The Best Hotels Closest to Mayo Clinic Florida in Jacksonville for 2026

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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.

A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.

An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

1.1 km from Mayo Clinic Florida

Michaelanne

SAR 513

SAR 583 total

includes taxes & fees

24 Oct - 25 Oct

An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

An outdoor patio with a pool, wooden pergola, and seating area.

A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.

A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.

2. TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

gregory

SAR 462

SAR 524 total

includes taxes & fees

25 Oct - 26 Oct

A modern restaurant with a bar area, wooden ceiling, and large windows.

A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

A modern lobby with a curved sofa, round coffee tables, and a large pillar.

A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.

3. Hilton Jacksonville at Mayo Clinic near Beaches

0.8 km from Mayo Clinic Florida

Patricia

SAR 635

SAR 721 total

includes taxes & fees

17 Oct - 18 Oct

A hotel lobby with a bar area, seating arrangements, and a reception desk.

A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.

A hotel pool area with a long, narrow pool, multiple lounge chairs, and a covered seating area.

A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

Patsy

SAR 411

SAR 467 total

includes taxes & fees

11 Oct - 12 Oct

A lobby with a reception desk, seating area, and a staircase.

A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.

A modern kitchen with a refrigerator, coffee machine, and a bakery display.

5. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.6 km from Mayo Clinic Florida

frances

SAR 379

SAR 430 total

includes taxes & fees

18 Oct - 19 Oct

An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.

A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

0.4 km from Mayo Clinic Florida

Patricia

SAR 571

SAR 648 total

includes taxes & fees

10 Oct - 11 Oct

A hotel room with two beds, a floral wallpaper, a ceiling light, and a wall-mounted air conditioner.

A door with the number 312, a window with blinds, a green door mat, a chair with a geometric pattern, and small plants.

A wooden fence with a blue and white striped umbrella, two green lounge chairs, and a white chair.

A backyard with a swimming pool, wooden deck, and outdoor furniture.

7. Hotel Palms

7.8 km from Mayo Clinic Florida

Vinny

SAR 597

SAR 677 total

includes taxes & fees

6 Oct - 7 Oct

A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.

A gym with treadmills, elliptical machines, and free weights.

A beverage refrigerator stocked with various drinks, a small refrigerator, and a wall-mounted display with promotional items.

A hotel room with two beds, a desk, a chair, and a large window with a view.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Southside, 7.7 km from Mayo Clinic Florida

Ian

SAR 447

SAR 507 total

includes taxes & fees

29 Oct - 30 Oct

A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.

A modern building entrance with a sign reading "element by Westin".

A modern conference room with a long table, several chairs, and pendant lighting.

A pathway leading to a sunset over a beach with sand and grass.

9. Element by Marriott Jacksonville Beach

5.4 km from Mayo Clinic Florida

Nick

SAR 541

SAR 614 total

includes taxes & fees

26 Oct - 27 Oct

A laptop on a wooden desk with a white mug, a spoon, and a smartphone.

10. Hyatt Studios Jacksonville/St Johns Town Center

Deerwood, 7.8 km from Mayo Clinic Florida

Corey

SAR 432

SAR 490 total

includes taxes & fees

30 Oct - 31 Oct

An outdoor seating area with a fire feature, chairs, and a table.

A modern bar area with a counter, bar stools, and a television screen.

A gym with treadmills, dumbbells, and exercise balls, overlooking a swimming pool.

A modern bar area with a curved counter, multiple bar stools, and a variety of liquor bottles.

11. Hotel Indigo Jacksonville-Deerwood Park by IHG

Southside, 10.8 km from Mayo Clinic Florida

Carol

SAR 492

SAR 558 total

includes taxes & fees

11 Oct - 12 Oct

A pool with a waterfall feature, surrounded by large rock formations.

A bar with a tiled roof, outdoor seating, and a view of the ocean.

A hotel with a pool, a parking lot, and a view of the ocean.

A beachfront hotel with multiple balconies, a sandy beach, and ocean views.

12. Hampton Inn Jacksonville Beach/Oceanfront

6.3 km from Mayo Clinic Florida

Hope

SAR 635

SAR 721 total

includes taxes & fees

11 Oct - 12 Oct

A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.

