Find hotels in East Prairie, MO from SAR 229

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Compare 83 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1005)
"Will stay again"
The price is SAR 383
SAR 440 total
includes taxes & fees
23 Aug - 24 Aug
Drury Inn & Suites Sikeston, MO

Fairfield Inn & Suites by Marriott Sikeston

2.5 star property
9.8 out of 10, Exceptional, (15)
"Nice hotel "
The price is SAR 446
SAR 505 total
includes taxes & fees
24 Jul - 25 Jul
Fairfield Inn & Suites by Marriott Sikeston

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1005)
"Great place to stay with kids "
The price is SAR 300
SAR 345 total
includes taxes & fees
28 Jul - 29 Jul
Pear Tree Inn Sikeston

Super 8 By Wyndham Marston

2.0 star property
8.0 out of 10, Very Good, (24)
"Perfect for weary travelers. Clean; quiet; safe; friendly night desk lady. "
The price is SAR 359
SAR 410 total
includes taxes & fees
26 Jul - 27 Jul
Super 8 By Wyndham Marston

Hampton Inn Sikeston

2.5 star property
8.8 out of 10, Excellent, (363)
"Clean, great breakfast, quiet, friendly staff"
The price is SAR 443
SAR 502 total
includes taxes & fees
16 Aug - 17 Aug
Hampton Inn Sikeston

Country Hearth Inn & Suites Union City

2.5 star property
8.8 out of 10, Excellent, (525)
"Property is old and very average. Clean w/comfortable beds. "
The price is SAR 270
SAR 321 total
includes taxes & fees
24 Jul - 25 Jul
Country Hearth Inn & Suites Union City

Best Western Plus Sikeston

2.5 star property
8.4 out of 10, Very Good, (1006)
"We enjoyed our stay and the breakfast was good!"
The price is SAR 331
SAR 377 total
includes taxes & fees
10 Aug - 11 Aug
Best Western Plus Sikeston

Quality Inn Union City US 51

2.5 star property
8.4 out of 10, Very Good, (457)
"Quite, clean, and good location."
The price is SAR 252
SAR 299 total
includes taxes & fees
10 Aug - 11 Aug
Quality Inn Union City US 51

Hampton Inn Union City

2.5 star property
9.4 out of 10, Exceptional, (142)
"A well-maintained hotel. "
The price is SAR 421
SAR 500 total
includes taxes & fees
10 Aug - 11 Aug
Hampton Inn Union City

Reelfoot Lake Inn

2.0 star property
7.2 out of 10, Good, (443)
"Staff was amazing and available anytime. Other than incredible bug problem my only real issue is the pet fee is $20 not $10 and having a pet forces you in a smoking room which had i known certainly would have changed my plans. Location though is perfect"
The price is SAR 229
SAR 615 total
includes taxes & fees
1 Aug - 2 Aug
Reelfoot Lake Inn

Holiday Inn Express & Suites Union City by IHG

2.5 star property
9.2 out of 10, Wonderful, (280)
"This hotel was directly across from the Discovery Park of America. Definitely recommend staying there!"
The price is SAR 431
SAR 512 total
includes taxes & fees
22 Aug - 23 Aug
Holiday Inn Express & Suites Union City by IHG

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property
8.4 out of 10, Very Good, (664)
"Property is always clean, rooms are nice."
The price is SAR 263
SAR 300 total
includes taxes & fees
25 Jul - 26 Jul
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sleep Inn at Discovery Park of America

2.5 star property
9.0 out of 10, Wonderful, (251)
"Staff was very friendly and the manager managed to go out of her way to help me get the room I actually paid for. Thanks Sleep In Staff."
The price is SAR 334
SAR 397 total
includes taxes & fees
3 Aug - 4 Aug
Sleep Inn at Discovery Park of America

