The Best Hotels Closest to Mayo Clinic Florida in Jacksonville for 2026

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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.

An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.

A modern kitchen with a bar area, seating, and a view of the outdoors.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

1.1 km from Mayo Clinic Florida

Michaelanne

SAR 513

SAR 582 total

includes taxes & fees

15 Nov - 16 Nov

A modern restaurant with a bar area, wooden ceiling, and large windows.

A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.

A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.

2. Hilton Jacksonville at Mayo Clinic near Beaches

0.8 km from Mayo Clinic Florida

Patricia

SAR 635

SAR 720 total

includes taxes & fees

24 Oct - 25 Oct

An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.

A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.

An outdoor patio with a pool, wooden pergola, and seating area.

3. TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

gregory

SAR 462

SAR 524 total

includes taxes & fees

25 Oct - 26 Oct

A lobby with a reception desk, seating area, and a staircase.

An indoor swimming pool with clear views of trees outside, a tiled floor, and a covered seating area.

A modern kitchen with a refrigerator, coffee machine, and a bakery display.

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.6 km from Mayo Clinic Florida

frances

SAR 387

SAR 439 total

includes taxes & fees

14 Nov - 15 Nov

A hotel lobby with a bar area, seating arrangements, and a reception desk.

A hotel pool area with a long, narrow pool, multiple lounge chairs, and a covered seating area.

A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.

A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.

5. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

Patsy

SAR 445

SAR 506 total

includes taxes & fees

18 Oct - 19 Oct

An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.

A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.

A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

0.4 km from Mayo Clinic Florida

Patricia

SAR 570

SAR 647 total

includes taxes & fees

24 Oct - 25 Oct

A round marble table with a magazine, a pair of glasses, and a coffee cup.

A backyard with a swimming pool, wooden deck, and outdoor furniture.

A living room with a sofa, a coffee table, a hanging light fixture, a framed picture, and a floor lamp.

A hotel room with two beds, a nightstand with a lamp, and a pair of slippers on the floor.

7. Hotel Palms

7.8 km from Mayo Clinic Florida

Vinny

SAR 716

SAR 812 total

includes taxes & fees

17 Nov - 18 Nov

A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.

A beverage refrigerator stocked with various drinks, a small refrigerator, and a wall-mounted display with promotional items.

A kitchen counter with a flat-screen TV displaying a breakfast menu, a coffee machine, and a sign for fresh pancakes.

A coastal cityscape with a long beach, a large hotel with a curved facade, and a clear sky.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Southside, 7.7 km from Mayo Clinic Florida

Aneudi

SAR 368

SAR 417 total

includes taxes & fees

29 Oct - 30 Oct

An outdoor patio area with seating, a fire pit, and a barbecue grill.

A modern living room with sofas, a coffee table, and a dining area.

A reception area with a modern design, featuring a reception desk, a refrigerator with snacks, and a wooden slatted wall.

A modern kitchen with wooden cabinets, a central island with jars, and a countertop with toasters.

9. TownePlace Suites by Marriott® Jacksonville Mayport

10.8 km from Mayo Clinic Florida

irina

SAR 447

SAR 507 total

includes taxes & fees

15 Nov - 16 Nov

A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.

A modern building entrance with a sign reading "element by Westin".

A modern hotel lobby with a long reception desk, seating area, and large windows.

A pathway leading to a sunset over a beach with sand and grass.

10. Element by Marriott Jacksonville Beach

5.4 km from Mayo Clinic Florida

Lisa

SAR 540

SAR 613 total

includes taxes & fees

1 Nov - 2 Nov

A laptop on a wooden desk with a white mug, a spoon, and a smartphone.

A conference room with multiple tables and chairs, large windows with curtains, and a flat-screen TV mounted on the wall.

11. Hyatt Studios Jacksonville/St Johns Town Center

Deerwood, 7.8 km from Mayo Clinic Florida

Camoya

SAR 454

SAR 515 total

includes taxes & fees

29 Oct - 30 Oct

An outdoor seating area with a fire feature, chairs, and a table.

A modern bar area with a curved counter, multiple bar stools, and a variety of liquor bottles.

A modern bar area with a counter, bar stools, and a television screen.

A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.