A modern hotel building with a flat facade, large windows, and a sign reading "ACHTEL JACKSONVILLE".

A modern hotel with a pool, palm trees, and a clear blue sky.

An outdoor seating area with white furniture and a well-maintained lawn, surrounded by large windows and a modern building facade.

13. AC Hotel Jacksonville St Johns Town Center

Southside, 8.1 km from Mayo Clinic Florida

Emily

SAR 672

SAR 763 total

includes taxes & fees

10 Oct - 11 Oct

An outdoor patio with seating, a fire pit, and string lights.

A modern bar area with a counter, bar stools, and a television screen. There are round tables with chairs in the dining area.

A multi-story hotel with a modern design, featuring a large number of windows and a flat roof.

A modern living room with a dining area, a flat-screen TV, and a bookshelf.

14. Hyatt Place Jacksonville / St. Johns Town Center

Southside, 8.6 km from Mayo Clinic Florida

Becky

SAR 478

SAR 542 total

includes taxes & fees

15 Oct - 16 Oct

A modern bar area with wooden accents, a variety of beverages, and seating arrangements.

A patio area with a stone fire pit, outdoor furniture, and a brick floor.

A modern hotel lobby with a sofa set, armchairs, a coffee table, and a patterned carpet.

A modern bar area with a wooden counter, multiple seating options including bar stools and round tables, and a menu board.

15. Courtyard by Marriott Jacksonville I-295/East Beltway

Arlington, 13.2 km from Mayo Clinic Florida

Chloie Marie

SAR 363

SAR 412 total

includes taxes & fees

10 Oct - 11 Oct

A self-service beverage station with a refrigerated display and a coffee machine.

A snack display in a store with various chips and snacks.

A hotel room with two beds, a desk, a chair, a TV, and a large window with a view.

A modern lounge area with seating, tables, and hanging lights.

16. Tru By Hilton Jacksonville St Johns Town Center

Southside, 8.7 km from Mayo Clinic Florida

Mary

SAR 411

SAR 467 total

includes taxes & fees

11 Oct - 12 Oct

A spacious lobby with a reception desk, seating area, and large windows.

A modern coffee shop interior with a central counter, shelves stocked with snacks, and a refrigerated section labeled 'FROZEN' and 'CHILLED'.

An indoor dining area with tables and chairs, a ceiling fan, and a view of the outdoors.

A bar area with wooden chairs, a round table, and a brick wall.

17. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

8.5 km from Mayo Clinic Florida

William

SAR 442

SAR 493 total

includes taxes & fees

20 Oct - 21 Oct

A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.

A golf course with a water hazard and a bridge.

A hotel room with a microwave, coffee maker, and refrigerator on the counter. There is a door with a sign and a towel rack visible.

A pier extending into the ocean at sunset with birds flying above.

18. Holiday Inn Express Jacksonville Beach by IHG

4.6 km from Mayo Clinic Florida

Bobby

SAR 413

SAR 469 total

includes taxes & fees

18 Oct - 19 Oct

A beach with a sandy shore, waves, and buildings in the background.

A balcony with two green chairs and a small table, overlooking a beach and a boardwalk.

A modern lobby with a grey sofa, two round tables, a reception desk, and a wooden wall with shelves displaying trophies and awards.

A Best Western hotel with a modern design, located near a beach with a pier.

19. Best Western Oceanfront

5.7 km from Mayo Clinic Florida

Stephanie

SAR 496

SAR 562 total

includes taxes & fees

14 Oct - 15 Oct

A terrace with wooden tables and chairs, overlooking a beach and a pier.

A modern living room with a sectional sofa, two round coffee tables, wicker chairs, and large windows with sheer curtains.

A beach with a wooden boardwalk leading to a pier.

A bar area with wooden beams, wicker hanging lights, and a bar stocked with bottles.

