The Best Hotels Closest to Lester E. Cox Medical Center South in Springfield for 2026

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Our top choices for Lester E. Cox Medical Center South hotels

1. Hampton Inn Springfield-South

Galloway Village, 2 km from Lester E. Cox Medical Center South

Ashley

SAR 382

SAR 434 total

includes taxes & fees

27 Sep - 28 Sep

Iron/ironing board, cribs (free), rollaway beds (surcharge), bed sheets

2. Homewood Suites by Hilton Springfield Medical District

Southside, 1.4 km from Lester E. Cox Medical Center South

Heather

SAR 524

SAR 594 total

includes taxes & fees

28 Sep - 29 Sep

Standard Room, 2 Queen Beds | Pillowtop beds, in-room safe, desk, laptop workspace

3. Holiday Inn Express and Suites Springfield Medical District by IHG

1.6 km from Lester E. Cox Medical Center South

Gwen

SAR 556

SAR 631 total

includes taxes & fees

27 Sep - 28 Sep

Studio Suite, 2 Double Beds, Kitchen | In-room safe, desk, iron/ironing board, WiFi (free)

In-room safe, desk, iron/ironing board, WiFi (free)

4. Candlewood Suites Springfield-Medical District

0.9 km from Lester E. Cox Medical Center South

Richard

SAR 458

SAR 520 total

includes taxes & fees

18 Oct - 19 Oct

5. Hilton Garden Inn Springfield, MO

Lake Springfield, 2.7 km from Lester E. Cox Medical Center South

Donald

SAR 440

SAR 504 total

includes taxes & fees

17 Oct - 18 Oct

Coffee/tea maker, full-size fridge, microwave, stovetop

Suite, 2 Bedrooms | Premium bedding, desk, iron/ironing board, cribs (free)

6. Residence Inn by Marriott Springfield

Southside, 0.8 km from Lester E. Cox Medical Center South

Darren

SAR 460

SAR 522 total

includes taxes & fees

11 Oct - 12 Oct

7. Element by Marriott Springfield South

Meador Park, 1.5 km from Lester E. Cox Medical Center South

Rebecca

SAR 541

SAR 614 total

includes taxes & fees

18 Oct - 19 Oct

Room, 2 Queen Beds, Non Smoking | Premium bedding, down comforters, pillowtop beds, in-room safe

Premium bedding, down comforters, pillowtop beds, in-room safe

8. La Quinta Inn & Suites by Wyndham Springfield South

Seminole Holland, 2.8 km from Lester E. Cox Medical Center South

Teresa

SAR 334

SAR 386 total

includes taxes & fees

27 Sep - 28 Sep

Suite, Multiple Beds, Non Smoking | Premium bedding, blackout drapes, iron/ironing board, WiFi (free)

9. MainStay Suites Springfield South - Battlefield Rd

Bradford Park, 1.7 km from Lester E. Cox Medical Center South

Katie

SAR 348

SAR 395 total

includes taxes & fees

19 Oct - 20 Oct

10. Comfort Inn South - Springfield

Galloway Village, 2.3 km from Lester E. Cox Medical Center South

Roger

SAR 372

SAR 422 total

includes taxes & fees

11 Oct - 12 Oct

Standard Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board (on request), WiFi (free)

11. The Bradford Hotel, an Ascend Collection Hotel

Bradford Park, 0.5 km from Lester E. Cox Medical Center South

William

SAR 327

SAR 372 total

includes taxes & fees

18 Oct - 19 Oct

Standard Room, 1 King Bed, Non Smoking | Desk, blackout drapes, iron/ironing board, WiFi (free)

12. Sleep Inn Springfield South I60 near Medical District

1.8 km from Lester E. Cox Medical Center South

Dina

SAR 322

SAR 365 total

includes taxes & fees

11 Oct - 12 Oct

Studio, 1 King Bed, Non Smoking | Desk, WiFi (free), bed sheets

Studio, 1 Queen Bed, Accessible, Non Smoking | Desk, WiFi (free), bed sheets

13. Extended Stay America Select Suites Springfield South

Southside, 0.9 km from Lester E. Cox Medical Center South

Crystal

SAR 308

SAR 349 total

includes taxes & fees

4 Oct - 5 Oct

Standard Room, 2 Queen Beds, Non Smoking | Premium bedding, desk, laptop workspace, blackout drapes

14. Clarion Pointe Springfield Southeast

Galloway Village, 4.8 km from Lester E. Cox Medical Center South

Stephen

SAR 323

SAR 366 total

includes taxes & fees

4 Oct - 5 Oct

Indoor pool, open 8:00 AM to 10:00 PM, sun loungers

Studio, 2 Queen Beds, Refrigerator & Microwave (Wet Bar) | Private kitchen | Fridge

15. Hampton Inn Springfield-Southeast

Galloway Village, 4.9 km from Lester E. Cox Medical Center South

Donna Sue

SAR 447

SAR 507 total

includes taxes & fees

28 Sep - 29 Sep

Premium bedding, in-room safe, desk, laptop workspace

16. Holiday Inn Express & Suites Springfield North by IHG

11.8 km from Lester E. Cox Medical Center South

Jerry

SAR 394

SAR 448 total

includes taxes & fees

27 Sep - 28 Sep

17. Drury Inn & Suites Springfield, MO

11.2 km from Lester E. Cox Medical Center South

Emily

SAR 398

SAR 456 total

includes taxes & fees

27 Sep - 28 Sep

Desk, laptop workspace, blackout drapes, iron/ironing board

18. SpringHill Suites by Marriott Springfield North

Parkwood, 11.6 km from Lester E. Cox Medical Center South

Lisa

SAR 428

SAR 503 total

includes taxes & fees

11 Oct - 12 Oct

Standard Room, 1 Queen Bed, Jetted Tub | Iron/ironing board, WiFi (free), individually decorated

