Photo by Jessica Richter

Find 4 Star Hotels in Southeast Missouri, MO

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Compare Southeast Missouri 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Property grounds
Urban Lofts
4.0 star property
Urban Lofts
Front of property
Old Caledonian Bed and Breakfast
4.0 star property
9.8 out of 10, Exceptional, (30)
"This is a beautiful property, and the hosts (Jon and Penny) are wonderful. Jon is a chef who prepares really tasty vegan meals. Highly recommended for a weekend getaway!"
Old Caledonian Bed and Breakfast

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Southeast Missouri?
To book a 4-star hotel in Southeast Missouri that matches your budget, take advantage of Expedia’s handy search filters. Browse the available options during your chosen dates and use our pricing filter to set your limit. You can also list your results by the cheapest stay first.

  • Search for the lowest price

What's the difference between 5-star and 4-star hotels in Southeast Missouri?
Treat yourself to refined living during your Southeast Missouri vacation by choosing a 4-star hotel. As well as featuring upmarket surroundings, these retreats are typically packed with amenities, including complimentary bathrobes, large beds and more. A 5-star hotel will go above and beyond to make your trip an even more lavish and memorable one. 24-hour front desk, on-site spas and gourmet dining are a few of the superior services and conveniences you’ll likely have access to.
Does Southeast Missouri have any 4-star all-inclusive resorts?
Enjoy a stress-free vacation experience where everything is included in the upfront price by using our “All inclusive” filter. Budgeting is easy when your room, meals and many activities are already taken care of. Eager for more ideas? Check out the amazing deals on Expedia’s standard 4-star hotels in and around Southeast Missouri too.
What are the top 4-star apartments in Southeast Missouri?
Make yourself at home at Urban Lofts in Perryville, Southeast Missouri. Our 4-star apartments offer the space and convenience to fully embrace the local culture, while giving you all the necessary comforts for a memorable vacation.