20. Springhill Suites By Marriott Jacksonville Beach Oceanfront

5.8 km from Mayo Clinic Florida

MELISSA

SAR 651

SAR 739 total

includes taxes & fees

25 Oct - 26 Oct

View all properties

Compare popular hotels close to Mayo Clinic Florida

Property	Property class	Guest rating
Residence Inn By Marriott Jacksonville - Mayo Clinic Area	9.4 Exceptional 604 reviews	View
TownePlace Suites by Marriott Jacksonville East	9.2 Wonderful 661 reviews	View
Hilton Jacksonville at Mayo Clinic near Beaches	9.2 Wonderful 365 reviews	View
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic	9.0 Wonderful 1,002 reviews	View
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG	9.0 Wonderful 1,002 reviews	View

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

10/10 Excellent

"Great hotel and loved the vibe and decor! (I do wish the shower had a door because it got a little cold showering, other than that it was awesome!)"

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

10/10 Excellent

"The property was very clean and spacious. The host was responsive.She was also helpful with area recommendations. She went above and beyond our expectations. The home is well-supplied with just about anything you could need.The beds were very comfortable.The property is located in a safe and convenient neighborhood.We would definitely stay again."

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

10/10 Excellent

"The staff was very helpful and the parking easy and, in parts, quite shady. It was within easy walking distance of the Mayo Clinic!"

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

8/10 Good

"The location was perfect for us, as I had appointments at Mayo Clinic. Leo was a great host and addressed our concerns promptly."

5/2 Pool Cottage, Walk to Beach close to Mayo

10/10 Excellent

"Very clean and had everything we needed. Well worth it. Easy access to Mayo Clinic, beach and shopping. Tons of space in a quite neighborhood. The pool and pool house was bonus !"

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

10/10 Excellent

"Place was exactly as pictured and perfect for our stay. Spacious, great amenities, and convenient location. Our family loved the putting green and pool table for some friendly competition. Top of our list as a place to stay the next time we're in JAX!"

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

10/10 Excellent

"Wonderful property! My family loved the pool table and darts. So much fun. Thanks for a great weekend."

Cozy & Comfy 3 bedroom residential home

10/10 Excellent

"Clean, close to Mayo Clinic, and host was very kind and quick to respond"

Quiet Coastal Home w/ Patio Near Beaches

8/10 Good

"It was a pleasure staying here, the house was exactly as pictured showed. We were close to shopping areas and was only 10 min from the beach, which was a plus. I enjoyed the enclosed porch and the large yard( please just make sure the grass is cut before guest arrives) I love that the host communicated quickly. I would definitely book again. Thank you!"

Frequently asked questions

What's the area like around Mayo Clinic Florida?

Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, check out the 44 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic Florida?

Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

How many hotels will I find near Mayo Clinic Florida?

Expedia has 44 hotels and other accommodations within a mile from Mayo Clinic Florida.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review the best deals available near Mayo Clinic Florida.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Florida?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Florida, head over to our customer service page.

What can I see and do near Mayo Clinic Florida?

You can catch a show at SeaWalk Pavillion, Players by the Sea, and Blue Jay Listening Room. Spend some time exploring the natural beauty of Huguenot Park, Oceanfront Park, and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

Find hotels near Mayo Clinic Florida, Jacksonville from SAR 412

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Our top choices for Mayo Clinic Florida hotels

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

2. TownePlace Suites by Marriott Jacksonville East

3. Hilton Jacksonville at Mayo Clinic near Beaches

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

5. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

7. Hotel Palms

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

9. Element by Marriott Jacksonville Beach

10. Hyatt Studios Jacksonville/St Johns Town Center

11. Hotel Indigo Jacksonville-Deerwood Park by IHG

12. Hampton Inn Jacksonville Beach/Oceanfront

13. AC Hotel Jacksonville St Johns Town Center

14. Hyatt Place Jacksonville / St. Johns Town Center

15. Courtyard by Marriott Jacksonville I-295/East Beltway

16. Tru By Hilton Jacksonville St Johns Town Center

17. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

18. Holiday Inn Express Jacksonville Beach by IHG

19. Best Western Oceanfront

20. Springhill Suites By Marriott Jacksonville Beach Oceanfront

Compare popular hotels close to Mayo Clinic Florida

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

5/2 Pool Cottage, Walk to Beach close to Mayo

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Cozy & Comfy 3 bedroom residential home

Quiet Coastal Home w/ Patio Near Beaches

Frequently asked questions