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Check prices for these dates

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27 Aug - 28 Aug
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28 Aug - 29 Aug
This weekend
28 Aug - 30 Aug
Next weekend
4 Sep - 6 Sep

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Our top choices for Mayo Clinic Florida hotels

Lobby lounge
Exterior
Bar (on property)
Reception

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
1.1 km from Mayo Clinic Florida
United States
Michaelanne
SAR 552
SAR 626 total
includes taxes & fees
18 Sep - 19 Sep
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Breakfast, lunch and dinner served
Lobby
Lobby
Cocktail bar

2. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
0.8 km from Mayo Clinic Florida
United States
Mercedes
SAR 567
SAR 643 total
includes taxes & fees
7 Sep - 8 Sep
Hilton Jacksonville at Mayo Clinic near Beaches
Terrace/patio
Exterior
Terrace/patio
Studio, 1 King Bed with Sofa bed | Desk, iron/ironing board, cribs (free), WiFi (free)

3. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
Tiffany
SAR 447
SAR 507 total
includes taxes & fees
6 Sep - 7 Sep
TownePlace Suites by Marriott Jacksonville East
Lobby sitting area
Lobby sitting area
In-room safe, desk, blackout drapes, iron/ironing board
Outdoor pool, open 8 AM to 10 PM, pool umbrellas, sun loungers

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.6 km from Mayo Clinic Florida
United States
Jorge
SAR 375
SAR 426 total
includes taxes & fees
20 Sep - 21 Sep
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Lobby
Fitness facility
Indoor pool
Egyptian cotton sheets, premium bedding, pillowtop beds, in-room safe

5. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
Patsy
SAR 480
SAR 545 total
includes taxes & fees
20 Sep - 21 Sep
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Terrace/patio
Bar (on property)
Lobby
Outdoor pool

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
0.4 km from Mayo Clinic Florida
United States
Troy
SAR 571
SAR 648 total
includes taxes & fees
12 Sep - 13 Sep
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Outdoor pool
Exterior
Blackout drapes, iron/ironing board (on request), WiFi (free)
Combined shower/tub, free toiletries, hair dryer, towels

7. The Hotel Palms Poolside

The Hotel Palms Poolside
7.8 km from Mayo Clinic Florida
United States
Vinny
SAR 640
SAR 727 total
includes taxes & fees
8 Sep - 9 Sep
The Hotel Palms Poolside
Property amenity
Lobby
Point of interest
View from property

8. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
5.4 km from Mayo Clinic Florida
United States
Tablo
SAR 571
SAR 648 total
includes taxes & fees
20 Sep - 21 Sep
Element by Marriott Jacksonville Beach
Property amenity
Reception
Lobby
Exterior

9. TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
10.8 km from Mayo Clinic Florida
United States
Paul
SAR 507
SAR 575 total
includes taxes & fees
7 Sep - 8 Sep
TownePlace Suites by Marriott® Jacksonville Mayport
Couples treatment rooms, sauna, hot tub, steam room, body treatments
View from property
On the beach, white sand, surfing
Standard Room, Oceanfront | Premium bedding, minibar, in-room safe, desk

10. Ponte Vedra Inn & Club

Ponte Vedra Inn & Club
6.3 km from Mayo Clinic Florida
United Kingdom
Michael
SAR 1,686
SAR 2,001 total
includes taxes & fees
8 Sep - 9 Sep
Ponte Vedra Inn & Club
Lobby
Bar (on property)
Exterior
Snack bar

11. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
8.5 km from Mayo Clinic Florida
United States
Brooke
SAR 463
SAR 517 total
includes taxes & fees
30 Aug - 31 Aug
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Point of interest
Exterior
Outdoor pool, open 7:00 AM to 10:00 PM, sun loungers
Exterior

12. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Southside, 7.7 km from Mayo Clinic Florida
United States
Satish
SAR 477
SAR 541 total
includes taxes & fees
27 Sep - 28 Sep
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
2 outdoor pools, open 7:00 AM to 9:00 PM, pool umbrellas, sun loungers
Exterior
View from room
2 bars/lounges

13. Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront
6.3 km from Mayo Clinic Florida
United States
Kevin
SAR 603
SAR 685 total
includes taxes & fees
8 Sep - 9 Sep
Hampton Inn Jacksonville Beach/Oceanfront
Desk, blackout drapes, iron/ironing board (on request), cribs (free)
Terrace/patio
Lobby
Free daily on-the-go breakfast

14. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
Deerwood, 7.8 km from Mayo Clinic Florida
United States
Michele
SAR 413
SAR 469 total
includes taxes & fees
8 Sep - 9 Sep
Hyatt Studios Jacksonville/St Johns Town Center
Outdoor pool, pool umbrellas, sun loungers
Exterior
1 bedroom, pillowtop beds, in-room safe, desk
Exterior

15. Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront
5.6 km from Mayo Clinic Florida
United States
Susan
SAR 627
SAR 712 total
includes taxes & fees
21 Sep - 22 Sep
Four Points by Sheraton Jacksonville Beachfront
On the beach
Exterior
Free daily full breakfast
Standard Room, 1 King Bed, Balcony, Oceanfront (with Sofabed) | Balcony view

