The Best Hotels Closest to Mayo Clinic Florida in Jacksonville for 2026

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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.

A modern kitchen with a bar area, seating, and a view of the outdoors.

A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

1.1 km from Mayo Clinic Florida

Michaelanne

SAR 514

SAR 583 total

includes taxes & fees

23 Oct - 24 Oct

An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

A hotel room with a bed, a sofa, a nightstand, and a wall-mounted lamp.

A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.

An outdoor patio with a pool, wooden pergola, and seating area.

2. TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

gregory

SAR 462

SAR 524 total

includes taxes & fees

25 Oct - 26 Oct

A modern restaurant with a bar area, wooden ceiling, and large windows.

A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.

A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

A modern lobby with a curved sofa, round coffee tables, and a large pillar.

3. Hilton Jacksonville at Mayo Clinic near Beaches

0.8 km from Mayo Clinic Florida

Patricia

SAR 635

SAR 721 total

includes taxes & fees

30 Oct - 31 Oct

A lobby with a reception desk, seating area, and a staircase.

A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.

A modern kitchen with a refrigerator, coffee machine, and a bakery display.

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.6 km from Mayo Clinic Florida

frances

SAR 361

SAR 409 total

includes taxes & fees

1 Nov - 2 Nov

A hotel lobby with a bar area, seating arrangements, and a reception desk.

A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.

An outdoor patio with a brick wall, a round table with striped chairs, and two large umbrellas.

A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.

5. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

Patsy

SAR 411

SAR 467 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

0.4 km from Mayo Clinic Florida

Patricia

SAR 571

SAR 648 total

includes taxes & fees

17 Oct - 18 Oct

A compact living space with a kitchenette, a woven chair, a round table, and a sofa.

A backyard with a swimming pool, wooden deck, and outdoor furniture.

A wooden fence with a blue and white striped umbrella, two green lounge chairs, and a white chair.

A room with a round marble table, two woven chairs, and wall decorations including seashells and a framed painting.

7. Hotel Palms

7.8 km from Mayo Clinic Florida

Vinny

SAR 716

SAR 813 total

includes taxes & fees

14 Oct - 15 Oct

A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.

A beverage refrigerator stocked with various drinks, a small refrigerator, and a wall-mounted display with promotional items.

A hotel room with two beds, a desk, a chair, and a large window with a view.

A coastal cityscape with a long beach, a large hotel with a curved facade, and a clear sky.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Southside, 7.7 km from Mayo Clinic Florida

Aneudi

SAR 447

SAR 507 total

includes taxes & fees

29 Oct - 30 Oct

An outdoor patio area with seating, a fire pit, and a barbecue grill.

A modern kitchen with wooden cabinets, a central island with jars, and a countertop with toasters.

A modern living room with sofas, a coffee table, and a dining area.

A modern hotel with a sign reading "Towneplace Suites by Marriott" and a parking lot in front.

9. TownePlace Suites by Marriott® Jacksonville Mayport

10.8 km from Mayo Clinic Florida

irina

SAR 477

SAR 541 total

includes taxes & fees

18 Oct - 19 Oct

A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.

A modern hotel lobby with a long reception desk, seating area, and large windows.

A modern building entrance with a sign reading "element by Westin".

A pathway leading to a sunset over a beach with sand and grass.

10. Element by Marriott Jacksonville Beach

5.4 km from Mayo Clinic Florida

Lisa

SAR 541

SAR 614 total

includes taxes & fees

25 Oct - 26 Oct

A laptop on a wooden desk with a white mug, a spoon, and a smartphone.

A modern hotel building with a flat roof, large windows, and a sign reading 'HYATT studios'.

11. Hyatt Studios Jacksonville/St Johns Town Center

Deerwood, 7.8 km from Mayo Clinic Florida

Camoya

SAR 436

SAR 495 total

includes taxes & fees

29 Oct - 30 Oct

An outdoor seating area with a fire feature, chairs, and a table.

A modern bar area with a curved counter, multiple bar stools, and a variety of liquor bottles.

A modern bar area with a counter, bar stools, and a television screen.

A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.

