"This was my second trip to Tokyo and staying at Shinagawa Prince was the perfect place to be. Shinagawa station is a gateway with its own Shinkansen lines and things like the Narita Express - but the best part about our stay was how CLOSE it was the to the subway station. Shinagawa is also great because it's a good halfway point between Tourist Tokyo (Ueno, Asakusa, etc) and Shibuya/Harajuku/Shinjuku. You have to stay specifically in the North Tower to get the ease of access to the station....