Find Family Hotels in Otay Mesa, CA

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Check availability on Otay Mesa Family Hotels

Tonight
7 Dec - 8 Dec
Tomorrow
8 Dec - 9 Dec
Next weekend
12 Dec - 14 Dec
In two weeks
19 Dec - 21 Dec

Top Otay Mesa Family Hotels

Desk, laptop workspace, blackout drapes, iron/ironing board
Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa

2.5 star property
Otay Mesa
7.0 out of 10, Good, (1002)
"Beautiful place "
United States
Joe
The price is SAR 334
SAR 380 total
includes taxes & fees
8 Dec - 9 Dec
Quality Suites San Diego Otay Mesa
Outdoor pool
Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG

3.5 star property
Mission Valley
7.8 out of 10, Good, (1007)
"Good value Nice place to stay "
United States
John
The price is SAR 319
SAR 368 total
includes taxes & fees
14 Dec - 15 Dec
Crowne Plaza San Diego - Mission Valley by IHG
Outdoor pool, sun loungers
Hilton San Diego Bayfront

Hilton San Diego Bayfront

4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1852)
"Enjoyed my stay"
United States
Brandon
The price is SAR 343
SAR 582 total
includes taxes & fees
20 Dec - 21 Dec
Hilton San Diego Bayfront
3 outdoor pools, open 7:00 AM to 10:00 PM, pool umbrellas, sun loungers
Sheraton San Diego Resort

Sheraton San Diego Resort

4.0 star property
Harbor Island
8.2 out of 10, Very Good, (3176)
"Great stay! "
United States
Melissa
The price is SAR 353
SAR 541 total
includes taxes & fees
28 Dec - 29 Dec
Sheraton San Diego Resort
Exterior
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

4.0 star property
Mission Bay
8.4 out of 10, Very Good, (1567)
"Loved our stay "
United States
Jeremy
The price is SAR 436
SAR 699 total
includes taxes & fees
16 Dec - 17 Dec
Hyatt Regency Mission Bay Spa and Marina
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillowtop beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3.0 star property
Downtown San Diego
8.8 out of 10, Excellent, (717)
"Great staff, great location, great value. "
United States
Juan
The price is SAR 387
SAR 449 total
includes taxes & fees
15 Dec - 16 Dec
The DEXTRO Little Italy, BW Premier Collection
Reception
Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina

3.0 star property
Point Loma
8.8 out of 10, Excellent, (1548)
"Clean room, happy, helpful staff, great resturant. It was the week we needed to get away."
United States
GERALD
The price is SAR 447
SAR 514 total
includes taxes & fees
4 Jan - 5 January 2026
Best Western Plus Island Palms Hotel & Marina
Reception
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

3.0 star property
Downtown San Diego
9.4 out of 10, Exceptional, (1007)
"The room was immaculate, the staff were helpful and friendly and our stay was so wonderful. "
United States
Samantha Erin
The price is SAR 447
SAR 627 total
includes taxes & fees
26 Dec - 27 Dec
Staypineapple, Hotel Z, Gaslamp San Diego
Property amenity
The Monsaraz San Diego, Tapestry Collection by Hilton

The Monsaraz San Diego, Tapestry Collection by Hilton

3.5 star property
Point Loma
8.6 out of 10, Excellent, (613)
"Great hotel "
United States
Judy
The price is SAR 477
SAR 549 total
includes taxes & fees
14 Dec - 15 Dec
The Monsaraz San Diego, Tapestry Collection by Hilton
Exterior
Hilton Garden Inn San Diego Old Town/SeaWorld Area

Hilton Garden Inn San Diego Old Town/SeaWorld Area

3.0 star property
Old Town San Diego
8.6 out of 10, Excellent, (1281)
"Good location, the room was specious and clean. We really enjoyed our stay!"
United States
Yana
The price is SAR 381
SAR 438 total
includes taxes & fees
18 Dec - 19 Dec
Hilton Garden Inn San Diego Old Town/SeaWorld Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Otay Mesa Hotel Reviews

Sheraton San Diego Resort

Sheraton San Diego Resort

10/10 Excellent
"Great view."
David 2-night trip
Posted 2 days ago
Sheraton San Diego Resort

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Frequently asked questions

What's Otay Mesa like for family-friendly vacations?
If you've been thinking about a trip with your kids, the culturally rich destination of Otay Mesa is a good choice. The beaches, sporting events, and restaurants are just some of the things that make this an attractive family vacation spot. Take to the air and fly into Tijuana Intl. Airport (TIJ), which is the closest airport, or San Diego Intl. Airport (SAN), which is located 17.7 mi (28.4 km) from the center of Otay Mesa.
What's there to see and do with your family in Otay Mesa?
Petco Park and High Performance Center in Tijuana are interesting attractions you and your family might enjoy exploring while you are staying in Otay Mesa. Make sure you have plenty of time to take in activities in the area like San Diego Zoo, San Ysidro Border Crossing, and Port of San Diego.