The Best Hotels Closest to Mayo Clinic Florida in Jacksonville for 2026

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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.

A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.

A modern kitchen with a bar area, seating, and a view of the outdoors.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

1.1 km from Mayo Clinic Florida

Michaelanne

SAR 513

SAR 583 total

includes taxes & fees

15 Nov - 16 Nov

An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

An outdoor patio with a pool, wooden pergola, and seating area.

A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.

A hotel room with a bed, a sofa, a nightstand, and a wall-mounted lamp.

2. TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

gregory

SAR 462

SAR 524 total

includes taxes & fees

25 Oct - 26 Oct

A modern restaurant with a bar area, wooden ceiling, and large windows.

A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.

A modern lobby with a curved sofa, round coffee tables, and a large pillar.

A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

3. Hilton Jacksonville at Mayo Clinic near Beaches

0.8 km from Mayo Clinic Florida

Patricia

SAR 635

SAR 721 total

includes taxes & fees

24 Oct - 25 Oct

A hotel lobby with a bar area, seating arrangements, and a reception desk.

A hotel pool area with a long, narrow pool, multiple lounge chairs, and a covered seating area.

An outdoor patio with a brick wall, a round table with striped chairs, and two large umbrellas.

A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

Patsy

SAR 428

SAR 486 total

includes taxes & fees

30 Oct - 31 Oct

A lobby with a reception desk, seating area, and a staircase.

A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.

A modern kitchen with a refrigerator, coffee machine, and a bakery display.

5. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.6 km from Mayo Clinic Florida

frances

SAR 387

SAR 439 total

includes taxes & fees

14 Nov - 15 Nov

An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

0.4 km from Mayo Clinic Florida

Patricia

SAR 875

SAR 993 total

includes taxes & fees

15 Nov - 16 Nov

A backyard with a swimming pool, wooden deck, and outdoor furniture.

A marble table with a book and a cup, a vase with green plants, and a brown sofa in the background.

A kitchen with a sink, a coffee maker, a bottle of Mountain Valley Spring Water, and a jar of cream cheese stuffed olives.

A bedroom with a bed, a bedside table with a lamp, a sofa, a coffee table with a book, and a painting on the wall.

7. Hotel Palms

7.8 km from Mayo Clinic Florida

Vinny

SAR 716

SAR 813 total

includes taxes & fees

28 Oct - 29 Oct

A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.

A hotel room with two beds, a desk, a chair, and a large window with a view.

A kitchen counter with a flat-screen TV displaying a breakfast menu, a coffee machine, and a sign for fresh pancakes.

A coastal cityscape with a long beach, a large hotel with a curved facade, and a clear sky.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Southside, 7.7 km from Mayo Clinic Florida

Aneudi

SAR 447

SAR 507 total

includes taxes & fees

29 Oct - 30 Oct

A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.

A pathway leading to a sunset over a beach with sand and grass.

A modern hotel lobby with a long reception desk, seating area, and large windows.

A modern building entrance with a sign reading "element by Westin".

9. Element by Marriott Jacksonville Beach

5.4 km from Mayo Clinic Florida

Lisa

SAR 541

SAR 614 total

includes taxes & fees

1 Nov - 2 Nov

A laptop on a wooden desk with a white mug, a spoon, and a smartphone.

10. Hyatt Studios Jacksonville/St Johns Town Center

Deerwood, 7.8 km from Mayo Clinic Florida

Camoya

SAR 454

SAR 516 total

includes taxes & fees

29 Oct - 30 Oct

An outdoor seating area with a fire feature, chairs, and a table.

A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.

A modern bar area with a counter, bar stools, and a television screen.

A gym with treadmills, dumbbells, and exercise balls, overlooking a swimming pool.

11. Hotel Indigo Jacksonville-Deerwood Park by IHG

Southside, 10.8 km from Mayo Clinic Florida

Carol

SAR 443

SAR 503 total

includes taxes & fees

12 Nov - 13 Nov

A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.

A modern hotel building with a flat facade, large windows, and a sign reading "ACHTEL JACKSONVILLE".

