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Find Luxury Hotels in South San Francisco, CA

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Check availability on South San Francisco Luxury Hotels

Our top choices for South San Francisco luxury hotels

Lobby
Travelodge by Wyndham San Francisco Airport North

Travelodge by Wyndham San Francisco Airport North

2.0 star property
South San Francisco
5.8 out of 10, (2902)
"Price and location were great"
United States
Tiber A.
The price is SAR 225
SAR 270 total
includes taxes & fees
14 Dec - 15 Dec
Travelodge by Wyndham San Francisco Airport North
Iron/ironing board, free WiFi, bed sheets, alarm clocks
Hotel Focus SFO

Hotel Focus SFO

3.0 star property
The East Side
7.6 out of 10, Good, (1523)
"Good hotel."
United States
Peter
The price is SAR 289
SAR 341 total
includes taxes & fees
30 Dec - 31 Dec
Hotel Focus SFO
Terrace/patio
Comfort Inn and Suites San Francisco Airport North

Comfort Inn and Suites San Francisco Airport North

2.5 star property
The East Side
7.8 out of 10, Good, (1002)
"Very nice room and staff "
United States
Robert
The price is SAR 348
SAR 410 total
includes taxes & fees
3 Jan - 4 January 2026
Comfort Inn and Suites San Francisco Airport North
Bar (on property)
Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point

3.5 star property
The East Side
8.6 out of 10, Excellent, (1231)
"Everything was just great the amenities the staff the cleanliness the breakfast I had a very relaxing and great time "
United States
Lily
The price is SAR 396
SAR 468 total
includes taxes & fees
9 Jan - 10 January 2026
Embassy Suites by Hilton San Francisco Airport Oyster Point
Exterior
Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North

3.0 star property
The East Side
8.4 out of 10, Very Good, (1009)
"Staff, amenities, clean rooms "
United States
ROMEO JR
The price is SAR 342
SAR 403 total
includes taxes & fees
20 Dec - 21 Dec
Hilton Garden Inn San Francisco Arpt North
Property entrance
Larkspur Landing Extended Stay Suites South San Francisco

Larkspur Landing Extended Stay Suites South San Francisco

3.0 star property
The East Side
7.8 out of 10, Good, (1002)
"The staff and the area is safe and clean"
United States
Em
The price is SAR 345
SAR 408 total
includes taxes & fees
19 Dec - 20 Dec
Larkspur Landing Extended Stay Suites South San Francisco
Lobby
Park Pointe Hotel

Park Pointe Hotel

2.0 star property
South San Francisco
5.8 out of 10, (1005)
"Great place to stay "
United States
shamika
The price is SAR 250
SAR 296 total
includes taxes & fees
10 Dec - 11 Dec
Park Pointe Hotel
Exterior
La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

3.0 star property
Downtown South San Francisco
8.0 out of 10, Very Good, (2008)
"Breakfast is great. Staff is great."
United States
Trina
The price is SAR 405
SAR 475 total
includes taxes & fees
2 Jan - 3 January 2026
La Quinta Inn & Suites by Wyndham San Francisco Airport N
Exterior
Hampton Inn San Francisco Airport

Hampton Inn San Francisco Airport

2.5 star property
The East Side
8.8 out of 10, Excellent, (1005)
"Amazing place, 100% recommend "
United States
Ana catherine
The price is SAR 402
SAR 477 total
includes taxes & fees
1 Jan - 2 January 2026
Hampton Inn San Francisco Airport
Standard Room, 2 Queen Beds | In-room safe, desk, blackout drapes, iron/ironing board
Days Inn by Wyndham San Francisco S/Oyster Point Airport

Days Inn by Wyndham San Francisco S/Oyster Point Airport

2.0 star property
Paradise Valley
6.4 out of 10, (1000)
"Rooms were wonderfully maintained!!"
United States
Thomas
The price is SAR 314
SAR 378 total
includes taxes & fees
13 Dec - 14 Dec
Days Inn by Wyndham San Francisco S/Oyster Point Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top South San Francisco Hotel Reviews

DoubleTree by Hilton Hotel Berkeley Marina

DoubleTree by Hilton Hotel Berkeley Marina

10/10 Excellent
"Staff was courteous "
Nicole 4-night trip
Posted 1 day ago
DoubleTree by Hilton Hotel Berkeley Marina

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Frequently asked questions

Are you searching for a great accommodation for your luxury trip to South San Francisco?
Let Expedia help you arrange your flight to San Francisco Intl. Airport (SFO) airport or Oakland Intl. Airport (OAK) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are important when you plan a vacation, so we make it easy to get what you'd like to make your stay special. If you want an upscale hotel that has fine dining, a spa, or several swimming pools, Expedia can assist you in finding the best luxury hotel experience that South San Francisco offers. During your visit, you might want to enjoy the sightseeing and tours which South San Francisco is known for.
When can I expect good weather in South San Francisco?
Planning for the weather is an important factor for making your trip to South San Francisco a success, especially when you're splurging. The hottest months are usually September and August with an average temp of 62°F, while the coldest months are February and January with an average of 53°F. Average annual precipitation for South San Francisco is 23 inches.
What's there to see and do in South San Francisco?
Take in some sights and attractions while you're in South San Francisco by visiting San Francisco Bay, Santa Cruz Mountains, and See's Candies. If you have spare time during your trip, you might want to make a stop at San Bruno Point Park and K1 Speed.
How can I get around South San Francisco?
It's easier to get around town in style when you know your options. Make your way to South San Francisco Metro Station to catch metro. To see more of the larger area, hop on a train at South San Francisco Station.