12. Hotel Indigo Jacksonville-Deerwood Park by IHG

Southside, 10.8 km from Mayo Clinic Florida

Carol

SAR 458

SAR 520 total

includes taxes & fees

12 Nov - 13 Nov

A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.

A modern hotel building with a flat facade, large windows, and a sign reading "ACHTEL JACKSONVILLE".

An outdoor seating area with white furniture and a well-maintained lawn, surrounded by large windows and a modern building facade.

A modern hotel with a pool, palm trees, and a clear blue sky.

13. AC Hotel Jacksonville St Johns Town Center

Southside, 8.1 km from Mayo Clinic Florida

Emily

SAR 672

SAR 762 total

includes taxes & fees

18 Oct - 19 Oct

A pool with a waterfall feature, surrounded by large rock formations.

A hotel room with two beds, a desk with a flat-screen TV, a chair, and a large window with a view of palm trees.

A beachfront hotel with multiple balconies, a sandy beach, and ocean views.

14. Hampton Inn Jacksonville Beach/Oceanfront

6.3 km from Mayo Clinic Florida

Hope

SAR 603

SAR 684 total

includes taxes & fees

25 Oct - 26 Oct

A self-service beverage station with a refrigerated display and a coffee machine.

A snack display in a store with various chips and snacks.

A modern lounge area with seating, tables, and hanging lights.

A modern hotel reception area with a curved wooden reception desk, a digital display, and a view of the lobby.

15. Tru By Hilton Jacksonville St Johns Town Center

Southside, 8.7 km from Mayo Clinic Florida

Josephine

SAR 411

SAR 466 total

includes taxes & fees

1 Nov - 2 Nov

A modern bar area with wooden accents, a variety of beverages, and seating arrangements.

A modern bar area with a wooden counter, multiple seating options including bar stools and round tables, and a menu board.

A multi-story hotel with a prominent entrance, a parking lot, and well-maintained landscaping.

A patio area with a stone fire pit, outdoor furniture, and a brick floor.

16. Courtyard by Marriott Jacksonville I-295/East Beltway

Arlington, 13.2 km from Mayo Clinic Florida

Chloie Marie

SAR 363

SAR 412 total

includes taxes & fees

22 Oct - 23 Oct

A spacious lobby with a reception desk, seating area, and large windows.

An indoor dining area with tables and chairs, a ceiling fan, and a view of the outdoors.

A modern coffee shop interior with a central counter, shelves stocked with snacks, and a refrigerated section labeled 'FROZEN' and 'CHILLED'.

A bar area with wooden chairs, a round table, and a brick wall.

17. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

8.5 km from Mayo Clinic Florida

Madison

SAR 442

SAR 493 total

includes taxes & fees

29 Oct - 30 Oct

A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.

A golf course with a water hazard and a bridge.

A hotel room with a microwave, coffee maker, and refrigerator on the counter. There is a door with a sign and a towel rack visible.

A coffee station with two espresso machines and a display of coffee products.

18. Holiday Inn Express Jacksonville Beach by IHG

4.6 km from Mayo Clinic Florida

Bobby

SAR 428

SAR 486 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor patio with seating, a fire pit, and string lights.

A multi-story hotel with a modern design, featuring a large number of windows and a flat roof.

A modern living room with a dining area, a flat-screen TV, and a bookshelf.

A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a fence.

19. Hyatt Place Jacksonville / St. Johns Town Center

Southside, 8.6 km from Mayo Clinic Florida

Becky

SAR 477

SAR 542 total

includes taxes & fees

22 Oct - 23 Oct

A beach with a sandy shore, waves, and buildings in the background.

A balcony with two green chairs and a small table, overlooking a beach and a boardwalk.

A modern cafe with a central counter, seating area, and a wooden accent wall with 'BW' letters.

A Best Western hotel with a modern design, located near a beach with a pier.

