The Best Hotels Closest to Lester E. Cox Medical Center South in Springfield for 2026

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Our top choices for Lester E. Cox Medical Center South hotels

A conference room with a granite table, cushioned chairs, a fruit bowl, framed pictures, and a flat-screen TV.

A living room with patterned armchairs, a dark sofa, a glass coffee table, and framed artwork on the walls.

A business center with two computers, a printer, and a lamp. There are signs indicating the business center is available 24 hours and providing emergency and front desk contact information.

The exterior of Hampton Inn with a clear sign, a welcome sign, and a clearance height sign.

1. Hampton Inn Springfield-South

Galloway Village, 2 km from Lester E. Cox Medical Center South

Ashley

SAR 396

SAR 449 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with a blue sofa, two single beds, a nightstand, a lamp, and a framed picture on the wall.

A coffee station with two coffee machines and a variety of coffee pods and cups.

A living room with a blue sofa, a small round table, a patterned carpet, and a kitchenette area.

A hotel dining area with a buffet, seating arrangements, and a kitchen counter.

2. Holiday Inn Express and Suites Springfield Medical District by IHG

1.6 km from Lester E. Cox Medical Center South

Gwen

SAR 473

SAR 537 total

includes taxes & fees

8 Nov - 9 Nov

An outdoor patio area with red seating, a fire feature, and tables and chairs.

A modern living room with a sectional sofa, a coffee table, and yellow armchairs. There is a dining area with a table and chairs in the background.

A modern hotel lobby with a bar, seating area, kitchen, and a TV.

A modern hotel with a dark facade, multiple windows, and an American flag.

3. Homewood Suites by Hilton Springfield Medical District

Southside, 1.4 km from Lester E. Cox Medical Center South

Aaron

SAR 506

SAR 575 total

includes taxes & fees

31 Oct - 1 Nov

A hotel room with two beds, a desk, a chair, a TV, and a bathroom with a sink and mirror.

A spacious lobby with a pool, comfortable seating, and a reception desk.

A modern hotel room with a sofa, armchair, and a dining area with a kitchen in the background.

A modern kitchen with a stainless steel microwave, a coffee maker, and a refrigerator.

4. Candlewood Suites Springfield-Medical District

0.9 km from Lester E. Cox Medical Center South

Richard

SAR 443

SAR 503 total

includes taxes & fees

1 Nov - 2 Nov

A spacious living area with large windows, a bar, and modern furniture.

A spacious kitchen with a large island, ample seating, and a view of the cityscape through large windows.

A modern kitchen with a bar area, featuring a large TV, wooden shelves, and bar stools.

A modern hotel building with a prominent 'element by Westin' sign, multiple floors, and a covered entrance area.

5. Element by Marriott Springfield South

Meador Park, 1.5 km from Lester E. Cox Medical Center South

Nathaniel

SAR 522

SAR 593 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor patio area with wicker furniture, a central fire pit, and large windows.

An indoor swimming pool with clear water, surrounded by a tiled floor and a glass wall.

A hotel with a stone facade, large windows, and a clear blue sky.

A spacious hotel lobby with high ceilings, large windows, and a central seating area with tables and chairs.

6. Hilton Garden Inn Springfield, MO

Lake Springfield, 2.7 km from Lester E. Cox Medical Center South

daryl

SAR 431

SAR 494 total

includes taxes & fees

31 Oct - 1 Nov

A spacious lounge area with comfortable seating, a fireplace, and artwork on the walls.

A buffet setup with various food items, a clock, and a coffee machine.

A hotel room with a desk, chair, TV, fireplace, bed, and a small dining area.

An outdoor patio with wicker furniture, a round table, and a grill area.

7. Residence Inn by Marriott Springfield

Southside, 0.8 km from Lester E. Cox Medical Center South

Jacob

SAR 444

SAR 504 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with two beds, a desk with a computer, a TV, and a coffee maker.

An indoor swimming pool with a tiled floor, a pool ladder, and a glass door leading to another room.

A hotel dining area with multiple tables and chairs, a kitchen counter with coffee machines, and a wall-mounted clock.

A hotel reception area with a counter displaying various alcohol bottles, a menu board, and artwork on the walls.