12. Hotel Indigo Jacksonville-Deerwood Park by IHG

Southside, 10.8 km from Mayo Clinic Florida

Carol

SAR 443

SAR 503 total

includes taxes & fees

12 Nov - 13 Nov

A pool with a waterfall feature, surrounded by large rock formations.

A hotel room with two beds, a desk with a flat-screen TV, a chair, and a large window with a view of palm trees.

A beachfront hotel with multiple balconies, a sandy beach, and ocean views.

13. Hampton Inn Jacksonville Beach/Oceanfront

6.3 km from Mayo Clinic Florida

Hope

SAR 603

SAR 685 total

includes taxes & fees

25 Oct - 26 Oct

A modern bar area with wooden accents, a variety of beverages, and seating arrangements.

A modern bar area with a wooden counter, multiple seating options including bar stools and round tables, and a menu board.

A multi-story hotel with a prominent entrance, a parking lot, and well-maintained landscaping.

A modern hotel lobby with a sofa set, armchairs, a coffee table, and a patterned carpet.

14. Courtyard by Marriott Jacksonville I-295/East Beltway

Arlington, 13.2 km from Mayo Clinic Florida

Chloie Marie

SAR 363

SAR 412 total

includes taxes & fees

26 Oct - 27 Oct

An outdoor patio with seating, a fire pit, and string lights.

A multi-story hotel with a modern design, featuring a large number of windows and a flat roof.

A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a fence.

A modern living room with a dining area, a flat-screen TV, and a bookshelf.

15. Hyatt Place Jacksonville / St. Johns Town Center

Southside, 8.6 km from Mayo Clinic Florida

Becky

SAR 478

SAR 542 total

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a reception desk, seating area, and large windows.

An indoor dining area with tables and chairs, a ceiling fan, and a view of the outdoors.

A modern coffee shop interior with a central counter, shelves stocked with snacks, and a refrigerated section labeled 'FROZEN' and 'CHILLED'.

A bar area with wooden chairs, a round table, and a brick wall.

16. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

8.5 km from Mayo Clinic Florida

William

SAR 442

SAR 493 total

includes taxes & fees

19 Oct - 20 Oct

A beach with a sandy shore, waves, and buildings in the background.

A modern lobby with a grey sofa, two round tables, a reception desk, and a wooden wall with shelves displaying trophies and awards.

A balcony with two green chairs and a small table, overlooking a beach and a boardwalk.

A modern cafe with a central counter, seating area, and a wooden accent wall with 'BW' letters.

17. Best Western Oceanfront

5.7 km from Mayo Clinic Florida

Stephanie

SAR 496

SAR 563 total

includes taxes & fees

19 Oct - 20 Oct

A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.

A coffee station with two espresso machines and a display of coffee products.

A hotel room with a microwave, coffee maker, and refrigerator on the counter. There is a door with a sign and a towel rack visible.

A golf course with a water hazard and a bridge.

18. Holiday Inn Express Jacksonville Beach by IHG

4.6 km from Mayo Clinic Florida

Bobby

SAR 413

SAR 469 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with a bed, a TV, a wooden dresser, a mirror, and a view of the sea.

A hotel room with a large bed, a desk, a chair, a TV, and a view of the ocean.

A hotel with a beach view, multiple parking levels, and a prominent 'Four Points' sign.

19. Four Points by Sheraton Jacksonville Beachfront

5.6 km from Mayo Clinic Florida

Rachel

SAR 667

SAR 757 total

includes taxes & fees

1 Nov - 2 Nov

A terrace with wooden tables and chairs, overlooking a beach and a pier.

A modern living room with a sectional sofa, two round coffee tables, wicker chairs, and large windows with sheer curtains.

A bar area with wooden beams, wicker hanging lights, and a bar stocked with bottles.

A spacious outdoor dining area with wooden tables and chairs, a bar with stools, and large windows offering a view of the ocean.