20. Best Western Oceanfront

5.7 km from Mayo Clinic Florida

Svetlana

SAR 490

SAR 556 total

includes taxes & fees

19 Oct - 20 Oct

View all properties

Compare popular hotels close to Mayo Clinic Florida

Property	Property class	Guest rating
Residence Inn By Marriott Jacksonville - Mayo Clinic Area	9.4 Exceptional 609 reviews	View
Hilton Jacksonville at Mayo Clinic near Beaches	9.2 Wonderful 376 reviews	View
TownePlace Suites by Marriott Jacksonville East	9.2 Wonderful 664 reviews	View
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG	9.0 Wonderful 1,005 reviews	View
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic	9.0 Wonderful 1,003 reviews	View

Top Mayo Clinic Florida Hotel Reviews

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

10/10 Excellent

"What a great stay in Jacksonville! We were there for appointments at Mayo. Check-in very friendly and helpful. The facility was immaculate. Breakfast was awesome! Fresh ground/brewed coffee by the cup. Very good selection. Fresh and appealing. Housekeeping was excellent. They have a free shuttle to Mayo and back every hour which was a tremendous benefit. We enjoyed our stay so much, we almost stayed an extra day!!"

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

8/10 Good

"Great room! Only complaint was noisy ac motor next to bed."

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent

"They were awesome and couldn t ask for better serving."

Holiday Inn Express Jacksonville Beach by IHG

10/10 Excellent

"Nice weekend stay for the price close to the beach. Quiet area."

Margaritaville Jacksonville Beach

10/10 Excellent

"The number one thing about our stay was the staff. John checked is in and everyone we interacted with was positive and helpful. They were generous with coffee and towels. When a little maintenance was needed, they were two quick to reply, the problem wasn't significant enough and we needed to rest. A wild party interrupted next door to us and I asked when quiet time started and at that time (10pm) the wild noise stopped. The TV was good, the balcony better, and the exercise room more than adequate. We did not eat on property but service is available. Thank you Margaritaville."

Cozy & Comfy 3 bedroom residential home

10/10 Excellent

"Nice clean. The amenities were great! Master bedroom bed was comfortable. Location was perfect short drive to beaches, resteraunts & entertainment"

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

10/10 Excellent

"Clean, cozy house with a quiet neighborhood, close to several restaurants and shopping. The only downfall was there was no tv in the bunk bed room, there was no grill as listed, and the beds were a little too firm. Would def stay here again! Very clean and well kept."

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

10/10 Excellent

"Carson was a great host. The communication process was excellent. He responded back to me fast and the property was cleaned and had everything that we needed. Would definitely come back again."

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

10/10 Excellent

"The property was very clean and spacious. The host was responsive.She was also helpful with area recommendations. She went above and beyond our expectations. The home is well-supplied with just about anything you could need.The beds were very comfortable.The property is located in a safe and convenient neighborhood.We would definitely stay again."

Frequently asked questions

What's the area like around Mayo Clinic Florida?

Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, check out the 44 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic Florida?

Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

How many hotels will I find near Mayo Clinic Florida?

Expedia has 44 hotels and other accommodations within a mile from Mayo Clinic Florida.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review the best deals available near Mayo Clinic Florida.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Florida?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Florida, head over to our customer service page.

What can I see and do near Mayo Clinic Florida?

You can catch a show at SeaWalk Pavillion, Players by the Sea, and Blue Jay Listening Room. Spend some time exploring the natural beauty of Huguenot Park, Oceanfront Park, and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

Find hotels near Mayo Clinic Florida, Jacksonville from SAR 412

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Our top choices for Mayo Clinic Florida hotels

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

2. Hilton Jacksonville at Mayo Clinic near Beaches

3. TownePlace Suites by Marriott Jacksonville East

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

5. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

7. Hotel Palms

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

9. TownePlace Suites by Marriott® Jacksonville Mayport

10. Element by Marriott Jacksonville Beach

11. Hyatt Studios Jacksonville/St Johns Town Center

12. Hotel Indigo Jacksonville-Deerwood Park by IHG

13. AC Hotel Jacksonville St Johns Town Center

14. Hampton Inn Jacksonville Beach/Oceanfront

15. Tru By Hilton Jacksonville St Johns Town Center

16. Courtyard by Marriott Jacksonville I-295/East Beltway

17. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

18. Holiday Inn Express Jacksonville Beach by IHG

19. Hyatt Place Jacksonville / St. Johns Town Center

20. Best Western Oceanfront

Compare popular hotels close to Mayo Clinic Florida

Top Mayo Clinic Florida Hotel Reviews

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Holiday Inn Express Jacksonville Beach by IHG

Margaritaville Jacksonville Beach

Cozy & Comfy 3 bedroom residential home

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

Frequently asked questions