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Check prices for these dates

Tonight
26 Sep - 27 Sep
Tomorrow
27 Sep - 28 Sep
Next weekend
2 Oct - 4 Oct
In two weeks
9 Oct - 11 Oct

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Our top choices for Mayo Clinic Florida hotels

Breakfast, lunch and dinner served
Cocktail bar
Lobby
Terrace/patio

1. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
0.8 km from Mayo Clinic Florida
United States
Patricia
SAR 613
SAR 695 total
includes taxes & fees
3 Oct - 4 Oct
Hilton Jacksonville at Mayo Clinic near Beaches
Lobby lounge
Bar (on property)
Reception
Reception

2. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
1.1 km from Mayo Clinic Florida
United States
Michaelanne
SAR 541
SAR 614 total
includes taxes & fees
25 Oct - 26 Oct
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Lobby
Egyptian cotton sheets, premium bedding, pillowtop beds, in-room safe
Fitness facility
Terrace/patio

3. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
Patsy
SAR 411
SAR 467 total
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Lobby sitting area
Outdoor pool, open 8 AM to 10 PM, pool umbrellas, sun loungers
In-room safe, desk, blackout drapes, iron/ironing board
Lobby sitting area

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.6 km from Mayo Clinic Florida
United States
frances
SAR 349
SAR 396 total
includes taxes & fees
25 Oct - 26 Oct
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Terrace/patio
Terrace/patio
Exterior
Free daily self-serve breakfast

5. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
gregory
SAR 447
SAR 507 total
includes taxes & fees
4 Oct - 5 Oct
TownePlace Suites by Marriott Jacksonville East
Terrace/patio
Bar (on property)
Lounge
Lobby

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
0.4 km from Mayo Clinic Florida
United States
Patricia
SAR 571
SAR 648 total
includes taxes & fees
3 Oct - 4 Oct
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Blackout drapes, iron/ironing board (on request), WiFi (free)
Exterior
Exterior
Exterior

7. Hotel Palms

Hotel Palms
7.8 km from Mayo Clinic Florida
United States
Vinny
SAR 533
SAR 605 total
includes taxes & fees
28 Sep - 29 Sep
Hotel Palms
Desk, blackout drapes, iron/ironing board (on request), cribs (free)
Lobby
Exterior
Desk, blackout drapes, iron/ironing board (on request), cribs (free)

8. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
Deerwood, 7.8 km from Mayo Clinic Florida
United States
Phi
SAR 432
SAR 490 total
includes taxes & fees
3 Oct - 4 Oct
Hyatt Studios Jacksonville/St Johns Town Center
Exterior
Down comforters, pillowtop beds, in-room safe, desk
Point of interest
Meeting facility

9. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Southside, 7.7 km from Mayo Clinic Florida
United States
Ian
SAR 477
SAR 541 total
includes taxes & fees
26 Oct - 27 Oct
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Exterior
Snack bar
Exterior
Fitness facility

10. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
4.2 km from Mayo Clinic Florida
United States
Robert
SAR 444
SAR 503 total
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Property amenity
Point of interest
Lobby
Lobby

11. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
5.4 km from Mayo Clinic Florida
United States
Nick
SAR 571
SAR 648 total
includes taxes & fees
1 Oct - 2 Oct
Element by Marriott Jacksonville Beach
Lobby
Exterior
Exterior
Bar (on property)

12. Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
5.9 km from Mayo Clinic Florida
United States
Keisha
SAR 560
SAR 636 total
includes taxes & fees
29 Sep - 30 Sep
Margaritaville Jacksonville Beach
Property amenity
Free daily continental breakfast
Lobby
Reception

13. TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
10.8 km from Mayo Clinic Florida
United States
irina
SAR 443
SAR 503 total
includes taxes & fees
30 Sep - 1 Oct
TownePlace Suites by Marriott® Jacksonville Mayport
Lobby
Bar (on property)
Snack bar
Breakfast, lunch and dinner served

14. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
8.5 km from Mayo Clinic Florida
United States
Joyce
SAR 442
SAR 493 total
includes taxes & fees
19 Oct - 20 Oct
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Snack bar
Snack bar
Lobby
Room, 2 Queen Beds | Egyptian cotton sheets, premium bedding, pillowtop beds, desk

15. Tru By Hilton Jacksonville St Johns Town Center

Tru By Hilton Jacksonville St Johns Town Center
Southside, 8.7 km from Mayo Clinic Florida
United States
Mary
SAR 411
SAR 467 total
includes taxes & fees
4 Oct - 5 Oct
Tru By Hilton Jacksonville St Johns Town Center
Exterior
Restaurant
Premium bedding, desk, laptop workspace, iron/ironing board
Bar (on property)

16. Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG
Southside, 10.8 km from Mayo Clinic Florida
United States
Carol
SAR 473
SAR 537 total
includes taxes & fees
25 Oct - 26 Oct
Hotel Indigo Jacksonville-Deerwood Park by IHG
Lounge
Exterior
Outdoor pool, pool umbrellas, sun loungers
Terrace/patio

17. AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center
Southside, 8.1 km from Mayo Clinic Florida
United States
Robert
SAR 653
SAR 741 total
includes taxes & fees
27 Sep - 28 Sep
AC Hotel Jacksonville St Johns Town Center
Bar (on property)
Exterior
Lobby
Property amenity

18. Courtyard by Marriott Jacksonville I-295/East Beltway

Courtyard by Marriott Jacksonville I-295/East Beltway
Arlington, 13.2 km from Mayo Clinic Florida
United States
Chloie Marie
SAR 412
SAR 467 total
includes taxes & fees
1 Oct - 2 Oct
Courtyard by Marriott Jacksonville I-295/East Beltway
Standard Room, 2 Queen Beds, Accessible (Accessible Tub) | In-room safe, desk, laptop workspace, blackout drapes
Point of interest
Point of interest
Room amenity

19. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
4.6 km from Mayo Clinic Florida
United States
Jose
SAR 413
SAR 469 total
includes taxes & fees
4 Oct - 5 Oct
Holiday Inn Express Jacksonville Beach by IHG
2 outdoor pools, open 7:00 AM to 9:00 PM, pool umbrellas, sun loungers
Exterior
2 bars/lounges
On the beach, white sand, beach towels, snorkeling

20. Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront
6.3 km from Mayo Clinic Florida
United States
Hope
SAR 635
SAR 721 total
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn Jacksonville Beach/Oceanfront
View all properties

Compare popular hotels close to Mayo Clinic Florida

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
Breakfast, lunch and dinner served
Hilton Jacksonville at Mayo Clinic near Beaches
9.4
Exceptional
363 reviews
View
Lobby lounge
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
9.4
Exceptional
602 reviews
View
Lobby
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
9.0
Wonderful
1,000 reviews
View
Lobby sitting area
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
9.0
Wonderful
1,011 reviews
View
Terrace/patio
TownePlace Suites by Marriott Jacksonville East
9.2
Wonderful
660 reviews
View

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

10/10 Excellent
"We liked the location, we were pleasantly surprised at how nice this beachfront hotel was."
mark 1-night trip
Posted 2 hours ago
Margaritaville Jacksonville Beach
Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches

10/10 Excellent
"Very nice stay!"
Patricia 1-night trip
Posted 1 day ago
Hilton Jacksonville at Mayo Clinic near Beaches
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

8/10 Good
"Love those scones and waffles"
Norval and Karen 3-night trip
Posted 1 day ago
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

10/10 Excellent
"Everything was nice and clean! Very well kept! The hosts are very responsive and friendly! Location was perfect and quiet! Definitely would stay here again!"
Julie L. 3-night trip
Posted 6 days ago
Light Grey Getaway under 2 miles to mayo, 4 miles to the beach
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

10/10 Excellent
"The staff was very helpful and the parking easy and, in parts, quite shady. It was within easy walking distance of the Mayo Clinic!"
Patricia 1-night trip
Posted 9 days ago
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

8/10 Good
"The location was perfect for us, as I had appointments at Mayo Clinic. Leo was a great host and addressed our concerns promptly."
Barbara G. 24-night trip
Posted 2 weeks ago
Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable
Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

10/10 Excellent
"Place was exactly as pictured and perfect for our stay. Spacious, great amenities, and convenient location. Our family loved the putting green and pool table for some friendly competition. Top of our list as a place to stay the next time we're in JAX!"
Erin L. 3-night trip
Posted 1 month ago
Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green
Heated Pool Family Fun Minutes to Mayo & Jax Beach

Heated Pool Family Fun Minutes to Mayo & Jax Beach

10/10 Excellent
"We had a fantastic time at this property! It was perfect for our trip."
Sam R. 3-night trip
Posted 1 month ago
Heated Pool Family Fun Minutes to Mayo & Jax Beach
Comfy Mayo Retreat: Pool & Close to Beach

Comfy Mayo Retreat: Pool & Close to Beach

10/10 Excellent
"Great location with a really nice park close by to walk the dogs. The pool was perfect!"
Rachael B. 7-night trip
Posted 2 months ago
Comfy Mayo Retreat: Pool & Close to Beach

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, check out the 44 hotels and other accommodations you'll find within a mile.
What's the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels will I find near Mayo Clinic Florida?
Expedia has 44 hotels and other accommodations within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review the best deals available near Mayo Clinic Florida.
Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Florida?
To access more information about picking new dates or cancelling your stay near Mayo Clinic Florida, head over to our customer service page.
What can I see and do near Mayo Clinic Florida?
You can catch a show at SeaWalk Pavillion, Wilson Center For the Arts, and Blue Jay Listening Room. Spend some time exploring the natural beauty of Huguenot Park, Oceanfront Park, and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.