8. La Quinta Inn & Suites by Wyndham Springfield South

Seminole Holland, 2.8 km from Lester E. Cox Medical Center South

Denise

SAR 337

SAR 389 total

includes taxes & fees

25 Oct - 26 Oct

A modern living room with a flat-screen TV, a fireplace, a sofa, and a dining area with a kitchen counter.

A compact kitchen with a microwave, toaster, and refrigerator.

A kitchen area with a coffee machine, a buffet setup, and a dining table with chairs.

A modern living room with a fireplace, a sofa, a TV, and a staircase leading to a bedroom.

9. MainStay Suites Springfield South - Battlefield Rd

Bradford Park, 1.7 km from Lester E. Cox Medical Center South

Arthur

SAR 348

SAR 395 total

includes taxes & fees

8 Nov - 9 Nov

An indoor swimming pool with a glass ceiling, surrounded by lounge chairs and a view of the outdoors.

A modern restaurant with a stone backsplash, wooden cabinets, and a herringbone floor pattern.

A modern living room with blue sofas, a stone accent wall, and a bookshelf.

A Comfort Inn hotel with a modern facade, a covered entrance, and a parking lot.

10. Comfort Inn South - Springfield

Galloway Village, 2.3 km from Lester E. Cox Medical Center South

Roger

SAR 362

SAR 411 total

includes taxes & fees

8 Nov - 9 Nov

A modern hotel lobby with a leather sofa, green chairs, a black coffee table, and a kitchen area with a green countertop.

A spacious indoor dining area with multiple round tables and chairs, large windows, and a modern staircase.

A hotel room with two beds, a desk with a chair, a flat-screen TV, and a large window with curtains.

A hotel with a prominent sign, a covered parking area, and a well-lit entrance.

11. The Bradford Hotel, an Ascend Collection Hotel

Bradford Park, 0.5 km from Lester E. Cox Medical Center South

William

SAR 342

SAR 388 total

includes taxes & fees

8 Nov - 9 Nov

A hotel lobby with a reception desk, a staircase, and a seating area.

A hotel room with a bed, a chair, a nightstand with a lamp, and framed pictures on the wall.

A modern hotel lobby with a sofa, armchairs, a coffee table, and a staircase.

A swimming pool with a hot tub, tiled floor, and a few lounge chairs.

12. Sleep Inn Springfield South I60 near Medical District

1.8 km from Lester E. Cox Medical Center South

Dina

SAR 316

SAR 359 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with a large bed, a chair, a nightstand, a lamp, and a door.

A hotel reception area with a reception desk, a framed artwork, and an exit sign.

A compact kitchenette with white cabinets, a sink, a microwave, and a refrigerator.

A hotel room with a brown leather sofa, a small table, a floor lamp, and a green accent wall.

13. Extended Stay America Select Suites Springfield South

Southside, 0.9 km from Lester E. Cox Medical Center South

Crystal

SAR 270

SAR 307 total

includes taxes & fees

30 Oct - 31 Oct

A hotel room with a bed, bedside table, lamp, and a painting of a sunset.

A modern dining area with blue chairs and white tables, a flat-screen TV mounted on the wall, and a wooden cabinet with items on it.

A gym with exercise equipment, a treadmill, and a wall mural of athletes.

14. Clarion Pointe Springfield Southeast

Galloway Village, 4.8 km from Lester E. Cox Medical Center South

Amanda

SAR 313

SAR 355 total

includes taxes & fees

19 Oct - 20 Oct

A modern hotel room with a large bed, a desk with a sink, and a view of the cityscape through large windows.

A bar area with a checkered floor, bar stools, and a long counter with a barista station.

A rooftop lounge with wooden flooring, various seating options including sofas and chairs, a round table, and potted plants.

A modern building with a prominent V-shaped entrance and large glass windows.

15. Hotel Vandivort

Downtown Springfield, 6.8 km from Lester E. Cox Medical Center South

George

SAR 588

SAR 670 total

includes taxes & fees

8 Nov - 9 Nov

A spacious indoor dining area with multiple tables and chairs, a kitchen area, and large windows allowing natural light.

