Find Business Hotels in South Carolina Midlands, SC
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Top South Carolina Midlands Business Hotels
Baymont by Wyndham Santee
Santee
8.0 out of 10, Very Good, (1407)
"The best stay"
Terez
The price is SAR 281
SAR 312 total
includes taxes & fees
10 Dec - 11 Dec
Howard Johnson by Wyndham Florence
Florence
8.8 out of 10, Excellent, (2486)
"I nice place to stay, very quiet, good breakfast, nice staff, spotless room. "
Timothy
The price is SAR 233
SAR 261 total
includes taxes & fees
10 Dec - 11 Dec
Holiday Inn Express & Suites Newberry by IHG
Newberry
9.0 out of 10, Wonderful, (632)
"Room was clean staff was great !"
R Scott
The price is SAR 319
SAR 345 total
includes taxes & fees
2 Jan - 3 January 2026
Courtyard by Marriott Columbia Cayce
Cayce
9.0 out of 10, Wonderful, (651)
"Room was clean.
staff was very pleasant.
Cafe / Bistro was good and convenient.
Easy parking on site."
joan
The price is SAR 379
SAR 421 total
includes taxes & fees
18 Dec - 19 Dec
Inn on the Square, an Ascend Collection Hotel
Uptown Greenwood
9.2 out of 10, Wonderful, (708)
"It was a very clean and beautiful lace to stay. We were there for our honeymoon "
Tracy
The price is SAR 410
SAR 455 total
includes taxes & fees
4 Jan - 5 January 2026
Tru by Hilton Orangeburg
Orangeburg
9.2 out of 10, Wonderful, (1005)
"Staff are great, room is clean and amenities very amusing "
Salah
The price is SAR 387
SAR 430 total
includes taxes & fees
15 Dec - 16 Dec
Hyatt Place Florence Downtown
Florence
8.8 out of 10, Excellent, (1002)
"Great stay"
Michaelle
The price is SAR 375
SAR 420 total
includes taxes & fees
5 Jan - 6 January 2026
Hilton Garden Inn Columbia/Harbison
Columbia
9.0 out of 10, Wonderful, (1867)
"This property and their staff were lovely!"
Mary
The price is SAR 297
SAR 333 total
includes taxes & fees
4 Jan - 5 January 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top South Carolina Midlands Hotel Reviews
Howard Johnson by Wyndham Florence
10/10 Excellent
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Hotels near popular South Carolina Midlands Attractions
- Hotels near Fort Jackson
- Hotels near University of South Carolina
- Hotels near Carowinds Theme Park
- Hotels near Riverbanks Zoo and Garden
- Hotels near Colonial Life Arena
- Hotels near Williams Brice Stadium
- Hotels near Florence Civic Center
- Hotels near Township Auditorium
- Hotels near Darlington Raceway
- Hotels near Columbia Metropolitan Convention Center
South Carolina Midlands Hotels by Star Rating
Explore more hotels
- Tru By Hilton Columbia Greystone
- Park Inn by Radisson Florence, SC
- La Quinta Inn by Wyndham Columbia NE/Fort Jackson
- Comfort Inn & Suites Florence Center Area
- Springhill Suites by Marriott Columbia near Fort Jackson
- Courtyard by Marriott Columbia Northeast/Fort Jackson Area
- Hyatt Place Columbia/Harbison
- Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG
- Country Inn & Suites by Radisson, Columbia, SC
- Courtyard by Marriott Columbia Downtown at USC
- Comfort Suites Columbia at Harbison
- Marriott Columbia
- Hyatt Place Columbia/Downtown/The Vista
- Tru By Hilton Santee
- Hyatt Place Florence Downtown
- Holiday Inn Columbia - Downtown by IHG
- Hampton Inn Columbia-I-26 Airport
- Baymont by Wyndham Santee
- Clarion Pointe Rock Hill Near University
- Spark by Hilton Rock Hill