A modern hotel with a pool, palm trees, and a clear blue sky.

An outdoor seating area with white furniture and a well-maintained lawn, surrounded by large windows and a modern building facade.

12. AC Hotel Jacksonville St Johns Town Center

Southside, 8.1 km from Mayo Clinic Florida

Emily

SAR 672

SAR 763 total

includes taxes & fees

16 Oct - 17 Oct

A pool with a waterfall feature, surrounded by large rock formations.

A hotel room with two beds, a desk with a flat-screen TV, a chair, and a large window with a view of palm trees.

A beachfront hotel with multiple balconies, a sandy beach, and ocean views.

A beachside bar with a long counter, multiple chairs, and a view of the ocean.

13. Hampton Inn Jacksonville Beach/Oceanfront

6.3 km from Mayo Clinic Florida

Hope

SAR 603

SAR 685 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor patio with seating, a fire pit, and string lights.

A modern living room with a dining area, a flat-screen TV, and a bookshelf.

A multi-story hotel with a modern design, featuring a large number of windows and a flat roof.

A modern bar area with a counter, bar stools, and a television screen. There are round tables with chairs in the dining area.

14. Hyatt Place Jacksonville / St. Johns Town Center

Southside, 8.6 km from Mayo Clinic Florida

Becky

SAR 478

SAR 542 total

includes taxes & fees

18 Oct - 19 Oct

A self-service beverage station with a refrigerated display and a coffee machine.

A hotel room with two beds, a desk, a chair, a TV, and a large window with a view.

A modern lounge area with seating, tables, and hanging lights.

A modern hotel reception area with a curved wooden reception desk, a digital display, and a view of the lobby.

15. Tru By Hilton Jacksonville St Johns Town Center

Southside, 8.7 km from Mayo Clinic Florida

Josephine

SAR 411

SAR 466 total

includes taxes & fees

18 Oct - 19 Oct

A modern bar area with wooden accents, a variety of beverages, and seating arrangements.

A modern bar area with a wooden counter, multiple seating options including bar stools and round tables, and a menu board.

A multi-story hotel with a prominent entrance, a parking lot, and well-maintained landscaping.

A modern hotel lobby with a sofa set, armchairs, a coffee table, and a patterned carpet.

16. Courtyard by Marriott Jacksonville I-295/East Beltway

Arlington, 13.2 km from Mayo Clinic Florida

Chloie Marie

SAR 363

SAR 412 total

includes taxes & fees

22 Oct - 23 Oct

A spacious lobby with a reception desk, seating area, and large windows.

A bar area with wooden chairs, a round table, and a brick wall.

A modern coffee shop interior with a central counter, shelves stocked with snacks, and a refrigerated section labeled 'FROZEN' and 'CHILLED'.

A multi-story hotel with a central entrance, large windows, and a well-lit facade.

17. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

8.5 km from Mayo Clinic Florida

William

SAR 442

SAR 493 total

includes taxes & fees

29 Oct - 30 Oct

A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.

A golf course with a water hazard and a bridge.

A hotel room with a microwave, coffee maker, and refrigerator on the counter. There is a door with a sign and a towel rack visible.

A pier extending into the ocean at sunset with birds flying above.

18. Holiday Inn Express Jacksonville Beach by IHG

4.6 km from Mayo Clinic Florida

Bobby

SAR 413

SAR 469 total

includes taxes & fees

18 Oct - 19 Oct

A beach with a sandy shore, waves, and buildings in the background.

A balcony with two green chairs and a small table, overlooking a beach and a boardwalk.

A modern cafe with a central counter, seating area, and a wooden accent wall with 'BW' letters.

A modern lobby with a grey sofa, two round tables, a reception desk, and a wooden wall with shelves displaying trophies and awards.

19. Best Western Oceanfront

5.7 km from Mayo Clinic Florida

Svetlana

SAR 496

SAR 562 total

includes taxes & fees

25 Oct - 26 Oct

A hotel with a beach view, multiple parking levels, and a prominent 'Four Points' sign.

A hotel room with a large bed, a desk, a chair, a TV, and a view of the ocean.