16. Best Western Oceanfront

Best Western Oceanfront
5.7 km from Mayo Clinic Florida
United States
Shawna
SAR 496
SAR 562 total
includes taxes & fees
8 Sep - 9 Sep
Best Western Oceanfront
Bar (on property)
Bar (on property)
View from property
Bar (on property)

17. Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront
5.8 km from Mayo Clinic Florida
United States
Patricia Ann
SAR 619
SAR 703 total
includes taxes & fees
7 Sep - 8 Sep
Springhill Suites By Marriott Jacksonville Beach Oceanfront
Lobby
Bar (on property)
Daily to-go breakfast for a fee
Exterior

18. Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
5.9 km from Mayo Clinic Florida
United States
Noelia
SAR 560
SAR 636 total
includes taxes & fees
31 Aug - 1 Sep
Margaritaville Jacksonville Beach
Lounge
Outdoor pool, pool umbrellas, sun loungers
Terrace/patio
Lounge

19. AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center
Southside, 8.1 km from Mayo Clinic Florida
United States
Alysha
SAR 672
SAR 763 total
includes taxes & fees
5 Sep - 6 Sep
AC Hotel Jacksonville St Johns Town Center
Studio Suite, 2 Queen Beds | Down comforters, desk, laptop workspace, blackout drapes
Studio Suite, 1 Queen Bed, Accessible (Roll-In Shower) | Room amenity
Property amenity
Exterior

20. Candlewood Suites Jacksonville - Mayport by IHG

Candlewood Suites Jacksonville - Mayport by IHG
9.2 km from Mayo Clinic Florida
United States
David
SAR 439
SAR 499 total
includes taxes & fees
10 Sep - 11 Sep
Candlewood Suites Jacksonville - Mayport by IHG
View all properties

Compare popular hotels close to Mayo Clinic Florida

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
Lobby lounge
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
9.4
Exceptional
588 reviews
View
Breakfast, lunch and dinner served
Hilton Jacksonville at Mayo Clinic near Beaches
9.4
Exceptional
335 reviews
View
Terrace/patio
TownePlace Suites by Marriott Jacksonville East
9.2
Wonderful
653 reviews
View
Lobby sitting area
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
9.0
Wonderful
1,029 reviews
View
Lobby
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
9.0
Wonderful
1,001 reviews
View

Top Mayo Clinic Florida Hotel Reviews

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

10/10 Excellent
"Clean rooms and various restaurants nearby"
Geisha 2-night trip
Posted 3 hours ago
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent
"Large rooms, very clean"
Melony 2-night trip
Posted 6 hours ago
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

10/10 Excellent
"Good"
Roberto 4-night trip
Posted 3 days ago
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG

10/10 Excellent
"It was very clean and the staff was amazing even the housekeepers. The breakfast was amazing and the coffee was amazing as well. I will definitely stay again when I travel back to Florida. I will definitely recommend to friends and family."
Amy 3-night trip
Posted 4 days ago
Holiday Inn Express Jacksonville Beach by IHG
Comfy Mayo Retreat: Pool & Close to Beach

Comfy Mayo Retreat: Pool & Close to Beach

10/10 Excellent
"Great location with a really nice park close by to walk the dogs. The pool was perfect!"
Rachael B. 7-night trip
Posted 12 days ago
Comfy Mayo Retreat: Pool & Close to Beach
Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

10/10 Excellent
"Cute, nicely decorated house in a quiet neighborhood but close to grocery and restaurants. Not far from the beach. Host was extremely helpful and responsive. Hope to stay here again soon."
pam s. 6-night trip
Posted 1 month ago
Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable
Private Pool Getaway • 5min Beach • Sleeps 9

Private Pool Getaway • 5min Beach • Sleeps 9

10/10 Excellent
"We had a wonder time ! Very clean and close to beaches and shopping ! Highly recommend!"
Amy C. 6-night trip
Posted 1 month ago
Private Pool Getaway • 5min Beach • Sleeps 9
Beach Retreat in Jacksonville: Pet/Family-Friendly

Beach Retreat in Jacksonville: Pet/Family-Friendly

10/10 Excellent
"Our stay was great there was plenty of room for our group of 12. The house was clean and the pool was a huge hit."
Billy W. 5-night trip
Posted 2 months ago
Beach Retreat in Jacksonville: Pet/Family-Friendly
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

10/10 Excellent
"Wonderful property! My family loved the pool table and darts. So much fun. Thanks for a great weekend."
Maureen C. 2-night trip
Posted 2 months ago
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, check out the 45 hotels and other accommodations you'll find within a mile.
What's the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels will I find near Mayo Clinic Florida?
Expedia has 45 hotels and other accommodations within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review the best deals available near Mayo Clinic Florida.
Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Florida?
To access more information about picking new dates or cancelling your stay near Mayo Clinic Florida, head over to our customer service page.
What can I see and do near Mayo Clinic Florida?
You can catch a show at SeaWalk Pavillion, Wilson Center For the Arts, and Blue Jay Listening Room. Spend some time exploring the natural beauty of Huguenot Park, Oceanfront Park, and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.