20. Springhill Suites By Marriott Jacksonville Beach Oceanfront

5.8 km from Mayo Clinic Florida

MELISSA

SAR 651

SAR 739 total

includes taxes & fees

25 Oct - 26 Oct

View all properties

Compare popular hotels close to Mayo Clinic Florida

Property	Property class	Guest rating
Residence Inn By Marriott Jacksonville - Mayo Clinic Area	9.4 Exceptional 606 reviews	View
TownePlace Suites by Marriott Jacksonville East	9.2 Wonderful 662 reviews	View
Hilton Jacksonville at Mayo Clinic near Beaches	9.2 Wonderful 371 reviews	View
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG	9.0 Wonderful 1,002 reviews	View
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic	9.0 Wonderful 1,005 reviews	View

Top Mayo Clinic Florida Hotel Reviews

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent

"Overall nice, very slight issue with kid noise let evening/ after 10 pm."

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

10/10 Excellent

"Clean and spacious room. Breakfast was good and had different options."

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

10/10 Excellent

"Clean, cozy house with a quiet neighborhood, close to several restaurants and shopping. The only downfall was there was no tv in the bunk bed room, there was no grill as listed, and the beds were a little too firm. Would def stay here again! Very clean and well kept."

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

10/10 Excellent

"Carson was a great host. The communication process was excellent. He responded back to me fast and the property was cleaned and had everything that we needed. Would definitely come back again."

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

10/10 Excellent

"The property was very clean and spacious. The host was responsive.She was also helpful with area recommendations. She went above and beyond our expectations. The home is well-supplied with just about anything you could need.The beds were very comfortable.The property is located in a safe and convenient neighborhood.We would definitely stay again."

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

8/10 Good

"The location was perfect for us, as I had appointments at Mayo Clinic. Leo was a great host and addressed our concerns promptly."

5/2 Pool Cottage, Walk to Beach close to Mayo

10/10 Excellent

"Very clean and had everything we needed. Well worth it. Easy access to Mayo Clinic, beach and shopping. Tons of space in a quite neighborhood. The pool and pool house was bonus !"

Cozy & Comfy 3 bedroom residential home

10/10 Excellent

"Clean, close to Mayo Clinic, and host was very kind and quick to respond"

Quiet Coastal Home w/ Patio Near Beaches

8/10 Good

"It was a pleasure staying here, the house was exactly as pictured showed. We were close to shopping areas and was only 10 min from the beach, which was a plus. I enjoyed the enclosed porch and the large yard( please just make sure the grass is cut before guest arrives) I love that the host communicated quickly. I would definitely book again. Thank you!"

Frequently asked questions

What's the area like around Mayo Clinic Florida?

Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, check out the 44 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic Florida?

Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

How many hotels will I find near Mayo Clinic Florida?

Expedia has 44 hotels and other accommodations within a mile from Mayo Clinic Florida.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review the best deals available near Mayo Clinic Florida.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Florida?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Florida, head over to our customer service page.

What can I see and do near Mayo Clinic Florida?

You can catch a show at SeaWalk Pavillion, Players by the Sea, and Blue Jay Listening Room. Spend some time exploring the natural beauty of Huguenot Park, Oceanfront Park, and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

Find hotels near Mayo Clinic Florida, Jacksonville from SAR 409

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Our top choices for Mayo Clinic Florida hotels

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

2. TownePlace Suites by Marriott Jacksonville East

3. Hilton Jacksonville at Mayo Clinic near Beaches

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

5. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

7. Hotel Palms

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

9. TownePlace Suites by Marriott® Jacksonville Mayport

10. Element by Marriott Jacksonville Beach

11. Hyatt Studios Jacksonville/St Johns Town Center

12. Hotel Indigo Jacksonville-Deerwood Park by IHG

13. Hampton Inn Jacksonville Beach/Oceanfront

14. Courtyard by Marriott Jacksonville I-295/East Beltway

15. Hyatt Place Jacksonville / St. Johns Town Center

16. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

17. Best Western Oceanfront

18. Holiday Inn Express Jacksonville Beach by IHG

19. Four Points by Sheraton Jacksonville Beachfront

20. Springhill Suites By Marriott Jacksonville Beach Oceanfront

Compare popular hotels close to Mayo Clinic Florida

Top Mayo Clinic Florida Hotel Reviews

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

5/2 Pool Cottage, Walk to Beach close to Mayo

Cozy & Comfy 3 bedroom residential home

Quiet Coastal Home w/ Patio Near Beaches

Frequently asked questions