Depew Vacation Rentals

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Check prices for these dates

In two weeks
27 Nov - 29 Nov
In two months
8 Jan - 10 Jan
In three months
5 Feb - 7 Feb
In four months
5 Mar - 7 Mar

Our top choices for Depew vacation rentals

A grand spiral staircase with stone walls and a piano in the landing area.

1. Waterfront Keystone Lake Gem: Private Dock, Kayaks

Waterfront Keystone Lake Gem: Private Dock, Kayaks
3.0 star property
Mannford
10.0 out of 10, Exceptional, (1 review)
"It was avery cute house with a very well stocked kitchen and other amenities. I will be staying here again. "
United States
Jacqueline
The price is SAR 953
SAR 2,193 total
includes taxes & fees
16 Nov - 17 Nov
Waterfront Keystone Lake Gem: Private Dock, Kayaks
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Find vacation rentals that suit your style

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Top Depew Hotel Reviews

A hotel room with two beds, wooden headboards, bedside tables with lamps, and an air conditioning unit on the wall.
Skyliner Motel

Skyliner Motel

Skyliner Motel
Stroud

10/10 Excellent

Really nice updates to this old motel. New everything! Fresh paint and carpet, bathroom tile, countertop and shower, etc. Very friendly and helpful staff. Delightful stay!
United States
Robert
Reviewed November 12, 2026
Skyliner Motel

Frequently Asked Questions

Can I find a vacation rental in Depew?

Yes, you can find vacation rentals near popular points of interest in Depew, or you can go with a more remote option if you're looking for relaxation.

What's the top vacation rental that Depew has to offer?

Serenity's Sanctuary in this quiet, peaceful 2 bdr 1 bath bungalow. Pet friendly: This vacation home rental outside of Depew offers a patio, a garden, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a fridge, a stovetop, and a microwave. Kick off your shoes and enjoy yourself with a selection of games and a hot tub.

What’s there to see and do in Depew?

While you're exploring the area, Whitlock Park and Way Park are a couple of picturesque spots to get outside and enjoy nature. In the larger area, you’ll find Lake Heyburn State Park and Cushing Country Club.

What’s a vacation rental in Depew like?

A vacation rental is a private property you can stay in for a few weeks or just a few days in Depew. Vacation rentals feature extras such as kitchens and laundry facilities so you'll feel just like you're at home. If you're concerned about a sanitized environment, a vacation rental can offer a sense of privacy away from shared hotel elevators and busy concierge desks while still allowing you the excitement and enjoyment of travel. You'll also get more space in a vacation rental than in a hotel, which makes a vacation rental a great choice for family trips or small group gatherings.