The Best Hotels Closest to Mcleod Regional Medical Center in Florence for 2026

A modern building with a curved glass facade, surrounded by a well-maintained lawn and several trees.

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Our top choices for Mcleod Regional Medical Center hotels

A spa room with two armchairs, a small table with a vase of flowers, and a sign that reads "SPA Florence".

A restaurant with brick walls, framed awards, and a bar area.

An outdoor patio area with a brick wall, a covered seating area with string lights, and potted plants.

A spacious living room with a wooden floor, a ceiling fan, and a dining area with a wooden table and chairs.

1. Hotel Florence, Tapestry Collection by Hilton

0.8 km from Mcleod Regional Medical Center

Ankh

SAR 520

SAR 582 total

includes taxes & fees

15 Nov - 16 Nov

2. Rodeway Inn Florence Downtown

1.2 km from Mcleod Regional Medical Center

SAR 159

SAR 184 total

includes taxes & fees

22 Nov - 23 Nov

A modern kitchen with stainless steel appliances, a gray sofa, and a ceiling fan.

A modern living room with a brick wall, a grey sofa, a wooden coffee table, and a view through large windows.

A modern living room with a grey sofa, a round coffee table, a grey armchair with patterned cushions, a floor lamp, and a large TV mounted on the wall.

A modern kitchen with grey cabinets, stainless steel appliances, and bar stools.

3. The Urban Flats

0.8 km from Mcleod Regional Medical Center

SAR 923

SAR 1,596 total

includes taxes & fees

27 Oct - 28 Oct

A spacious lobby with a checkered floor, a reception desk, and a chandelier.

A two-story building with a brick facade, a flat roof, and a covered entrance area.

A vending area with snack and drink options, including Pepsi refrigerators and a 'MARKET' display with various products.

A hotel room with two beds, a desk with a computer, a chair, and a bathroom with a mirror.

4. Howard Johnson by Wyndham Florence

5.5 km from Mcleod Regional Medical Center

Alanda

SAR 242

SAR 271 total

includes taxes & fees

9 Nov - 10 Nov

A hotel lobby with a reception desk, seating area, and a television screen.

A hotel room with a sectional sofa, two ottomans, a bed with a green bedspread, and framed pictures on the wall.

A Comfort Inn & Suites hotel with a covered entrance, brick facade, and multiple windows.

A spacious dining area with multiple tables and chairs, large windows, and a flat-screen TV mounted on the wall.

5. Comfort Inn & Suites Florence Center Area

7 km from Mcleod Regional Medical Center

Mila

SAR 393

SAR 440 total

includes taxes & fees

1 Nov - 2 Nov

A modern living room with a grey sofa, two black hanging chairs, a small table, and a TV mounted on the wall.

A hotel room with a large bed, a desk with a lamp, a chair, a TV, and a window with curtains.

A modern hotel with a 'Park Inn by Radisson' sign, featuring a covered entrance, multiple windows, and a parking lot.

A modern kitchen with a patterned backsplash, wooden cabinets, and stainless steel appliances.

6. Park Inn by Radisson Florence, SC

5.5 km from Mcleod Regional Medical Center

Amy

SAR 339

SAR 379 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with two beds, a desk with a TV, and a bathroom visible through an open door.

A coffee station with two coffee machines, a coffee press, and various coffee-related items on a wooden counter.

A large, two-story building with a central entrance flanked by columns, labeled "DIR FRANK B. LEE NURSING BUILDING."

A hotel lobby with a reception desk, a seating area with green sofas, and a dining area with tables and chairs.

7. Holiday Inn Express & Suites Florence I-95 @ Hwy 327 by IHG

9.1 km from Mcleod Regional Medical Center

Christopher

SAR 458

SAR 550 total

includes taxes & fees

8 Nov - 9 Nov

A spacious hotel lobby with multiple seating areas, including tables and chairs, a reception desk, and a staircase leading to an upper level.

A corridor with shelves stocked with snacks and a frozen food display.

An indoor swimming pool with clear water, surrounded by a checkered wall pattern, and equipped with multiple seating areas and a lifeguard station.

A lobby with leather sofas, a coffee table, potted plants, and a reception desk.

8. Hampton Inn & Suites Florence-North-I-95

5.7 km from Mcleod Regional Medical Center

Ladavish

SAR 399

SAR 446 total

includes taxes & fees

12 Nov - 13 Nov

A hotel room with two beds, a desk with chairs, a television, and artwork on the walls.

A reception area with a wooden desk, a map on the wall, and a sign welcoming visitors to Florence, SC.

A modern hotel room with a kitchenette, a grey sofa, a dining area, and a sign that reads "A Great Day Starts With Breakfast."

A modern lounge area with a sofa, armchairs, and small tables.

9. TownePlace Suites by Marriott Florence

7 km from Mcleod Regional Medical Center

Crystal

SAR 411

SAR 461 total

includes taxes & fees

1 Nov - 2 Nov

A hotel entrance with a stone facade, glass doors, and a number '501' above.

An indoor swimming pool with a tiled floor, a pool ladder, and lounge chairs.

