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Compare Eastern Panama 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Ordovician Beach Resort
Ordovician Beach Resort
10.0 out of 10, Exceptional, (1)

Mandalas Ecolodge
Mandalas Ecolodge

El Otro Lado
El Otro Lado
9.8 out of 10, Exceptional, (8)

Portobello Historico
Portobello Historico
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Learn more about Eastern Panama
Explore attractions like Cayos Holandeses and Chagres National Park as you discover things to see and do in Eastern Panama.

Top Eastern Panama Hotel Reviews
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Eastern Panama Hotels by Star Rating
Stay near popular Eastern Panama attractions
- Hotels near Isla Mamey
- Hotels near Cayos Holandeses
- Hotels near Portobelo National Park
- Hotels near Museum of the Kuna Nation
- Hotels near Isla Chichime
- Hotels near Museum
- Hotels near Porvenir Museum
- Hotels near Isla Diablo
- Hotels near Colon Free Zone
- Hotels near Blanca Beach
- Hotels near Chagres National Park
- Hotels near Playa La Angosta
- Hotels near Darien National Park
- Hotels near Limon Bay
- Hotels near Galeta Island Marine Education Center
- Hotels near San Felipe Church
- Hotels near Chepo Regional Hospital
- Hotels near Fuerte San Fernando
- Hotels near Real Aduana de Portobelo
- Hotels near Chepo Youth Recreation Center
More Hotel Options in Eastern Panama
- Adventure Hotels in Eastern Panama
- Beach Hotels in Eastern Panama
- Business Hotels in Eastern Panama
- Family Hotels in Eastern Panama
- Hotel with a Concierge in Eastern Panama
- Hotels with Bars in Eastern Panama
- Hotels with WiFi in Eastern Panama
- Hotels with a Pool in Eastern Panama
- Hotels with smoking rooms in Eastern Panama
- Pet-friendly Hotels in Eastern Panama
More Accommodation Types in Eastern Panama
- Vacation Homes in Eastern Panama
- Cabin Rentals in Eastern Panama
- Houseboats in Eastern Panama
- Apartments in Eastern Panama
- Lodges in Eastern Panama
- Villas in Eastern Panama
- B&B in Eastern Panama
- Hostels in Eastern Panama
- Farmstay in Eastern Panama
- RV Parks in Eastern Panama
- Condo Rentals in Eastern Panama
- Guest Houses in Eastern Panama
Explore more hotels
- Cocoloco - Catamaran Lagoon 52F SAN BLAS
- Private Over-Water Cabins on San Blas Island
- Cabaña La Punta op het Strand!!
- Konsenda San Blas
- Paradise Over the Water Cabins in San Blas
- San Blas Private Oceanfront Cabin
- BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES
- San Blas Private Over-the-Water Cabin
- San Blas Private Beach Cabin
- Casa Anzuelo is an oceanfront home that is all about the water and nature.
- Casa Frente al Mar - Isla Grande
- Private Over-the-Water Cabin in San Blas including Meals
- Cabins in Chichime Island
- Private cabin in San Blas
- Casa Congo - Rayo Verde - Restaurante
- B&B Lodgings
- La Posada del Buzo
- Hotel La 24
- PLEASANT HOSTAL PANAMA
- Spacious Beach House on the ocean front with huge pool and patio.