Quality Inn Cairo I-57

2.5 star property
6.6 out of 10, (262)
"The hotel is in need of some serious upkeep and cleaning. It is in fairly poor condition, but it the only hotel in town."
The price is SAR 274
SAR 304 total
includes taxes & fees
29 Jul - 30 Jul
Quality Inn Cairo I-57

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 star property
8.6 out of 10, Excellent, (416)
"Best free breakfast I’ve had in a long time."
The price is SAR 495
SAR 561 total
includes taxes & fees
3 Aug - 4 Aug
Holiday Inn Express & Suites Sikeston Southwest by IHG

Days Inn and Suites by Wyndham Sikeston

2.0 star property
7.2 out of 10, Good, (1003)
"We were there to get a good nights sleep and we did."
The price is SAR 271
SAR 309 total
includes taxes & fees
27 Jul - 28 Jul
Days Inn and Suites by Wyndham Sikeston

Comfort Inn & Suites Sikeston I-55

2.5 star property
8.4 out of 10, Very Good, (270)
"The facility was very nice. "
The price is SAR 334
SAR 381 total
includes taxes & fees
10 Aug - 11 Aug
Comfort Inn & Suites Sikeston I-55

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
6.6 out of 10, (576)
"Everything worked like it should and bed was comfortable "
The price is SAR 240
SAR 266 total
includes taxes & fees
27 Jul - 28 Jul
Super 8 by Wyndham Charleston/Sikeston East MO

New Orleans Inn Portageville

2.5 star property
8.0 out of 10, Very Good, (672)
"Great stay"
New Orleans Inn Portageville

Quality Inn Charleston - Sikeston

2.5 star property
6.8 out of 10, (392)
"Very friendly and accommodating "
The price is SAR 244
SAR 271 total
includes taxes & fees
29 Jul - 30 Jul
Quality Inn Charleston - Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular East Prairie attractions

Big Oak Tree State Park

Big Oak Tree State Park

4.5/5(3 reviews)

You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.

Learn more about East Prairie

Explore attractions like Big Oak Tree State Park and Mississippi River as you discover things to see and do in East Prairie.

Top East Prairie Hotel Reviews

Frequently asked questions

What's the best place for a stay in East Prairie?

Best Western Plus Sikeston, located 11.1 mi (17.9 km) from the heart of East Prairie, is a top choice for your stay based on our traveler data. Other good options for your visit to the area are Drury Inn & Suites Sikeston, MO and Pear Tree Inn Sikeston. See all available top hotels, or vacation rentals in East Prairie.

What are some of the best vacation rentals that East Prairie has to offer?

The Tackle Box at Reelfoot Lake, 1 bed 1 bath Tiny House Pet Friendly: Visitors like this East Prairie vacation home rental. It is located on a lake and has a fireplace, a barbecue grill, and air-conditioning to put you at ease in your new surroundings. Kitchen amenities include a fridge, a stovetop, and a microwave. See all vacation rentals in East Prairie.

If I need to cancel my hotel reservation in East Prairie, will I receive a refund?

Yes! The majority of hotel room reservations are fully refundable if you cancel before the hotel’s cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.

Where can I learn more about changing or cancelling my trip to East Prairie?

To access more information about rescheduling or cancelling your trip to East Prairie, click here.

What's the best hotel for staying near Cape Girardeau Municipal Airport (CGI)?

Candlewood Suites Cape Girardeau is one of the top choices for your stay and is a popular hotel, featuring an indoor pool and free WiFi. It's located 4.4 mi (7 km) from Cape Girardeau Municipal Airport.

What's it like to stay in East Prairie?

Visitors are sure to enjoy all that East Prairie has to offer. There are 30 hotels and other accommodations in the surrounding area. Find out more about East Prairie.

What should I do while I'm visiting East Prairie?

The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Sikeston Depot Museum and Columbus-Belmont State Park in the area. Check out what more to see and do in Expedia's East Prairie guide.

What's the weather like in East Prairie?

The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for East Prairie is 60 inches.