A modern living room with a stone fireplace, a blue sofa, a brown leather chair, and a round coffee table.

A hotel reception area with a wooden floor, a reception desk, a seating area with chairs, and a decorative wall with a tree pattern.

10. Fairfield Inn & Suites by Marriott Florence I-20

6.9 km from Mcleod Regional Medical Center

Alma

SAR 443

SAR 496 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a desk, chair, bed, and a yellow sofa.

A hotel with a green roof, a sign reading 'Quality Inn & Suites by Choice Hotels,' and a landscaped front yard with small trees and shrubs.

A swimming pool with lounge chairs and a building with balconies.

A hotel dining area with wooden tables and chairs, a fireplace, and a television.

11. Quality Inn & Suites Florence Civic Center

7.5 km from Mcleod Regional Medical Center

Sharhonda

SAR 334

SAR 374 total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a high ceiling, a central seating area with armchairs and a coffee table, a flat-screen TV, and a dining area with tables and chairs.

A hotel with a modern design, featuring multiple floors and a parking lot.

A spacious lobby with a large seating area, a flat-screen TV, and a fireplace.

A modern hotel lobby with a central seating area, a large abstract painting, and a patterned carpet.

12. Residence Inn Marriott Florence

7.2 km from Mcleod Regional Medical Center

Teri

SAR 402

SAR 450 total

includes taxes & fees

16 Nov - 17 Nov

A spacious lobby with a high ceiling, a central seating area, and a staircase leading to an upper level.

A modern breakfast area with a buffet setup, including a microwave, coffee maker, and various food items.

A hotel room with a bed, a sofa, a desk, and a TV.

A hotel room with a bed, sofa, TV, and a desk.

13. La Quinta Inn & Suites by Wyndham Florence

5.7 km from Mcleod Regional Medical Center

Brenda

SAR 321

SAR 359 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor seating area with a fire pit, cushioned seating, and a pergola with string lights.

A modern hotel with a prominent 'TRU by Hilton' sign, a well-lit entrance, and a landscaped front yard.

A modern lounge area with seating, tables, and a pool table.

A snack kiosk with a variety of snacks and beverages, a sign for a 24/7 market, and a sign for local items.

14. Tru by Hilton Florence I-95

5.9 km from Mcleod Regional Medical Center

Margarita

SAR 341

SAR 404 total

includes taxes & fees

8 Nov - 9 Nov

A spacious lobby with a reception desk, seating area, and large windows.

A spacious lobby with a large fireplace, comfortable seating, and potted plants.

A Hilton Garden Inn with a large, multi-story building, a covered entrance, and a parking lot.

A reception area with a counter, a sign for 'The Pavilion Pantry', and a green wall.

15. Hilton Garden Inn Florence

7.2 km from Mcleod Regional Medical Center

Derrick

SAR 443

SAR 496 total

includes taxes & fees

8 Nov - 9 Nov

A hotel with a modern design, multiple floors, and a parking lot.

A hotel room with a checkered sofa, a bed, a desk, and a framed picture on the wall.

A reception area with a Best Western sign, a reception desk, a waiting area with a blue patterned sofa, and a potted plant.

A swimming pool with lounge chairs and a building with balconies in the background.

16. Best Western Inn

4.7 km from Mcleod Regional Medical Center

Steward Heikes

SAR 334

SAR 374 total

includes taxes & fees

28 Oct - 29 Oct

A hotel room with a large bed, a desk with a chair, a television, and a walk-in closet.

A snack and beverage display area with shelves stocked with various brands and a refrigerator with beverages.

A modern indoor space with a counter, seating area, and a blue accent wall.

An outdoor patio area with lounge chairs and tables, a brick building, and a clear sky.

17. Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

8 km from Mcleod Regional Medical Center

Leigh

SAR 428

SAR 479 total

includes taxes & fees

1 Nov - 2 Nov

A hotel lobby with a wooden floor, multiple dining tables, chairs, and a seating area with a sofa.

A hotel room with two beds, a desk, a TV, and a window with patterned curtains.

A hotel lobby with a reception desk, seating area, and a welcome mat.

A Hampton Inn & Suites with a large sign, brick facade, and a parking lot.

18. Hampton Inn & Suites Florence Center

7.2 km from Mcleod Regional Medical Center

William

SAR 360

SAR 404 total

includes taxes & fees

15 Nov - 16 Nov

A modern hotel with a covered entrance, large windows, and a sign indicating it is a hotel.

A modern kitchen with a white countertop, three black stools, and a red accent wall.

A modern lounge area with a pool table, sofas, and yellow chairs.

19. Aloft by Marriott Florence

7.6 km from Mcleod Regional Medical Center

Darlene

SAR 417

SAR 490 total

includes taxes & fees

27 Oct - 28 Oct

A modern lobby with a stone column, a fireplace, and yellow rocking chairs around a central table.

A modern cafeteria with long wooden tables, green chairs, and yellow accents.

A hotel with a modern design, featuring a prominent sign for the 'Country Inn & Suites by Radisson.'

