Find Resorts & Hotels with Spas in Downtown Cincinnati, OH

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Downtown Cincinnati Resorts & Hotels with Spas

Tonight
7 Dec - 8 Dec
Tomorrow
8 Dec - 9 Dec
Next weekend
12 Dec - 14 Dec
In two weeks
19 Dec - 21 Dec

Top Downtown Cincinnati Resorts & Hotels with Spas

Body treatments, hydrotherapy, hot stone massages, deep-tissue massages
21c Museum Hotel Cincinnati

21c Museum Hotel Cincinnati

4.5 star property
Downtown Cincinnati
8.6 out of 10, Excellent, (1006)
"Very clean rooms, great bar, friendly staff."
United States
Theodore
The price is SAR 539
SAR 662 total
includes taxes & fees
2 Jan - 3 January 2026
21c Museum Hotel Cincinnati
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Downtown Cincinnati Hotel Reviews

21c Museum Hotel Cincinnati

21c Museum Hotel Cincinnati

10/10 Excellent
"Beautiful stay in 21C. The only thing that was unusual was the amount of time it took to be served Brunch on Sunday. They were severely understaffed. "
Ellen 1-night trip
Posted 3 days ago
21c Museum Hotel Cincinnati

Explore a world of travel with Expedia

Frequently asked questions

Looking for a spa hotel in Downtown Cincinnati?
Forget the stress of everyday life and book yourself a hotel with a spa. Travelers highly recommend the restaurants in Downtown Cincinnati. Take in the culture at the museums and art galleries during your stay. Hotels with spas are the perfect way to take a break from your daily routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Downtown Cincinnati?
21c Museum Hotel Cincinnati is a top luxury spa hotel featuring a 24-hour fitness center, a bar, and a restaurant. Enjoy a facial, body scrub, or Swedish massage at the onsite spa.
How many spa hotels will I find in Downtown Cincinnati?
Among Expedia's 372 accommodation options in Downtown Cincinnati, there is 1 spa hotel.
What's there to see and do in Downtown Cincinnati?
Enjoy Downtown Cincinnati and visit Fountain Square, Paycor Stadium, and National Underground Railroad Freedom Center. If you have extra time while you're in the area, you might want to stop by The Andrew J Brady Music Center and Aronoff Center for the Arts.
What is a Downtown Cincinnati spa hotel?
Spa hotels in Downtown Cincinnati provide lodging and have an on-site spa offering services such as therapies as well as beauty treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.