A modern lobby with a reception desk, seating area, and a high ceiling with recessed lighting.

A spa area with a hot tub, a pool, and a seating area with tables and chairs.

A Drury Inn & Suites hotel with a modern design, featuring a prominent entrance and stone pillars.

16. Drury Inn & Suites Springfield, MO

11.2 km from Lester E. Cox Medical Center South

Renee

SAR 398

SAR 456 total

includes taxes & fees

25 Oct - 26 Oct

A cozy living room with a stone fireplace, comfortable seating, and a large mirror reflecting the room.

A hotel lobby with a large bar area, seating, a fireplace, and framed pictures on the walls.

A hotel room with a bed, bedside lamps, a desk with a sink, and a framed picture on the wall.

A hotel with a clear entrance, a covered waiting area, and a parking lot.

17. Hampton Inn Springfield-Southeast

Galloway Village, 4.9 km from Lester E. Cox Medical Center South

Donna Sue

SAR 441

SAR 500 total

includes taxes & fees

1 Nov - 2 Nov

A modern hotel room with a kitchenette, a flat-screen TV, a bed, and a large window.

A modern kitchen with wooden cabinets, a countertop with various kitchen items, and a wall-mounted shelf with decorative objects.

An outdoor patio area with a stone wall, wooden pergola, and seating arrangements including a sofa and chairs.

A modern hotel room with a dark grey sofa, a wooden side table, a desk with a chair, and two abstract paintings on the walls.

18. SpringHill Suites by Marriott Springfield North

Parkwood, 11.6 km from Lester E. Cox Medical Center South

Amanda

SAR 428

SAR 503 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with two beds, a wooden headboard, bedside tables with lamps, and a small nightstand.

A coffee station with two espresso machines, a coffee press, and various coffee cups and containers.

A conference room with rows of tables and chairs, a flat-screen TV on the wall, and a door in the background.

A gym with treadmills, weight machines, and exercise mats.

19. Holiday Inn Express & Suites Springfield North by IHG

11.8 km from Lester E. Cox Medical Center South

Jerry

SAR 428

SAR 486 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor patio with stone walls, round tables, chairs, and umbrellas.

An indoor swimming pool with clear glass walls, lounge chairs, and a lifeguard chair.

A Fairfield Inn & Suites Marriott hotel with a modern design, featuring a prominent entrance and a parking lot.

A modern living room with a wooden dining table, comfortable seating, a stone accent wall, and a large window.

20. Fairfield Inn & Suites by Marriott Springfield North

Doling, 10.7 km from Lester E. Cox Medical Center South

Kristal

SAR 396

SAR 459 total

includes taxes & fees

25 Oct - 26 Oct

View all properties

Compare popular hotels close to Lester E. Cox Medical Center South

Property	Property class	Guest rating
Hampton Inn Springfield-South	9.4 Exceptional 717 reviews	View
Holiday Inn Express and Suites Springfield Medical District by IHG	9.4 Exceptional 1,003 reviews	View
Homewood Suites by Hilton Springfield Medical District	9.4 Exceptional 566 reviews	View
Candlewood Suites Springfield-Medical District	9.2 Wonderful 434 reviews	View
Element by Marriott Springfield South	9.2 Wonderful 158 reviews	View

Top Lester E. Cox Medical Center South Hotel Reviews

Bass Pro Shops Angler's Lodge

10/10 Excellent

"Easy check in and convenient location"

Holiday Inn Express and Suites Springfield Medical District by IHG

10/10 Excellent

"Nice breakfast"

MainStay Suites Springfield South - Battlefield Rd

8/10 Good

"Clean room. Comfortable beds. Plenty of accomadations. Hot water didn’t last in the shower. Not sure if it was attached to the room next door because we could hear the shower running there too. Figured it was one water heater feeding both rooms."

Comfort Inn South - Springfield

10/10 Excellent

"This is a clean, well located property with multiple tasty breakfast options. There are many stores and restaurants very close by and good access to the main roads for travel."