A hotel room with a bed, a TV, a wooden dresser, a mirror, and a view of the sea.

20. Four Points by Sheraton Jacksonville Beachfront

5.6 km from Mayo Clinic Florida

Rachel

SAR 667

SAR 757 total

includes taxes & fees

1 Nov - 2 Nov

View all properties

Compare popular hotels close to Mayo Clinic Florida

Property	Property class	Guest rating
Residence Inn By Marriott Jacksonville - Mayo Clinic Area	9.4 Exceptional 607 reviews	View
TownePlace Suites by Marriott Jacksonville East	9.2 Wonderful 663 reviews	View
Hilton Jacksonville at Mayo Clinic near Beaches	9.2 Wonderful 374 reviews	View
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic	9.0 Wonderful 1,001 reviews	View
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG	9.0 Wonderful 1,004 reviews	View

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

10/10 Excellent

"Great place to stay, friendly staff, clean rooms, would definitely stay again"

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

10/10 Excellent

"Everything was good. Will visit again"

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent

"Great location"

Cozy & Comfy 3 bedroom residential home

10/10 Excellent

"Nice clean. The amenities were great! Master bedroom bed was comfortable. Location was perfect short drive to beaches, resteraunts & entertainment"

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

10/10 Excellent

"Clean, cozy house with a quiet neighborhood, close to several restaurants and shopping. The only downfall was there was no tv in the bunk bed room, there was no grill as listed, and the beds were a little too firm. Would def stay here again! Very clean and well kept."

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

10/10 Excellent

"Carson was a great host. The communication process was excellent. He responded back to me fast and the property was cleaned and had everything that we needed. Would definitely come back again."

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

10/10 Excellent

"The property was very clean and spacious. The host was responsive.She was also helpful with area recommendations. She went above and beyond our expectations. The home is well-supplied with just about anything you could need.The beds were very comfortable.The property is located in a safe and convenient neighborhood.We would definitely stay again."

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

8/10 Good

"The location was perfect for us, as I had appointments at Mayo Clinic. Leo was a great host and addressed our concerns promptly."

5/2 Pool Cottage, Walk to Beach close to Mayo

10/10 Excellent

"Very clean and had everything we needed. Well worth it. Easy access to Mayo Clinic, beach and shopping. Tons of space in a quite neighborhood. The pool and pool house was bonus !"

Frequently asked questions

What's the area like around Mayo Clinic Florida?

Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, check out the 44 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic Florida?

Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

How many hotels will I find near Mayo Clinic Florida?

Expedia has 44 hotels and other accommodations within a mile from Mayo Clinic Florida.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review the best deals available near Mayo Clinic Florida.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Florida?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Florida, head over to our customer service page.

What can I see and do near Mayo Clinic Florida?

You can catch a show at SeaWalk Pavillion, Players by the Sea, and Blue Jay Listening Room. Spend some time exploring the natural beauty of Huguenot Park, Oceanfront Park, and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

Find hotels near Mayo Clinic Florida, Jacksonville from SAR 412

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Our top choices for Mayo Clinic Florida hotels

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

2. TownePlace Suites by Marriott Jacksonville East

3. Hilton Jacksonville at Mayo Clinic near Beaches

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

5. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

7. Hotel Palms

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

9. Element by Marriott Jacksonville Beach

10. Hyatt Studios Jacksonville/St Johns Town Center

11. Hotel Indigo Jacksonville-Deerwood Park by IHG

12. AC Hotel Jacksonville St Johns Town Center

13. Hampton Inn Jacksonville Beach/Oceanfront

14. Hyatt Place Jacksonville / St. Johns Town Center

15. Tru By Hilton Jacksonville St Johns Town Center

16. Courtyard by Marriott Jacksonville I-295/East Beltway

17. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

18. Holiday Inn Express Jacksonville Beach by IHG

19. Best Western Oceanfront

20. Four Points by Sheraton Jacksonville Beachfront

Compare popular hotels close to Mayo Clinic Florida

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Cozy & Comfy 3 bedroom residential home

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

5/2 Pool Cottage, Walk to Beach close to Mayo

Frequently asked questions