Photo by Karen Leone
Find Business Hotels in South San Diego, CA
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on South San Diego Business Hotels
Our top choices for South San Diego business-friendly hotels
Hampton Inn & Suites Imperial Beach San Diego
Imperial Beach
9.4 out of 10, Exceptional, (947)
"Great stay"
Crystal
The price is SAR 417
SAR 476 total
includes taxes & fees
15 Dec - 16 Dec
Pier South Resort, Autograph Collection by Marriott
Imperial Beach
8.4 out of 10, Very Good, (1001)
"Staff was amazing room with the view was just stunning "
Alisa
The price is SAR 589
SAR 757 total
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express San Diego South - Chula Vista by IHG
Chula Vista
9.2 out of 10, Wonderful, (1016)
"room is clean and staff really nice to guest. "
Yu
The price is SAR 484
SAR 533 total
includes taxes & fees
4 Jan - 5 January 2026
Best Western Chula Vista/Otay Valley Hotel
Otay
7.8 out of 10, Good, (1540)
"Great place to stay, staff was fantastic "
Pamela
The price is SAR 380
SAR 418 total
includes taxes & fees
15 Dec - 16 Dec
The Rambler
Chula Vista
9.2 out of 10, Wonderful, (1997)
"Nice staff, good location"
Joshua
The price is SAR 346
SAR 400 total
includes taxes & fees
15 Dec - 16 Dec
Comfort Inn Chula Vista San Diego South
Chula Vista
8.2 out of 10, Very Good, (1236)
"Perfect family hotel "
Lucia
The price is SAR 364
SAR 401 total
includes taxes & fees
21 Dec - 22 Dec
Hercor Hotel - Urban Boutique
Chula Vista
8.6 out of 10, Excellent, (1316)
"Great value and location "
Andrew
The price is SAR 316
SAR 348 total
includes taxes & fees
16 Dec - 17 Dec
La Quinta Inn by Wyndham San Diego Chula Vista
Chula Vista
8.6 out of 10, Excellent, (1495)
"Good for a short stay "
Sandra
The price is SAR 382
SAR 420 total
includes taxes & fees
4 Jan - 5 January 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top South San Diego Hotel Reviews
Embassy Suites by Hilton San Diego La Jolla
10/10 Excellent
Explore a world of travel with Expedia
Top neighborhoods for Business Hotels
Find More Hotels near South San Diego
More Hotel Options in South San Diego
- Adventure Hotels in South San Diego
- Beach Hotels in South San Diego
- Boutique Hotels in South San Diego
- Casinos in South San Diego
- Cheap Hotels in South San Diego
- Family Hotels in South San Diego
- Golf Hotels in South San Diego
- Green Hotels in South San Diego
- Historic Hotels in South San Diego
- Hotel Wedding Venues in South San Diego
- Hotel with a Concierge in South San Diego
- Hotels with Bars in South San Diego
- Hotels with Free Parking in South San Diego
- Hotels with Hot Tubs in South San Diego
- Hotels with WiFi in South San Diego
- Hotels with a Pool in South San Diego
- Hotels with smoking rooms in South San Diego
- Luxury Hotels in South San Diego
- Pet-friendly Hotels in South San Diego
- Resorts & Hotels with Spas in South San Diego
- Romantic Hotels in South San Diego
- Shopping Hotels in South San Diego
- Waterpark Hotels in South San Diego
- Winery Hotels in South San Diego
More Accommodation Types in South San Diego
- Vacation Homes in California
- Condo Rentals in California
- Apartments in California
- Cabin Rentals in California
- Cottages in California
- Villas in California
- Motels in California
- Resorts in California
- Guest Houses in California
- Aparthotels in California
- B&B in California
- Farmstay in California
- Chalets in California
- Lodges in California
- RV Parks in California
- Hostels in California
- Inns in California
- Houseboats in California
- Condo Resorts in California
- Town Houses in California
- Castles in California
- Residences in California
- Holiday Park Resorts in California
- Ranches in California
- Country Houses in California
- Capsule Hotels in California
- Safari Tentalow in California
- Treehouses in California
Hotels near popular South San Diego Attractions
- Hotels near Las Americas Premium Outlets
- Hotels near Sesame Place San Diego
- Hotels near North Island Credit Union Amphitheatre
- Hotels near Chula Vista Center
- Hotels near Chula Vista Elite Athlete Training Center
- Hotels near Sharp Chula Vista Medical Center
- Hotels near Eastlake Country Club
- Hotels near Kaiser Permanente Otay Mesa Medical Offices
- Hotels near Chula Vista Bayside Park
- Hotels near Otay Ranch Town Center
South San Diego Hotels by Star Rating
Explore more hotels
- Sheraton Mission Valley San Diego Hotel
- Courtyard by Marriott San Diego Downtown Little Italy
- Wyndham San Diego Bayside
- Embassy Suites by Hilton San Diego La Jolla
- San Diego Marriott La Jolla
- The Dana on Mission Bay
- The Sofia Hotel
- Kings Inn San Diego
- Hotel del Coronado, Curio Collection by Hilton
- Days Inn by Wyndham San Diego Hotel Circle
- The Bristol Hotel San Diego
- GreenTree Inn San Diego Mission Bay
- DoubleTree by Hilton San Diego - Hotel Circle
- Marriott Marquis San Diego Marina
- Four Points by Sheraton San Diego
- Margaritaville Hotel San Diego Gaslamp Quarter
- Sentral Gaslamp Quarter
- California Suites Hotel
- Wyndham Garden San Diego Near SeaWorld
- Best Western Inn & Suites San Diego – Zoo/SeaWorld Area