A cityscape with a park, a river, and a large building with a red roof.

Find 5 Star Hotels in Texas Medical Center, TX from SAR 366

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Check availability on Texas Medical Center 5 Star Hotels

Next weekend
13 Nov - 15 Nov
In two weeks
20 Nov - 22 Nov

Our top choices for Texas Medical Center 5-star hotels

A pool area with lounge chairs and palm trees, surrounded by a building with large windows.

1. The Post Oak Hotel at Uptown Houston

The Post Oak Hotel at Uptown Houston
5.0 star property
The Galleria
9.6 out of 10, Exceptional, (1,002 reviews)
"The hotel service was absolutely beautiful, and the accommodations were of the highest quality."
United States
Michael
The price is SAR 1,919
SAR 2,245 total
includes taxes & fees
26 Nov - 27 Nov
The Post Oak Hotel at Uptown Houston
A modern building entrance with a black car parked in front.

2. Four Seasons Hotel Houston

Four Seasons Hotel Houston
5.0 star property
Downtown Houston
9.2 out of 10, Wonderful, (1,000 reviews)
"Very pleasant stay per usual!!!"
United States
Alexander
The price is SAR 2,196
SAR 2,588 total
includes taxes & fees
23 Nov - 24 Nov
Four Seasons Hotel Houston
A rooftop pool area with lounge chairs, a bar, and a view of the city skyline.

3. JW Marriott Houston Downtown

JW Marriott Houston Downtown
5.0 star property
Downtown Houston
9.0 out of 10, Wonderful, (1,000 reviews)
"The hotel was clean, and the staff were great. Perfect location to walk around downtown."
United States
Alyssa
The price is SAR 922
SAR 1,105 total
includes taxes & fees
20 Nov - 21 Nov
JW Marriott Houston Downtown
A grand staircase with a green garland and golden bows, flanked by wooden paneling and framed artwork on the walls.

4. La Colombe d'Or Hotel

La Colombe d'Or Hotel
5.0 star property
Montrose
9.4 out of 10, Exceptional, (223 reviews)
"Excellent place to stay"
United States
Keeshaun
The price is SAR 1,459
SAR 1,707 total
includes taxes & fees
29 Nov - 30 Nov
La Colombe d'Or Hotel
A modern hotel with a large building, a landscaped garden, and a well-lit entrance.

5. Houston Grand Hotel - River Oaks

Houston Grand Hotel - River Oaks
5.0 star property
The Galleria
9.2 out of 10, Wonderful, (525 reviews)
"Great Classic Hotel in Houston"
United States
William
The price is SAR 635
SAR 743 total
includes taxes & fees
22 Nov - 23 Nov
Houston Grand Hotel - River Oaks
A hotel entrance with a red carpet, a staircase, and a door with a wreath.

6. TUSCAN VILLA

TUSCAN VILLA
5.0 star property
Greater Uptown
2.0 out of 10, (3 reviews)
"Would not recommend . We booked on the same day as check in, no one would answer the phone or let you into the property without 72 hours notice. We purchased the Villa for one night due to a flight cancellation, tried phoning multiple times and messaging before check in closed but no one would answer the phone. We couldn’t stay at the property because we had no information on how to get in. We were charged full price and no refund given, I suggest you book somewhere else that has better...
United States
James
TUSCAN VILLA
Living area

7. 7550 Kirby Dr

7550 Kirby Dr
5.0 star property
Braeswood Place
8.2 out of 10, Very good, (43 reviews)
"Perfect place to stay."
United States
kaitlyn
7550 Kirby Dr
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Texas Medical Center.
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

1085 Rusk Street Houston TX
The price is SAR 313 per night from Nov 10 to Nov 11
SAR 313
SAR 366 total
10 Nov - 11 Nov
includes taxes & fees
8.6/10 Excellent! (4,592 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Texas Medical Center Hotel Reviews

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Texas Medical Center?
You'll find a range of pricing options for 5-star hotels in Texas Medical Center on Expedia. How much you'll pay will depend on your vacation dates, length of stay and other factors. Compare available properties for your preferred dates and make use of our pricing and other filters to score the perfect luxury stay.

  • Search for the lowest price per night from SAR 366

What makes a hotel 5 stars in Texas Medical Center?
From gourmet restaurants and 24/7 fitness centers to swimming pools and dreamy bedding, the 5-star experience in Texas Medical Center is all about comfort and luxury. But it takes more than just top-notch amenities to receive a 5-star rating. Accommodations also have to deliver superior services like in-room massage treatments, on-site laundry and 24-hour concierge services.
Are there any 5-star all-inclusive resorts in Texas Medical Center?
Our filter tool is the best way to search for exactly what you want. Select "5-star" and "All inclusive" to see the most luxurious resorts in Texas Medical Center where your meals, accommodations, activities and entertainment are included in the upfront price. At these stays, your vacation is pure extravagance from the moment you check in.