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Find Family Hotels in Cape Girardeau, MO

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Check availability on Cape Girardeau Family Hotels

Tonight
8 Dec - 9 Dec
Tomorrow
9 Dec - 10 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

Top Cape Girardeau Family Hotels

Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1001)
"Great place and staff, very accommodating!"
United States
Megan
The price is SAR 338
SAR 381 total
includes taxes & fees
14 Dec - 15 Dec
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (139)
"Nice hotel, clean and comfortable "
United States
Laura
The price is SAR 330
SAR 373 total
includes taxes & fees
18 Dec - 19 Dec
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1005)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is SAR 263
SAR 296 total
includes taxes & fees
14 Dec - 15 Dec
Pear Tree Inn Cape Girardeau Near the Medical Center
Property amenity
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 star property
Cape Girardeau
8.2 out of 10, Very Good, (878)
"Clean room, low noise and very comfortable!"
United States
Richard
The price is SAR 263
SAR 317 total
includes taxes & fees
14 Dec - 15 Dec
Candlewood Suites Cape Girardeau by IHG
Fridge, microwave, oven, stovetop
Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space

Cape Girardeau
10.0 out of 10, Exceptional, (148)
"Such a great place and location"
United States
Tracy H.
The price is SAR 563
SAR 919 total
includes taxes & fees
10 Dec - 11 Dec
Serenity South -- Gardens, River-Views, and Refreshing Space
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1004)
"Great stay"
United States
Heather
The price is SAR 263
SAR 296 total
includes taxes & fees
14 Dec - 15 Dec
Pear Tree Inn Cape Girardeau West
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
Jackson
8.8 out of 10, Excellent, (661)
"Great place "
United States
GUY
The price is SAR 294
SAR 318 total
includes taxes & fees
4 Jan - 5 January 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Free daily on-the-go breakfast
Hotel 7 Inn Anna

Hotel 7 Inn Anna

2.5 star property
Anna
6.6 out of 10, (217)
"The staff was wonderful"
United States
Donna
The price is SAR 329
SAR 382 total
includes taxes & fees
10 Dec - 11 Dec
Hotel 7 Inn Anna
Outdoor dining
Beautiful location in the secluded woods

Beautiful location in the secluded woods

Pomona
10.0 out of 10, Exceptional, (60)
"It was very nice and clean. We really enjoyed staying there. We would love to rent this place again. "
United States
susan B.
The price is SAR 335
SAR 633 total
includes taxes & fees
10 Dec - 11 Dec
Beautiful location in the secluded woods
Terrace/patio
Contemporary Glamping with Native American Appeal

Contemporary Glamping with Native American Appeal

Anna
9.8 out of 10, Exceptional, (155)
"Our 2nd time staying here and it was perfect"
United States
machelle p.
Contemporary Glamping with Native American Appeal
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cape Girardeau Hotel Reviews

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

10/10 Excellent
"Very nice staff and very clean"
Jacquelyn 1-night trip
Posted 5 days ago
Pear Tree Inn Cape Girardeau Near the Medical Center

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Frequently asked questions

What's Cape Girardeau like for family-friendly vacations?
You might want to consider the historic destination of Cape Girardeau if you've been thinking about a trip for the whole family. The restaurants here makes this an attractive vacation spot for families. Fly into Cape Girardeau, MO (CGI-Cape Girardeau Municipal), which is the closest airport, or Cairo, IL (CIR-Cairo Regional), which is located 23.4 mi (37.6 km) from the city center.
What's the best accommodation for a family vacation to Cape Girardeau?
Drury Plaza Hotel Cape Girardeau Conference Center is a hotel with an indoor pool and a restaurant, and it's a top choice on Expedia for families. Other good options for your family trip include Pear Tree Inn Cape Girardeau West and Pear Tree Inn Cape Girardeau Near the Medical Center.
When's the best time to book a family-friendly vacation in Cape Girardeau?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 40°F. Average annual precipitation for Cape Girardeau is 59 inches.
What's there to see and do with your family in Cape Girardeau?
While you and your family are visiting Cape Girardeau, you might want to check out some kid-friendly attractions such as Show Me Center, Cape Splash Family Aquatic Center, and The Glenn House. Make sure you have lots of time for activities like Cape Girardeau Conservation Nature Center and Lazy L Safari Park.