Search Vacation Homes in St. Charles

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
12 Dec - 14 Dec
In two weeks
19 Dec - 21 Dec
In one month
2 Jan - 4 Jan
In two months
30 Jan - 1 Feb

Vacation Homes in St. Charles

Interior
5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1

Vacation Home in St. Charles Historic District

9.2 out of 10, Wonderful, (12)
"The place wonderful and comfortable! Location was great and convenient. We would use this place again!"
United States
Anthony A.
The price is SAR 334
SAR 899 total
includes taxes & fees
3 Dec - 4 Dec
5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1
Private kitchen
The Below Deck Suite

Vacation Home in Saint Charles

9.0 out of 10, Wonderful, (2)
"Overall good place for a family. The neighborhood is quiet and there is a good amount of space. Easy to find and to get places. You will hear the people upstairs and one bed was very squeaky. It was very clean and the couches are very comfy. "
United States
Amy B.
The price is SAR 372
SAR 886 total
includes taxes & fees
3 Dec - 4 Dec
The Below Deck Suite
Fridge, microwave, oven, stovetop
Adorable 2 King Bed Frenchtown Home

Vacation Home in Saint Charles

2.0 star property
The price is SAR 368
SAR 1,140 total
includes taxes & fees
3 Dec - 4 Dec
Adorable 2 King Bed Frenchtown Home
Private kitchen
The Olive House - Near Main Street- Fully rehabbed

Vacation Home in Saint Charles

8.6 out of 10, Excellent, (8)
"Perfect location for buddies golf trip... clean comfortable house...very helpful host!"
United States
Mark H.
The price is SAR 469
SAR 1,308 total
includes taxes & fees
3 Dec - 4 Dec
The Olive House - Near Main Street- Fully rehabbed
Private kitchen
1st Capitol Mansion - Suite 401

Vacation Home in St. Charles Historic District

8.4 out of 10, Very Good, (7)
"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"
United States
Emily L.
The price is SAR 334
SAR 899 total
includes taxes & fees
3 Dec - 4 Dec
1st Capitol Mansion - Suite 401
Fridge, microwave, oven, stovetop
Saint Charles 2 Bedroom Townhome by StayLage

Vacation Home in Saint Charles

9.2 out of 10, Wonderful, (7)
"We were very happy with our experience. Everything was as advertised, all of the basics were covered for us. Great place to stay. Thanks"
United States
bill r.
The price is SAR 446
SAR 1,182 total
includes taxes & fees
3 Dec - 4 Dec
Saint Charles 2 Bedroom Townhome by StayLage
Paper towels
Saint Charles White House

Vacation Home in Saint Charles

8.6 out of 10, Excellent, (4)
"It was great Needed towels but otherwise great"
United States
Jennifer R.
The price is SAR 1,355
SAR 2,192 total
includes taxes & fees
2 Jan - 3 January 2026
Saint Charles White House
2 bedrooms, desk, iron/ironing board, travel crib
Madison House 1 -Walk to Main St

Vacation Home in St. Charles Historic District

8.6 out of 10, Excellent, (14)
"The house was clean and well stocked, location was great, and plenty of street parking. "
United States
Brad K.
The price is SAR 372
SAR 949 total
includes taxes & fees
14 Dec - 15 Dec
Madison House 1 -Walk to Main St
Dining
Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway

Vacation Home in St. Charles Historic District

9.6 out of 10, Exceptional, (58)
"This is a fun property perfectly located just a couple blocks from Main Street and all its shops and restaurants. Very clean, very comfortable and a nice yard for our dogs.Thanks for sharing your home!"
United States
Barry K.
The price is SAR 503
SAR 1,246 total
includes taxes & fees
3 Dec - 4 Dec
Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway
Fridge, microwave, oven, stovetop
Casa de Saint Charles

Vacation Home in Saint Charles

9.2 out of 10, Wonderful, (17)
"We group of senior ladies thoroughly enjoyed our weekend at Casa de Saint Charles. The accommodations were perfect, inside and out. Our hosts were very accessible and made sure all our wants and needs were taken care of. What a wonderful home! "
United States
Rosalind W.
The price is SAR 394
SAR 1,058 total
includes taxes & fees
3 Dec - 4 Dec
Casa de Saint Charles
Fridge, oven, stovetop, coffee/tea maker
Spacious 2 Bedroom Townhome by StayLage