Sleep Inn Springfield South I60 near Medical District

10/10 Excellent

"The room was cleaned"

Peaceful Retreat near Medical Mile in Springfield

10/10 Excellent

"Soooo clean. Has everything you need!!! Love this property!!! Will be back"

Candlewood Suites Springfield-Medical District

10/10 Excellent

"There was some issues with smells from other unit, people use these for extended stays and must cook alot in them, so we woke up to burning smells throughout the night and early morning."

Comfortable Home Near CoxHealth & MSU - Fenced Yard

10/10 Excellent

"The house was better than described, very comfortable and everything is right there I mean right there, I was pleasantly surprised on how I was able to get ot everything in no time flat, the only thing that was a hike was the airport."

Cozy Central Home by CoxHealth & MSU - Fenced Yard

10/10 Excellent

"Property was clean and properly prepared for our stay. The deck was a wonderful addition for our gatherings."

Frequently asked questions

What's the area like around Lester E. Cox Medical Center South?

Lester E. Cox Medical Center South is located in a welcoming area of Springfield that travelers like for its sporting events and opera houses. If you're looking for a convenient place to stay, check out the 19 hotels and other accommodations you'll find within a mile.

What's the best hotel to stay close to Lester E. Cox Medical Center South?

Residence Inn by Marriott Springfield is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a restaurant. It's located just a short 0.5 mi (0.8 km) from Lester E. Cox Medical Center South. Other good choices close by include The Bradford Hotel, an Ascend Collection Hotel and Extended Stay America Select Suites Springfield South.

How many hotels are there close to Lester E. Cox Medical Center South?

Expedia has 19 hotels and other accommodations within a mile from Lester E. Cox Medical Center South.

If I need to cancel the hotel reservation for my stay near Lester E. Cox Medical Center South, will I receive a refund?

Yes, the majority of hotel room reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the top deals on offer near Lester E. Cox Medical Center South.

Where can I learn more about changing or cancelling my trip in the area near Lester E. Cox Medical Center South?

For more information about picking new dates or cancelling your stay near Lester E. Cox Medical Center South, go to https://www.expedia.com/service/.

What can I see and do near Lester E. Cox Medical Center South?

You'll want to browse the exhibits at Springfield Art Museum and Discovery Center of Springfield. Sights like Abou Ben Adhem Shrine and Landers Theater highlight some of the local culture. You might spend a leisurely day outdoors at Nathanael Greene/Close Memorial Park and Mizumoto Japanese Stroll Garden.

Find hotels near Lester E. Cox Medical Center South, Springfield from SAR 307

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Be picky

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Our top choices for Lester E. Cox Medical Center South hotels

1. Hampton Inn Springfield-South

2. Holiday Inn Express and Suites Springfield Medical District by IHG

3. Homewood Suites by Hilton Springfield Medical District

4. Candlewood Suites Springfield-Medical District

5. Element by Marriott Springfield South

6. Hilton Garden Inn Springfield, MO

7. Residence Inn by Marriott Springfield

8. La Quinta Inn & Suites by Wyndham Springfield South

9. MainStay Suites Springfield South - Battlefield Rd

10. Comfort Inn South - Springfield

11. The Bradford Hotel, an Ascend Collection Hotel

12. Sleep Inn Springfield South I60 near Medical District

13. Extended Stay America Select Suites Springfield South

14. Clarion Pointe Springfield Southeast

15. Hotel Vandivort

16. Drury Inn & Suites Springfield, MO

17. Hampton Inn Springfield-Southeast

18. SpringHill Suites by Marriott Springfield North

19. Holiday Inn Express & Suites Springfield North by IHG

20. Fairfield Inn & Suites by Marriott Springfield North

Compare popular hotels close to Lester E. Cox Medical Center South

Top Lester E. Cox Medical Center South Hotel Reviews

Bass Pro Shops Angler's Lodge

Holiday Inn Express and Suites Springfield Medical District by IHG

MainStay Suites Springfield South - Battlefield Rd

Comfort Inn South - Springfield

Sleep Inn Springfield South I60 near Medical District

Peaceful Retreat near Medical Mile in Springfield

Candlewood Suites Springfield-Medical District

Comfortable Home Near CoxHealth & MSU - Fenced Yard

Cozy Central Home by CoxHealth & MSU - Fenced Yard

Frequently asked questions