building, a covered entrance, and a parking lot.

17. Hilton Garden Inn Florence

7.2 km from Mcleod Regional Medical Center

Derrick

SAR 443

SAR 496 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a desk, chair, bed, and a yellow sofa.

A hotel with a green roof, a sign reading 'Quality Inn & Suites by Choice Hotels,' and a landscaped front yard with small trees and shrubs.

A reception desk with a stone wall backdrop, a sign reading 'Quality Choice Hotels,' and a reception area with a wooden reception desk and two chairs.

A swimming pool with lounge chairs and a building with balconies.

18. Quality Inn & Suites Florence Civic Center

7.5 km from Mcleod Regional Medical Center

Sharhonda

SAR 334

SAR 374 total

includes taxes & fees

28 Oct - 29 Oct

A hotel room with a large bed, a desk with a chair, a television, and a walk-in closet.

A snack and beverage display area with shelves stocked with various brands and a refrigerator with beverages.

An outdoor patio area with lounge chairs and tables, a brick building, and a clear sky.

A modern indoor space with a counter, seating area, and a blue accent wall.

19. Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

8 km from Mcleod Regional Medical Center

Leigh

SAR 428

SAR 479 total

includes taxes & fees

25 Oct - 26 Oct

A hotel lobby with a wooden floor, multiple dining tables, chairs, and a seating area with a sofa.

A Hampton Inn & Suites with a large sign, brick facade, and a parking lot.

A hotel lobby with a reception desk, seating area, and a welcome mat.

A hotel room with two beds, a desk, a TV, and a window with patterned curtains.

20. Hampton Inn & Suites Florence Center

7.2 km from Mcleod Regional Medical Center

William

SAR 427

SAR 479 total

includes taxes & fees

8 Nov - 9 Nov

View all properties

Compare top hotels near Mcleod Regional Medical Center

Hyatt Place Florence Downtown 0.7 km from Mcleod Regional Medical Center View	Hotel Florence, Tapestry Collection by Hilton 0.8 km from Mcleod Regional Medical Center View	Rodeway Inn Florence Downtown 1.2 km from Mcleod Regional Medical Center View	Park Inn by Radisson Florence, SC 5.5 km from Mcleod Regional Medical Center View	Comfort Inn & Suites Florence Center Area 7 km from Mcleod Regional Medical Center View
9.0 Wonderful 1,006 reviews	8.8 Excellent 658 reviews	5.4 8 reviews	9.0 Wonderful 2,477 reviews	9.0 Wonderful 1,374 reviews
SAR 375 SAR 420 total includes taxes & fees 3 Nov - 4 Nov	SAR 520 SAR 582 total includes taxes & fees 31 Oct - 1 Nov	SAR 169 SAR 194 total includes taxes & fees 4 Nov - 5 Nov	SAR 339 SAR 379 total includes taxes & fees 8 Nov - 9 Nov	SAR 379 SAR 425 total includes taxes & fees 10 Nov - 11 Nov

Top Mcleod Regional Medical Center Hotel Reviews

Hyatt Place Florence Downtown

10/10 Excellent

"The staff was amazing, went over and beyond the call of customer service. Everything was reasonably priced especially with all that is offered with the hotel and the surrounding area."

Hampton Inn & Suites Florence Center

8/10 Good

"very attentive staff"

Howard Johnson by Wyndham Florence

10/10 Excellent

"Hotel was good, the breakfast was great, with a huge selection. Price was very good. The rooms were nice, too."

Hotel Florence, Tapestry Collection by Hilton

8/10 Good

"The staff were great!! Parking was close by and easy. The restaurant bar was a great stop. If you want a refrigerator in your room you need to ask prior to arrival."

Come Stay A While

10/10 Excellent

"Loved the in unit washer and dryer. The house was visibly clean and smelled clean. Plenty of towels. The kitchen had cutting boards and pots and pans. Very comfortable and nice neighborhood. Host was very responsive."

Frequently asked questions

What's the area like around Mcleod Regional Medical Center?

Mcleod Regional Medical Center is located in a welcoming area of Florence known for its array of dining options. If you're looking for a convenient place to stay, check out the 18 hotels and other accommodations you'll find within a mile.

What's the best hotel to stay near Mcleod Regional Medical Center?

Hyatt Place Florence Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a restaurant. It's located just a short 0.4 mi (0.7 km) from Mcleod Regional Medical Center. Other good options within a short distance include Hotel Florence, Tapestry Collection by Hilton and The Urban Flats.

How many hotels will I find near Mcleod Regional Medical Center?

Expedia has 18 hotels and other accommodations within a mile from Mcleod Regional Medical Center.

If I need to cancel the hotel reservation for my stay near Mcleod Regional Medical Center, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to view the best deals near Mcleod Regional Medical Center.

Where can I learn more about changing or cancelling my trip in the area near Mcleod Regional Medical Center?

For more information about updating your stay near Mcleod Regional Medical Center or cancelling it, click here.

What can I see and do near Mcleod Regional Medical Center?

You can enjoy live performances at FMU Performing Arts Center and Florence Little Theatre. You might spend a leisurely day outdoors at Florence Veterans Park and Greenwood Baseball Park and Playground. Create some family memories at Sky Zone Trampoline Park and Tilt Studio.

Find hotels near Mcleod Regional Medical Center, Florence from SAR 194

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Mcleod Regional Medical Center hotels

1. Hyatt Place Florence Downtown

2. Hotel Florence, Tapestry Collection by Hilton

3. Rodeway Inn Florence Downtown

4. The Urban Flats

5. Park Inn by Radisson Florence, SC

6. Comfort Inn & Suites Florence Center Area

7. Howard Johnson by Wyndham Florence

8. Staybridge Suites Florence - Civic Center by IHG

9. Holiday Inn Express & Suites Florence I-95 @ Hwy 327 by IHG

10. Hampton Inn & Suites Florence-North-I-95

11. Fairfield Inn & Suites by Marriott Florence I-20

12. TownePlace Suites by Marriott Florence

13. Tru by Hilton Florence I-95

14. Spark by Hilton Florence North I-95, SC

15. Affordable Suites Florence

16. Residence Inn Marriott Florence

17. Hilton Garden Inn Florence

18. Quality Inn & Suites Florence Civic Center

19. Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

20. Hampton Inn & Suites Florence Center

Compare top hotels near Mcleod Regional Medical Center

Hyatt Place Florence Downtown

Hotel Florence, Tapestry Collection by Hilton

Rodeway Inn Florence Downtown

Park Inn by Radisson Florence, SC

Comfort Inn & Suites Florence Center Area

Top Mcleod Regional Medical Center Hotel Reviews

Hyatt Place Florence Downtown

Hampton Inn & Suites Florence Center

Howard Johnson by Wyndham Florence

Hotel Florence, Tapestry Collection by Hilton

Come Stay A While

Frequently asked questions