Vacation Home in Saint Charles

8.6 out of 10, Excellent, (8)
"The place was a good place for me and my husband to stay. We enjoyed the peace. "
United States
Dannia W.
The price is SAR 466
SAR 1,206 total
includes taxes & fees
3 Dec - 4 Dec
Spacious 2 Bedroom Townhome by StayLage
Fridge, microwave, oven, stovetop
2 Bed Townhome w/ Backyard and Laundry by StayLage

Vacation Home in Saint Charles

8.8 out of 10, Excellent, (16)
"Wish we would have had more time to stay a little longer. Will definitely stay again in the future!"
United States
Rebecca O.
The price is SAR 426
SAR 1,156 total
includes taxes & fees
3 Dec - 4 Dec
2 Bed Townhome w/ Backyard and Laundry by StayLage
Microwave, oven, stovetop, dishwasher
Stunning 1890's Home - Sleeps 8!

Vacation Home in St. Charles Historic District

10.0 out of 10, Exceptional, (95)
"Check-in was easy and the house was lovely "
United States
Delfino A.
The price is SAR 379
SAR 1,081 total
includes taxes & fees
3 Dec - 4 Dec
Stunning 1890's Home - Sleeps 8!
Fridge, microwave, oven, stovetop
Victorian Gem Steps from Main St - Sleeps 9 & Pets

Vacation Home in St. Charles Historic District

9.8 out of 10, Exceptional, (21)
"Great location and accommodation for a business trip with some colleagues. Easy to check in and find everything we needed! Super cute and cozy!"
United States
Yvi M.
Victorian Gem Steps from Main St - Sleeps 9 & Pets
Fridge, microwave, oven, stovetop
St. Charles 1860's Gem - Sleeps 6!

Vacation Home in St. Charles Historic District

9.8 out of 10, Exceptional, (132)
"This was such a cute historical home and was perfect for our weekend in St Charles!"
United States
Isabelle C.
The price is SAR 469
SAR 953 total
includes taxes & fees
3 Dec - 4 Dec
St. Charles 1860's Gem - Sleeps 6!
TV
Two King and Two Twin Beds in the Heart of French Town

Vacation Home in St. Charles Historic District

2.0 star property
10.0 out of 10, Exceptional, (1)
"Cute house and great location! "
United States
Courtney A.
The price is SAR 389
SAR 1,188 total
includes taxes & fees
3 Dec - 4 Dec
Two King and Two Twin Beds in the Heart of French Town
Interior
Charming open 4bd and screen-in porch! Sleeps 10!

Vacation Home in Saint Charles

9.2 out of 10, Wonderful, (31)
"House and yard were great! Loved the location."
United States
Jennifer P.
The price is SAR 722
SAR 1,697 total
includes taxes & fees
3 Dec - 4 Dec
Charming open 4bd and screen-in porch! Sleeps 10!
Fridge, microwave, oven, stovetop
The Original Custom House!

Vacation Home in St. Charles Historic District

9.8 out of 10, Exceptional, (35)
"Everything we needed. Only complaint was the couch was very hard. Very accommodating otherwise. Thank you :)"
United States
Rosanna T.
The Original Custom House!
TV
Completely Renovated Home in St. Charles, Missouri

Vacation Home in Saint Charles

2.0 star property
The price is SAR 589
SAR 1,541 total
includes taxes & fees
2 Jan - 3 January 2026
Completely Renovated Home in St. Charles, Missouri
Outdoor dining
Honky Tonk Hideaway

Vacation Home in St. Charles Historic District

8.8 out of 10, Excellent, (12)
"Great location close to historic district."
United States
Hugh S.
The price is SAR 338
SAR 1,105 total
includes taxes & fees
3 Dec - 4 Dec
Honky Tonk Hideaway
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

White Friday Sale

Limited-time deals: Save up to 50% on select hotels
Book now
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top St. Charles Hotel Reviews

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent
"The front desk staff was amazing, they were all very kind and helpful. Our room got upgraded for free with a partial view of the arch. Which made my kids extremely happy. The room was really nice and clean. The food was very good with a great selection. My family will definitely be staying again when we go back to Saint Louis. "
Felicia 1-night trip
Posted 3 days ago
Drury Plaza Hotel St. Louis at the Arch

Explore a world of travel with Expedia