Find Luxury Hotels in Otay Mesa, CA

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Check availability on Otay Mesa Luxury Hotels

Tonight
6 Dec - 7 Dec
Tomorrow
7 Dec - 8 Dec
Next weekend
12 Dec - 14 Dec
In two weeks
19 Dec - 21 Dec

Top Otay Mesa Luxury Hotels

Desk, laptop workspace, blackout drapes, iron/ironing board
Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa

2.5 star property
Otay Mesa
7.0 out of 10, Good, (1002)
"Beautiful place "
United States
Joe
The price is SAR 334
SAR 380 total
includes taxes & fees
8 Dec - 9 Dec
Quality Suites San Diego Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Otay Mesa Hotel Reviews

Sheraton San Diego Resort

Sheraton San Diego Resort

10/10 Excellent
"Great view."
David 2-night trip
Posted 1 day ago
Sheraton San Diego Resort

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Frequently asked questions

Are you searching for the perfect hotel for your luxury getaway to Otay Mesa?
Use Expedia to arrange your flight to Tijuana Intl. Airport (TIJ) airport or San Diego Intl. Airport (SAN) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are an important consideration when you plan a vacation, so we make it easy to get what you want to make your stay special. If you want a posh hotel that has fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Otay Mesa has to offer. During your visit, you might want to enjoy the restaurants which Otay Mesa is known for.
What's there to see and do in Otay Mesa?
Enjoy Otay Mesa and visit San Diego Zoo, San Ysidro Border Crossing, and Petco Park. If you have a bit of extra time while you're in the area, you might want to check out Port of San Diego and High Performance Center in Tijuana.