19. Walnut Street Inn

6.7 km from Lester E. Cox Medical Center South

Alan

SAR 521

SAR 591 total

includes taxes & fees

21 Sep - 22 Sep

20. Best Western Courtview Hotel

Galloway Village, 5 km from Lester E. Cox Medical Center South

gillian

SAR 319

SAR 362 total

includes taxes & fees

30 Sep - 1 Oct

View all properties

Compare popular hotels close to Lester E. Cox Medical Center South

Property	Property class	Guest rating
Hampton Inn Springfield-South	9.4 Exceptional 711 reviews	View
Homewood Suites by Hilton Springfield Medical District	9.4 Exceptional 556 reviews	View
Holiday Inn Express and Suites Springfield Medical District by IHG	9.4 Exceptional 1,002 reviews	View
Candlewood Suites Springfield-Medical District	9.2 Wonderful 433 reviews	View
Hilton Garden Inn Springfield, MO	9.0 Wonderful 874 reviews	View

Top Lester E. Cox Medical Center South Hotel Reviews

The Bradford Hotel, an Ascend Collection Hotel

8/10 Good

"Great value. Fully remodeled rooms. Good location. Room was clean but one of the beds had a blood stain on the sheets. Needs better shower heads, water pressure was good though. Housekeeping carts were loud in the morning rolling around outside the room."

Comfort Inn South - Springfield

10/10 Excellent

"It was comforting"

Sleep Inn Springfield South I60 near Medical District

10/10 Excellent

"Great experience"

MainStay Suites Springfield South - Battlefield Rd

8/10 Good

"The property over all was perfect for us for the weekend. We had all the things we needed available and plenty of space for everyone."

Homewood Suites by Hilton Springfield Medical District

10/10 Excellent

"No issues"

Element by Marriott Springfield South

10/10 Excellent

"Super clean, great amenities, planning to stay here anytime we visit Springfield."

Residence Inn by Marriott Springfield

10/10 Excellent

"Room was exceptionally clean. Hotel staff were very friendly. The continental breakfast was extremely good."

Peaceful Retreat near Medical Mile in Springfield

10/10 Excellent

"What a beautiful & stocked house! It truly is a home away from home. We loved the fenced yard for our dogs. Would definitely rent this property again!!"

Cozy Central Home by CoxHealth & MSU - Fenced Yard

10/10 Excellent

"Good location and beautiful home."

Frequently asked questions

What's the area like around Lester E. Cox Medical Center South?

Lester E. Cox Medical Center South is located in a welcoming area of Springfield that travelers like for its sporting events and opera houses. If you're looking for a convenient place to stay, check out the 20 hotels and other accommodations you'll find within a mile.

What's the best hotel to stay close to Lester E. Cox Medical Center South?

Residence Inn by Marriott Springfield is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a restaurant. It's located just a short 0.5 mi (0.8 km) from Lester E. Cox Medical Center South. Other good choices close by include The Bradford Hotel, an Ascend Collection Hotel and Extended Stay America Select Suites Springfield South.

How many hotels are there close to Lester E. Cox Medical Center South?

Expedia has 20 hotels and other accommodations within a mile from Lester E. Cox Medical Center South.

If I need to cancel the hotel reservation for my stay near Lester E. Cox Medical Center South, will I receive a refund?

Yes, the majority of hotel room reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the top deals on offer near Lester E. Cox Medical Center South.

Where can I learn more about changing or cancelling my trip in the area near Lester E. Cox Medical Center South?

For more information about picking new dates or cancelling your stay near Lester E. Cox Medical Center South, go to https://www.expedia.com/service/.

What can I see and do near Lester E. Cox Medical Center South?

You'll want to browse the exhibits at Springfield Art Museum and Discovery Center of Springfield. Sights like Abou Ben Adhem Shrine and Landers Theater highlight some of the local culture. You might spend a leisurely day outdoors at Nathanael Greene/Close Memorial Park and Mizumoto Japanese Stroll Garden.

Find hotels near Lester E. Cox Medical Center South, Springfield from SAR 349

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for Lester E. Cox Medical Center South hotels

1. Hampton Inn Springfield-South

2. Homewood Suites by Hilton Springfield Medical District

3. Holiday Inn Express and Suites Springfield Medical District by IHG

4. Candlewood Suites Springfield-Medical District

5. Hilton Garden Inn Springfield, MO

6. Residence Inn by Marriott Springfield

7. Element by Marriott Springfield South

8. La Quinta Inn & Suites by Wyndham Springfield South

9. MainStay Suites Springfield South - Battlefield Rd

10. Comfort Inn South - Springfield

11. The Bradford Hotel, an Ascend Collection Hotel

12. Sleep Inn Springfield South I60 near Medical District

13. Extended Stay America Select Suites Springfield South

14. Clarion Pointe Springfield Southeast

15. Hampton Inn Springfield-Southeast

16. Holiday Inn Express & Suites Springfield North by IHG

17. Drury Inn & Suites Springfield, MO

18. SpringHill Suites by Marriott Springfield North

19. Walnut Street Inn

20. Best Western Courtview Hotel

Compare popular hotels close to Lester E. Cox Medical Center South

Top Lester E. Cox Medical Center South Hotel Reviews

The Bradford Hotel, an Ascend Collection Hotel

Comfort Inn South - Springfield

Sleep Inn Springfield South I60 near Medical District

MainStay Suites Springfield South - Battlefield Rd

Homewood Suites by Hilton Springfield Medical District

Element by Marriott Springfield South

Residence Inn by Marriott Springfield

Peaceful Retreat near Medical Mile in Springfield

Cozy Central Home by CoxHealth & MSU - Fenced Yard

Frequently asked questions