4/5 - Good
Verified traveler
Due to the coronavirus, we didn't really have an opportunity to check out Cape Girardeau, visiting with friends in their home instead. Next time though!
Cape Girardeau, MO
Travel Guide
Visit Cape Girardeau
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is SAR 338 per night from Jun 15 to Jun 16
SAR 338
SAR 381 total
15 Jun - 16 Jun
includes taxes & fees
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,003 reviews)
"Nice property, trouble with reservation due to processing between Expedia/Drury/third party, staff could be friendlier and more professional"
Reviewed on 5 June 2025
The Riverview
777 Main St, Cape Girardeau, MO
The price is SAR 395 per night from Jun 8 to Jun 9
SAR 395
SAR 446 total
8 Jun - 9 Jun
includes taxes & fees
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront Park are ...
9.2/10 Wonderful! (286 reviews)
"It was great!"
Reviewed on 6 June 2025
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street, Cape Girardeau, MO
The price is SAR 371 per night from Jun 22 to Jun 23
SAR 371
SAR 419 total
22 Jun - 23 Jun
includes taxes & fees
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,000 reviews)
"Staff is phenomenal, and the room was very clean, accommodating all my needs."
Reviewed on 31 May 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Quaint, Beautiful Home next to SEMO and Hospital
Cape Girardeau
Stay at this vacation home in Cape Girardeau. Enjoy laundry facilities, an in-room coffeemaker, and in-room fireplaces. Popular attractions Show Me Center and ...
9.8/10 Exceptional! (35 reviews)
Perfect spot
"Quaint, little property with roomy accommodations. So much better than 4 people sharing a hotel room…everyone had their own space. The location was convenient, quiet and the neighborhood felt safe."
Reviewed on 28 May 2025
The Twisted Sassafras Treehouse
Cape Girardeau
Stay at this cabin in Cape Girardeau. Enjoy a garden, patios, and an in-room coffeemaker. Popular attractions Cape Girardeau Conservation Nature Center and Cape ...
Great spot for a romantic retreat!
"My wife and I thoroughly enjoyed our stay here! A beautiful place built on a beautiful property; we enjoyed the hot tub under the stars and the morning coffee on the porch (and another hot tub ). Great place for some R&R, and excellent communication with the owner in advance. Wouldn’t hesitate to ..."
Reviewed on 28 March 2025
Little Blue Cottage on Spanish
Cape Girardeau
Stay at this vacation home in Cape Girardeau. Popular attractions eDen Spa & Salon and The Glenn House are located nearby.
8.4/10 Very Good! (40 reviews)
Reasonable price and close to downtown
"Very easy process and a great location for a convenient stay downtown"
Reviewed on 20 December 2024
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
Southeast Missouri State University
4.5/5(76 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Isle Casino Cape Girardeau
4.5/5(48 reviews)
Why not roll the dice with a visit to Isle Casino Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.
Riverfront Bridge Park
4.5/5(43 reviews)
Riverfront Bridge Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savor the top-notch restaurants.
Saint Francis Medical Center
Though Saint Francis Medical Center might be what brings you to town, perhaps you'll have a chance to explore more of Cape Girardeau while you are here.
Cape Splash Family Aquatic Center
4.5/5(4 reviews)
Bring the family to Cape Splash Family Aquatic Center and enjoy this exciting amusement park in Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Show Me Center
Catch an event at Show Me Center during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Reviews of Cape Girardeau
4.3
Top Destination
5/5 - Excellent
Verified traveler
We appreciated the close proximity of dining options enabling us to walk rather than getting back in the car after a long travel day.
3/5 - Okay
Verified traveler
I live here. Reason for the hotel was so my daughter could swim with her friends. And have a small birthday pool party and get out of the house for a night
5/5 - Excellent
Verified traveler
Just loved it all, the people,place's it was just wonderful..
5/5 - Excellent
Verified traveler
Love this city. Go see the bridge over into IL - beautiful!!! The city is a very pleasant place to visit.
4/5 - Good
Verified traveler
I really enjoyed the Missouri Wall of Fame.
- Southeast Missouri State University
- Isle Casino Cape Girardeau
- Riverfront Bridge Park
- Cape Splash Family Aquatic Center
- Riverfront Park
- Hunter Valley Winery
- eDen Spa & Salon
- Cape Rock Park
- Cape Girardeau Conservation Nature Center
- Lazy L Safari Park
- Fort D Historic Site
- Shawnee National Forest
- Mississippi River
- Trail of Tears State Park