Find Family Hotels in Charleston, MO

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Charleston Family Hotels

Our top choices for Charleston family-friendly hotels

Front of property - evening/night
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
Charleston
6.6 out of 10, (612)
"Staff was great! Room was nice. "
United States
Lana
The price is SAR 233
SAR 259 total
includes taxes & fees
14 Dec - 15 Dec
Super 8 by Wyndham Charleston/Sikeston East MO
Desk, laptop workspace, blackout drapes, iron/ironing board
Quality Inn Charleston - Sikeston

Quality Inn Charleston - Sikeston

2.5 star property
Charleston
6.8 out of 10, (406)
"The staff was very friendly and accommodating "
United States
Arturo
The price is SAR 245
SAR 272 total
includes taxes & fees
27 Dec - 28 Dec
Quality Inn Charleston - Sikeston
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1003)
"Clean room, great location and friendly staff"
United States
Mark
The price is SAR 338
SAR 388 total
includes taxes & fees
14 Dec - 15 Dec
Drury Inn & Suites Sikeston, MO
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1005)
"I liked how comfortable the beds and pillows were."
United States
Christine
The price is SAR 263
SAR 296 total
includes taxes & fees
15 Dec - 16 Dec
Pear Tree Inn Cape Girardeau Near the Medical Center
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1001)
"Great place and staff, very accommodating!"
United States
Megan
The price is SAR 338
SAR 381 total
includes taxes & fees
16 Dec - 17 Dec
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1002)
"Everything was clean, staff was friendly "
United States
Matthew
The price is SAR 281
SAR 324 total
includes taxes & fees
7 Jan - 8 January 2026
Pear Tree Inn Sikeston
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (139)
"Nice hotel, clean and comfortable "
United States
Laura
The price is SAR 330
SAR 373 total
includes taxes & fees
21 Dec - 22 Dec
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby
Quality Inn Cairo I-57

Quality Inn Cairo I-57

2.5 star property
Cairo
6.6 out of 10, (273)
"Break fast was excellent "
United States
Uma
The price is SAR 269
SAR 298 total
includes taxes & fees
27 Dec - 28 Dec
Quality Inn Cairo I-57
Property amenity
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 star property
Cape Girardeau
8.2 out of 10, Very Good, (880)
"Clean room, low noise and very comfortable!"
United States
Richard
The price is SAR 263
SAR 317 total
includes taxes & fees
14 Dec - 15 Dec
Candlewood Suites Cape Girardeau by IHG
Fridge, microwave, oven, stovetop
Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space

Cape Girardeau
10.0 out of 10, Exceptional, (148)
"Such a great place and location"
United States
Tracy H.
The price is SAR 563
SAR 919 total
includes taxes & fees
10 Dec - 11 Dec
Serenity South -- Gardens, River-Views, and Refreshing Space
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Charleston Hotel Reviews

Best Western Plus Sikeston

Best Western Plus Sikeston

10/10 Excellent
"Easy parking , quiet and comfortable bed , we’ll stop again on our way back "
joseph 1-night trip
Posted 2 days ago
Best Western Plus Sikeston

Explore a world of travel with Expedia

Frequently asked questions

What's Charleston like for family-friendly vacations?
The destination of Charleston is a good option if you've been considering a getaway with the kids. The entertainment, theaters, and restaurants are just a few things that make this an attractive family vacation spot. Arrange a flight into Cairo, IL (CIR-Cairo Regional), which is located 11.8 mi (19 km) from the city center.
When's the best time to book a family-friendly vacation in Charleston?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Charleston is 59 inches.
What's there to see and do with your family in Charleston?
While you and the family are vacationing in Charleston, you might want to check out some of the attractions here such as Front Street Studio & Art Gallery, Mississippi River, and Ohio River. Make sure you have lots of time for activities like Shawnee National Forest and Ohio River Valley.