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

20. Spark by Hilton Florence North I-95, SC

5.5 km from Mcleod Regional Medical Center

Tienia

SAR 363

SAR 422 total

includes taxes & fees

2 Nov - 3 Nov

View all properties

Compare top hotels near Mcleod Regional Medical Center

Hotel Florence, Tapestry Collection by Hilton 0.8 km from Mcleod Regional Medical Center View	Rodeway Inn Florence Downtown 1.2 km from Mcleod Regional Medical Center View	Howard Johnson by Wyndham Florence 5.5 km from Mcleod Regional Medical Center View	Comfort Inn & Suites Florence Center Area 7 km from Mcleod Regional Medical Center View	Park Inn by Radisson Florence, SC 5.5 km from Mcleod Regional Medical Center View
8.8 Excellent 658 reviews	5.4 8 reviews	8.6 Excellent 2,748 reviews	9.0 Wonderful 1,373 reviews	9.0 Wonderful 2,476 reviews
SAR 520 SAR 582 total includes taxes & fees 15 Nov - 16 Nov	SAR 159 SAR 184 total includes taxes & fees 22 Nov - 23 Nov	SAR 242 SAR 271 total includes taxes & fees 9 Nov - 10 Nov	SAR 393 SAR 440 total includes taxes & fees 1 Nov - 2 Nov	SAR 339 SAR 379 total includes taxes & fees 25 Oct - 26 Oct

Top Mcleod Regional Medical Center Hotel Reviews

La Quinta Inn & Suites by Wyndham Florence

10/10 Excellent

"Close to the restaurants and shopping."

Days Inn by Wyndham Florence Near Civic Center

8/10 Good

"Room was great, but the complimentary breakfast was very poor."

Hotel Florence, Tapestry Collection by Hilton

8/10 Good

"The staff were great!! Parking was close by and easy. The restaurant bar was a great stop. If you want a refrigerator in your room you need to ask prior to arrival."

Come Stay A While

10/10 Excellent

"Loved the in unit washer and dryer. The house was visibly clean and smelled clean. Plenty of towels. The kitchen had cutting boards and pots and pans. Very comfortable and nice neighborhood. Host was very responsive."

Frequently asked questions

What's the area like around Mcleod Regional Medical Center?

Mcleod Regional Medical Center is located in a welcoming area of Florence known for its array of dining options. If you're looking for a convenient place to stay, check out the 18 hotels and other accommodations you'll find within a mile.

What's the best hotel to stay near Mcleod Regional Medical Center?

Hyatt Place Florence Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a restaurant. It's located just a short 0.4 mi (0.7 km) from Mcleod Regional Medical Center. Other good options within a short distance include Hotel Florence, Tapestry Collection by Hilton and The Urban Flats.

How many hotels will I find near Mcleod Regional Medical Center?

Expedia has 18 hotels and other accommodations within a mile from Mcleod Regional Medical Center.

If I need to cancel the hotel reservation for my stay near Mcleod Regional Medical Center, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to view the best deals near Mcleod Regional Medical Center.

Where can I learn more about changing or cancelling my trip in the area near Mcleod Regional Medical Center?

For more information about updating your stay near Mcleod Regional Medical Center or cancelling it, click here.

What can I see and do near Mcleod Regional Medical Center?

You can enjoy live performances at FMU Performing Arts Center and Florence Little Theatre. You might spend a leisurely day outdoors at Florence Veterans Park and Greenwood Baseball Park and Playground. Create some family memories at Sky Zone Trampoline Park and Tilt Studio.

Find hotels near Mcleod Regional Medical Center, Florence from SAR 184

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Our top choices for Mcleod Regional Medical Center hotels

1. Hotel Florence, Tapestry Collection by Hilton

2. Rodeway Inn Florence Downtown

3. The Urban Flats

4. Howard Johnson by Wyndham Florence

5. Comfort Inn & Suites Florence Center Area

6. Park Inn by Radisson Florence, SC

7. Holiday Inn Express & Suites Florence I-95 @ Hwy 327 by IHG

8. Hampton Inn & Suites Florence-North-I-95

9. TownePlace Suites by Marriott Florence

10. Fairfield Inn & Suites by Marriott Florence I-20

11. Quality Inn & Suites Florence Civic Center

12. Residence Inn Marriott Florence

13. La Quinta Inn & Suites by Wyndham Florence

14. Tru by Hilton Florence I-95

15. Hilton Garden Inn Florence

16. Best Western Inn

17. Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

18. Hampton Inn & Suites Florence Center

19. Aloft by Marriott Florence

20. Spark by Hilton Florence North I-95, SC

Compare top hotels near Mcleod Regional Medical Center

Hotel Florence, Tapestry Collection by Hilton

Rodeway Inn Florence Downtown

Howard Johnson by Wyndham Florence

Comfort Inn & Suites Florence Center Area

Park Inn by Radisson Florence, SC

Top Mcleod Regional Medical Center Hotel Reviews

La Quinta Inn & Suites by Wyndham Florence

Days Inn by Wyndham Florence Near Civic Center

Hotel Florence, Tapestry Collection by Hilton

Come Stay A While

Frequently asked questions