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Compare Isla Grande 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Ordovician Beach Resort
Ordovician Beach Resort
10.0 out of 10, Exceptional, (2)

El Otro Lado
El Otro Lado
9.8 out of 10, Exceptional, (8)

Portobello Historico
Portobello Historico
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Learn more about Isla Grande
Snorkel through crystal-clear waters to spot colorful coral reefs and tropical fish just off the white-sand beaches. Hike to the historic Spanish fort on the island's edge or take boat tours to nearby Portobelo National Park.

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Isla Grande Hotels by Star Rating
Stay near popular Isla Grande attractions
- Hotels near Blanca Beach
- Hotels near Isla Mamey
- Hotels near Playa La Angosta
- Hotels near Chagres National Park
- Hotels near San Felipe Church
- Hotels near Portobelo National Park
- Hotels near Real Aduana de Portobelo
- Hotels near Fuerte San Jerónimo
- Hotels near Fuerte San Fernando
- Hotels near Mirador Perú
- Hotels near Fuerte Santiago
- Hotels near Safarick's Zoo
More Accommodation Types in Isla Grande
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- Cabaña La Punta op het Strand!!
- Casa Dinis - Casa Grande - Centro DE Portobelo
- Piscina Mar en el Paraíso Caribe
- Caribbean Beach House with Pool
- Bala Bliss Charming 2-bedroom apartment with WiFi, AC in Maria Chiquita
- Casa Dinis - Loft - CON Vistas Bahia DE Portobelo
- Alquiler vacacional en Playa Escondida and Marina /Descuento semanal/mensual
- Cara al mar Cacique
- Nice house in Portobelo, Skybluebyguanche
- BEAUTIFUL APARTMENT IN FRONT OF THE SEA
- A fantastic place between the sea and the jungle
- Casa Frente al Mar - Isla Grande
- Caribbean Paradise - Beachfront Getaway
- Pebos Reef with amazing terrace over the sea - apartment #1
- Despierta sobre el mar
- Casa Anzuelo is an oceanfront home that is all about the water and nature.
- Rancho Juancho
- 4-bedroom beachfront paradise in Palenque with AC, pool, walking trail and more!
- ScubaPortobelo
- Perfect getaway to the sea - Family apartment in exclusive Resort